Avidin-dendrimer-(1B4M-Gd)254: A tumor-targeting therapeutic agent for gadolinium neutron capture therapy of intraperitoneal disseminated tumor which can be monitored by MRI

Bioconjugate Chemistry

Volumn 12, Issue 4, 2001, Pages 587-593

  Kobayashi, H ^a   Kawamoto, S ^b   Saga, T ^c   Sato, N ^c   Ishimori, T ^c   Konishi, J ^c   Ono, K ^d   Togashi, K ^a   Brechbiel, M W ^e  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OTSU MUNICIPAL HOSPITAL   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d KYOTO UNIVERSITY   (Japan)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATOMS; DENDRIMERS; DISEASES; GADOLINIUM COMPOUNDS; GLYCOPROTEINS; MAGNETIC RESONANCE IMAGING; NEUTRON IRRADIATION; NEUTRONS; ONCOLOGY;

BIODISTRIBUTIONS; GADOLINIA; GD-DTPA; IN-VITRO; INTRAPERITONEAL; LATE STAGE; NEUTRON CAPTURE THERAPY; PERITONEAL CARCINOMATOSIS; THERAPEUTIC AGENTS; TUMOR-TARGETING;

TUMORS;

ANIMALIA; MUS MUSCULUS;

EID: 0034924638     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc010002o     Document Type: Article

References (31)

1. Boron neutron capture therapy for cancer
2. Principles and history of neutron capture therapy
3. New horizons for therapy based on the boron neutron capture reaction
4. Transport calculations of depth-dose distributions for gadolinium neutron capture therapy
5. Suppression of rabbit VX-2 subcutaneous tumor growth by gadolinium neutron capture therapy
6. Electron-equivalent dose for the effect of gadolinium neutron capture therapy on the growth of subcutaneously inoculated Ehrlich tumor cells in mice
7. Induction of double-strand breaks following neutron capture by DNA-bound 157Gd
8. Neutron capture therapy with gadopentetate dimeglumine: Experiments on tumor-bearing rats
9. Gadolinium neutron capture therapy (GdNCT) of melanoma cells and solid tumors with the magnetic resonance imaging contrast agent Gadobutrol
10. Gadolinium(III) chelates as MRI contrast agents: Structure, dynamics, and applications
11. 3D-micro-MR angiography of mice using macromolecular MR contrast agents with polyamidoamine dendrimer core with references to their pharmacokinetic properties
12. Targeted radiotherapy using Auger electron emitters
13. Biodistribution of gadolinium incorporated in lipid emulsions intraperitoneally administered for neutron-capture therapy with tumor-bearing hamsters
14. Imaging of intraperitoneal tumors with technetium-99m GSA
15. The relationship of glycosylation and isoelectric point with tumor accumulation of avidin
16. Avidin targeting of intraperitoneal tumor xenografts
17. Improved clearance of radiolabeled biotinylated monoclonal antibody following the infusion of avidin as a chase without decreased accumulation in the target tumor
18. Starburst dendrimers: Molecular-level control of size, shape, surface chemistry, topology, and flexibility from atoms to macroscopic matter
19. Metal-chelate-dendrimer-antibody constructs for use in radioimmunotherapy and imaging
20. Starburst dendrimers: Enhanced performance and flexibility for immunoassays
21. Boronated starburst dendrimer-monoclonal antibody immunoconjugates: Evaluation as a potential delivery system for neutron capture therapy
22. Evaluation of the in vivo biodistribution of indium-111 and yttrium-88 labeled dendrimer-1B4M-DTPA and its conjugation with antiTac monoclonal antibody
23. Dendrimer-based metal chelates: A new class of magnetic resonance imaging contrast agents
24. Evaluation of the effects of intravascular MR contrast media (gadolinium dendrimer) on 3D time-of-flight magnetic resonance angiography of the body
25. Avidin
26. Methods to avoid adverse effect of circulating antigen on biodistribution of 125I-labeled antiTac dsFv: Preinjection of intact antibody versus clearance of antigen with adivin-biotin system
27. Scintigraphic detection of neural-cell-derived small-cell lung cancer using glioma-specific antibody
28. Comparison of the macromolecular MR contrast agents with ethylenediamine-core versus ammonia-core generation-6 polyamidoamine dendrimer
29. Neutron-capture therapy of murine ascites tumor with gadolinium-containing microcapsules
30. Comparison of radiation effects of gadolinium and boron neutron capture reactions
31. Gd-DTPA relaxivity depends on macromolecular content