Expansion of FOXP3high regulatory T cells by human dendritic cells (DCs) in vitro and after injection of cytokine-matured DCs in myeloma patients

Blood

Volumn 108, Issue 8, 2006, Pages 2655-2661

  Banerjee, Devi K ^b   Dhodapkar, Madhav V ^b   Matayeva, Elyana ^b   Steinman, Ralph M ^b   Dhodapkar, Kavita M ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; CYTOKINE; INTERLEUKIN 2; TRANSCRIPTION FACTOR FOXP3; CD86 PROTEIN, HUMAN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN;

ARTICLE; CD25+ T LYMPHOCYTE; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MYELOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; ADOPTIVE TRANSFER; CELL COMMUNICATION; CELL DIFFERENTIATION; COCULTURE; CYTOLOGY; DRUG EFFECT; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; METABOLISM; MIXED LYMPHOCYTE CULTURE; MULTIPLE MYELOMA; TRANSPLANTATION;

ADOPTIVE TRANSFER; ANTIGENS, CD80; ANTIGENS, CD86; CELL COMMUNICATION; CELL DIFFERENTIATION; COCULTURE TECHNIQUES; CYTOKINES; DENDRITIC CELLS; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INTERLEUKIN-2; LYMPHOCYTE CULTURE TEST, MIXED; MULTIPLE MYELOMA; SELF TOLERANCE; T-LYMPHOCYTES, REGULATORY;

EID: 33750614944     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-03-011353     Document Type: Article

References (39)

1. + regulatory T cells in immunological tolerance to self and non-self. Nat Immunol. 2005;6:345-352.
2. Roncarolo MG, Levings MK. The role of different subsets of T regulatory cells in controlling autoimmunity. Curr Opin Immunol. 2000;12:676-683.
3. von Boehmer H. Mechanisms of suppression by suppressor T cells. Nat Immunol. 2005;6:338-344.
4. Kronenberg M. Toward an understanding of NKT cell biology: progress and paradoxes. Annu Rev Immunol. 2005;23:877-900.
5. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299:1057-1061.
6. + regulatory T cells. Nat Immunol. 2003;4:330-336.
7. Bennett CL, Christie J, Ramsdell F, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet. 2001;27:20-21.
8. Brunkow ME, Jeffery EW, Hjerrild KA, et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet. 2001;27:68-73.
9. Wildin RS, Ramsdell F, Peake J, et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet. 2001;27:18-20.
10. + T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J Exp Med. 2004;199:1467-1477.
11. + regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2004;101:15434-15439.
12. + regulatory cells within the central nervous system. J Immunol. 2005;175:3025-3032.
13. Belkaid Y, Rouse BT. Natural regulatory T cells in infectious disease. Nat Immunol. 2005;6:353-360.
14. Liu A, Hu P, Khawli LA, Epstein AL. Combination B7-Fc fusion protein treatment and Treg cell depletion therapy. Clin Cancer Res. 2005;11:8492-8502.
15. + regulatory T cells. J Immunol. 2005;174:90-98.
16. Dannull J, Su Z, Rizzieri D, et al. Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells. J Clin Invest. 2005;115:3623-3633.
17. Sutmuller RP, van Duivenvoorde LM, van Elsas A, et al. Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses. J Exp Med. 2001;194:823-832.
18. Woo EY, Chu CS, Goletz TJ, et al. Regulatory CD4(+)CD25(+) T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer. Cancer Res. 2001;61:4766-4772.
19. - cells. Proc Natl Acad Sci U S A. 2005;102:4103-4108.
20. + regulatory T cells at the single-cell level. Eur J Immunol. 2005;35:1681-1691.
21. Mellman I, Steinman RM. Dendritic cells: specialized and regulated antigen processing machines. Cell. 2001;106:255-258.
22. Steinman RM, Dhodapkar M. Active immunization against cancer with dendritic cells: the near future. Int J Cancer. 2001;94:459-473.
23. Jonuleit H, Kuhn U, Muller G, et al. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol. 1997;27:3135-3142.
24. Dhodapkar KM, Kaufman JL, Ehlers M, et al. Selective blockade of inhibitory Fcγ receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibodycoated tumor cells. Proc Natl Acad Sci U S A. 2005;102:2910-2915.
25. Chang DH, Osman K, Connolly J, et al. Sustained expansion of NKT cells and antigen-specific T cells after injection of á-galactosyl-ceramide loaded mature dendritic cells in cancer patients. J Exp Med. 2005;201:1503-1517.
26. Ziegler SF. FOXP3: of mice and men. Annu Rev Immunol. 2006;24:209-226.
27. + immunoregulatory T cells that control autoimmune diabetes. Immunity. 2000;12:431-440.
28. Fontenot JD, Rasmussen JP, Gavin MA, Rudensky AY. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol. 2005;6:1142-1151.
29. + regulatory T cells by antigen-processing dendritic cells. J Exp Med. 2003;198:235-247.
30. Jonuleit H, Schmitt E, Schuler G, Knop J, Enk AH. Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med. 2000;192:1213-1222.
31. Dhodapkar MV, Steinman RM. Antigen-bearing immature dendritic cells induce peptide-specific CD8(+) regulatory T cells in vivo in humans. Blood. 2002;100:174-177.
32. + and type 1 regulatory T cells. Curr Top Microbiol Immunol. 2005;293:303-326.
33. + regulatory T cells in cancer patients. Blood. 2006;107:2409-2414.
34. + regulatory T cells by dendritic cells during the mixed leukocyte reaction. Proc Natl Acad Sci U S A. 2006;103:2758-2763.
35. Baecher-Allan C, Anderson DE. Immune regulation in tumor-bearing hosts. Curr Opin Immunol. 2006;18:214-219.
36. Klein B, Bataille R. Cytokine network in human multiple myeloma. Hematol Oncol Clin North Am. 1992;6:273-284.
37. + regulatory T cells in patients with multiple myeloma. Blood. 2006;107:3940-3949.
38. Prabhala RH, Neri P, Bae JE, et al. Dysfunctional T regulatory cells in multiple myeloma. Blood. 2006;107:301-304.
39. Zhou G, Drake CG, Levitsky HI. Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines. Blood. 2006;107:628-636.