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Volumn 51, Issue 2, 2011, Pages 539-551

ROS-activated p38 MAPK/ERK-Akt cascade plays a central role in palmitic acid-stimulated hepatocyte proliferation

Author keywords

Akt; Cell cycle; MAPKs; Nrf2; Palmitic acid; Proliferation; ROS

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE P38; PALMITIC ACID; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; MITOGEN ACTIVATED PROTEIN KINASE; PRIMER DNA;

EID: 79959362322     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.04.019     Document Type: Article
Times cited : (131)

References (50)
  • 1
    • 34748912615 scopus 로고    scopus 로고
    • Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
    • DOI 10.1038/nrc2222, PII NRC2222
    • J.A. Menendez, and R. Lupu Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis Nat. Rev. Cancer 7 2007 763 777 (Pubitemid 47469806)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.10 , pp. 763-777
    • Menendez, J.A.1    Lupu, R.2
  • 2
    • 33745728461 scopus 로고    scopus 로고
    • Fatty acid synthase and cancer: New application of an old pathway
    • F.P. Kuhajda Fatty acid synthase and cancer: new application of an old pathway Cancer Res. 66 2006 5977 5980
    • (2006) Cancer Res. , vol.66 , pp. 5977-5980
    • Kuhajda, F.P.1
  • 3
    • 3543072186 scopus 로고    scopus 로고
    • Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms
    • E.E. Calle, and R. Kaaks Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms Nat. Rev. Cancer 4 2004 579 591 (Pubitemid 39025053)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.8 , pp. 579-591
    • Calle, E.E.1    Kaaks, R.2
  • 4
    • 0030038191 scopus 로고    scopus 로고
    • Fatty acid synthase (FAS): A target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells
    • E. Pizer, F. Wood, G. Pasternack, and F. Kuhajda Fatty acid synthase (FAS): a target for cytotoxic antimetabolites in HL60 promyelocytic leukemia cells Cancer Res. 56 1996 745 751 (Pubitemid 26055462)
    • (1996) Cancer Research , vol.56 , Issue.4 , pp. 745-751
    • Pizer, E.S.1    Wood, F.D.2    Pasternack, G.R.3    Kuhajda, F.P.4
  • 5
    • 48449083426 scopus 로고    scopus 로고
    • Saturated fatty acids modulate cell response to DNA damage: Implication for their role in tumorigenesis
    • L. Zeng, G.Z. Wu, K.J. Goh, Y.M. Lee, C.C. Ng, A.B. You, J. Wang, D. Jia, A. Hao, Q. Yu, and B. Li Saturated fatty acids modulate cell response to DNA damage: implication for their role in tumorigenesis PLoS One 3 2008 2329
    • (2008) PLoS One , vol.3 , pp. 2329
    • Zeng, L.1    Wu, G.Z.2    Goh, K.J.3    Lee, Y.M.4    Ng, C.C.5    You, A.B.6    Wang, J.7    Jia, D.8    Hao, A.9    Yu, Q.10    Li, B.11
  • 6
    • 0141755328 scopus 로고    scopus 로고
    • A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes
    • DOI 10.2337/diabetes.52.10.2461
    • S. Kashyap, R. Belfort, A. Gastaldelli, T. Pratipanawatr, R. Berria, W. Pratipanawatr, M. Bajaj, L. Mandarino, R. DeFronzo, and K. Cusi A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes Diabetes 52 2003 2461 2474 (Pubitemid 37210533)
    • (2003) Diabetes , vol.52 , Issue.10 , pp. 2461-2474
    • Kashyap, S.1    Belfort, R.2    Gastaldelli, A.3    Pratipanawatr, T.4    Berria, R.5    Pratipanawatr, W.6    Bajaj, M.7    Mandarino, L.8    DeFronzo, R.9    Cusi, K.10
  • 7
    • 0026684963 scopus 로고
    • Carbohydrate restriction regulates the adaptive response to fasting
    • S. Klein, and R. Wolfe Carbohydrate restriction regulates the adaptive response to fasting Am. J. Physiol. 262 1992 631
    • (1992) Am. J. Physiol. , vol.262 , pp. 631
    • Klein, S.1    Wolfe, R.2
  • 8
    • 34347405554 scopus 로고    scopus 로고
    • Mechanisms of growth arrest by zinc ribbon domain-containing 1 in gastric cancer cells
    • DOI 10.1093/carcin/bgm064
    • L. Hong, Y. Zhao, Y. Han, W. Guo, H. Jin, T. Qiao, Z. Che, and D. Fan Mechanisms of growth arrest by zinc ribbon domain-containing 1 in gastric cancer cells Carcinogenesis 28 2007 1622 1628 (Pubitemid 47289022)
    • (2007) Carcinogenesis , vol.28 , Issue.8 , pp. 1622-1628
    • Hong, L.1    Zhao, Y.2    Han, Y.3    Guo, W.4    Jin, H.5    Qiao, T.6    Che, Z.7    Fan, D.8
  • 10
    • 65949099937 scopus 로고    scopus 로고
    • Activation and reversal of lipotoxicity in PC12 and rat cortical cells following exposure to palmitic acid
    • F.G. Almaguel, J.W. Liu, F.J. Pacheco, C.A. Casiano, and M. De Leon Activation and reversal of lipotoxicity in PC12 and rat cortical cells following exposure to palmitic acid J. Neurosci. Res. 87 2009 1207 1218
    • (2009) J. Neurosci. Res. , vol.87 , pp. 1207-1218
    • Almaguel, F.G.1    Liu, J.W.2    Pacheco, F.J.3    Casiano, C.A.4    De Leon, M.5
  • 12
    • 73749087888 scopus 로고    scopus 로고
    • The protective effects of Acanthopanax senticosus harms aqueous extracts against oxidative stress: Role of Nrf2 and antioxidant enzymes
    • X. Wang, C.X. Hai, X. Liang, S.X. Yu, W. Zhang, and Y.L. Li The protective effects of Acanthopanax senticosus harms aqueous extracts against oxidative stress: role of Nrf2 and antioxidant enzymes J. Ethnopharmacol. 127 2010 424 432
    • (2010) J. Ethnopharmacol. , vol.127 , pp. 424-432
    • Wang, X.1    Hai, C.X.2    Liang, X.3    Yu, S.X.4    Zhang, W.5    Li, Y.L.6
  • 13
    • 0029897419 scopus 로고    scopus 로고
    • The involvement of protein phosphatases in the activation of ICE/CED-3 protease, intracellular acidification, DNA digestion, and apoptosis
    • DOI 10.1074/jbc.271.30.18263
    • S.J. Morana, C.M. Wolf, J. Li, J.E. Reynolds, M.K. Brown, and A. Eastman The involvement of protein phosphatases in the activation of ICE/CED-3 protease, intracellular acidification, DNA digestion, and apoptosis J. Biol. Chem. 271 1996 18263 18271 (Pubitemid 26250821)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.30 , pp. 18263-18271
    • Morana, S.J.1    Wolf, C.M.2    Li, J.3    Reynolds, J.E.4    Brown, M.K.5    Eastman, A.6
  • 14
    • 77953699065 scopus 로고    scopus 로고
    • ATP stimulates the proliferation of MCF-7 cells through the PI3K/Akt signaling pathway
    • P.S. Bilbao, G. Santillan, and R. Boland ATP stimulates the proliferation of MCF-7 cells through the PI3K/Akt signaling pathway Arch. Biochem. Biophys. 499 2010 40 48
    • (2010) Arch. Biochem. Biophys. , vol.499 , pp. 40-48
    • Bilbao, P.S.1    Santillan, G.2    Boland, R.3
  • 15
    • 33646698671 scopus 로고    scopus 로고
    • Hydrogen peroxide: A signaling messenger
    • Stone Jr., and S. Yang Hydrogen peroxide: a signaling messenger Antioxid. Redox Signal. 8 2006 243
    • (2006) Antioxid. Redox Signal. , vol.8 , pp. 243
    • Stone, J.1    Yang, S.2
  • 16
    • 57249104720 scopus 로고    scopus 로고
    • Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes
    • X. He, H. Kan, L. Cai, and Q. Ma Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes J. Mol. Cell. Cardiol. 46 2009 47 58
    • (2009) J. Mol. Cell. Cardiol. , vol.46 , pp. 47-58
    • He, X.1    Kan, H.2    Cai, L.3    Ma, Q.4
  • 17
    • 33745116619 scopus 로고    scopus 로고
    • Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress which may contribute to INS-1 pancreatic beta-cell apoptosis
    • E. Karaskov, C. Scott, L. Zhang, T. Teodoro, M. Ravazzola, and A. Volchuk Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress which may contribute to INS-1 pancreatic beta-cell apoptosis Endocrinology 147 2006 3398
    • (2006) Endocrinology , vol.147 , pp. 3398
    • Karaskov, E.1    Scott, C.2    Zhang, L.3    Teodoro, T.4    Ravazzola, M.5    Volchuk, A.6
  • 18
  • 20
    • 73449084413 scopus 로고    scopus 로고
    • Regulation and importance of the PI3K/Akt/mTOR signaling pathway in hematologic malignancies
    • K. Kawauchi, T. Ogasawara, M. Yasuyama, K. Otsuka, and O. Yamada Regulation and importance of the PI3K/Akt/mTOR signaling pathway in hematologic malignancies Anticancer Agents Med Chem. 9 2009 1024 1038
    • (2009) Anticancer Agents Med Chem. , vol.9 , pp. 1024-1038
    • Kawauchi, K.1    Ogasawara, T.2    Yasuyama, M.3    Otsuka, K.4    Yamada, O.5
  • 21
    • 0036469122 scopus 로고    scopus 로고
    • Role of the phosphatidylinositol 3′-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells
    • S. Van De, E. De Schrijver, W. Heyns, G. Verhoeven, and J. Swinnen Role of the phosphatidylinositol 39-kinase/PTEN/Akt kinase pathway in the overexpression of fatty acid synthase in LNCaP prostate cancer cells Cancer Res. 62 2002 642 646 (Pubitemid 34126933)
    • (2002) Cancer Research , vol.62 , Issue.3 , pp. 642-646
    • Van De Sande, T.1    De Schrijver, E.2    Heyns, W.3    Verhoeven, G.4    Swinnen, J.V.5
  • 22
    • 0036385719 scopus 로고    scopus 로고
    • Activation of fatty acid synthesis during neoplastic transformation: Role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase
    • Y.A. Yang, W.F. Han, P.J. Morin, F.J. Chrest, and E.S. Pizer Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase Exp. Cell Res. 279 2002 80 90
    • (2002) Exp. Cell Res. , vol.279 , pp. 80-90
    • Yang, Y.A.1    Han, W.F.2    Morin, P.J.3    Chrest, F.J.4    Pizer, E.S.5
  • 23
    • 51849111556 scopus 로고    scopus 로고
    • PI3K pathway alterations in cancer: Variations on a theme
    • T.L. Yuan, and L.C. Cantley PI3K pathway alterations in cancer: variations on a theme Oncogene 27 2008 5497 5510
    • (2008) Oncogene , vol.27 , pp. 5497-5510
    • Yuan, T.L.1    Cantley, L.C.2
  • 24
    • 77954029857 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 induces phosphorylation of PI3K-Akt/PKB to potentiate proliferation of smooth muscle cells in human saphenous vein
    • G. Jia, A.K. Mitra, D.M. Gangahar, and D.K. Agrawal Insulin-like growth factor-1 induces phosphorylation of PI3K-Akt/PKB to potentiate proliferation of smooth muscle cells in human saphenous vein Exp. Mol. Pathol. 2010 10
    • (2010) Exp. Mol. Pathol. , pp. 10
    • Jia, G.1    Mitra, A.K.2    Gangahar, D.M.3    Agrawal, D.K.4
  • 25
    • 33845998875 scopus 로고    scopus 로고
    • ATP stimulates mouse embryonic stem cell proliferation via protein kinase C, phosphatidylinositol3-kinase/AKT, and mitogen-activated protein kinase signaling pathways
    • J.S. Heo, and H.J. Han ATP stimulates mouse embryonic stem cell proliferation via protein kinase C, phosphatidylinositol3-kinase/AKT, and mitogen-activated protein kinase signaling pathways Stem Cells 24 2006 2637 2648
    • (2006) Stem Cells , vol.24 , pp. 2637-2648
    • Heo, J.S.1    Han, H.J.2
  • 26
    • 58849125861 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 promotes G1/S cell cycle progression through bidirectional regulation of cyclins and cyclin-dependent kinase inhibitors via the phosphatidylinositol3-kinase/AKT pathway in developing rat cerebral cortex
    • G. Mairet-Coello, A. Tury, and E. DiCicco-Bloom Insulin-like growth factor-1 promotes G1/S cell cycle progression through bidirectional regulation of cyclins and cyclin-dependent kinase inhibitors via the phosphatidylinositol3- kinase/AKT pathway in developing rat cerebral cortex J. Neurosci. 29 2009 775 788
    • (2009) J. Neurosci. , vol.29 , pp. 775-788
    • Mairet-Coello, G.1    Tury, A.2    Dicicco-Bloom, E.3
  • 27
    • 79952426996 scopus 로고    scopus 로고
    • Sporamin induce apoptosis in human tongue carcinoma cells by down-regulating Akt/GSK-3 signaling
    • J. Yao, and C. Qian Sporamin induce apoptosis in human tongue carcinoma cells by down-regulating Akt/GSK-3 signaling Fundam. Clin. Pharmacol. 25 2011 229 236
    • (2011) Fundam. Clin. Pharmacol. , vol.25 , pp. 229-236
    • Yao, J.1    Qian, C.2
  • 28
    • 77950867726 scopus 로고    scopus 로고
    • CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3beta/beta-catenin signaling
    • S. Trazzi, M. Steger, V.M. Mitrugno, R. Bartesaghi, and E. Ciani CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3beta/beta-catenin signaling J. Biol. Chem. 285 2010 10098 10109
    • (2010) J. Biol. Chem. , vol.285 , pp. 10098-10109
    • Trazzi, S.1    Steger, M.2    Mitrugno, V.M.3    Bartesaghi, R.4    Ciani, E.5
  • 29
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • T. Schmelzle, and M.N. Hall TOR, a central controller of cell growth Cell 103 2000 253 262
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 30
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • DOI 10.1038/ncb839
    • K. Inoki, Y. Li, T. Zhu, J. Wu, and K.L. Guan TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling Nat. Cell Biol. 4 2002 648 657 (Pubitemid 34993700)
    • (2002) Nature Cell Biology , vol.4 , Issue.9 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.-L.5
  • 31
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI(3)K and mTOR signalling controls tumour cell growth
    • DOI 10.1038/nature04869, PII NATURE04869
    • R.J. Shaw, and L.C. Cantley Ras, PI(3)K and mTOR signaling controls tumour cell growth Nature 441 2006 424 430 (Pubitemid 44050136)
    • (2006) Nature , vol.441 , Issue.7092 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 33
    • 77951221760 scopus 로고    scopus 로고
    • Epidermal growth factor induces HCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pancreatic cancer cells
    • Z. Xu, Y. Zhang, J. Jiang, Y. Yang, R. Shi, B. Hao, Z. Zhang, Z. Huang, J.W. Kim, and G. Zhang Epidermal growth factor induces HCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pancreatic cancer cells BMC Cancer 10 2010 161 171
    • (2010) BMC Cancer , vol.10 , pp. 161-171
    • Xu, Z.1    Zhang, Y.2    Jiang, J.3    Yang, Y.4    Shi, R.5    Hao, B.6    Zhang, Z.7    Huang, Z.8    Kim, J.W.9    Zhang, G.10
  • 34
    • 77950797954 scopus 로고    scopus 로고
    • Akt-mTOR signaling is involved in Notch-1-mediated glioma cell survival and proliferation
    • N. Zhao, Y. Guo, M. Zhang, L. Lin, and Z. Zheng Akt-mTOR signaling is involved in Notch-1-mediated glioma cell survival and proliferation Oncol. Rep. 23 2010 1443 1447
    • (2010) Oncol. Rep. , vol.23 , pp. 1443-1447
    • Zhao, N.1    Guo, Y.2    Zhang, M.3    Lin, L.4    Zheng, Z.5
  • 35
    • 77950234271 scopus 로고    scopus 로고
    • Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway
    • X. Pang, Z. Yi, J. Zhang, B. Lu, B. Sung, W. Qu, B.B. Aggarwal, and M. Liu Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway Cancer Res. 70 2010 1951 1959
    • (2010) Cancer Res. , vol.70 , pp. 1951-1959
    • Pang, X.1    Yi, Z.2    Zhang, J.3    Lu, B.4    Sung, B.5    Qu, W.6    Aggarwal, B.B.7    Liu, M.8
  • 36
    • 34248572839 scopus 로고    scopus 로고
    • MAP kinases and the control of nuclear events
    • DOI 10.1038/sj.onc.1210415, PII 1210415
    • A. Turjanski, J. Vaque, and J. Gutkind MAP kinases and the control of nuclear events Oncogene 26 2007 3240 3253 (Pubitemid 46763018)
    • (2007) Oncogene , vol.26 , Issue.22 , pp. 3240-3253
    • Turjanski, A.G.1    Vaque, J.P.2    Gutkind, J.S.3
  • 37
    • 69049096930 scopus 로고    scopus 로고
    • Lycopene inhibits PDGF-BB-induced retinal pigment epithelial cell migration by suppression of PI3K/Akt and MAPK pathways
    • C.M. Chan, J.Y. Fang, H.H. Lin, C.Y. Yang, and C.F. Hung Lycopene inhibits PDGF-BB-induced retinal pigment epithelial cell migration by suppression of PI3K/Akt and MAPK pathways Biochem. Biophys. Res. Commun. 388 2009 172 176
    • (2009) Biochem. Biophys. Res. Commun. , vol.388 , pp. 172-176
    • Chan, C.M.1    Fang, J.Y.2    Lin, H.H.3    Yang, C.Y.4    Hung, C.F.5
  • 39
    • 0034011261 scopus 로고    scopus 로고
    • Oxyradicals and DNA damage
    • L.J. Marnett Oxyradicals and DNA damage Carcinogenesis 21 2000 361 370 (Pubitemid 30137921)
    • (2000) Carcinogenesis , vol.21 , Issue.3 , pp. 361-370
    • Marnett, L.J.1
  • 42
    • 0034961888 scopus 로고    scopus 로고
    • Role of reactive oxygen species in cell signalling pathways
    • DOI 10.1042/0300-5127:0290345
    • J. Hancock, R. Desikan, and S. Neill Role of reactive oxygen species in cell signalling pathways Biochem. Soc. Trans. 29 2001 345 350 (Pubitemid 32587530)
    • (2001) Biochemical Society Transactions , vol.29 , Issue.2 , pp. 345-350
    • Hancock, J.T.1    Desikan, R.2    Neill, S.J.3
  • 43
    • 0034873185 scopus 로고    scopus 로고
    • Reactive oxygen species as intracellular messengers during cell growth and differentiation
    • DOI 10.1159/000047804
    • H. Sauer, M. Wartenberg, and J. Hescheler Reactive oxygen species as intracellular messengers during cell growth and differentiation Cell. Physiol. Biochem. 11 2001 173 186 (Pubitemid 32786086)
    • (2001) Cellular Physiology and Biochemistry , vol.11 , Issue.4 , pp. 173-186
    • Sauer, H.1    Wartenberg, M.2    Hescheler, J.3
  • 44
    • 0142043984 scopus 로고    scopus 로고
    • Redox signaling and the MAP kinase pathways
    • M. Torres, and H. Forman Redox signaling and the MAP kinase pathways Biofactors 17 2003 287 296 (Pubitemid 37267162)
    • (2003) BioFactors , vol.17 , Issue.1-4 , pp. 287-296
    • Torres, M.1    Forman, H.J.2
  • 45
    • 33746500168 scopus 로고    scopus 로고
    • GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development
    • DOI 10.1128/MCB.00779-06
    • S.Z. Luo, C.H. Mao, B. Lee, and A.S. Lee GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development Mol. Cell. Biol. 26 2006 5688 5697 (Pubitemid 44134326)
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.15 , pp. 5688-5697
    • Luo, S.1    Mao, C.2    Lee, B.3    Lee, A.S.4
  • 46
    • 33847050801 scopus 로고    scopus 로고
    • Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    • T. Kensler, N. Wakabayashi, and S. Biswal Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway Annu. Rev. Pharmacol. Toxicol. 47 2007 89
    • (2007) Annu. Rev. Pharmacol. Toxicol. , vol.47 , pp. 89
    • Kensler, T.1    Wakabayashi, N.2    Biswal, S.3
  • 47
  • 49
    • 1942520367 scopus 로고    scopus 로고
    • Nrf2 signaling in coordinated activation of antioxidant gene expression
    • DOI 10.1016/j.freeradbiomed.2004.02.074, PII S0891584904001923
    • A.K. Jaiswal Nrf2 signaling in coordinated activation of antioxidant gene expression Free Radic. Biol. Med. 36 2004 1199 1207 (Pubitemid 38526313)
    • (2004) Free Radical Biology and Medicine , vol.36 , Issue.10 , pp. 1199-1207
    • Jaiswal, A.K.1


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