-
1
-
-
0035668779
-
A choice of death-the signal-transduction of immune-mediated beta-cell apoptosis
-
Eizirik D.L., Mandrup-Poulsen T. A choice of death-the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 2001, 44:2115-2133.
-
(2001)
Diabetologia
, vol.44
, pp. 2115-2133
-
-
Eizirik, D.L.1
Mandrup-Poulsen, T.2
-
2
-
-
33644749322
-
Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities
-
Cnop M., Welsh N., Jonas J.C., Jorns A., Lenzen S., Eizirik D.L. Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 2005, 54(Suppl. 2):S97-S107.
-
(2005)
Diabetes
, vol.54
, Issue.SUPPL. 2
-
-
Cnop, M.1
Welsh, N.2
Jonas, J.C.3
Jorns, A.4
Lenzen, S.5
Eizirik, D.L.6
-
3
-
-
42449154297
-
Interaction between pro-inflammatory and anti-inflammatory cytokines in insulin-producing cells
-
Souza K.L., Gurgul-Convey E., Elsner M., Lenzen S. Interaction between pro-inflammatory and anti-inflammatory cytokines in insulin-producing cells. J Endocrinol 2008, 197:139-150.
-
(2008)
J Endocrinol
, vol.197
, pp. 139-150
-
-
Souza, K.L.1
Gurgul-Convey, E.2
Elsner, M.3
Lenzen, S.4
-
4
-
-
0035124874
-
Beta-cell apoptosis and defense mechanisms: lessons from type 1 diabetes
-
Eizirik D.L., Darville M.I. Beta-cell apoptosis and defense mechanisms: lessons from type 1 diabetes. Diabetes 2001, 50(Suppl. 1):S64-S69.
-
(2001)
Diabetes
, vol.50
, Issue.SUPPL. 1
-
-
Eizirik, D.L.1
Darville, M.I.2
-
5
-
-
0031827241
-
Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells
-
Darville M.I., Eizirik D.L. Regulation by cytokines of the inducible nitric oxide synthase promoter in insulin-producing cells. Diabetologia 1998, 41:1101-1108.
-
(1998)
Diabetologia
, vol.41
, pp. 1101-1108
-
-
Darville, M.I.1
Eizirik, D.L.2
-
6
-
-
0037219109
-
Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-kappaB activation in insulin-producing cells
-
Azevedo-Martins A.K., Lortz S., Lenzen S., Curi R., Eizirik D.L., Tiedge M. Improvement of the mitochondrial antioxidant defense status prevents cytokine-induced nuclear factor-kappaB activation in insulin-producing cells. Diabetes 2003, 52:93-101.
-
(2003)
Diabetes
, vol.52
, pp. 93-101
-
-
Azevedo-Martins, A.K.1
Lortz, S.2
Lenzen, S.3
Curi, R.4
Eizirik, D.L.5
Tiedge, M.6
-
7
-
-
23844470618
-
Importance of mitochondrial superoxide dismutase expression in insulin-producing cells for the toxicity of reactive oxygen species and proinflammatory cytokines
-
Lortz S., Gurgul-Convey E., Lenzen S., Tiedge M. Importance of mitochondrial superoxide dismutase expression in insulin-producing cells for the toxicity of reactive oxygen species and proinflammatory cytokines. Diabetologia 2005, 48:1541-1548.
-
(2005)
Diabetologia
, vol.48
, pp. 1541-1548
-
-
Lortz, S.1
Gurgul-Convey, E.2
Lenzen, S.3
Tiedge, M.4
-
8
-
-
85047685938
-
NF-kappaB is required for cytokine-induced manganese superoxide dismutase expression in insulin-producing cells
-
Darville M.I., Ho Y.S., Eizirik D.L. NF-kappaB is required for cytokine-induced manganese superoxide dismutase expression in insulin-producing cells. Endocrinology 2000, 141:153-162.
-
(2000)
Endocrinology
, vol.141
, pp. 153-162
-
-
Darville, M.I.1
Ho, Y.S.2
Eizirik, D.L.3
-
9
-
-
34047235220
-
Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells
-
Pirot P., Ortis F., Cnop M., Ma Y., Hendershot L.M., Eizirik D.L., et al. Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells. Diabetes 2007, 56:1069-1077.
-
(2007)
Diabetes
, vol.56
, pp. 1069-1077
-
-
Pirot, P.1
Ortis, F.2
Cnop, M.3
Ma, Y.4
Hendershot, L.M.5
Eizirik, D.L.6
-
10
-
-
0027934873
-
TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide
-
Cetkovic-Cvrlje M., Eizirik D.L. TNF-alpha and IFN-gamma potentiate the deleterious effects of IL-1 beta on mouse pancreatic islets mainly via generation of nitric oxide. Cytokine 1994, 6:399-406.
-
(1994)
Cytokine
, vol.6
, pp. 399-406
-
-
Cetkovic-Cvrlje, M.1
Eizirik, D.L.2
-
11
-
-
2342526515
-
P38 MAPK inhibits JNK2 and mediates cytokine-activated iNOS induction and apoptosis independently of NF-KB translocation in insulin-producing cells
-
Saldeen J., Welsh N. P38 MAPK inhibits JNK2 and mediates cytokine-activated iNOS induction and apoptosis independently of NF-KB translocation in insulin-producing cells. Eur Cytokine Netw 2004, 15:47-52.
-
(2004)
Eur Cytokine Netw
, vol.15
, pp. 47-52
-
-
Saldeen, J.1
Welsh, N.2
-
12
-
-
0141888306
-
Novel roles for palmitoylation of Ras in IL-1 beta-induced nitric oxide release and caspase 3 activation in insulin-secreting beta cells
-
Chen H.Q., Tannous M., Veluthakal R., Amin R., Kowluru A. Novel roles for palmitoylation of Ras in IL-1 beta-induced nitric oxide release and caspase 3 activation in insulin-secreting beta cells. Biochem Pharmacol 2003, 66:1681-1694.
-
(2003)
Biochem Pharmacol
, vol.66
, pp. 1681-1694
-
-
Chen, H.Q.1
Tannous, M.2
Veluthakal, R.3
Amin, R.4
Kowluru, A.5
-
13
-
-
4544350049
-
Interleukin-1 beta induces posttranslational carboxymethylation and alterations in subnuclear distribution of lamin B in insulin-secreting RINm5F cells
-
Veluthakal R., Amin R., Kowluru A. Interleukin-1 beta induces posttranslational carboxymethylation and alterations in subnuclear distribution of lamin B in insulin-secreting RINm5F cells. Am J Physiol Cell Physiol 2004, 287:C1152-C1162.
-
(2004)
Am J Physiol Cell Physiol
, vol.287
-
-
Veluthakal, R.1
Amin, R.2
Kowluru, A.3
-
14
-
-
7544226867
-
TNF-alpha in vivo stimulates apoptosis in fibroblasts through caspase-8 activation and modulates the expression of pro-apoptotic genes
-
Alikhani M., Alikhani Z., Raptis M., Graves D.T. TNF-alpha in vivo stimulates apoptosis in fibroblasts through caspase-8 activation and modulates the expression of pro-apoptotic genes. J Cell Physiol 2004, 201:341-348.
-
(2004)
J Cell Physiol
, vol.201
, pp. 341-348
-
-
Alikhani, M.1
Alikhani, Z.2
Raptis, M.3
Graves, D.T.4
-
15
-
-
0034453105
-
Interferon-gamma induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism
-
Karlsen A.E., Pavlovic D., Nielsen K., Jensen J., Andersen H.U., Pociot F., et al. Interferon-gamma induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism. J Clin Endocrinol Metab 2000, 85:830-836.
-
(2000)
J Clin Endocrinol Metab
, vol.85
, pp. 830-836
-
-
Karlsen, A.E.1
Pavlovic, D.2
Nielsen, K.3
Jensen, J.4
Andersen, H.U.5
Pociot, F.6
-
16
-
-
77951240575
-
Protection against cytokine toxicity through endoplasmic reticulum and mitochondrial stress prevention by prostacyclin synthase overexpression in insulin-producing cells
-
Gurgul-Convey E., Lenzen S. Protection against cytokine toxicity through endoplasmic reticulum and mitochondrial stress prevention by prostacyclin synthase overexpression in insulin-producing cells. J Biol Chem 2010, 285:8-11121.
-
(2010)
J Biol Chem
, vol.285
, pp. 8-11121
-
-
Gurgul-Convey, E.1
Lenzen, S.2
-
17
-
-
26444442450
-
Endoplasmic reticulum stress: cell life and death decisions
-
Xu C., Bailly-Maitre B., Reed J.C. Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 2005, 115:2656-2664.
-
(2005)
J Clin Invest
, vol.115
, pp. 2656-2664
-
-
Xu, C.1
Bailly-Maitre, B.2
Reed, J.C.3
-
18
-
-
39149104320
-
The role for endoplasmic reticulum stress in diabetes mellitus
-
Eizirik D.L., Cardozo A.K., Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 2008, 29:42-61.
-
(2008)
Endocr Rev
, vol.29
, pp. 42-61
-
-
Eizirik, D.L.1
Cardozo, A.K.2
Cnop, M.3
-
19
-
-
77952574173
-
-
ER stress in pancreatic beta cells: the thin red line between adaptation and failure. Sci Signal 3: pe7.
-
Eizirik DL, Cnop M. ER stress in pancreatic beta cells: the thin red line between adaptation and failure. Sci Signal 3: pe7.
-
-
-
Eizirik, D.L.1
Cnop, M.2
-
20
-
-
0035845568
-
Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway
-
Oyadomari S., Takeda K., Takiguchi M., Gotoh T., Matsumoto M., Wada I., et al. Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway. Proc Nat Acad Sci USA 2001, 98:10845-10850.
-
(2001)
Proc Nat Acad Sci USA
, vol.98
, pp. 10845-10850
-
-
Oyadomari, S.1
Takeda, K.2
Takiguchi, M.3
Gotoh, T.4
Matsumoto, M.5
Wada, I.6
-
21
-
-
0029938805
-
Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase
-
Wang X.Z., Ron D. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase. Science 1996, 272:1347-1349.
-
(1996)
Science
, vol.272
, pp. 1347-1349
-
-
Wang, X.Z.1
Ron, D.2
-
22
-
-
0035144493
-
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state
-
McCullough K.D., Martindale J.L., Klotz L.O., Aw T.Y., Holbrook N.J. Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state. Mol Cell Biol 2001, 21:1249-1259.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 1249-1259
-
-
McCullough, K.D.1
Martindale, J.L.2
Klotz, L.O.3
Aw, T.Y.4
Holbrook, N.J.5
-
23
-
-
34247623066
-
Triiodothyronine (T3)-mediated toxicity and induction of apoptosis in insulin-producing INS-1 cells
-
Ximenes H.M., Lortz S., Jorns A., Lenzen S. Triiodothyronine (T3)-mediated toxicity and induction of apoptosis in insulin-producing INS-1 cells. Life Sci 2007, 80:2045-2050.
-
(2007)
Life Sci
, vol.80
, pp. 2045-2050
-
-
Ximenes, H.M.1
Lortz, S.2
Jorns, A.3
Lenzen, S.4
-
24
-
-
0021061819
-
Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
-
Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983, 65:55-63.
-
(1983)
J Immunol Methods
, vol.65
, pp. 55-63
-
-
Mosmann, T.1
-
25
-
-
0032791152
-
Protection against the co-operative toxicity of nitric oxide and oxygen free radicals by overexpression of antioxidant enzymes in bioengineered insulin-producing RINm5F cells
-
Tiedge M., Lortz S., Munday R., Lenzen S. Protection against the co-operative toxicity of nitric oxide and oxygen free radicals by overexpression of antioxidant enzymes in bioengineered insulin-producing RINm5F cells. Diabetologia 1999, 42:849-855.
-
(1999)
Diabetologia
, vol.42
, pp. 849-855
-
-
Tiedge, M.1
Lortz, S.2
Munday, R.3
Lenzen, S.4
-
26
-
-
77958041253
-
-
Neuronal nitric oxide synthase protects the pancreatic beta cell from glucolipotoxicity-induced endoplasmic reticulum stress and apoptosis. Diabetologia
-
Bachar E, Ariav Y, Cerasi E, Kaiser N, Leibowitz G. Neuronal nitric oxide synthase protects the pancreatic beta cell from glucolipotoxicity-induced endoplasmic reticulum stress and apoptosis. Diabetologia 53: 2177-87.
-
, vol.53
, pp. 2177-87
-
-
Bachar, E.1
Ariav, Y.2
Cerasi, E.3
Kaiser, N.4
Leibowitz, G.5
-
27
-
-
0037344294
-
Regulation of tissue factor expression in smooth muscle cells with nitric oxide
-
Kibbe M.R., Johnnides C., Gleixner S., Kovesdi I., Lizonova A., Zuckerbraun B., et al. Regulation of tissue factor expression in smooth muscle cells with nitric oxide. J Vasc Surg 2003, 37:650-659.
-
(2003)
J Vasc Surg
, vol.37
, pp. 650-659
-
-
Kibbe, M.R.1
Johnnides, C.2
Gleixner, S.3
Kovesdi, I.4
Lizonova, A.5
Zuckerbraun, B.6
-
28
-
-
0034610743
-
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
-
Nakagawa T., Zhu H., Morishima N., Li E., Xu J., Yankner B.A., et al. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 2000, 403:98-103.
-
(2000)
Nature
, vol.403
, pp. 98-103
-
-
Nakagawa, T.1
Zhu, H.2
Morishima, N.3
Li, E.4
Xu, J.5
Yankner, B.A.6
-
29
-
-
9244231766
-
Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress
-
Kharroubi I., Ladriere L., Cardozo A.K., Dogusan Z., Cnop M., Eizirik D.L. Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress. Endocrinology 2004, 145:5087-5096.
-
(2004)
Endocrinology
, vol.145
, pp. 5087-5096
-
-
Kharroubi, I.1
Ladriere, L.2
Cardozo, A.K.3
Dogusan, Z.4
Cnop, M.5
Eizirik, D.L.6
-
30
-
-
38449122843
-
The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death
-
Chambers K.T., Unverferth J.A., Weber S.M., Wek R.C., Urano F., Corbett J.A. The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death. Diabetes 2008, 57:124-132.
-
(2008)
Diabetes
, vol.57
, pp. 124-132
-
-
Chambers, K.T.1
Unverferth, J.A.2
Weber, S.M.3
Wek, R.C.4
Urano, F.5
Corbett, J.A.6
-
31
-
-
19944432792
-
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells
-
Cardozo A.K., Ortis F., Storling J., Feng Y.M., Rasschaert J., Tonnesen M., et al. Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells. Diabetes 2005, 54:452-461.
-
(2005)
Diabetes
, vol.54
, pp. 452-461
-
-
Cardozo, A.K.1
Ortis, F.2
Storling, J.3
Feng, Y.M.4
Rasschaert, J.5
Tonnesen, M.6
-
32
-
-
34548381411
-
Glucose regulated proteins 78 protects insulinoma cells (NIT-1) from death induced by streptozotocin, cytokines or cytotoxic T lymphocytes
-
Wang M., Zhao X.R., Wang P., Li L., Dai Y., Huang H., et al. Glucose regulated proteins 78 protects insulinoma cells (NIT-1) from death induced by streptozotocin, cytokines or cytotoxic T lymphocytes. Int J Biochem Cell Biol 2007, 39:2076-2082.
-
(2007)
Int J Biochem Cell Biol
, vol.39
, pp. 2076-2082
-
-
Wang, M.1
Zhao, X.R.2
Wang, P.3
Li, L.4
Dai, Y.5
Huang, H.6
-
33
-
-
33646533330
-
Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms
-
Pirot P., Eizirik D.L., Cardozo A.K. Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms. Diabetologia 2006, 49:1229-1236.
-
(2006)
Diabetologia
, vol.49
, pp. 1229-1236
-
-
Pirot, P.1
Eizirik, D.L.2
Cardozo, A.K.3
|