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Volumn 3, Issue 2, 2011, Pages 2195-2213

Harnessing dendritic cells for tumor antigen presentation stefan

Author keywords

Antigen presentation; Antigen processing; Dendritic cell; Tumor antigen

Indexed keywords

ADENOVIRUS VECTOR; CYCLOPHOSPHAMIDE; DENDRITIC CELL VACCINE; DENILEUKIN DIFTITOX; DNA; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; TUMOR ANTIGEN;

EID: 79959726017     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers3022195     Document Type: Review
Times cited : (10)

References (135)
  • 1
    • 0026481133 scopus 로고
    • Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
    • Inaba, K.; Inaba, M.; Romani, N.; Aya, H.; Deguchi, M.; Ikehara, S.; Muramatsu, S.; Steinman, R.M. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 1992, 176, 1693-1702.
    • (1992) J. Exp. Med , vol.176 , pp. 1693-1702
    • Inaba, K.1    Inaba, M.2    Romani, N.3    Aya, H.4    Deguchi, M.5    Ikehara, S.6    Muramatsu, S.7    Steinman, R.M.8
  • 2
    • 17144417748 scopus 로고    scopus 로고
    • Dendritic cells as therapeutic vaccines against cancer
    • Banchereau, J.; Palucka, A.K. Dendritic cells as therapeutic vaccines against cancer. Nat. Rev. Immunol. 2005, 5, 296-306.
    • (2005) Nat. Rev. Immunol , vol.5 , pp. 296-306
    • Banchereau, J.1    Palucka, A.K.2
  • 3
    • 14844331400 scopus 로고    scopus 로고
    • Dendritic-cell-based therapeutic vaccination against cancer
    • Nestle, F.O.; Farkas, A.; Conrad, C. Dendritic-cell-based therapeutic vaccination against cancer. Curr. Opin. Immunol. 2005, 17, 163-169.
    • (2005) Curr. Opin. Immunol , vol.17 , pp. 163-169
    • Nestle, F.O.1    Farkas, A.2    Conrad, C.3
  • 6
    • 0030603986 scopus 로고    scopus 로고
    • Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood
    • Bender, A.; Sapp, M.; Schuler, G.; Steinman, R.M.; Bhardwaj, N. Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood. J. Immunol. Methods 1996, 196, 121-135.
    • (1996) J. Immunol. Methods , vol.196 , pp. 121-135
    • Bender, A.1    Sapp, M.2    Schuler, G.3    Steinman, R.M.4    Bhardwaj, N.5
  • 8
    • 79959761645 scopus 로고    scopus 로고
    • Clinical Trials. gov database, accessed 20 April 2011
    • Clinical Trials. gov database. http://www.clinicaltrials.gov/ (accessed 20 April 2011).
  • 9
    • 77955437801 scopus 로고    scopus 로고
    • The expanding family of dendritic cell subsets
    • Ueno, H.; Palucka, A.K.; Banchereau, J. The expanding family of dendritic cell subsets. Nat. Biotechnol. 2010, 28, 813-815.
    • (2010) Nat. Biotechnol , vol.28 , pp. 813-815
    • Ueno, H.1    Palucka, A.K.2    Banchereau, J.3
  • 10
    • 34547449658 scopus 로고    scopus 로고
    • A full scale comparative study of methods for generation of functional dendritic cells for use as cancer vaccines
    • Jarnjak-Jankovic, S.; Hammerstad, H.; Saeboe-Larssen, S.; Kvalheim, G.; Gaudernack, G. A full scale comparative study of methods for generation of functional dendritic cells for use as cancer vaccines. BMC Cancer 2007, 7, 119.
    • (2007) BMC Cancer , vol.7 , pp. 119
    • Jarnjak-Jankovic, S.1    Hammerstad, H.2    Saeboe-Larssen, S.3    Kvalheim, G.4    Gaudernack, G.5
  • 11
    • 44449088893 scopus 로고    scopus 로고
    • Differentiation of peripheral blood monocytes into dendritic cells
    • 10.1002/0471142735.im22f04s67
    • Oneill, D.W.; Bhardwaj, N. Differentiation of peripheral blood monocytes into dendritic cells. Curr. Protoc. Immunol. 2005, doi: 10.1002/0471142735.im22f04s67.
    • (2005) Curr. Protoc. Immunol
    • Oneill, D.W.1    Bhardwaj, N.2
  • 12
    • 0036378101 scopus 로고    scopus 로고
    • Immature, but not inactive: The tolerogenic function of immature dendritic cells
    • Mahnke, K.; Schmitt, E.; Bonifaz, L.; Enk, A.H.; Jonuleit, H. Immature, but not inactive: The tolerogenic function of immature dendritic cells. Immunol. Cell. Biol. 2002, 80, 477-483.
    • (2002) Immunol. Cell. Biol , vol.80 , pp. 477-483
    • Mahnke, K.1    Schmitt, E.2    Bonifaz, L.3    Enk, A.H.4    Jonuleit, H.5
  • 13
    • 35549004528 scopus 로고    scopus 로고
    • Balancing between immunity and tolerance: An interplay between dendritic cells, regulatory T cells, and effector T cells
    • Cools, N.; Ponsaerts, P.; Van Tendeloo, V.F.; Berneman, Z.N. Balancing between immunity and tolerance: An interplay between dendritic cells, regulatory T cells, and effector T cells. J. Leukoc. Biol. 2007, 82, 1365-1374.
    • (2007) J. Leukoc. Biol , vol.82 , pp. 1365-1374
    • Cools, N.1    Ponsaerts, P.2    van Tendeloo, V.F.3    Berneman, Z.N.4
  • 14
    • 33745673358 scopus 로고    scopus 로고
    • The dynamics of dendritic cell-T cell interactions in priming and tolerance
    • Hugues, S.; Boissonnas, A.; Amigorena, S.; Fetler, L. The dynamics of dendritic cell-T cell interactions in priming and tolerance. Curr. Opin. Immunol. 2006, 18, 491-495.
    • (2006) Curr. Opin. Immunol , vol.18 , pp. 491-495
    • Hugues, S.1    Boissonnas, A.2    Amigorena, S.3    Fetler, L.4
  • 15
  • 17
    • 0029812593 scopus 로고    scopus 로고
    • Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
    • Cella, M.; Scheidegger, D.; Palmer-Lehmann, K.; Lane, P.; Lanzavecchia, A.; Alber, G. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 1996, 184, 747-752.
    • (1996) J. Exp. Med , vol.184 , pp. 747-752
    • Cella, M.1    Scheidegger, D.2    Palmer-Lehmann, K.3    Lane, P.4    Lanzavecchia, A.5    Alber, G.6
  • 18
    • 0032482474 scopus 로고    scopus 로고
    • T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
    • Schoenberger, S.P.; Toes, R.E.; van der Voort, E.I.; Offringa, R.; Melief, C.J. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature 1998, 393, 480-483.
    • (1998) Nature , vol.393 , pp. 480-483
    • Schoenberger, S.P.1    Toes, R.E.2    van der Voort, E.I.3    Offringa, R.4    Melief, C.J.5
  • 19
    • 0032482337 scopus 로고    scopus 로고
    • A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
    • Ridge, J.P.; Di Rosa, F.; Matzinger, P. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature 1998, 393, 474-478.
    • (1998) Nature , vol.393 , pp. 474-478
    • Ridge, J.P.1    di Rosa, F.2    Matzinger, P.3
  • 21
    • 0032695108 scopus 로고    scopus 로고
    • Natural adjuvants: Endogenous activators of dendritic cells
    • Gallucci, S.; Lolkema, M.; Matzinger, P. Natural adjuvants: Endogenous activators of dendritic cells. Nat. Med. 1999, 5, 1249-1255.
    • (1999) Nat. Med , vol.5 , pp. 1249-1255
    • Gallucci, S.1    Lolkema, M.2    Matzinger, P.3
  • 22
    • 0141998606 scopus 로고    scopus 로고
    • Molecular identification of a danger signal that alerts the immune system to dying cells
    • Shi, Y.; Evans, J.E.; Rock, K.L. Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 2003, 425, 516-521.
    • (2003) Nature , vol.425 , pp. 516-521
    • Shi, Y.1    Evans, J.E.2    Rock, K.L.3
  • 24
    • 0029851719 scopus 로고    scopus 로고
    • The role of cytokines in functional regulation and differentiation of dendritic cells
    • Lutz, M.B.; Girolomoni, G.; Ricciardi-Castagnoli, P. The role of cytokines in functional regulation and differentiation of dendritic cells. Immunobiology 1996, 195, 431-455.
    • (1996) Immunobiology , vol.195 , pp. 431-455
    • Lutz, M.B.1    Girolomoni, G.2    Ricciardi-Castagnoli, P.3
  • 25
    • 34247588096 scopus 로고    scopus 로고
    • Requirements for CD8 T-cell priming, memory generation and maintenance
    • Prlic, M.; Williams, M.A.; Bevan, M.J. Requirements for CD8 T-cell priming, memory generation and maintenance. Curr. Opin. Immunol. 2007, 19, 315-319.
    • (2007) Curr. Opin. Immunol , vol.19 , pp. 315-319
    • Prlic, M.1    Williams, M.A.2    Bevan, M.J.3
  • 29
    • 0037432787 scopus 로고    scopus 로고
    • Requirement for CD4 T cell help in generating functional CD8 T cell memory
    • Shedlock, D.J.; Shen, H. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 2003, 300, 337-339.
    • (2003) Science , vol.300 , pp. 337-339
    • Shedlock, D.J.1    Shen, H.2
  • 30
    • 0037432776 scopus 로고    scopus 로고
    • Defective CD8 T cell memory following acute infection without CD4 T cell help
    • Sun, J.C.; Bevan, M.J. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 2003, 300, 339-342.
    • (2003) Science , vol.300 , pp. 339-342
    • Sun, J.C.1    Bevan, M.J.2
  • 33
    • 0033662405 scopus 로고    scopus 로고
    • CD4+ T cell-mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFN gamma receptor expression by nonhematopoietic cells
    • Qin, Z.; Blankenstein, T. CD4+ T cell-mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFN gamma receptor expression by nonhematopoietic cells. Immunity 2000, 12, 677-686.
    • (2000) Immunity , vol.12 , pp. 677-686
    • Qin, Z.1    Blankenstein, T.2
  • 34
    • 84934443503 scopus 로고    scopus 로고
    • CD4+ T cells cooperate with macrophages for specific elimination of MHC class II-negative cancer cells
    • Corthay, A. CD4+ T cells cooperate with macrophages for specific elimination of MHC class II-negative cancer cells. Adv. Exp. Med. Biol. 2007, 590, 195-208.
    • (2007) Adv. Exp. Med. Biol , vol.590 , pp. 195-208
    • Corthay, A.1
  • 36
    • 78649993460 scopus 로고    scopus 로고
    • CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation
    • Rakhra, K.; Bachireddy, P.; Zabuawala, T.; Zeiser, R.; Xu, L.; Kopelman, A.; Fan, A.C.; Yang, Q.; Braunstein, L.; Crosby, E.; et al. CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. Cancer Cell 2010, 18, 485-498.
    • (2010) Cancer Cell , vol.18 , pp. 485-498
    • Rakhra, K.1    Bachireddy, P.2    Zabuawala, T.3    Zeiser, R.4    Xu, L.5    Kopelman, A.6    Fan, A.C.7    Yang, Q.8    Braunstein, L.9    Crosby, E.10
  • 37
    • 78449290135 scopus 로고    scopus 로고
    • CD4+ T-cell help in the tumor milieu is required for recruitment and cytolytic function of CD8+ T lymphocytes
    • Bos, R.; Sherman, L.A. CD4+ T-cell help in the tumor milieu is required for recruitment and cytolytic function of CD8+ T lymphocytes. Cancer Res. 2010, 70, 8368-8377.
    • (2010) Cancer Res , vol.70 , pp. 8368-8377
    • Bos, R.1    Sherman, L.A.2
  • 38
    • 33845510147 scopus 로고    scopus 로고
    • Tumour-host interactions: Implications for developing anti-cancer therapies
    • Gadea, B.B.; Joyce, J.A. Tumour-host interactions: Implications for developing anti-cancer therapies. Expert Rev. Mol. Med. 2006, 8, 1-32.
    • (2006) Expert. Rev. Mol. Med , vol.8 , pp. 1-32
    • Gadea, B.B.1    Joyce, J.A.2
  • 39
    • 7644237187 scopus 로고    scopus 로고
    • Tumor-host immune interactions and dendritic cell dysfunction
    • Yang, L.; Carbone, D.P. Tumor-host immune interactions and dendritic cell dysfunction. Adv. Cancer Res. 2004, 92, 13-27.
    • (2004) Adv. Cancer Res , vol.92 , pp. 13-27
    • Yang, L.1    Carbone, D.P.2
  • 40
    • 0036369305 scopus 로고    scopus 로고
    • Immune dysfunction in cancer patients
    • (Williston Park NY)
    • Ohm, J.E.; Carbone, D.P. Immune dysfunction in cancer patients. Oncology (Williston Park, NY) 2002, 16 (Suppl.1), 11-18.
    • (2002) Oncology , vol.16 , Issue.SUPPL. 1 , pp. 11-18
    • Ohm, J.E.1    Carbone, D.P.2
  • 42
    • 33748987908 scopus 로고    scopus 로고
    • Cancer despite immunosurveillance: Immunoselection and immunosubversion
    • Zitvogel, L.; Tesniere, A.; Kroemer, G. Cancer despite immunosurveillance: Immunoselection and immunosubversion. Nat. Rev. Immunol. 2006, 6, 715-727.
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 715-727
    • Zitvogel, L.1    Tesniere, A.2    Kroemer, G.3
  • 43
    • 33745945647 scopus 로고    scopus 로고
    • Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo
    • Warger, T.; Osterloh, P.; Rechtsteiner, G.; Fassbender, M.; Heib, V.; Schmid, B.; Schmitt, E.; Schild, H.; Radsak, M.P. Synergistic activation of dendritic cells by combined Toll-like receptor ligation induces superior CTL responses in vivo. Blood 2006, 108, 544-550.
    • (2006) Blood , vol.108 , pp. 544-550
    • Warger, T.1    Osterloh, P.2    Rechtsteiner, G.3    Fassbender, M.4    Heib, V.5    Schmid, B.6    Schmitt, E.7    Schild, H.8    Radsak, M.P.9
  • 44
    • 4944223122 scopus 로고    scopus 로고
    • Manipulating dendritic cell biology for the active immunotherapy of cancer
    • Oneill, D.W.; Adams, S.; Bhardwaj, N. Manipulating dendritic cell biology for the active immunotherapy of cancer. Blood 2004, 104, 2235-2246.
    • (2004) Blood , vol.104 , pp. 2235-2246
    • Oneill, D.W.1    Adams, S.2    Bhardwaj, N.3
  • 45
    • 0035862333 scopus 로고    scopus 로고
    • Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells
    • Dhodapkar, M.V.; Steinman, R.M.; Krasovsky, J.; Munz, C.; Bhardwaj, N. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J. Exp. Med. 2001, 193, 233-238.
    • (2001) J. Exp. Med , vol.193 , pp. 233-238
    • Dhodapkar, M.V.1    Steinman, R.M.2    Krasovsky, J.3    Munz, C.4    Bhardwaj, N.5
  • 46
    • 0036659913 scopus 로고    scopus 로고
    • Antigen-bearing immature dendritic cells induce peptide-specific CD8(+) regulatory T cells in vivo in humans
    • Dhodapkar, M.V.; Steinman, R.M. Antigen-bearing immature dendritic cells induce peptide-specific CD8(+) regulatory T cells in vivo in humans. Blood 2002, 100, 174-177.
    • (2002) Blood , vol.100 , pp. 174-177
    • Dhodapkar, M.V.1    Steinman, R.M.2
  • 47
    • 33750614944 scopus 로고    scopus 로고
    • Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patients
    • Banerjee, D.K.; Dhodapkar, M.V.; Matayeva, E.; Steinman, R.M.; Dhodapkar, K.M. Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patients. Blood 2006, 108, 2655-2661.
    • (2006) Blood , vol.108 , pp. 2655-2661
    • Banerjee, D.K.1    Dhodapkar, M.V.2    Matayeva, E.3    Steinman, R.M.4    Dhodapkar, K.M.5
  • 49
    • 24144495503 scopus 로고    scopus 로고
    • Th1-polarizing capacity of clinical-grade dendritic cells is triggered by Ribomunyl but is compromised by PGE2: The importance of maturation cocktails
    • Jongmans, W.; Tiemessen, D.M.; van Vlodrop, I.J.; Mulders, P.F.; Oosterwijk, E. Th1-polarizing capacity of clinical-grade dendritic cells is triggered by Ribomunyl but is compromised by PGE2: The importance of maturation cocktails. J. Immunother. 2005, 28, 480-487.
    • (2005) J. Immunother , vol.28 , pp. 480-487
    • Jongmans, W.1    Tiemessen, D.M.2    van Vlodrop, I.J.3    Mulders, P.F.4    Oosterwijk, E.5
  • 50
    • 0345346375 scopus 로고    scopus 로고
    • Final maturation of dendritic cells is associated with impaired responsiveness to IFN-gamma and to bacterial IL-12 inducers: Decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells
    • Kalinski, P.; Schuitemaker, J.H.; Hilkens, C.M.; Wierenga, E.A.; Kapsenberg, M.L. Final maturation of dendritic cells is associated with impaired responsiveness to IFN-gamma and to bacterial IL-12 inducers: Decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells. J. Immunol. 1999, 162, 3231-3236.
    • (1999) J. Immunol , vol.162 , pp. 3231-3236
    • Kalinski, P.1    Schuitemaker, J.H.2    Hilkens, C.M.3    Wierenga, E.A.4    Kapsenberg, M.L.5
  • 51
    • 0037103261 scopus 로고    scopus 로고
    • Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: Prostaglandin E(2) regulates the migratory capacity of specific DC subsets
    • Luft, T.; Jefford, M.; Luetjens, P.; Toy, T.; Hochrein, H.; Masterman, K.A.; Maliszewski, C.; Shortman, K.; Cebon, J.; Maraskovsky, E. Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: Prostaglandin E(2) regulates the migratory capacity of specific DC subsets. Blood 2002, 100, 1362-1372.
    • (2002) Blood , vol.100 , pp. 1362-1372
    • Luft, T.1    Jefford, M.2    Luetjens, P.3    Toy, T.4    Hochrein, H.5    Masterman, K.A.6    Maliszewski, C.7    Shortman, K.8    Cebon, J.9    Maraskovsky, E.10
  • 52
    • 33846935228 scopus 로고    scopus 로고
    • Unique human tumor antigens: Immunobiology and use in clinical trials
    • Parmiani, G.; De Filippo, A.; Novellino, L.; Castelli, C. Unique human tumor antigens: Immunobiology and use in clinical trials. J. Immunol. 2007, 178, 1975-1979.
    • (2007) J. Immunol , vol.178 , pp. 1975-1979
    • Parmiani, G.1    de Filippo, A.2    Novellino, L.3    Castelli, C.4
  • 54
    • 34250893815 scopus 로고    scopus 로고
    • Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo
    • Villadangos, J.A.; Schnorrer, P. Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo. Nat. Rev. 2007, 7, 543-555.
    • (2007) Nat. Rev , vol.7 , pp. 543-555
    • Villadangos, J.A.1    Schnorrer, P.2
  • 55
    • 26244465086 scopus 로고    scopus 로고
    • Control of MHC class II antigen presentation in dendritic cells: A balance between creative and destructive forces
    • Villadangos, J.A.; Schnorrer, P.; Wilson, N.S. Control of MHC class II antigen presentation in dendritic cells: A balance between creative and destructive forces. Immunol. Rev. 2005, 207, 191-205.
    • (2005) Immunol. Rev , vol.207 , pp. 191-205
    • Villadangos, J.A.1    Schnorrer, P.2    Wilson, N.S.3
  • 56
    • 0030175501 scopus 로고    scopus 로고
    • Mechanisms of antigen uptake for presentation
    • Lanzavecchia, A. Mechanisms of antigen uptake for presentation. Curr. Opin. Immunol. 1996, 8, 348-354.
    • (1996) Curr. Opin. Immunol , vol.8 , pp. 348-354
    • Lanzavecchia, A.1
  • 57
    • 0025240576 scopus 로고
    • Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T lymphocytes
    • Lanzavecchia, A. Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T lymphocytes. Ann. Rev. Immunol. 1990, 8, 773-793.
    • (1990) Ann. Rev. Immunol , vol.8 , pp. 773-793
    • Lanzavecchia, A.1
  • 58
    • 60549098295 scopus 로고    scopus 로고
    • Differential expression of constitutive and inducible proteasome subunits in human monocyte-derived DC differentiated in the presence of IFN-alpha or IL-4
    • Tosello, V.; Zamarchi, R.; Merlo, A.; Gorza, M.; Piovan, E.; Mandruzzato, S.; Bronte, V.; Wang, X.; Ferrone, S.; Amadori, A.; et al. Differential expression of constitutive and inducible proteasome subunits in human monocyte-derived DC differentiated in the presence of IFN-alpha or IL-4. Eur. J. Immunol. 2009, 39, 56-66.
    • (2009) Eur. J. Immunol , vol.39 , pp. 56-66
    • Tosello, V.1    Zamarchi, R.2    Merlo, A.3    Gorza, M.4    Piovan, E.5    Mandruzzato, S.6    Bronte, V.7    Wang, X.8    Ferrone, S.9    Amadori, A.10
  • 59
    • 0035873704 scopus 로고    scopus 로고
    • 26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide
    • Cascio, P.; Hilton, C.; Kisselev, A.F.; Rock, K.L.; Goldberg, A.L. 26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide. EMBO J. 2001, 20, 2357-2366.
    • (2001) EMBO J , vol.20 , pp. 2357-2366
    • Cascio, P.1    Hilton, C.2    Kisselev, A.F.3    Rock, K.L.4    Goldberg, A.L.5
  • 60
    • 77249160619 scopus 로고    scopus 로고
    • Intracellular mechanisms of antigen cross presentation in dendritic cells
    • Amigorena, S.; Savina, A. Intracellular mechanisms of antigen cross presentation in dendritic cells. Curr. Opin. Immunol. 2010, 22, 109-117.
    • (2010) Curr. Opin. Immunol , vol.22 , pp. 109-117
    • Amigorena, S.1    Savina, A.2
  • 61
    • 0028910938 scopus 로고
    • A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules
    • Kovacsovics-Bankowski, M.; Rock, K.L. A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules. Science 1995, 267, 243-246.
    • (1995) Science , vol.267 , pp. 243-246
    • Kovacsovics-Bankowski, M.1    Rock, K.L.2
  • 62
    • 33749512465 scopus 로고    scopus 로고
    • Exiting the outside world for cross-presentation
    • Rock, K.L. Exiting the outside world for cross-presentation. Immunity 2006, 25, 523-525.
    • (2006) Immunity , vol.25 , pp. 523-525
    • Rock, K.L.1
  • 63
    • 73949158437 scopus 로고    scopus 로고
    • Proteases in MHC class I presentation and cross-presentation
    • Rock, K.L.; Farfan-Arribas, D.J.; Shen, L. Proteases in MHC class I presentation and cross-presentation. J. Immunol. 2010, 184, 9-15.
    • (2010) J. Immunol , vol.184 , pp. 9-15
    • Rock, K.L.1    Farfan-Arribas, D.J.2    Shen, L.3
  • 65
    • 34547216748 scopus 로고    scopus 로고
    • A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum
    • Ploegh, H.L. A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum. Nature 2007, 448, 435-438.
    • (2007) Nature , vol.448 , pp. 435-438
    • Ploegh, H.L.1
  • 66
    • 33749522738 scopus 로고    scopus 로고
    • A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells
    • Ackerman, A.L.; Giodini, A.; Cresswell, P. A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells. Immunity 2006, 25, 607-617.
    • (2006) Immunity , vol.25 , pp. 607-617
    • Ackerman, A.L.1    Giodini, A.2    Cresswell, P.3
  • 67
    • 0242331619 scopus 로고    scopus 로고
    • Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens
    • Ackerman, A.L.; Kyritsis, C.; Tampe, R.; Cresswell, P. Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens. Proc. Natl. Acad. Sci. USA 2003, 100, 12889-12894.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 12889-12894
    • Ackerman, A.L.1    Kyritsis, C.2    Tampe, R.3    Cresswell, P.4
  • 68
    • 48749092592 scopus 로고    scopus 로고
    • The known unknowns of antigen processing and presentation
    • Vyas, J.M.; Van der Veen, A.G.; Ploegh, H.L. The known unknowns of antigen processing and presentation. Nat. Rev. Immunol. 2008, 8, 607-618.
    • (2008) Nat. Rev. Immunol , vol.8 , pp. 607-618
    • Vyas, J.M.1    van der Veen, A.G.2    Ploegh, H.L.3
  • 70
    • 33748848754 scopus 로고    scopus 로고
    • On regulation of phagosome maturation and antigen presentation
    • Blander, J.M.; Medzhitov, R. On regulation of phagosome maturation and antigen presentation. Nat. Immunol. 2006, 7, 1029-1035.
    • (2006) Nat. Immunol , vol.7 , pp. 1029-1035
    • Blander, J.M.1    Medzhitov, R.2
  • 71
    • 79959732230 scopus 로고    scopus 로고
    • Cancer Immunity Home Page, accessed 20 April 2011
    • Cancer Immunity Home Page. http://www.cancerimmunity.org/peptidedatabase/Tcellepitopes.htm/ (accessed 20 April 2011).
  • 74
    • 0037379961 scopus 로고    scopus 로고
    • Suboptimal activation of CD8(+) T cells by melanoma-derived altered peptide ligands: Role of Melan-A/MART-1 optimized analogues
    • Carrabba, M.G.; Castelli, C.; Maeurer, M.J.; Squarcina, P.; Cova, A.; Pilla, L.; Renkvist, N.; Parmiani, G.; Rivoltini, L. Suboptimal activation of CD8(+) T cells by melanoma-derived altered peptide ligands: Role of Melan-A/MART-1 optimized analogues. Cancer Res. 2003, 63, 1560-1567.
    • (2003) Cancer Res , vol.63 , pp. 1560-1567
    • Carrabba, M.G.1    Castelli, C.2    Maeurer, M.J.3    Squarcina, P.4    Cova, A.5    Pilla, L.6    Renkvist, N.7    Parmiani, G.8    Rivoltini, L.9
  • 77
    • 30744465074 scopus 로고    scopus 로고
    • Destructive cleavage of antigenic peptides either by the immunoproteasome or by the standard proteasome results in differential antigen presentation
    • Chapiro, J.; Claverol, S.; Piette, F.; Ma, W.; Stroobant, V.; Guillaume, B.; Gairin, J.E.; Morel, S.; Burlet-Schiltz, O.; Monsarrat, B.; et al. Destructive cleavage of antigenic peptides either by the immunoproteasome or by the standard proteasome results in differential antigen presentation. J. Immunol. 2006, 176, 1053-1061.
    • (2006) J. Immunol , vol.176 , pp. 1053-1061
    • Chapiro, J.1    Claverol, S.2    Piette, F.3    Ma, W.4    Stroobant, V.5    Guillaume, B.6    Gairin, J.E.7    Morel, S.8    Burlet-Schiltz, O.9    Monsarrat, B.10
  • 78
    • 0035139983 scopus 로고    scopus 로고
    • Danger signals: SOS to the immune system
    • Gallucci, S.; Matzinger, P. Danger signals: SOS to the immune system. Curr. Opin. Immunol. 2001, 13, 114-119.
    • (2001) Curr. Opin. Immunol , vol.13 , pp. 114-119
    • Gallucci, S.1    Matzinger, P.2
  • 79
    • 77953187290 scopus 로고    scopus 로고
    • Uric acid promotes an acute inflammatory response to sterile cell death in mice
    • Kono, H.; Chen, C.J.; Ontiveros, F.; Rock, K.L. Uric acid promotes an acute inflammatory response to sterile cell death in mice. J. Clin. Invest. 2010, 120, 1939-1949.
    • (2010) J. Clin. Invest , vol.120 , pp. 1939-1949
    • Kono, H.1    Chen, C.J.2    Ontiveros, F.3    Rock, K.L.4
  • 81
    • 77950366886 scopus 로고    scopus 로고
    • Decoding cell death signals in inflammation and immunity
    • Zitvogel, L.; Kepp, O.; Kroemer, G. Decoding cell death signals in inflammation and immunity. Cell 2010, 140, 798-804.
    • (2010) Cell , vol.140 , pp. 798-804
    • Zitvogel, L.1    Kepp, O.2    Kroemer, G.3
  • 84
    • 42149187760 scopus 로고    scopus 로고
    • Apoptotic cells induce dendritic cell-mediated suppression via interferon-gamma-induced IDO
    • Williams, C.A.; Harry, R.A.; McLeod, J.D. Apoptotic cells induce dendritic cell-mediated suppression via interferon-gamma-induced IDO. Immunology 2008, 124, 89-101.
    • (2008) Immunology , vol.124 , pp. 89-101
    • Williams, C.A.1    Harry, R.A.2    McLeod, J.D.3
  • 85
    • 38049017419 scopus 로고    scopus 로고
    • Peripheral CD8 T-cell responses to apoptotic cell proteins and peptides
    • Peng, Y.F.; Elkon, K.B. Peripheral CD8 T-cell responses to apoptotic cell proteins and peptides. Crit. Rev. Immunol. 2007, 27, 357-365.
    • (2007) Crit. Rev. Immunol , vol.27 , pp. 357-365
    • Peng, Y.F.1    Elkon, K.B.2
  • 86
    • 23844476034 scopus 로고    scopus 로고
    • Signals from dying cells: Tolerance induction by the dendritic cell
    • Ferguson, T.A.; Kazama, H. Signals from dying cells: Tolerance induction by the dendritic cell. Immunol. Res. 2005, 32, 99-108.
    • (2005) Immunol. Res , vol.32 , pp. 99-108
    • Ferguson, T.A.1    Kazama, H.2
  • 87
  • 89
    • 0030904482 scopus 로고    scopus 로고
    • Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells
    • Gong, J.; Chen, D.; Kashiwaba, M.; Kufe, D. Induction of antitumor activity by immunization with fusions of dendritic and carcinoma cells. Nat. Med. 1997, 3, 558-561.
    • (1997) Nat. Med , vol.3 , pp. 558-561
    • Gong, J.1    Chen, D.2    Kashiwaba, M.3    Kufe, D.4
  • 91
    • 0036036401 scopus 로고    scopus 로고
    • Cell fusion: An approach to generating constitutively proliferating human tumor antigen-presenting cells
    • Jantscheff, P.; Spagnoli, G.; Zajac, P.; Rochlitz, C.F. Cell fusion: An approach to generating constitutively proliferating human tumor antigen-presenting cells. Cancer Immunol. Immunother. 2002, 51, 367-375.
    • (2002) Cancer Immunol. Immunother , vol.51 , pp. 367-375
    • Jantscheff, P.1    Spagnoli, G.2    Zajac, P.3    Rochlitz, C.F.4
  • 93
    • 0037457018 scopus 로고    scopus 로고
    • Allogeneic dendritic cells fused with tumor cells: Preclinical results and outcome of a clinical phase I/II trial in patients with metastatic renal cell carcinoma
    • Marten, A.; Renoth, S.; Heinicke, T.; Albers, P.; Pauli, A.; Mey, U.; Caspari, R.; Flieger, D.; Hanfland, P.; Von Ruecker, A.; et al. Allogeneic dendritic cells fused with tumor cells: Preclinical results and outcome of a clinical phase I/II trial in patients with metastatic renal cell carcinoma. Hum. Gene. Ther. 2003, 14, 483-494.
    • (2003) Hum. Gene. Ther , vol.14 , pp. 483-494
    • Marten, A.1    Renoth, S.2    Heinicke, T.3    Albers, P.4    Pauli, A.5    Mey, U.6    Caspari, R.7    Flieger, D.8    Hanfland, P.9    Von Ruecker, A.10
  • 94
    • 4644265021 scopus 로고    scopus 로고
    • Interim safety and efficacy results from a phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma
    • Avigan, D.E.; George, D.J. Interim safety and efficacy results from a phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma. J. Clin. Oncol. 2004, 22, 169.
    • (2004) J. Clin. Oncol , vol.22 , pp. 169
    • Avigan, D.E.1    George, D.J.2
  • 95
    • 0037379315 scopus 로고    scopus 로고
    • Tumor-derived TGF-beta reduces the efficacy of dendritic cell/tumor fusion vaccine
    • Kao, J.Y.; Gong, Y.; Chen, C.M.; Zheng, Q.D.; Chen, J.J. Tumor-derived TGF-beta reduces the efficacy of dendritic cell/tumor fusion vaccine. J. Immunol. 2003, 170, 3806-3811.
    • (2003) J. Immunol , vol.170 , pp. 3806-3811
    • Kao, J.Y.1    Gong, Y.2    Chen, C.M.3    Zheng, Q.D.4    Chen, J.J.5
  • 96
    • 54049140895 scopus 로고    scopus 로고
    • Priming of a novel subset of CD28+ rapidly expanding high-avidity effector memory CTL by post maturation electroporation-CD40L dendritic cells is IL-12 dependent
    • DeBenedette, M.A.; Calderhead, D.M.; Ketteringham, H.; Gamble, A.H.; Horvatinovich, J.M.; Tcherepanova, I.Y.; Nicolette, C.A.; Healey, D.G. Priming of a novel subset of CD28+ rapidly expanding high-avidity effector memory CTL by post maturation electroporation-CD40L dendritic cells is IL-12 dependent. J. Immunol. 2008, 181, 5296-5305.
    • (2008) J. Immunol , vol.181 , pp. 5296-5305
    • Debenedette, M.A.1    Calderhead, D.M.2    Ketteringham, H.3    Gamble, A.H.4    Horvatinovich, J.M.5    Tcherepanova, I.Y.6    Nicolette, C.A.7    Healey, D.G.8
  • 99
    • 70350247570 scopus 로고    scopus 로고
    • Human suppressor of cytokine signaling 1 controls immunostimulatory activity of monocyte-derived dendritic cells
    • Hong, B.; Ren, W.; Song, X.T.; Evel-Kabler, K.; Chen, S.Y.; Huang, X.F. Human suppressor of cytokine signaling 1 controls immunostimulatory activity of monocyte-derived dendritic cells. Cancer Res. 2009, 69, 8076-8084.
    • (2009) Cancer Res , vol.69 , pp. 8076-8084
    • Hong, B.1    Ren, W.2    Song, X.T.3    Evel-Kabler, K.4    Chen, S.Y.5    Huang, X.F.6
  • 101
    • 20144364773 scopus 로고    scopus 로고
    • Telomerase mRNA-transfected dendritic cells stimulate antigen-specific CD8+ and CD4+ T cell responses in patients with metastatic prostate cancer
    • Su, Z.; Dannull, J.; Yang, B.K.; Dahm, P.; Coleman, D.; Yancey, D.; Sichi, S.; Niedzwiecki, D.; Boczkowski, D.; Gilboa, E.; et al. Telomerase mRNA-transfected dendritic cells stimulate antigen-specific CD8+ and CD4+ T cell responses in patients with metastatic prostate cancer. J. Immunol. 2005, 174, 3798-3807.
    • (2005) J. Immunol , vol.174 , pp. 3798-3807
    • Su, Z.1    Dannull, J.2    Yang, B.K.3    Dahm, P.4    Coleman, D.5    Yancey, D.6    Sichi, S.7    Niedzwiecki, D.8    Boczkowski, D.9    Gilboa, E.10
  • 102
    • 0031960397 scopus 로고    scopus 로고
    • Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA
    • Nair, S.K.; Boczkowski, D.; Morse, M.; Cumming, R.I.; Lyerly, H.K.; Gilboa, E. Induction of primary carcinoembryonic antigen (CEA)-specific cytotoxic T lymphocytes in vitro using human dendritic cells transfected with RNA. Nat. Biotechnol. 1998, 16, 364-369.
    • (1998) Nat. Biotechnol , vol.16 , pp. 364-369
    • Nair, S.K.1    Boczkowski, D.2    Morse, M.3    Cumming, R.I.4    Lyerly, H.K.5    Gilboa, E.6
  • 103
    • 79251586236 scopus 로고    scopus 로고
    • Gene carriers and transfection systems used in the recombination of dendritic cells for effective cancer immunotherapy
    • Chen, Y.Z.; Yao, X.L.; Tabata, Y.; Nakagawa, S.; Gao, J.Q. Gene carriers and transfection systems used in the recombination of dendritic cells for effective cancer immunotherapy. Clin. Dev. Immunol. 2010, 565643.
    • (2010) Clin. Dev. Immunol , vol.2010 , pp. 565643
    • Chen, Y.Z.1    Yao, X.L.2    Tabata, Y.3    Nakagawa, S.4    Gao, J.Q.5
  • 106
    • 77956221935 scopus 로고    scopus 로고
    • The change of immunoactivity of dendritic cells induced by mouse 4-1BBL recombinant adenovirus
    • Youlin, K.; Xiaodong, W.; Xiuheng, L.; Zhiyuan, C.; Hengcheng, Z.; Hui, C.; Botao, J. The change of immunoactivity of dendritic cells induced by mouse 4-1BBL recombinant adenovirus. Yonsei Med. J. 2010, 51, 594-598.
    • (2010) Yonsei Med. J , vol.51 , pp. 594-598
    • Youlin, K.1    Xiaodong, W.2    Xiuheng, L.3    Zhiyuan, C.4    Hengcheng, Z.5    Hui, C.6    Botao, J.7
  • 108
    • 0035871844 scopus 로고    scopus 로고
    • Greenberg, P.D. Targeting antigen in mature dendritic cells for simultaneous stimulation of CD4+ and CD8+ T cells
    • Bonini, C.; Lee, S.P.; Riddell, S.R.; Greenberg, P.D. Targeting antigen in mature dendritic cells for simultaneous stimulation of CD4+ and CD8+ T cells. J. Immunol. 2001, 166, 5250-5257.
    • (2001) J. Immunol , vol.166 , pp. 5250-5257
    • Bonini, C.1    Lee, S.P.2    Riddell, S.R.3
  • 110
    • 0037108592 scopus 로고    scopus 로고
    • Helper-dependent adenoviral vectors efficiently express transgenes in human dendritic cells but still stimulate antiviral immune responses
    • Roth, M.D.; Cheng, Q.; Harui, A.; Basak, S.K.; Mitani, K.; Low, T.A.; Kiertscher, S.M. Helper-dependent adenoviral vectors efficiently express transgenes in human dendritic cells but still stimulate antiviral immune responses. J. Immunol. 2002, 169, 4651-4656.
    • (2002) J. Immunol , vol.169 , pp. 4651-4656
    • Roth, M.D.1    Cheng, Q.2    Harui, A.3    Basak, S.K.4    Mitani, K.5    Low, T.A.6    Kiertscher, S.M.7
  • 111
    • 0035887664 scopus 로고    scopus 로고
    • Retrovirally transduced human dendritic cells can generate T cells recognizing multiple MHC class I and class II epitopes from the melanoma antigen glycoprotein 100
    • Lapointe, R.; Royal, R.E.; Reeves, M.E.; Altomare, I.; Robbins, P.F.; Hwu, P. Retrovirally transduced human dendritic cells can generate T cells recognizing multiple MHC class I and class II epitopes from the melanoma antigen glycoprotein 100. J. Immunol. 2001, 167, 4758-4764.
    • (2001) J. Immunol , vol.167 , pp. 4758-4764
    • Lapointe, R.1    Royal, R.E.2    Reeves, M.E.3    Altomare, I.4    Robbins, P.F.5    Hwu, P.6
  • 112
    • 0030866293 scopus 로고    scopus 로고
    • Retrovirally transduced human dendritic cells express a normal phenotype and potent T-cell stimulatory capacity
    • Szabolcs, P.; Gallardo, H.F.; Ciocon, D.H.; Sadelain, M.; Young, J.W. Retrovirally transduced human dendritic cells express a normal phenotype and potent T-cell stimulatory capacity. Blood 1997, 90, 2160-2167.
    • (1997) Blood , vol.90 , pp. 2160-2167
    • Szabolcs, P.1    Gallardo, H.F.2    Ciocon, D.H.3    Sadelain, M.4    Young, J.W.5
  • 113
    • 0031580663 scopus 로고    scopus 로고
    • Efficient retrovirus-mediated gene transfer of dendritic cells generated from CD34+ cord blood cells under serum-free conditions
    • Bello-Fernandez, C.; Matyash, M.; Strobl, H.; Pickl, W.F.; Majdic, O.; Lyman, S.D.; Knapp, W. Efficient retrovirus-mediated gene transfer of dendritic cells generated from CD34+ cord blood cells under serum-free conditions. Hum. Gene. Ther. 1997, 8, 1651-1658.
    • (1997) Hum. Gene. Ther , vol.8 , pp. 1651-1658
    • Bello-Fernandez, C.1    Matyash, M.2    Strobl, H.3    Pickl, W.F.4    Majdic, O.5    Lyman, S.D.6    Knapp, W.7
  • 114
    • 0036288752 scopus 로고    scopus 로고
    • Efficient transduction of dendritic cells and induction of a T-cell response by third-generation lentivectors
    • Esslinger, C.; Romero, P.; MacDonald, H.R. Efficient transduction of dendritic cells and induction of a T-cell response by third-generation lentivectors. Hum. Gene Ther. 2002, 13, 1091-1100.
    • (2002) Hum. Gene Ther , vol.13 , pp. 1091-1100
    • Esslinger, C.1    Romero, P.2    Mac Donald, H.R.3
  • 115
    • 1842636260 scopus 로고    scopus 로고
    • Lentivirus vector-mediated expression of tumor-associated epitopes by human antigen presenting cells
    • Lizee, G.; Gonzales, M.I.; Topalian, S.L. Lentivirus vector-mediated expression of tumor-associated epitopes by human antigen presenting cells. Hum. Gene Ther. 2004, 15, 393-404.
    • (2004) Hum. Gene Ther , vol.15 , pp. 393-404
    • Lizee, G.1    Gonzales, M.I.2    Topalian, S.L.3
  • 116
    • 70350574597 scopus 로고    scopus 로고
    • Gene delivery efficiency in bone marrow-derived dendritic cells: Comparison of four methods and optimization for lentivirus transduction
    • Li, G.B.; Lu, G.X. Gene delivery efficiency in bone marrow-derived dendritic cells: Comparison of four methods and optimization for lentivirus transduction. Mol. Biotechnol. 2009, 43, 250-256.
    • (2009) Mol. Biotechnol , vol.43 , pp. 250-256
    • Li, G.B.1    Lu, G.X.2
  • 119
    • 70449084880 scopus 로고    scopus 로고
    • Self-inactivating retroviral vector-mediated gene transfer induces oncogene activation and immortalization of primary murine bone marrow cells
    • Bosticardo, M.; Ghosh, A.; Du, Y.; Jenkins, N.A.; Copeland, N.G.; Candotti, F. Self-inactivating retroviral vector-mediated gene transfer induces oncogene activation and immortalization of primary murine bone marrow cells. Mol. Ther. 2009, 17, 1910-1918.
    • (2009) Mol. Ther , vol.17 , pp. 1910-1918
    • Bosticardo, M.1    Ghosh, A.2    Du, Y.3    Jenkins, N.A.4    Copeland, N.G.5    Candotti, F.6
  • 120
    • 33646887376 scopus 로고    scopus 로고
    • Genotoxicity of retroviral integration in hematopoietic cells
    • Nienhuis, A.W.; Dunbar, C.E.; Sorrentino, B.P. Genotoxicity of retroviral integration in hematopoietic cells. Mol. Ther. 2006, 13, 1031-1049.
    • (2006) Mol. Ther , vol.13 , pp. 1031-1049
    • Nienhuis, A.W.1    Dunbar, C.E.2    Sorrentino, B.P.3
  • 123
    • 25144456061 scopus 로고    scopus 로고
    • Type I interferons as regulators of the differentiation/activation of human dendritic cells: Methods for the evaluation of IFN-induced effects
    • Santini, S.M.; Lapenta, C.; Belardelli, F. Type I interferons as regulators of the differentiation/activation of human dendritic cells: Methods for the evaluation of IFN-induced effects. Methods Mol. Med. 2005, 116, 167-181.
    • (2005) Methods Mol. Med , vol.116 , pp. 167-181
    • Santini, S.M.1    Lapenta, C.2    Belardelli, F.3    Type, I.4
  • 124
    • 0345447557 scopus 로고    scopus 로고
    • Injection of immature dendritic cells into adjuvant-treated skin obviates the need for ex vivo maturation
    • Nair, S.; McLaughlin, C.; Weizer, A.; Su, Z.; Boczkowski, D.; Dannull, J.; Vieweg, J.; Gilboa, E. Injection of immature dendritic cells into adjuvant-treated skin obviates the need for ex vivo maturation. J. Immunol. 2003, 171, 6275-6282.
    • (2003) J. Immunol , vol.171 , pp. 6275-6282
    • Nair, S.1    McLaughlin, C.2    Weizer, A.3    Su, Z.4    Boczkowski, D.5    Dannull, J.6    Vieweg, J.7    Gilboa, E.8
  • 125
    • 58149481281 scopus 로고    scopus 로고
    • Immune barriers to successful gene therapy
    • Wu, T.L.; Ertl, H.C. Immune barriers to successful gene therapy. Trends Mol. Med. 2009, 15, 32-39.
    • (2009) Trends Mol. Med , vol.15 , pp. 32-39
    • Wu, T.L.1    Ertl, H.C.2
  • 126
  • 129
    • 55349100505 scopus 로고    scopus 로고
    • Optimizing denileukin diftitox (Ontak) therapy
    • Duvic, M.; Talpur, R. Optimizing denileukin diftitox (Ontak) therapy. Future Oncol. 2008, 4, 457-469.
    • (2008) Future Oncol , vol.4 , pp. 457-469
    • Duvic, M.1    Talpur, R.2
  • 130
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • Iwai, Y.; Ishida, M.; Tanaka, Y.; Okazaki, T.; Honjo, T.; Minato, N. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc. Natl. Acad. Sci. USA 2002, 99, 12293-12297.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 12293-12297
    • Iwai, Y.1    Ishida, M.2    Tanaka, Y.3    Okazaki, T.4    Honjo, T.5    Minato, N.6
  • 131
    • 67449136111 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-beta-mediated immunosuppression in tumor-draining lymph nodes augments antitumor responses by various immunologic cell types
    • Fujita, T.; Teramoto, K.; Ozaki, Y.; Hanaoka, J.; Tezuka, N.; Itoh, Y.; Asai, T.; Fujino, S.; Kontani, K.; Ogasawara, K. Inhibition of transforming growth factor-beta-mediated immunosuppression in tumor-draining lymph nodes augments antitumor responses by various immunologic cell types. Cancer Res. 2009, 69, 5142-5150.
    • (2009) Cancer Res , vol.69 , pp. 5142-5150
    • Fujita, T.1    Teramoto, K.2    Ozaki, Y.3    Hanaoka, J.4    Tezuka, N.5    Itoh, Y.6    Asai, T.7    Fujino, S.8    Kontani, K.9    Ogasawara, K.10
  • 134
    • 0034332403 scopus 로고    scopus 로고
    • Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo
    • Schluns, K.S.; Kieper, W.C.; Jameson, S.C.; Lefrancois, L. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat. Immunol. 2000, 1, 426-432.
    • (2000) Nat. Immunol , vol.1 , pp. 426-432
    • Schluns, K.S.1    Kieper, W.C.2    Jameson, S.C.3    Lefrancois, L.4
  • 135
    • 0037096878 scopus 로고    scopus 로고
    • Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells
    • May, K.F., Jr.; Chen, L.; Zheng, P.; Liu, Y. Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells. Cancer Res. 2002, 62, 3459-3465.
    • (2002) Cancer Res , vol.62 , pp. 3459-3465
    • May Jr., K.F.1    Chen, L.2    Zheng, P.3    Liu, Y.4


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