Biodegradable dendritic positron-emitting nanoprobes for the noninvasive imaging of angiogenesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 3, 2009, Pages 685-690

  Almutairi, Adah ^a   Rossin, Raffaella ^b   Shokeen, Monica ^b   Hagooly, Aviv ^b   Ananth, Ashwin ^b   Capoccia, Benjamin ^b   Guillaudeu, Steve ^a   Abendschein, Dana ^b   Anderson, Carolyn J ^b   Welch, Michael J ^b   Fréchet, Jean M J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

Dendrimer; Molecular imaging

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; BROMINE 76; BROMINE 77; CYSTEINYLARGINYLGLYCYLASPARTYLCYSTEINE; HALOGEN; IMIDAZOLE DERIVATIVE; INTEGRIN RECEPTOR; IODINE 123; IODINE 124; IODINE 125; IODINE 131; LYSYLCYSTEINYLARGINYLGLYCYLASPARTYLCYSTEINE; MACROGOL; PENTAERYTHRITOL; PEPTIDE; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BIODEGRADABILITY; BIOENGINEERING; CELL TRANSPORT; CONTROLLED STUDY; DEHALOGENATION; DIAGNOSTIC IMAGING; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG EXCRETION; DRUG HALF LIFE; DRUG STABILITY; DRUG UPTAKE; ENDOCYTOSIS; FEMORAL ARTERY; GENE OVEREXPRESSION; HINDLIMB; HUMAN; HUMAN CELL; IC 50; ISOTOPE LABELING; KIDNEY TUBULE ABSORPTION; LEG ISCHEMIA; LIGHT SCATTERING; MALE; MOUSE; MUSCLE ISCHEMIA; NANOPROBE; NON INVASIVE PROCEDURE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN TARGETING; RECEPTOR BINDING;

ANIMALS; DENDRIMERS; HINDLIMB; INTEGRIN ALPHAVBETA3; ISCHEMIA; MALE; MICE; MICE, INBRED C57BL; NANOTECHNOLOGY; NEOVASCULARIZATION, PHYSIOLOGIC; OLIGOPEPTIDES; POLYETHYLENE GLYCOLS; POSITRON-EMISSION TOMOGRAPHY; TISSUE DISTRIBUTION;

MURINAE;

EID: 58849120616     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0811757106     Document Type: Article

References (24)

1. Couvreur P, Vauthier C (2006) Nanotechnology: Intelligent design to treat complex disease. Pharmacol Res 23:1417-1450.
2. Dobrucki LW, Sinusas AJ (2007) Imaging angiogenesis. Curr Opin Biotechnol 18:90-96.
3. Sinusas AJ (2004) Imaging of angiogenesis. J Nucl Cardiol 11:617-633.
4. Carlson CB, Mowery P, Owen RM, Dykhuizen EC, Kiessling LL (2007) Selective tumor cell targeting using low-affinity, multivalent interactions. ACS Chem Biol 2:119-127.
5. Dobrucki LW, Sinusas AJ (2005) Molecular imaging - new approach to nuclear cardiology. Q J Nucl Med Mol Imaging 49:106-115.
6. Almutairi A, Guillaudeu SJ, Berezin MY, Achilefu S, Fréchet JMJ (2008) Biodegradable pH-sensing dendritic nanoprobes for near-infrared fluorescence lifetime and intensity imaging. J Am Chem Soc 130:444-445.
7. Gillies ER, Dy E, Fréchet JMJ, Szoka FC (2005) Biological evaluation of polyester dendrimer: Poly(ethylene oxide) "bow-tie" hybrids with tunable molecular weight and architecture. Mol Pharmacol 2:129-138.
8. Dijkgraaf I, et al. (2007) Synthesis of DOTA-conjugated multivalent cyclic-RGD peptide dendrimers via 1,3-dipolar cycloaddition and their biological evaluation: Implications for tumor targeting and tumor imaging purposes. Org Biomol Chem 5:935-944.
9. Weissleder R, Mahmood U (2001) Molecular imaging. Radiology 219:316-333.
10. Lee CC, MacKay JA, Fréchet JMJ, Szoka FC (2005) Designing dendrimers for biological applications. Nat Biotechnol 23:1517-1526.
11. Gillies ER, Fréchet JMJ (2005) Dendrimers and dendritic polymers in drug delivery. Drug Discovery Today 10:35-43.
12. Lee CC, et al. (2006) A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas. Proc Natl Acad Sci USA 103:16649-16654.
13. DeJesus OLP, Ihre HR, Gagne L, Fréchet JMJ, Szoka FC (2002) Polyester dendritic systems for drug delivery applications: In vitro and in vivo evaluation. Bioconjugate Chem 13:453-461.
14. Adam MJ, Wilbur DS (2005) Radiohalogens for imaging and therapy. Chem Soc Rev 34:153-163.
15. Gillies ER, Fréchet JMJ (2002) Designing macromolecules for therapeutic applications: Polyester dendrimer-poly(ethylene oxide) "bow-tie" hybrids with tunable molecular weight and architecture. J Am Chem Soc 124:14137-14146.
16. Jeppesen C, et al. (2001) Impact of polymer tether length on multiple ligand-receptor bond formation. Science 293:465-468.
17. Yamada T, Kidera A (1996) Tailoring echistatin to possess higher affinity for integrin alpha(IIb)beta(3). FEBS Lett 387:11-15.
18. Zhang MR, Suzuki K (2007) F-18 fluoroalkyl agents: Synthesis, reactivity and application for development of PET ligands in molecular imaging. Curr Top Med Chem 7:1817-1828.
19. Sprague JE, et al. 2007) Noninvasive imaging of osteoclasts in parathyroid hormone-induced osteolysis using a Cu-64-labeled RGD peptide. J Nucl Med 48:311-318.
20. Romanov V, et al. (1997) Two novel probes reveal tubular and vascular Arg-Gly-Asp (RGD) binding sites in the ischemic rat kidney. Kidney Int 52:93-102.
21. Rossin R, Berndorff D, Friebe M, Dinkelborg LM, Welch MJ (2007) Small-animal PET of tumor angiogenesis using a Br-76-labeled human recombinant antibody fragment to the ED-B domain of fibronectin. J Nucl Med 48:1172-1179.
22. Guillaudeu SJ, et al. (2008) PEGylated dendrimers with core functionality for biological applications. Bioconjugate Chem 19:461-469.
23. Couffinhal T, et al. (1998) Mouse model of angiogenesis. American Journal of Pathology 152(6):1667-1679.
24. Hua J, et al. (2005) Noninvasive imaging of angiogenesis with a Tc-99m-labeled peptide targeted at alpha(v) beta(3) integrin after murine hindlimb ischemia. Circulation 111:3255-3260.