Saturated fatty acids modulate cell response to DNA damage: Implication for their role in tumorigenesis

PLoS ONE

Volumn 3, Issue 6, 2008, Pages

  Zeng, Li ^a   Wu, Guang Zhi ^a,b   Goh, Kim Jee ^a   Lee, Yew Mun ^a   Ng, Chuo Chung ^a   You, Ang Ben ^a   Wang, Jianhe ^a   Jia, Deyong ^c   Hao, Aijun ^c   Yu, Qiang ^d   Li, Baojie ^a  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b JILIN UNIVERSITY   (China)

^c Shandong University   (China)

^d GENOME INSTITUTE OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; DNA; DOUBLE STRANDED DNA; DOXORUBICIN; FATTY ACID SYNTHASE; HYDROXYUREA; MYRISTIC ACID; PALMITIC ACID; PROTEIN BAX; PROTEIN P21; PROTEIN P53; SATURATED FATTY ACID; SINGLE STRANDED DNA; STEARIC ACID; FATTY ACID;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL CYCLE ARREST; CELL PROLIFERATION; CELL STRAIN 3T3; CELL STRAIN HCT116; CELL STRAIN MCF 7; CELL TRANSFORMATION; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; EMBRYO; ENZYME INHIBITION; FATTY ACID SYNTHESIS; FIBROBLAST; GENE EXPRESSION REGULATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MALIGNANT NEOPLASTIC DISEASE; MOUSE; NONHUMAN; OSTEOBLAST; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR GROWTH; ANIMAL; BIOSYNTHESIS; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; IONIZING RADIATION; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; WESTERN BLOTTING;

MURINAE;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CELL PROLIFERATION; DNA DAMAGE; DOXORUBICIN; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; HYDROXYUREA; MICE; ONCOGENE PROTEIN P21(RAS); OSTEOBLASTS; PHOSPHORYLATION; RADIATION, IONIZING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 48449083426     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0002329     Document Type: Article

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