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Volumn 15, Issue 1, 2009, Pages 32-39

Immune barriers to successful gene therapy

Author keywords

[No Author keywords available]

Indexed keywords

DACLIZUMAB; LENTIVIRUS VECTOR; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NEUTRALIZING ANTIBODY; PARVOVIRUS VECTOR; RAPAMYCIN;

EID: 58149481281     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2008.11.005     Document Type: Review
Times cited : (42)

References (84)
  • 1
    • 33644820684 scopus 로고    scopus 로고
    • Successful transduction of liver in hemophilia by AAV-factor IX and limitations imposed by the host immune response
    • Manno C.S., et al. Successful transduction of liver in hemophilia by AAV-factor IX and limitations imposed by the host immune response. Nat. Med. 12 (2006) 342-347
    • (2006) Nat. Med. , vol.12 , pp. 342-347
    • Manno, C.S.1
  • 2
    • 44249085878 scopus 로고    scopus 로고
    • Safety and efficacy of gene transfer for Leber's congenital amaurosis
    • Maguire A.M., et al. Safety and efficacy of gene transfer for Leber's congenital amaurosis. N. Engl. J. Med. 358 (2008) 2240-2248
    • (2008) N. Engl. J. Med. , vol.358 , pp. 2240-2248
    • Maguire, A.M.1
  • 3
    • 44249120315 scopus 로고    scopus 로고
    • Effect of gene therapy on visual function in Leber's congenital amaurosis
    • Bainbridge J.W., et al. Effect of gene therapy on visual function in Leber's congenital amaurosis. N. Engl. J. Med. 358 (2008) 2231-2239
    • (2008) N. Engl. J. Med. , vol.358 , pp. 2231-2239
    • Bainbridge, J.W.1
  • 4
    • 54449085219 scopus 로고    scopus 로고
    • Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics
    • Cideciyan A.V., et al. Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 15112-15117
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 15112-15117
    • Cideciyan, A.V.1
  • 5
    • 0033579358 scopus 로고    scopus 로고
    • Gene therapy death prompts review of adenovirus vector
    • Marshall E. Gene therapy death prompts review of adenovirus vector. Science 286 (1999) 2244-2245
    • (1999) Science , vol.286 , pp. 2244-2245
    • Marshall, E.1
  • 6
    • 33646196844 scopus 로고    scopus 로고
    • Current strategies and future directions for eluding adenoviral vector immunity
    • Bangari D.S., and Mittal S.K. Current strategies and future directions for eluding adenoviral vector immunity. Curr. Gene Ther. 6 (2006) 215-226
    • (2006) Curr. Gene Ther. , vol.6 , pp. 215-226
    • Bangari, D.S.1    Mittal, S.K.2
  • 7
    • 26844496786 scopus 로고    scopus 로고
    • HSV-1-derived recombinant and amplicon vectors for gene transfer and gene therapy
    • Epstein A.L., et al. HSV-1-derived recombinant and amplicon vectors for gene transfer and gene therapy. Curr. Gene Ther. 5 (2005) 445-458
    • (2005) Curr. Gene Ther. , vol.5 , pp. 445-458
    • Epstein, A.L.1
  • 8
    • 40449097257 scopus 로고    scopus 로고
    • The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
    • Muruve D.A., et al. The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 452 (2008) 103-107
    • (2008) Nature , vol.452 , pp. 103-107
    • Muruve, D.A.1
  • 9
    • 33746801474 scopus 로고    scopus 로고
    • Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid
    • Vandenberghe L.H., et al. Heparin binding directs activation of T cells against adeno-associated virus serotype 2 capsid. Nat. Med. 12 (2006) 967-971
    • (2006) Nat. Med. , vol.12 , pp. 967-971
    • Vandenberghe, L.H.1
  • 10
    • 0035871709 scopus 로고    scopus 로고
    • Cutting edge: recombinant adenoviruses induce CD8 T cell responses to an inserted protein whose expression is limited to nonimmune cells
    • Prasad S.A., et al. Cutting edge: recombinant adenoviruses induce CD8 T cell responses to an inserted protein whose expression is limited to nonimmune cells. J. Immunol. 166 (2001) 4809-4812
    • (2001) J. Immunol. , vol.166 , pp. 4809-4812
    • Prasad, S.A.1
  • 11
    • 2942674463 scopus 로고    scopus 로고
    • Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses
    • Wang S., and Chen L. Co-signaling molecules of the B7-CD28 family in positive and negative regulation of T lymphocyte responses. Microbes Infect. 6 (2004) 759-766
    • (2004) Microbes Infect. , vol.6 , pp. 759-766
    • Wang, S.1    Chen, L.2
  • 12
    • 0037455003 scopus 로고    scopus 로고
    • + effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10
    • + effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10. J. Exp. Med. 197 (2003) 181-193
    • (2003) J. Exp. Med. , vol.197 , pp. 181-193
    • Löhning, M.1
  • 13
    • 0032736029 scopus 로고    scopus 로고
    • B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
    • Dong H., et al. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat. Med. 5 (1999) 1365-1369
    • (1999) Nat. Med. , vol.5 , pp. 1365-1369
    • Dong, H.1
  • 14
    • 5844264920 scopus 로고    scopus 로고
    • PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    • Latchman Y., et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol. 2 (2001) 261-268
    • (2001) Nat. Immunol. , vol.2 , pp. 261-268
    • Latchman, Y.1
  • 15
    • 0037810670 scopus 로고    scopus 로고
    • BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
    • Watanabe N., et al. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat. Immunol. 4 (2003) 670-679
    • (2003) Nat. Immunol. , vol.4 , pp. 670-679
    • Watanabe, N.1
  • 16
    • 19944433635 scopus 로고    scopus 로고
    • B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator
    • Sedy J.R., et al. B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Nat. Immunol. 6 (2005) 90-98
    • (2005) Nat. Immunol. , vol.6 , pp. 90-98
    • Sedy, J.R.1
  • 17
    • 0041381300 scopus 로고    scopus 로고
    • The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses
    • Suh W.K., et al. The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat. Immunol. 4 (2003) 899-906
    • (2003) Nat. Immunol. , vol.4 , pp. 899-906
    • Suh, W.K.1
  • 18
    • 0038094524 scopus 로고    scopus 로고
    • B7-H4, a molecule of the B7 family, negatively regulates T cell immunity
    • Sica G.L., et al. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 18 (2003) 849-861
    • (2003) Immunity , vol.18 , pp. 849-861
    • Sica, G.L.1
  • 19
    • 45749110171 scopus 로고    scopus 로고
    • A critical role for type I IFN-dependent NK cell activation in innate immune elimination of adenoviral vectors in vivo
    • Zhu J., et al. A critical role for type I IFN-dependent NK cell activation in innate immune elimination of adenoviral vectors in vivo. Mol. Ther. 16 (2008) 1300-1307
    • (2008) Mol. Ther. , vol.16 , pp. 1300-1307
    • Zhu, J.1
  • 20
    • 42549161844 scopus 로고    scopus 로고
    • The host response to adenovirus, helper-dependent adenovirus, and adeno-associated virus in mouse liver
    • McCaffrey A.P., et al. The host response to adenovirus, helper-dependent adenovirus, and adeno-associated virus in mouse liver. Mol. Ther. 16 (2008) 931-941
    • (2008) Mol. Ther. , vol.16 , pp. 931-941
    • McCaffrey, A.P.1
  • 21
    • 33947583453 scopus 로고    scopus 로고
    • In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance
    • Brown B.D., et al. In vivo administration of lentiviral vectors triggers a type I interferon response that restricts hepatocyte gene transfer and promotes vector clearance. Blood 109 (2007) 2797-2805
    • (2007) Blood , vol.109 , pp. 2797-2805
    • Brown, B.D.1
  • 22
    • 25444439797 scopus 로고    scopus 로고
    • A novel role of hepatocyte growth factor as an immune regulator through suppressing dendritic cell function
    • Okunishi K., et al. A novel role of hepatocyte growth factor as an immune regulator through suppressing dendritic cell function. J. Immunol. 175 (2005) 4745-4753
    • (2005) J. Immunol. , vol.175 , pp. 4745-4753
    • Okunishi, K.1
  • 23
    • 33745616804 scopus 로고    scopus 로고
    • low/neg accessory cells with dendritic-cell features
    • low/neg accessory cells with dendritic-cell features. Blood 108 (2006) 218-227
    • (2006) Blood , vol.108 , pp. 218-227
    • Rutella, S.1
  • 24
    • 18544364477 scopus 로고    scopus 로고
    • Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase
    • Munn D.H., et al. Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science 297 (2002) 1867-1870
    • (2002) Science , vol.297 , pp. 1867-1870
    • Munn, D.H.1
  • 25
    • 34248173331 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase and tumor-induced tolerance
    • Munn D.H., and Mellor A.L. Indoleamine 2,3-dioxygenase and tumor-induced tolerance. J. Clin. Invest. 117 (2007) 1147-1154
    • (2007) J. Clin. Invest. , vol.117 , pp. 1147-1154
    • Munn, D.H.1    Mellor, A.L.2
  • 26
    • 33750699056 scopus 로고    scopus 로고
    • The tryptophan catabolite l-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function
    • Della Chiesa M., et al. The tryptophan catabolite l-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function. Blood 108 (2006) 4118-4125
    • (2006) Blood , vol.108 , pp. 4118-4125
    • Della Chiesa, M.1
  • 27
    • 41549136378 scopus 로고    scopus 로고
    • The NKG2D receptor: sensing stressed cells
    • López-Larrea C., et al. The NKG2D receptor: sensing stressed cells. Trends Mol. Med. 14 (2008) 179-189
    • (2008) Trends Mol. Med. , vol.14 , pp. 179-189
    • López-Larrea, C.1
  • 28
    • 27144508046 scopus 로고    scopus 로고
    • + T cell induction, is dependent on type I IFN signaling during vaccination with adenovirus vectors
    • + T cell induction, is dependent on type I IFN signaling during vaccination with adenovirus vectors. J. Immunol. 175 (2005) 6032-6041
    • (2005) J. Immunol. , vol.175 , pp. 6032-6041
    • Hensley, S.E.1
  • 29
    • 47249136914 scopus 로고    scopus 로고
    • Glycoprotein-dependent and TLR2-independent innate immune recognition of herpes simplex virus-1 by dendritic cells
    • Reske A., et al. Glycoprotein-dependent and TLR2-independent innate immune recognition of herpes simplex virus-1 by dendritic cells. J. Immunol. 180 (2008) 7525-7536
    • (2008) J. Immunol. , vol.180 , pp. 7525-7536
    • Reske, A.1
  • 30
    • 0031907988 scopus 로고    scopus 로고
    • LIGHT, a new member of the TNF superfamily, and lymphotoxin α are ligands for herpesvirus entry mediator
    • Mauri D.N., et al. LIGHT, a new member of the TNF superfamily, and lymphotoxin α are ligands for herpesvirus entry mediator. Immunity 8 (1998) 21-30
    • (1998) Immunity , vol.8 , pp. 21-30
    • Mauri, D.N.1
  • 31
    • 34548757951 scopus 로고    scopus 로고
    • The multipartite system that mediates entry of herpes simplex virus into the cell
    • Campadelli-Fiume G., et al. The multipartite system that mediates entry of herpes simplex virus into the cell. Rev. Med. Virol. 17 (2007) 313-326
    • (2007) Rev. Med. Virol. , vol.17 , pp. 313-326
    • Campadelli-Fiume, G.1
  • 32
    • 54449089926 scopus 로고    scopus 로고
    • Dendritic cells mediate herpes simplex virus infection and transmission through the C-type lectin DC-SIGN
    • de Jong M.A., et al. Dendritic cells mediate herpes simplex virus infection and transmission through the C-type lectin DC-SIGN. J. Gen. Virol. 89 (2008) 2398-2409
    • (2008) J. Gen. Virol. , vol.89 , pp. 2398-2409
    • de Jong, M.A.1
  • 33
    • 34248544993 scopus 로고    scopus 로고
    • C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-κB
    • Gringhuis S.I., et al. C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-κB. Immunity 26 (2007) 605-616
    • (2007) Immunity , vol.26 , pp. 605-616
    • Gringhuis, S.I.1
  • 34
    • 34447129549 scopus 로고    scopus 로고
    • Activation of immature monocyte-derived dendritic cells after transduction with high doses of lentiviral vectors
    • Breckpot K., et al. Activation of immature monocyte-derived dendritic cells after transduction with high doses of lentiviral vectors. Hum. Gene Ther. 18 (2007) 536-546
    • (2007) Hum. Gene Ther. , vol.18 , pp. 536-546
    • Breckpot, K.1
  • 35
    • 34247577195 scopus 로고    scopus 로고
    • Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway
    • Georgel P., et al. Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. Virology 362 (2007) 304-313
    • (2007) Virology , vol.362 , pp. 304-313
    • Georgel, P.1
  • 36
    • 0033882190 scopus 로고    scopus 로고
    • CD40 ligand-dependent activation of cytotoxic T lymphocytes by adeno-associated virus vectors in vivo: role of immature dendritic cells
    • Zhang Y., et al. CD40 ligand-dependent activation of cytotoxic T lymphocytes by adeno-associated virus vectors in vivo: role of immature dendritic cells. J. Virol. 74 (2000) 8003-8010
    • (2000) J. Virol. , vol.74 , pp. 8003-8010
    • Zhang, Y.1
  • 37
    • 0036147989 scopus 로고    scopus 로고
    • Efficient generation of cytotoxic T lymphocytes against cervical cancer cells by adeno-associated virus/human papillomavirus type 16 E7 antigen gene transduction into dendritic cells
    • Chiriva-Internati M., et al. Efficient generation of cytotoxic T lymphocytes against cervical cancer cells by adeno-associated virus/human papillomavirus type 16 E7 antigen gene transduction into dendritic cells. Eur. J. Immunol. 32 (2002) 30-38
    • (2002) Eur. J. Immunol. , vol.32 , pp. 30-38
    • Chiriva-Internati, M.1
  • 38
    • 0038805302 scopus 로고    scopus 로고
    • Immunity to adenovirus and adeno-associated viral vectors: implications for gene therapy
    • Jooss K., and Chirmule N. Immunity to adenovirus and adeno-associated viral vectors: implications for gene therapy. Gene Ther. 10 (2003) 955-963
    • (2003) Gene Ther. , vol.10 , pp. 955-963
    • Jooss, K.1    Chirmule, N.2
  • 39
    • 44049083209 scopus 로고    scopus 로고
    • Immunity to adeno-associated virus vectors in animals and humans: a continued challenge
    • Zaiss A.K., and Muruve D.A. Immunity to adeno-associated virus vectors in animals and humans: a continued challenge. Gene Ther. 15 (2008) 808-816
    • (2008) Gene Ther. , vol.15 , pp. 808-816
    • Zaiss, A.K.1    Muruve, D.A.2
  • 40
    • 35349024379 scopus 로고    scopus 로고
    • Immune responses to lentiviral vectors
    • Follenzi A., et al. Immune responses to lentiviral vectors. Curr. Gene Ther. 7 (2007) 306-315
    • (2007) Curr. Gene Ther. , vol.7 , pp. 306-315
    • Follenzi, A.1
  • 41
    • 2542574206 scopus 로고    scopus 로고
    • + T cell cross-priming via transfer of proteasome substrates
    • + T cell cross-priming via transfer of proteasome substrates. Science 304 (2004) 1318-1321
    • (2004) Science , vol.304 , pp. 1318-1321
    • Norbury, C.C.1
  • 42
    • 9244220682 scopus 로고    scopus 로고
    • Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo
    • Yang Y., et al. Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo. Gene Ther. 3 (1996) 137-144
    • (1996) Gene Ther. , vol.3 , pp. 137-144
    • Yang, Y.1
  • 43
    • 2342561729 scopus 로고    scopus 로고
    • Targeting lentiviral vector expression to hepatocytes limits transgene-specific immune response and establishes long-term expression of human antihemophilic factor IX in mice
    • Follenzi A., et al. Targeting lentiviral vector expression to hepatocytes limits transgene-specific immune response and establishes long-term expression of human antihemophilic factor IX in mice. Blood 103 (2004) 3700-3709
    • (2004) Blood , vol.103 , pp. 3700-3709
    • Follenzi, A.1
  • 44
    • 36849011734 scopus 로고    scopus 로고
    • + T cells in mice
    • + T cells in mice. J. Clin. Invest. 117 (2007) 3958-3970
    • (2007) J. Clin. Invest. , vol.117 , pp. 3958-3970
    • Lin, S.W.1
  • 45
    • 34147098413 scopus 로고    scopus 로고
    • + T-cell responses to adeno-associated virus capsid in humans
    • + T-cell responses to adeno-associated virus capsid in humans. Nat. Med. 13 (2007) 419-422
    • (2007) Nat. Med. , vol.13 , pp. 419-422
    • Mingozzi, F.1
  • 46
    • 42149169184 scopus 로고    scopus 로고
    • Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target
    • Sojka D.K., et al. Mechanisms of regulatory T-cell suppression - a diverse arsenal for a moving target. Immunology 124 (2008) 13-22
    • (2008) Immunology , vol.124 , pp. 13-22
    • Sojka, D.K.1
  • 47
    • 39449126502 scopus 로고    scopus 로고
    • + regulatory T cell: a jack of all trades, master of regulation
    • + regulatory T cell: a jack of all trades, master of regulation. Nat. Immunol. 9 (2008) 239-244
    • (2008) Nat. Immunol. , vol.9 , pp. 239-244
    • Tang, Q.1    Bluestone, J.A.2
  • 49
    • 34547498762 scopus 로고    scopus 로고
    • + T cells in tolerance to the transgene product following hepatic in vivo gene transfer
    • + T cells in tolerance to the transgene product following hepatic in vivo gene transfer. Blood 110 (2007) 1132-1140
    • (2007) Blood , vol.110 , pp. 1132-1140
    • Cao, O.1
  • 50
    • 33645107513 scopus 로고    scopus 로고
    • See no evil, hear no evil, do no evil: the lessons of immune privilege
    • Niederkorn J.Y. See no evil, hear no evil, do no evil: the lessons of immune privilege. Nat. Immunol. 7 (2006) 354-359
    • (2006) Nat. Immunol. , vol.7 , pp. 354-359
    • Niederkorn, J.Y.1
  • 51
    • 33845628839 scopus 로고    scopus 로고
    • What is immune privilege (not)?
    • Galea I., et al. What is immune privilege (not)?. Trends Immunol. 28 (2007) 12-18
    • (2007) Trends Immunol. , vol.28 , pp. 12-18
    • Galea, I.1
  • 52
    • 33750350800 scopus 로고    scopus 로고
    • B7-H1-induced apoptosis as a mechanism of immune privilege of corneal allografts
    • Hori J., et al. B7-H1-induced apoptosis as a mechanism of immune privilege of corneal allografts. J. Immunol. 177 (2006) 5928-5935
    • (2006) J. Immunol. , vol.177 , pp. 5928-5935
    • Hori, J.1
  • 53
    • 28544437702 scopus 로고    scopus 로고
    • Immune privilege of the eye and fetus: parallel universes?
    • Niederkorn J.Y., and Wang S. Immune privilege of the eye and fetus: parallel universes?. Transplantation 80 (2005) 1139-1144
    • (2005) Transplantation , vol.80 , pp. 1139-1144
    • Niederkorn, J.Y.1    Wang, S.2
  • 54
    • 36749022743 scopus 로고    scopus 로고
    • Functional expression of B7H1 on retinal pigment epithelial cells
    • Usui Y., et al. Functional expression of B7H1 on retinal pigment epithelial cells. Exp. Eye Res. 86 (2008) 52-59
    • (2008) Exp. Eye Res. , vol.86 , pp. 52-59
    • Usui, Y.1
  • 55
    • 33644955010 scopus 로고    scopus 로고
    • Function of indoleamine 2,3-dioxygenase in corneal allograft rejection and prolongation of allograft survival by over-expression
    • Beutelspacher S.C., et al. Function of indoleamine 2,3-dioxygenase in corneal allograft rejection and prolongation of allograft survival by over-expression. Eur. J. Immunol. 36 (2006) 690-700
    • (2006) Eur. J. Immunol. , vol.36 , pp. 690-700
    • Beutelspacher, S.C.1
  • 57
    • 18644381515 scopus 로고    scopus 로고
    • Testicular immune privilege promotes transplantation tolerance by altering the balance between memory and regulatory T cells
    • Nasr I.W., et al. Testicular immune privilege promotes transplantation tolerance by altering the balance between memory and regulatory T cells. J. Immunol. 174 (2005) 6161-6168
    • (2005) J. Immunol. , vol.174 , pp. 6161-6168
    • Nasr, I.W.1
  • 58
    • 44349136847 scopus 로고    scopus 로고
    • Treatment of late infantile neuronal ceroid lipofuscinosis by CNS administration of a serotype 2 adeno-associated virus expressing CLN2 cDNA
    • Worgall S., et al. Treatment of late infantile neuronal ceroid lipofuscinosis by CNS administration of a serotype 2 adeno-associated virus expressing CLN2 cDNA. Hum. Gene Ther. 19 (2008) 463-474
    • (2008) Hum. Gene Ther. , vol.19 , pp. 463-474
    • Worgall, S.1
  • 59
    • 0029760296 scopus 로고    scopus 로고
    • Role of T cells in inflammation caused by adenovirus vectors in the brain
    • Byrnes A.P., et al. Role of T cells in inflammation caused by adenovirus vectors in the brain. Gene Ther. 3 (1996) 644-651
    • (1996) Gene Ther. , vol.3 , pp. 644-651
    • Byrnes, A.P.1
  • 60
    • 33646006698 scopus 로고    scopus 로고
    • Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses
    • Xiong W., et al. Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses. J. Virol. 80 (2006) 27-37
    • (2006) J. Virol. , vol.80 , pp. 27-37
    • Xiong, W.1
  • 61
    • 54849392000 scopus 로고    scopus 로고
    • Stable transgene expression from HSV amplicon vectors in the brain: potential involvement of immunoregulatory signals
    • Suzuki M., et al. Stable transgene expression from HSV amplicon vectors in the brain: potential involvement of immunoregulatory signals. Mol. Ther. 16 (2008) 1727-1736
    • (2008) Mol. Ther. , vol.16 , pp. 1727-1736
    • Suzuki, M.1
  • 62
    • 0038128347 scopus 로고    scopus 로고
    • Immune response following intraocular delivery of recombinant viral vectors
    • Bennett J. Immune response following intraocular delivery of recombinant viral vectors. Gene Ther. 10 (2003) 977-982
    • (2003) Gene Ther. , vol.10 , pp. 977-982
    • Bennett, J.1
  • 63
    • 0030874508 scopus 로고    scopus 로고
    • Cell-mediated immune response and stability of intraocular transgene expression after adenovirus-mediated delivery
    • Hoffman L.M., et al. Cell-mediated immune response and stability of intraocular transgene expression after adenovirus-mediated delivery. Invest. Ophthalmol. Vis. Sci. 38 (1997) 2224-2233
    • (1997) Invest. Ophthalmol. Vis. Sci. , vol.38 , pp. 2224-2233
    • Hoffman, L.M.1
  • 64
    • 0037988905 scopus 로고    scopus 로고
    • Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer
    • Mingozzi F., et al. Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer. J. Clin. Invest. 111 (2003) 1347-1356
    • (2003) J. Clin. Invest. , vol.111 , pp. 1347-1356
    • Mingozzi, F.1
  • 65
    • 37749031215 scopus 로고    scopus 로고
    • Dendritic cells, the liver, and transplantation
    • Sumpter T.L., et al. Dendritic cells, the liver, and transplantation. Hepatology 46 (2007) 2021-2031
    • (2007) Hepatology , vol.46 , pp. 2021-2031
    • Sumpter, T.L.1
  • 66
    • 13544277095 scopus 로고    scopus 로고
    • Immunoadsorption of factor VIII inhibitors
    • Freedman J., and Garvey M.B. Immunoadsorption of factor VIII inhibitors. Curr. Opin. Hematol. 11 (2004) 327-333
    • (2004) Curr. Opin. Hematol. , vol.11 , pp. 327-333
    • Freedman, J.1    Garvey, M.B.2
  • 67
    • 37549007218 scopus 로고    scopus 로고
    • Present techniques for antibody removal
    • Tydén G., et al. Present techniques for antibody removal. Transplantation 84 (2007) S27-S29
    • (2007) Transplantation , vol.84
    • Tydén, G.1
  • 68
    • 26944480735 scopus 로고    scopus 로고
    • Utility of PEGylated recombinant adeno-associated viruses for gene transfer
    • Le H.T., et al. Utility of PEGylated recombinant adeno-associated viruses for gene transfer. J. Control. Release 108 (2005) 161-177
    • (2005) J. Control. Release , vol.108 , pp. 161-177
    • Le, H.T.1
  • 69
    • 44249124272 scopus 로고    scopus 로고
    • Polymers for viral gene delivery
    • Wang C., and Pham P.T. Polymers for viral gene delivery. Expert Opin. Drug Deliv. 5 (2008) 385-401
    • (2008) Expert Opin. Drug Deliv. , vol.5 , pp. 385-401
    • Wang, C.1    Pham, P.T.2
  • 70
    • 0037947557 scopus 로고    scopus 로고
    • Adeno-associated viruses undergo substantial evolution in primates during natural infections
    • Gao G., et al. Adeno-associated viruses undergo substantial evolution in primates during natural infections. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 6081-6086
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 6081-6086
    • Gao, G.1
  • 71
    • 35548955563 scopus 로고    scopus 로고
    • Characterization of the relationship of AAV capsid domain swapping to liver transduction efficiency
    • Shen X., et al. Characterization of the relationship of AAV capsid domain swapping to liver transduction efficiency. Mol. Ther. 15 (2007) 1955-1962
    • (2007) Mol. Ther. , vol.15 , pp. 1955-1962
    • Shen, X.1
  • 72
    • 1642329197 scopus 로고    scopus 로고
    • Monomethylfumarate affects polarization of monocyte-derived dendritic cells resulting in down-regulated Th1 lymphocyte responses
    • Litjens N.H., et al. Monomethylfumarate affects polarization of monocyte-derived dendritic cells resulting in down-regulated Th1 lymphocyte responses. Eur. J. Immunol. 34 (2004) 565-575
    • (2004) Eur. J. Immunol. , vol.34 , pp. 565-575
    • Litjens, N.H.1
  • 73
    • 34948855431 scopus 로고    scopus 로고
    • Modulation of tolerance to the transgene product in a nonhuman primate model of AAV-mediated gene transfer to liver
    • Mingozzi F., et al. Modulation of tolerance to the transgene product in a nonhuman primate model of AAV-mediated gene transfer to liver. Blood 110 (2007) 2334-2341
    • (2007) Blood , vol.110 , pp. 2334-2341
    • Mingozzi, F.1
  • 74
    • 4644266469 scopus 로고    scopus 로고
    • CTLA4Ig delivered by high-capacity adenoviral vector induces stable expression of dystrophin in mdx mouse muscle
    • Jiang Z., et al. CTLA4Ig delivered by high-capacity adenoviral vector induces stable expression of dystrophin in mdx mouse muscle. Gene Ther. 11 (2004) 1453-1461
    • (2004) Gene Ther. , vol.11 , pp. 1453-1461
    • Jiang, Z.1
  • 75
    • 0034952675 scopus 로고    scopus 로고
    • Local high-capacity adenovirus-mediated mCTLA4Ig and mCD40Ig expression prolongs recombinant gene expression in skeletal muscle
    • Jiang Z.L., et al. Local high-capacity adenovirus-mediated mCTLA4Ig and mCD40Ig expression prolongs recombinant gene expression in skeletal muscle. Mol. Ther. 3 (2001) 892-900
    • (2001) Mol. Ther. , vol.3 , pp. 892-900
    • Jiang, Z.L.1
  • 76
    • 4644345267 scopus 로고    scopus 로고
    • Sustained muscle expression of dystrophin from a high-capacity adenoviral vector with systemic gene transfer of T cell costimulatory blockade
    • Jiang Z., et al. Sustained muscle expression of dystrophin from a high-capacity adenoviral vector with systemic gene transfer of T cell costimulatory blockade. Mol. Ther. 10 (2004) 688-696
    • (2004) Mol. Ther. , vol.10 , pp. 688-696
    • Jiang, Z.1
  • 77
    • 10744229480 scopus 로고    scopus 로고
    • Inhibition of costimulation allows for repeated systemic administration of adenoviral vector in rhesus monkeys
    • Haegel-Kronenberger H., et al. Inhibition of costimulation allows for repeated systemic administration of adenoviral vector in rhesus monkeys. Gene Ther. 11 (2004) 241-252
    • (2004) Gene Ther. , vol.11 , pp. 241-252
    • Haegel-Kronenberger, H.1
  • 78
    • 33751571787 scopus 로고    scopus 로고
    • Control of memory CD4 T cell recall by the CD28/B7 costimulatory pathway
    • Ndejembi M.P., et al. Control of memory CD4 T cell recall by the CD28/B7 costimulatory pathway. J. Immunol. 177 (2006) 7698-7706
    • (2006) J. Immunol. , vol.177 , pp. 7698-7706
    • Ndejembi, M.P.1
  • 79
    • 33947599936 scopus 로고    scopus 로고
    • Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28
    • Mirenda V., et al. Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28. Blood 109 (2007) 2968-2977
    • (2007) Blood , vol.109 , pp. 2968-2977
    • Mirenda, V.1
  • 80
    • 34447570588 scopus 로고    scopus 로고
    • The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells
    • Mahajan S., et al. The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells. Eur. J. Immunol. 37 (2007) 1796-1808
    • (2007) Eur. J. Immunol. , vol.37 , pp. 1796-1808
    • Mahajan, S.1
  • 81
    • 31144460031 scopus 로고    scopus 로고
    • Critical, but conditional, role of OX40 in memory T cell-mediated rejection
    • Vu M.D., et al. Critical, but conditional, role of OX40 in memory T cell-mediated rejection. J. Immunol. 176 (2006) 1394-1401
    • (2006) J. Immunol. , vol.176 , pp. 1394-1401
    • Vu, M.D.1
  • 82
    • 33847218321 scopus 로고    scopus 로고
    • +T cells in mice
    • +T cells in mice. Transpl. Immunol. 17 (2007) 153-161
    • (2007) Transpl. Immunol. , vol.17 , pp. 153-161
    • Qu, Y.1
  • 83
    • 33845379986 scopus 로고    scopus 로고
    • + regulatory T cells of both healthy subjects and type 1 diabetic patients
    • + regulatory T cells of both healthy subjects and type 1 diabetic patients. J. Immunol. 177 (2006) 8338-8347
    • (2006) J. Immunol. , vol.177 , pp. 8338-8347
    • Battaglia, M.1
  • 84
    • 36849053006 scopus 로고    scopus 로고
    • A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice
    • Brown B.D., et al. A microRNA-regulated lentiviral vector mediates stable correction of hemophilia B mice. Blood 110 (2007) 4144-4152
    • (2007) Blood , vol.110 , pp. 4144-4152
    • Brown, B.D.1


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