Nrf2 is critical in defense against high glucose-induced oxidative damage in cardiomyocytes

Journal of Molecular and Cellular Cardiology

Volumn 46, Issue 1, 2009, Pages 47-58

  He, Xiaoqing ^a   Kan, Hong ^b   Cai, Lu ^c   Ma, Qiang ^a  

^a Health Effects Laboratory Division   (United States)

^b WEST VIRGINIA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c University of Louisville School of Medicine   (United States)

Author keywords

Antioxidant; Diabetic cardiomyopathy; Glucose; Nrf2; Oxidative stress; Reactive oxygen species

Indexed keywords

3 NITROPROPIONIC ACID; GLUCOSE; ISOPRENALINE; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIABETES MELLITUS; GENE; GENE EXPRESSION; HEART; HEART MUSCLE CELL; HO1 GENE; MALE; MOUSE; NEWBORN; NONHUMAN; NQO1 GENE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; TIME; WILD TYPE;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; DIABETES MELLITUS, EXPERIMENTAL; GLUCOSE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCYTES, CARDIAC; NF-E2-RELATED FACTOR 2; NITRO COMPOUNDS; OXIDATIVE STRESS; PROPIONIC ACIDS; REACTIVE OXYGEN SPECIES; TISSUE DISTRIBUTION;

MUS;

EID: 57249104720     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2008.10.007     Document Type: Article

References (43)

1. Zimmet P., Alberti K.G., and Shaw J. Global and societal implications of the diabetes epidemic. Nature 414 6865 (2001, Dec 13) 782-787
2. Trost S., and LeWinter M. Diabetic cardiomyopathy. Curr. Treatm. Opt. Cardiovasc. Med. 3 (2001) 481-492
3. Francis G.S. Diabetic cardiomyopathy: fact or fiction. Heart 85 3 (2001, Mar) 247-248
4. Cai L., and Kang Y.J. Oxidative stress and diabetic cardiomyopathy. Cardiovasc. Toxicol. 1 (2001) 181-193
5. Ma Q. Xenobiotic-activated receptors: from transcription to drug metabolism to disease. Chem. Res. Toxicol. 21 9 (2008, Sep) 1651-1671
6. Kensler T.W., Wakabayashi N., and Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu. Rev. Pharmacol. Toxicol. 47 (2007) 89-116
7. Chan K., and Kan Y.W. Nrf2 is essential for protection against acute pulmonary injury in mice. Proc. Natl. Acad. Sci. U. S. A. 96 22 (1999, Oct 26) 12731-12736
8. Kobayashi A., Kang M.I., Okawa H., Ohtsuji M., Zenke Y., Chiba T., et al. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol. Cell. Biol. 24 16 (2004, Aug) 7130-7139
9. Ma Q., Kinneer K., Bi Y., Chan J.Y., and Kan Y.W. Induction of murine NAD(P)H:quinone oxidoreductase by 2,3,7,8-tetrachlorodibenzo-p-dioxin requires the CNC (cap 'n' collar) basic leucine zipper transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2): cross-interaction between AhR (aryl hydrocarbon receptor) and Nrf2 signal transduction. Biochem. J. 377 Pt 1 (2004, Jan 1) 205-213
10. He X., Chen M.G., Lin G.X., and Ma Q. Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2·Keap1·Cul3 complex and recruiting Nrf2·Maf to the antioxidant response element enhancer. J. Biol. Chem. 281 33 (2006, Aug 18) 23620-23631
11. Dinkova-Kostova A.T., Holtzclaw W.D., Cole R.N., Itoh K., Wakabayashi N., Katoh Y., et al. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc. Natl. Acad. Sci. U. S. A. 99 18 (2002, Sep 3) 11908-11913
12. Nguyen T., Sherratt P.J., and Pickett C.B. Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu. Rev. Pharmacol. Toxicol. 43 (2003) 233-260
13. Itoh K., Chiba T., Takahashi S., Ishii T., Igarashi K., Katoh Y., et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. Biochem. Biophys. Res. Commun. 236 2 (1997, Jul 18) 313-322
14. Leung L., Kwong M., Hou S., Lee C., and Chan J.Y. Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress. J. Biol. Chem. 278 48 (2003, Nov 28) 48021-48029
15. Chan K., Han X.D., and Kan Y.W. An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc. Natl. Acad. Sci. U. S. A. 98 8 (2001, Apr 10) 4611-4616
16. Ramos-Gomez M., Kwak M.K., Dolan P.M., Itoh K., Yamamoto M., Talalay P., et al. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc. Natl. Acad. Sci. U. S. A. 98 6 (2001, Mar 13) 3410-3415
17. Hu X., Roberts J.R., Apopa P.L., Kan Y.W., and Ma Q. Accelerated ovarian failure induced by 4-vinyl cyclohexene diepoxide in Nrf2 null mice. Mol. Cell. Biol. 26 3 (2006, Feb) 940-954
18. Hubbs A.F., Benkovic S.A., Miller D.B., O'Callaghan J.P., Battelli L., Schwegler-Berry D., et al. Vacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2. Am. J. Pathol. 170 6 (2007, Jun) 2068-2076
19. He X., Lin G.X., Chen M.G., Zhang J.X., and Ma Q. Protection against chromium (VI)-induced oxidative stress and apoptosis by Nrf2. Recruiting Nrf2 into the nucleus and disrupting the nuclear Nrf2/Keap1 association. Toxicol. Sci. 98 1 (2007, Jul) 298-309
20. He X., Chen M.G., and Ma Q. Activation of Nrf2 in defense against cadmium-induced oxidative stress. Chem. Res. Toxicol. 21 7 (2008, Jul) 1375-1383
21. Ma Q., Battelli L., and Hubbs A.F. Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2. Am. J. Pathol. 168 6 (2006, Jun) 1960-1974
22. Zhu H., Jia Z., Misra B.R., Zhang L., Cao Z., Yamamoto M., et al. Nuclear factor E2-related factor 2-dependent myocardiac cytoprotection against oxidative and electrophilic stress. Cardiovasc. Toxicol. 8 2 (2008, Summer) 71-85
23. Wang G.W., and Kang Y.J. Inhibition of doxorubicin toxicity in cultured neonatal mouse cardiomyocytes with elevated metallothionein levels. J. Pharmacol. Exp. Ther. 288 3 (1999, Mar) 938-944
24. Kan H., Xie Z., and Finkel M.S. iPLA2 inhibitor blocks negative inotropic effect of HIV gp120 on cardiac myocytes. J. Mol. Cell. Cardiol. 40 1 (2006, Jan) 131-137
25. Carter W.O., Narayanan P.K., and Robinson J.P. Intracellular hydrogen peroxide and superoxide anion detection in endothelial cells. J. Leukoc. Biol. 55 2 (1994, Feb) 253-258
26. Ma Q., Renzelli A.J., Baldwin K.T., and Antonini J.M. Superinduction of CYP1A1 gene expression. Regulation of 2,3,7, 8-tetrachlorodibenzo-p-dioxin-induced degradation of Ah receptor by cycloheximide. J. Biol. Chem. 275 17 (2000 Apr, 28) 12676-12683
27. Amaral S., Oliveira P.J., and Ramalho-Santos J. Diabetes and the impairment of reproductive function: possible role of mitochondria and reactive oxygen species. Curr. Diabetes Rev. 4 1 (2008, Feb) 46-54
28. Maasen J.A. Mitochondria, body fat and type 2 diabetes: what is the connection. Minerva Med. 99 3 (2008, Jun) 241-251
29. Newsholme P., Haber E.P., Hirabara S.M., Rebelato E.L., Procopio J., Morgan D., et al. Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity. J. Physiol. 583 Pt 1 (2007, Aug 15) 9-24
30. Nishikawa T., Kukidome D., Sonoda K., Fujisawa K., Matsuhisa T., Motoshima H., et al. Impact of mitochondrial ROS production in the pathogenesis of insulin resistance. Diabetes Res. Clin. Pract. 77 Suppl 1 (2007, Sep) S161-S164
31. Nishikawa T., Kukidome D., Sonoda K., Fujisawa K., Matsuhisa T., Motoshima H., et al. Impact of mitochondrial ROS production on diabetic vascular complications. Diabetes Res. Clin. Pract. 77 Suppl 1 (2007, Sep) S41-S45
32. Song Y., Du Y., Prabhu S.D., and Epstein P.N. Diabetic cardiomyopathy in OVE26 mice shows mitochondrial ROS production and divergence between in vivo and in vitro contractility. Rev. Diabet. Stud. 4 3 (2007, Fall) 159-168
33. Houstis N., Rosen E.D., and Lander E.S. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 440 7086 (2006, Apr 13) 944-948
34. Meigs J.B., Larson M.G., Fox C.S., Keaney Jr. J.F., Vasan R.S., and Benjamin E.J. Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham offspring study. Diabetes Care 30 10 (2007, Oct) 2529-2535
35. Schapira A.H. Oxidative stress and mitochondrial dysfunction in neurodegeneration. Curr. Opin. Neurol. 9 4 (1996, Aug) 260-264
36. Brouillet E., Conde F., Beal M.F., and Hantraye P. Replicating Huntington's disease phenotype in experimental animals. Prog. Neurobiol. 59 5 (1999, Dec) 427-468
37. Liu X., Wei J., Peng D.H., Layne M.D., and Yet S.F. Absence of heme oxygenase-1 exacerbates myocardial ischemia/reperfusion injury in diabetic mice. Diabetes 54 3 (2005, Mar) 778-784
38. Chen K., Gunter K., and Maines M.D. Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death. J. Neurochem. 75 1 (2000, Jul) 304-313
39. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 414 6865 (2001, Dec 13) 813-820
40. Bierhaus A., Humpert P.M., Morcos M., Wendt T., Chavakis T., Arnold B., et al. Understanding RAGE, the receptor for advanced glycation end products. J. Mol. Med. 83 11 (2005, Nov) 876-886
41. Ramasamy R., Yan S.F., Herold K., Clynes R., and Schmidt A.M. Receptor for advanced glycation end products: fundamental roles in the inflammatory response: winding the way to the pathogenesis of endothelial dysfunction and atherosclerosis. Ann. N.Y. Acad. Sci. 1126 (2008, Apr) 7-13
42. Huang L.S., Sun G., Cobessi D., Wang A.C., Shen J.T., Tung E.Y., et al. 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J. Biol. Chem. 281 9 (2006, Mar 3) 5965-5972
43. Kwak M.K., Itoh K., Yamamoto M., and Kensler T.W. Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter. Mol. Cell. Biol. 22 9 (2002, May) 2883-2892