A full scale comparative study of methods for generation of functional Dendritic cells for use as cancer vaccines

BMC Cancer

Volumn 7, Issue , 2007, Pages

  Jarnjak Jankovic, Silvija ^a   Hammerstad, Hege ^b   Sæbøe Larssen, Stein ^b   Kvalheim, Gunnar ^b   Gaudernack, Gustav ^b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER VACCINE; CD14 ANTIGEN; CD209 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CD83 ANTIGEN; CD86 ANTIGEN; CHEMOKINE RECEPTOR CCR7; DENDRITIC CELL LYSOSOME ASSOCIATED MEMBRANE PROTEIN; DENDRITIC CELL VACCINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HLA DR ANTIGEN; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA;

ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CULTURE; CELL DIFFERENTIATION; CELL ISOLATION; CELL MATURATION; CELL SELECTION; CELLULAR IMMUNITY; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE RELEASE; DENDRITIC CELL; ELECTROPORATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TIME; INTERMETHOD COMPARISON; LEUKAPHERESIS; LEUKEMIA CELL LINE; MONOCYTE; T LYMPHOCYTE; APHERESIS; COMPARATIVE STUDY; CULTURE TECHNIQUE; CYTOLOGY; IMMUNOLOGY; IMMUNOMAGNETIC SEPARATION; IMMUNOPHENOTYPING; MALE; METHODOLOGY; NEOPLASM; SENSITIVITY AND SPECIFICITY; TUMOR CELL LINE;

ANTIGEN-PRESENTING CELLS; BLOOD COMPONENT REMOVAL; CANCER VACCINES; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; DENDRITIC CELLS; HUMANS; IMMUNOMAGNETIC SEPARATION; IMMUNOPHENOTYPING; MALE; MONOCYTES; NEOPLASMS; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY; T-LYMPHOCYTES; TRANSFECTION;

EID: 34547449658     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-7-119     Document Type: Article

References (20)

1. Celluzzi CM Welbon C Dendritic cell culture: A simple closed culture system using ficoll, monocytes, and a table-top centrifuge Journal of hematotherapy & stem cell research 2003 12 5 575-585 10.1089/ 152581603322448286 14594514
2. Cella M Engering A Pinet V Pieters J Lanzavecchia A Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells Nature 1997 388 6644 782-787 10.1038/42030 9285591
3. Austyn JM Antigen uptake and presentation by dendritic leukocytes Seminars in immunology 1992 4 4 227-236 1391797
4. Schnurr M Then F Galambos P Scholz C Siegmund B Endres S Eigler A Extracellular ATP and TNF-alpha synergize in the activation and maturation of human dendritic cells J Immunol 2000 165 8 4704-4709 11035114
5. Mu LJ Lazarova P Gaudernack G Saeboe-Larssen S Kvalheim G Development of a clinical grade procedure for generation of mRNA transfected dendritic cells from purified frozen CD34(+) blood progenitor cells International journal of immunopathology and pharmacology 2004 17 3 255-263
6. Romani N Gruner S Brang D Kampgen E Lenz A Trockenbacher B Konwalinka G Fritsch PO Steinman RM Schuler G Proliferating dendritic cell progenitors in human blood The Journal of experimental medicine 1994 180 1 83-93 10.1084/jem.180.1.83 8006603
7. Sallusto F Lanzavecchia A Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha The Journal of experimental medicine 1994 179 4 1109-1118 10.1084/jem.179.4.1109 8145033
8. Curti A Ferri E Pandolfi S Isidori A Lemoli RM Dendritic cell differentiation J Immunol 2004 172 1 3; author reply 3 4
9. Jarnjak-Jankovic S Pettersen RD Saeboe-Larssen S Wesenberg F Olafsen MR Gaudernack G Preclinical evaluation of autologous dendritic cells transfected with mRNA or loaded with apoptotic cells for immunotherapy of high-risk neuroblastoma Cancer gene therapy 2005 12 8 699-707 10.1038/ sj.cgt.7700820 15846368
10. Dauer M Obermaier B Herten J Haerle C Pohl K Rothenfusser S Schnurr M Endres S Eigler A Mature dendritic cells derived from human monocytes within 48 hours: A novel strategy for dendritic cell differentiation from blood precursors J Immunol 2003 170 8 4069-4076 12682236
11. Obermaier B Dauer M Herten J Schad K Endres S Eigler A Development of a new protocol for 2-day generation of mature dendritic cells from human monocytes Biol Proced Online 2003 5 197-203 248478 14615816 10.1251/bpo62
12. Mu LJ Kyte JA Kvalheim G Aamdal S Dueland S Hauser M Hammerstad H Waehre H Raabe N Gaudernack G Immunotherapy with allotumour mRNA-transfected dendritic cells in androgen-resistant prostate cancer patients British journal of cancer 2005 93 7 749-756 10.1038/sj.bjc.6602761 16136047
13. Mu LJ Gaudernack G Saeboe-Larssen S Hammerstad H Tierens A Kvalheim G A protocol for generation of clinical grade mRNA-transfected monocyte-derived dendritic cells for cancer vaccines Scandinavian journal of immunology 2003 58 5 578-586 10.1046/j.1365-3083.2003.01333.x 14629630
14. Saeboe-Larssen S Fossberg E Gaudernack G mRNA-based electrotransfection of human dendritic cells and induction of cytotoxic T lymphocyte responses against the telomerase catalytic subunit (hTERT) Journal of immunological methods 2002 259 1-2 191-203 10.1016/S0022-1759(01)00506-3 11730854
15. Dauer M Schad K Junkmann J Bauer C Herten J Kiefl R Schnurr M Endres S Eigler A IFN-alpha promotes definitive maturation of dendritic cells generated by short-term culture of monocytes with GM-CSF and IL-4 Journal of leukocyte biology 2006 80 2 278-286 10.1189/jlb.1005592 16769767
16. Granelli-Piperno A Pritsker A Pack M Shimeliovich I Arrighi JF Park CG Trumpfheller C Piguet V Moran TM Steinman RM Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin/CD209 is abundant on macrophages in the normal human lymph node and is not required for dendritic cell stimulation of the mixed leukocyte reaction J Immunol 2005 175 7 4265-4273 1378112 16177066
17. Kyte JA Kvalheim G Aamdal S Saeboe-Larssen S Gaudernack G Preclinical full-scale evaluation of dendritic cells transfected with autologous tumor-mRNA for melanoma vaccination Cancer gene therapy 2005 12 6 579-591 10.1038/sj.cgt.7700837 15818380
18. Kyte JA Gaudernack G Immuno-gene therapy of cancer with tumour-mRNA transfected dendritic cells Cancer Immunol Immunother 2006 55 11 1432-1442 10.1007/s00262-006-0161-7 16612595
19. Kyte JA Kvalheim G Lislerud K Thor Straten P Dueland S Aamdal S Gaudernack G T cell responses in melanoma patients after vaccination with tumor-mRNA transfected dendritic cells Cancer Immunol Immunother 2007 56 5 659-675 10.1007/s00262-006-0222-y 16947019
20. Kyte JA Mu L Aamdal S Kvalheim G Dueland S Hauser M Gullestad HP Ryder T Lislerud K Hammerstad H Gaudernack G Phase I/II trial of melanoma therapy with dendritic cells transfected with autologous tumor-mRNA Cancer gene therapy 2006 13 10 905-918 10.1038/sj.cgt.7700961 16710345