Protection against cytokine toxicity through endoplasmic reticulum and mitochondrial stress prevention by prostacyclin synthase overexpression in insulin-producing cells

Journal of Biological Chemistry

Volumn 285, Issue 15, 2010, Pages 11121-11128

  Gurgul Convey, Ewa ^a   Lenzen, Sigurd ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACIDS; AUTOIMMUNE DISEASE; CASPASE-3 ACTIVATION; CELL TYPES; CELL-DEATH PATHWAYS; CYCLOOXYGENASES; CYTOKINES; ENDOPLASMIC RETICULUM; GLUCOSE OXIDATION; MITOCHONDRIAL STRESS; OVER-EXPRESSION; PROINFLAMMATORY CYTOKINES; PROTECTIVE EFFECTS; PROTEIN EXPRESSIONS; SYNTHASES; TYPE 1 DIABETES MELLITUS;

CELL DEATH; CELL PROLIFERATION; ENZYME INHIBITION; GLUCOSE; INSULIN; REDUCTION; TRANSCRIPTION FACTORS;

TOXICITY;

CASPASE 12; CASPASE 3; CASPASE 9; COMPLEMENTARY DNA; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; NITRITE; PROSTACYCLIN SYNTHASE;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL PROTECTION; CELL STRESS; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; GENE OVEREXPRESSION; MITOCHONDRION; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CASPASES; CELL PROLIFERATION; CYTOCHROME P-450 ENZYME SYSTEM; CYTOKINES; ENDOPLASMIC RETICULUM; EPOPROSTENOL; HUMANS; INSULIN; INSULIN-SECRETING CELLS; INTRAMOLECULAR OXIDOREDUCTASES; MITOCHONDRIA; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RATS;

EID: 77951240575     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.054775     Document Type: Article

References (71)

1. Bach, J. F. (1994) Endocr. Rev. 15, 516-542
2. McDaniel, M. L., Kwon, G., Hill, J. R., Marshall, C. A., and Corbett, J. A. (1996) Proc. Soc. Exp. Biol. Med. 211, 24-32
3. Yang, Z., Chen, M., Ellett, J. D., Carter, J. D., Brayman, K. L., and Nadler, J. L. (2005) Am. J. Transplant 5, 475-483
4. Cnop, M., Welsh, N., Jonas, J. C., Jörns, A., Lenzen, S., and Eizirik, D. L. (2005) Diabetes 54, (Suppl. 2) S97-S107
5. Eizirik, D. L. (1996) Horm. Metab. Res. 28, 302-305
6. Eizirik, D. L., and Mandrup-Poulsen, T. (2001) Diabetologia 44, 2115-2133
7. Lenzen, S. (2008) Biochem. Soc. Trans. 36, 343-347
8. Mandrup-Poulsen, T. (1996) Diabetologia 39, 1005-1029
9. Mandrup-Poulsen, T. (2003) Ann. N.Y. Acad. Sci. 1005, 32-42
10. Sorli, C. H., Zhang, H. J., Armstrong, M. B., Rajotte, R. V., Maclouf, J., and Robertson, R. P. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 1788-1793
11. Robertson, R. P. (1998) Diabetes 47, 1379-1383
12. Jobin, C., Morteau, O., Han, D. S., and Balfour Sartor, R. (1998) Immunology 95, 537-543
13. Tabatabaie, T., Vasquez-Weldon, A., Moore, D. R., and Kotake, Y. (2003) Diabetes 52, 1994-1999
14. Heitmeier, M. R., Kelly, C. B., Ensor, N. J., Gibson, K. A., Mullis, K. G., Corbett, J. A., and Maziasz, T. J. (2004) J. Biol. Chem. 279, 53145-53151
15. Kwon, G., Corbett, J. A., Hauser, S., Hill, J. R., Turk, J., and McDaniel, M. L. (1998) Diabetes 47, 583-591
16. Marnett, L. J. (2000) Ernst Schering Research Foundation Workshop 31, 65-83
17. Marnett, L. J., Panthananickal, A., and Reed, G. A. (1982) Drug Metab. Rev. 13, 235-247
18. Tran, P. O., Gleason, C. E., Poitout, V., and Robertson, R. P. (1999) J. Biol. Chem. 274, 31245-31248
19. Chambers, K. T., Weber, S. M., and Corbett, J. A. (2007) Am. J. Physiol. Endocrinol. Metab. 292, E1052-E1061
20. Siegle, I., Klein, T., Zou, M. H., Fritz, P., and Kömhoff, M. (2000) J. Histochem. Cytochem. 48, 631-641
21. Hatae, T., Wada, M., Yokoyama, C., Shimonishi, M., and Tanabe, T. (2001) J. Biol. Chem. 276, 46260-46267
22. Wu, K. K., and Liou, J. Y. (2005) Biochem. Biophys. Res. Commun. 338, 45-52
23. Liou, J. Y., Lee, S., Ghelani, D., Matijevic-Aleksic, N., and Wu, K. K. (2006) Arterioscler. Thromb. Vasc. Biol. 26, 1481-1487
24. Tran, P. O., Gleason, C. E., and Robertson, R. P. (2002) Diabetes 51, 1772-1778
25. Arita, S., Kasraie, A., Une, S., Ohtsuka, S., Kawahara, T., Shevlin, L., Matusda, N., Amirmoazzami, S., and Mullen, Y. (1997) Transplant. Proc. 29, 1977
26. Arita, S., Kasraie, A., Une, S., Ohtsuka, S., Kawahara, T., Smith, C. V., and Mullen, Y. (1999) Pancreas 19, 289-296
27. Arita, S., Une, S., Ohtsuka, S., Kawahara, T., Kasraie, A., Shevlin, L., and Mullen, Y. (1998) Transplant. Proc. 30, 366
28. Arita, S., Une, S., Ohtsuka, S., Kawahara, T., Kasraie, A., Smith, C. V., and Mullen, Y. (2001) Pancreas 23, 62-67
29. Yeǧen, C., Aktan, A. O., Döşlüoǧlu, H. H., Ercan, S., and Yalin, R. (1994) Prostaglandins Leukot. Essent. Fatty Acids 51, 257-262
30. Lortz, S., Tiedge, M., Nachtwey, T., Karlsen, A. E., Nerup, J., and Lenzen, S. (2000) Diabetes 49, 1123-1130
31. Elsner, M., Tiedge, M., Guldbakke, B., Munday, R., and Lenzen, S. (2002) Diabetologia 45, 1542-1549
32. Mosmann, T. (1983) J. Immunol. Methods 65, 55-63
33. Gurgul, E., Lortz, S., Tiedge, M., Jörns, A., and Lenzen, S. (2004) Diabetes 53, 2271-2280
34. Azevedo-Martins, A. K., Lortz, S., Lenzen, S., Curi, R., Eizirik, D. L., and Tiedge, M. (2003) Diabetes 52, 93-101
35. Souza, K. L., Gurgul-Convey, E., Elsner, M., and Lenzen, S. (2008) J. Endocrinol. 197, 139-150
36. Schreiber, E., Matthias, P., Müller, M. M., and Schaffner, W. (1989) Nucleic Acids Res. 17, 6419
37. Tiedge, M., Lortz, S., Munday, R., and Lenzen, S. (1999) Diabetologia 42, 849-855
38. Lenzen, S., and Panten, U. (1980) Biochem. J. 186, 135-144
39. Eizirik, D. L. (1988) Acta Endocrinol. 119, 321-325
40. Eizirik, D. L. (1991) Autoimmunity 10, 107-113
41. Eizirik, D. L., Bendtzen, K., and Sandler, S. (1991) Endocrinology 128, 1611-1616
42. Eizirik, D. L., Sandler, S., Welsh, N., Cetkovic-Cvrlje, M., Nieman, A., Geller, D. A., Pipeleers, D. G., Bendtzen, K., and Hellerström, C. (1994) J. Clin. Invest. 93, 1968-1974
43. Rønn, S. G., Billestrup, N., and Mandrup-Poulsen, T. (2007) Diabetes 56, 541-548
44. Sandler, S., Eizirik, D. L., Svensson, C., Strandell, E., Welsh, M., and Welsh, N. (1992) Lakartidningen 89, 1777-1779
45. Bast, A., Wolf, G., Oberbäumer, I., and Walther, R. (2002) Diabetologia 45, 867-876
46. Lortz, S., Gurgul-Convey, E., Lenzen, S., and Tiedge, M. (2005) Diabetologia 48, 1541-1548
47. Lortz, S., and Tiedge, M. (2003) Free Radic. Biol. Med. 34, 683-688
48. Størling, J., Binzer, J., Andersson, A. K., Züllig, R. A., Tonnesen, M., Lehmann, R., Spinas, G. A., Sandler, S., Billestrup, N., and Mandrup-Poulsen, T. (2005) Diabetologia 48, 2039-2050
49. Suarez-Pinzon, W. L., Mabley, J. G., Strynadka, K., Power, R. F., Szabó, C., and Rabinovitch, A. (2001) J. Autoimmun. 16, 449-455
50. Paolisso, G., Di Maro, G., D'Amore, A., Passariello, N., Gambardella, A., Varricchio, M., and D'Onofrio, F. (1995) Diabetes Care 18, 200-205
51. Eldor, R., Yeffet, A., Baum, K., Doviner, V., Amar, D., Ben-Neriah, Y., Christofori, G., Peled, A., Carel, J. C., Boitard, C., Klein, T., Serup, P., Eizirik, D. L., and Melloul, D. (2006) Proc. Natl. Acad. Sci. U.S.A. 103, 5072-5077
52. Flodström, M., Tyrberg, B., Eizirik, D. L., and Sandler, S. (1999) Diabetes 48, 706-713
53. Maggi, L. B., Jr., Sadeghi, H., Weigand, C., Scarim, A. L., Heitmeier, M. R., and Corbett, J. A. (2000) Diabetes 49, 346-355
54. Weber, S. M., Scarim, A. L., and Corbett, J. A. (2003) Am. J. Physiol. Endocrinol. Metab. 284, E883-E891
55. Rossi, A., Kapahi, P., Natoli, G., Takahashi, T., Chen, Y., Karin, M., and Santoro, M. G. (2000) Nature 403, 103-108
56. Rossi, A., Elia, G., and Santoro, M. G. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 746-750
57. Darville, M. I., and Eizirik, D. L. (1998) Diabetologia 41, 1101-1108
58. Eizirik, D. L., and Leijerstam, F. (1994) Diabetes Metab. 20, 116-122
59. Flodström, M., Welsh, N., and Eizirik, D. L. (1996) FEBS Lett. 385, 4-6
60. Petrova, T. V., Akama, K. T., and Van Eldik, L. J. (1999) Proc. Natl. Acad. Sci. U.S.A. 96, 4668-4673
61. Ortis, F., Pirot, P., Naamane, N., Kreins, A. Y., Rasschaert, J., Moore, F., Théâtre, E., Verhaeghe, C., Magnusson, N. E., Chariot, A., Orntoft, T. F., and Eizirik, D. L. (2008) Diabetologia 51, 1213-1225
62. Tonnesen, M. F., Grunnet, L. G., Friberg, J., Cardozo, A. K., Billestrup, N., Eizirik, D. L., Størling, J., and Mandrup-Poulsen, T. (2009) Endocrinology 150, 4094-4103
63. Chambers, K. T., Unverferth, J. A., Weber, S. M., Wek, R. C., Urano, F., and Corbett, J. A. (2008) Diabetes 57, 124-132
64. Weber, S. M., Chambers, K. T., Bensch, K. G., Scarim, A. L., and Corbett, J. A. (2004) Am. J. Physiol. Endocrinol. Metab. 287, E1171-E1177
65. Eizirik, D. L., Cardozo, A. K., and Cnop, M. (2008) Endocr. Rev. 29, 42-61
66. Scarim, A. L., Heitmeier, M. R., and Corbett, J. A. (1997) Endocrinology 138, 5301-5307
67. Pakrasi, P. L., and Jain, A. K. (2007) Life Sci. 80, 1503-1507
68. Pakrasi, P. L., and Jain, A. K. (2008) Prostaglandins Leukot. Essent. Fatty Acids 79, 27-33
69. Kunugiza, Y., Tomita, N., Taniyama, Y., Tomita, T., Osako, M. K., Tamai, K., Tanabe, T., Kaneda, Y., Yoshikawa, H., and Morishita, R. (2006) Gene Ther. 13, 1143-1152
70. Paolisso, G., Gambardella, A., Saccomanno, F., Varricchio, G., D'Amore, A., and Varricchio, M. (1995) Eur. J. Clin. Pharmacol. 48, 333-338
71. Scheeren, T., Susanto, F., Reinauer, H., Tarnow, J., and Radermacher, P. (1994) J. Crit. Care 9, 175-184