Neuronal nitric oxide synthase protects the pancreatic beta cell from glucolipotoxicity-induced endoplasmic reticulum stress and apoptosis

Diabetologia

Volumn 53, Issue 10, 2010, Pages 2177-2187

  Bachar, E ^a   Ariav, Y ^a   Cerasi, E ^a   Kaiser, N ^a   Leibowitz, G ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Apoptosis; Beta cells; Endoplasmic reticulum stress; Islets; Nitric oxide synthase; Type 2 diabetes

Indexed keywords

GLUCOSE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INDUCIBLE NITRIC OXIDE SYNTHASE; INOSITOL REQUIRING ENDOPLASMIC RETICULUM TO NUCLEUS SIGNAL KINASE 1; INSULIN; NEURONAL NITRIC OXIDE SYNTHASE; PALMITIC ACID; PHOSPHOTRANSFERASE; PROINSULIN; PROTEIN KINASE LIKE ENDOPLASMIC RETICULUM ASSOCIATED KINASE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SYNTHESIS; INSULIN RELEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PSAMMOMYS OBESUS; RAT;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE; CELLS, CULTURED; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; MAP KINASE KINASE 4; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE TYPE I; PALMITIC ACID; PHOSPHORYLATION; RADIOIMMUNOASSAY; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 77958041253     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1833-6     Document Type: Article

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