Monoclonal antibody-dendrimer conjugates enable radiolabeling of antibody with markedly high specific activity with minimal loss of immunoreactivity

European Journal of Nuclear Medicine

Volumn 27, Issue 9, 2000, Pages 1334-1339

  Kobayashi, Hisataka ^a   Sato, Noriko ^a   Saga, Tsuneo ^a   Nakamoto, Yuji ^a   Ishimori, Takayoshi ^a   Toyama, Sakuji ^b   Togashi, Kaori ^a   Konishi, Junji ^a   Brechbiel, Martin W ^c  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Antibody; Dendrimer; Gadolinium; Indium

Indexed keywords

DENDRIMER; GADOLINIUM 153; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; INDIUM 111; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY OST7; PENTETIC ACID; POLYAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER GRAFT; CANCER IMMUNOTHERAPY; CONJUGATION; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DISTRIBUTION; FEMALE; IMMUNOREACTIVITY; ISOTOPE LABELING; MOUSE; NONHUMAN; RADIOIMMUNOTHERAPY;

ANIMALS; ANTIBODIES, MONOCLONAL; FEMALE; GADOLINIUM; INDIUM RADIOISOTOPES; ISOTOPE LABELING; MICE; MICE, INBRED BALB C; NEOPLASMS, EXPERIMENTAL; POLYAMINES; RADIOIMMUNOTHERAPY; TISSUE DISTRIBUTION;

EID: 0033866567     PISSN: 03406997     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002590000293     Document Type: Article

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