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Volumn 12, Issue 8, 2011, Pages 1194-1201

Rho GTPase effector functions in tumor cell invasion and metastasis

Author keywords

IQGAP; Oncogenesis; PAK; Rho GTPase; ROCK

Indexed keywords

BETA CATENIN; IQ MOTIF CONTAINING GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 1; MIXED LINEAGE KINASE 3; P21 ACTIVATED KINASE; PHOSPHOLIPASE C GAMMA1; PHOSPHOLIPASE D1; PROTEIN KINASE C ALPHA; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO KINASE; STAT3 PROTEIN; SYNAPTOJANIN; UVOMORULIN; WISKOTT ALDRICH SYNDROME PROTEIN;

EID: 79959322098     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/138945011795906534     Document Type: Article
Times cited : (30)

References (110)
  • 1
    • 0036488510 scopus 로고    scopus 로고
    • RHO-GTPases and cancer
    • Sahai E, Marshall CJ. RHO-GTPases and cancer. Nat Rev Cancer 2002; 2(2): 133-42.
    • (2002) Nat Rev Cancer , vol.2 , Issue.2 , pp. 133-142
    • Sahai, E.1    Marshall, C.J.2
  • 2
    • 36348966706 scopus 로고    scopus 로고
    • Rho GTPases: Functions and association with cancer
    • Ellenbroek SI, Collard JG. Rho GTPases: functions and association with cancer. Clin Exp Metastasis 2007; 24(8): 657-72.
    • (2007) Clin Exp Metastasis , vol.24 , Issue.8 , pp. 657-672
    • Ellenbroek, S.I.1    Collard, J.G.2
  • 3
    • 62949149568 scopus 로고    scopus 로고
    • Rho GTPases in hepatocellular carcinoma
    • Grise F, Bidaud A, Moreau V. Rho GTPases in hepatocellular carcinoma. Biochim Biophys Acta 2009; 1795(2): 137-51.
    • (2009) Biochim Biophys Acta , vol.1795 , Issue.2 , pp. 137-151
    • Grise, F.1    Bidaud, A.2    Moreau, V.3
  • 4
    • 27944479854 scopus 로고    scopus 로고
    • Rho GTPases: Biochemistry and biology
    • Jaffe AB, Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 2005; 21: 247-69.
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 247-269
    • Jaffe, A.B.1    Hall, A.2
  • 5
    • 0032589269 scopus 로고    scopus 로고
    • Effectors for the Rho GTPases
    • Aspenstrom P. Effectors for the Rho GTPases. Curr Opin Cell Biol 1999; 11(1): 95-102.
    • (1999) Curr Opin Cell Biol , vol.11 , Issue.1 , pp. 95-102
    • Aspenstrom, P.1
  • 6
    • 34547852267 scopus 로고    scopus 로고
    • Rho GTPase-activating bacterial toxins: From bacterial virulence regulation to eukaryotic cell biology
    • Lemonnier M, Landraud L, Lemichez E. Rho GTPase-activating bacterial toxins: from bacterial virulence regulation to eukaryotic cell biology. FEMS Microbiol Rev 2007; 31(5): 515-34.
    • (2007) FEMS Microbiol Rev , vol.31 , Issue.5 , pp. 515-534
    • Lemonnier, M.1    Landraud, L.2    Lemichez, E.3
  • 10
    • 9944251987 scopus 로고    scopus 로고
    • Rho GTPases in human cancer: An unresolved link to upstream and downstream transcriptional regulation
    • Benitah SA, Valeron PF, van Aelst L, Marshall CJ, Lacal JC. Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation. Biochim Biophys Acta 2004; 1705(2): 121-32.
    • (2004) Biochim Biophys Acta , vol.1705 , Issue.2 , pp. 121-132
    • Benitah, S.A.1    Valeron, P.F.2    van Aelst, L.3    Marshall, C.J.4    Lacal, J.C.5
  • 11
    • 34247175312 scopus 로고    scopus 로고
    • GTP-binding proteins of the Rho/Rac family: Regulation, effectors and functions in vivo
    • Bustelo XR, Sauzeau V, Berenjeno IM. GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo. Bioessays 2007; 29(4): 356-70.
    • (2007) Bioessays , vol.29 , Issue.4 , pp. 356-370
    • Bustelo, X.R.1    Sauzeau, V.2    Berenjeno, I.M.3
  • 12
    • 9444242736 scopus 로고    scopus 로고
    • Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
    • Kimura K, Ito M, Amano M, et al. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 1996; 273(5272): 245-8.
    • (1996) Science , vol.273 , Issue.5272 , pp. 245-248
    • Kimura, K.1    Ito, M.2    Amano, M.3
  • 13
    • 0029786313 scopus 로고    scopus 로고
    • Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)
    • Amano M, Ito M, Kimura K, et al. Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J Biol Chem 1996; 271(34): 20246-9.
    • (1996) J Biol Chem , vol.271 , Issue.34 , pp. 20246-20249
    • Amano, M.1    Ito, M.2    Kimura, K.3
  • 15
    • 34248154652 scopus 로고    scopus 로고
    • Mechanism and function of formins in the control of actin assembly
    • Goode BL, Eck MJ. Mechanism and function of formins in the control of actin assembly. Annu Rev Biochem 2007; 76: 593-627.
    • (2007) Annu Rev Biochem , vol.76 , pp. 593-627
    • Goode, B.L.1    Eck, M.J.2
  • 16
    • 0036305635 scopus 로고    scopus 로고
    • ROCK and Dia have opposing effects on adherens junctions downstream of Rho
    • Sahai E, Marshall CJ. ROCK and Dia have opposing effects on adherens junctions downstream of Rho. Nat Cell Biol 2002; 4(6): 408-15.
    • (2002) Nat Cell Biol , vol.4 , Issue.6 , pp. 408-415
    • Sahai, E.1    Marshall, C.J.2
  • 17
    • 13844257513 scopus 로고    scopus 로고
    • DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development
    • Durkin ME, Avner MR, Huh CG, Yuan BZ, Thorgeirsson SS, Popescu NC. DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development. FEBS Lett 2005; 579(5): 1191-6.
    • (2005) FEBS Lett , vol.579 , Issue.5 , pp. 1191-1196
    • Durkin, M.E.1    Avner, M.R.2    Huh, C.G.3    Yuan, B.Z.4    Thorgeirsson, S.S.5    Popescu, N.C.6
  • 18
    • 55349116044 scopus 로고    scopus 로고
    • Deleted in liver cancer 1 controls cell migration through a Dia1-dependent signaling pathway
    • Holeiter G, Heering J, Erlmann P, Schmid S, Jahne R, Olayioye MA. Deleted in liver cancer 1 controls cell migration through a Dia1-dependent signaling pathway. Cancer Res 2008; 68(21): 8743-51.
    • (2008) Cancer Res , vol.68 , Issue.21 , pp. 8743-8751
    • Holeiter, G.1    Heering, J.2    Erlmann, P.3    Schmid, S.4    Jahne, R.5    Olayioye, M.A.6
  • 19
    • 33745055712 scopus 로고    scopus 로고
    • The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms
    • Croft DR, Olson MF. The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms. Mol Cell Biol 2006; 26(12): 4612-27.
    • (2006) Mol Cell Biol , vol.26 , Issue.12 , pp. 4612-4627
    • Croft, D.R.1    Olson, M.F.2
  • 20
    • 0037817325 scopus 로고    scopus 로고
    • Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer
    • Kamai T, Tsujii T, Arai K, et al. Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer. Clin Cancer Res 2003; 9(7): 2632-41.
    • (2003) Clin Cancer Res , vol.9 , Issue.7 , pp. 2632-2641
    • Kamai, T.1    Tsujii, T.2    Arai, K.3
  • 21
    • 55649111840 scopus 로고    scopus 로고
    • The expression and prognostic value of the guanine nucleotide exchange factors (GEFs) Trio, Vav1 and TIAM-1 in human breast cancer
    • Lane J, Martin TA, Mansel RE, Jiang WG. The expression and prognostic value of the guanine nucleotide exchange factors (GEFs) Trio, Vav1 and TIAM-1 in human breast cancer. Int Semin Surg Oncol 2008; 5: 23.
    • (2008) Int Semin Surg Oncol , vol.5 , pp. 23
    • Lane, J.1    Martin, T.A.2    Mansel, R.E.3    Jiang, W.G.4
  • 22
    • 72249097073 scopus 로고    scopus 로고
    • Inhibition of rho-associated kinase signaling prevents breast cancer metastasis to human bone
    • Liu S, Goldstein RH, Scepansky EM, Rosenblatt M. Inhibition of rho-associated kinase signaling prevents breast cancer metastasis to human bone. Cancer Res 2009; 69(22): 8742-51.
    • (2009) Cancer Res , vol.69 , Issue.22 , pp. 8742-8751
    • Liu, S.1    Goldstein, R.H.2    Scepansky, E.M.3    Rosenblatt, M.4
  • 23
    • 4444314331 scopus 로고    scopus 로고
    • Overexpression of rho effector rhotekin confers increased survival in gastric adenocarcinoma
    • Liu CA, Wang MJ, Chi CW, Wu CW, Chen JY. Overexpression of rho effector rhotekin confers increased survival in gastric adenocarcinoma. J Biomed Sci 2004; 11(5): 661-70.
    • (2004) J Biomed Sci , vol.11 , Issue.5 , pp. 661-670
    • Liu, C.A.1    Wang, M.J.2    Chi, C.W.3    Wu, C.W.4    Chen, J.Y.5
  • 24
    • 9944252386 scopus 로고    scopus 로고
    • Rho/Rhotekinmediated NF-kappaB activation confers resistance to apoptosis
    • Liu CA, Wang MJ, Chi CW, Wu CW, Chen JY. Rho/Rhotekinmediated NF-kappaB activation confers resistance to apoptosis. Oncogene 2004; 23(54): 8731-42.
    • (2004) Oncogene , vol.23 , Issue.54 , pp. 8731-8742
    • Liu, C.A.1    Wang, M.J.2    Chi, C.W.3    Wu, C.W.4    Chen, J.Y.5
  • 25
    • 12344264742 scopus 로고    scopus 로고
    • Targeting key steps in metastatic tumour progression
    • Eccles SA. Targeting key steps in metastatic tumour progression. Curr Opin Genet Dev 2005; 15(1): 77-86.
    • (2005) Curr Opin Genet Dev , vol.15 , Issue.1 , pp. 77-86
    • Eccles, S.A.1
  • 26
    • 0028985929 scopus 로고
    • Expression of phospholipases gamma 1, beta 1, and delta 1 in primary human colon carcinomas and colon carcinoma cell lines
    • Nomoto K, Tomita N, Miyake M, Xhu DB, LoGerfo PR, Weinstein IB. Expression of phospholipases gamma 1, beta 1, and delta 1 in primary human colon carcinomas and colon carcinoma cell lines. Mol Carcinog 1995; 12(3): 146-52.
    • (1995) Mol Carcinog , vol.12 , Issue.3 , pp. 146-152
    • Nomoto, K.1    Tomita, N.2    Miyake, M.3    Xhu, D.B.4    Logerfo, P.R.5    Weinstein, I.B.6
  • 27
    • 0025880895 scopus 로고
    • Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas
    • Arteaga CL, Johnson MD, Todderud G, Coffey RJ, Carpenter G, Page DL. Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas. Proc Natl Acad Sci USA 1991; 88(23): 10435-9.
    • (1991) Proc Natl Acad Sci USA , vol.88 , Issue.23 , pp. 10435-10439
    • Arteaga, C.L.1    Johnson, M.D.2    Todderud, G.3    Coffey, R.J.4    Carpenter, G.5    Page, D.L.6
  • 28
    • 57749118818 scopus 로고    scopus 로고
    • Phospholipase Cgamma1 is required for metastasis development and progression
    • Sala G, Dituri F, Raimondi C, et al. Phospholipase Cgamma1 is required for metastasis development and progression. Cancer Res 2008; 68(24): 10187-96.
    • (2008) Cancer Res , vol.68 , Issue.24 , pp. 10187-96
    • Sala, G.1    Dituri, F.2    Raimondi, C.3
  • 30
    • 0028078824 scopus 로고
    • A brain serine/threonine protein kinase activated by Cdc42 and Rac1
    • Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 1994; 367(6458): 40-6.
    • (1994) Nature , vol.367 , Issue.6458 , pp. 40-46
    • Manser, E.1    Leung, T.2    Salihuddin, H.3    Zhao, Z.S.4    Lim, L.5
  • 32
  • 33
    • 0842288222 scopus 로고    scopus 로고
    • Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts
    • Totsukawa G, Wu Y, Sasaki Y, et al. Distinct roles of MLCK and ROCK in the regulation of membrane protrusions and focal adhesion dynamics during cell migration of fibroblasts. J Cell Biol 2004; 164(3): 427-39.
    • (2004) J Cell Biol , vol.164 , Issue.3 , pp. 427-439
    • Totsukawa, G.1    Wu, Y.2    Sasaki, Y.3
  • 34
    • 0141480275 scopus 로고    scopus 로고
    • LIM kinase 1 is essential for the invasive growth of prostate epithelial cells: Implications in prostate cancer
    • Davila M, Frost AR, Grizzle WE, Chakrabarti R. LIM kinase 1 is essential for the invasive growth of prostate epithelial cells: implications in prostate cancer. J Biol Chem 2003; 278(38): 36868-75.
    • (2003) J Biol Chem , vol.278 , Issue.38 , pp. 36868-75
    • Davila, M.1    Frost, A.R.2    Grizzle, W.E.3    Chakrabarti, R.4
  • 35
    • 33646376457 scopus 로고    scopus 로고
    • LIM kinase 1 increases tumor metastasis of human breast cancer cells via regulation of the urokinase-type plasminogen activator system
    • Bagheri-Yarmand R, Mazumdar A, Sahin AA, Kumar R. LIM kinase 1 increases tumor metastasis of human breast cancer cells via regulation of the urokinase-type plasminogen activator system. Int J Cancer 2006; 118(11): 2703-10.
    • (2006) Int J Cancer , vol.118 , Issue.11 , pp. 2703-2710
    • Bagheri-Yarmand, R.1    Mazumdar, A.2    Sahin, A.A.3    Kumar, R.4
  • 36
    • 0035999990 scopus 로고    scopus 로고
    • Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway
    • Brown MC, West KA, Turner CE. Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway. Mol Biol Cell 2002; 13(5): 1550-65.
    • (2002) Mol Biol Cell , vol.13 , Issue.5 , pp. 1550-1565
    • Brown, M.C.1    West, K.A.2    Turner, C.E.3
  • 37
    • 34247209087 scopus 로고    scopus 로고
    • Changes in the balance between caldesmon regulated by p21-activated kinases and the Arp2/3 complex govern podosome formation
    • Morita T, Mayanagi T, Yoshio T, Sobue K. Changes in the balance between caldesmon regulated by p21-activated kinases and the Arp2/3 complex govern podosome formation. J Biol Chem 2007; 282(11): 8454-63.
    • (2007) J Biol Chem , vol.282 , Issue.11 , pp. 8454-8463
    • Morita, T.1    Mayanagi, T.2    Yoshio, T.3    Sobue, K.4
  • 38
    • 12744271503 scopus 로고    scopus 로고
    • Cortactin phosphorylation as a switch for actin cytoskeletal network and cell dynamics control
    • Lua BL, Low BC. Cortactin phosphorylation as a switch for actin cytoskeletal network and cell dynamics control. FEBS Lett 2005; 579(3): 577-85.
    • (2005) FEBS Lett , vol.579 , Issue.3 , pp. 577-585
    • Lua, B.L.1    Low, B.C.2
  • 39
    • 1242271991 scopus 로고    scopus 로고
    • Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1
    • Wittmann T, Bokoch GM, Waterman-Storer CM. Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1. J Biol Chem 2004; 279(7): 6196-203.
    • (2004) J Biol Chem , vol.279 , Issue.7 , pp. 6196-6203
    • Wittmann, T.1    Bokoch, G.M.2    Waterman-Storer, C.M.3
  • 40
    • 0034601442 scopus 로고    scopus 로고
    • Evidence for a function of CtBP in epithelial gene regulation and anoikis
    • Grooteclaes ML, Frisch SM. Evidence for a function of CtBP in epithelial gene regulation and anoikis. Oncogene 2000; 19(33): 3823-8.
    • (2000) Oncogene , vol.19 , Issue.33 , pp. 3823-3828
    • Grooteclaes, M.L.1    Frisch, S.M.2
  • 41
    • 16844377441 scopus 로고    scopus 로고
    • Pak1 phosphorylation of snail, a master regulator of epithelial-tomesenchyme transition, modulates snail's subcellular localization and functions
    • Yang Z, Rayala S, Nguyen D, Vadlamudi RK, Chen S, Kumar R. Pak1 phosphorylation of snail, a master regulator of epithelial-tomesenchyme transition, modulates snail's subcellular localization and functions. Cancer Res 2005; 65(8): 3179-84.
    • (2005) Cancer Res , vol.65 , Issue.8 , pp. 3179-3184
    • Yang, Z.1    Rayala, S.2    Nguyen, D.3    Vadlamudi, R.K.4    Chen, S.5    Kumar, R.6
  • 42
    • 0000202186 scopus 로고    scopus 로고
    • A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity
    • Lin D, Edwards AS, Fawcett JP, Mbamalu G, Scott JD, Pawson T. A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nat Cell Biol 2000; 2(8): 540-7.
    • (2000) Nat Cell Biol , vol.2 , Issue.8 , pp. 540-547
    • Lin, D.1    Edwards, A.S.2    Fawcett, J.P.3    Mbamalu, G.4    Scott, J.D.5    Pawson, T.6
  • 43
    • 33751347857 scopus 로고    scopus 로고
    • The Scribble and Par complexes in polarity and migration: Friends or foes?
    • Humbert PO, Dow LE, Russell SM. The Scribble and Par complexes in polarity and migration: friends or foes? Trends Cell Biol 2006; 16(12): 622-30.
    • (2006) Trends Cell Biol , vol.16 , Issue.12 , pp. 622-630
    • Humbert, P.O.1    Dow, L.E.2    Russell, S.M.3
  • 44
    • 55249109939 scopus 로고    scopus 로고
    • The prognostic impact of NF-kappaB p105, vimentin, E-cadherin and Par6 expression in epithelial and stromal compartment in non-small-cell lung cancer
    • Al-Saad S, Al-Shibli K, Donnem T, Persson M, Bremnes RM, Busund LT. The prognostic impact of NF-kappaB p105, vimentin, E-cadherin and Par6 expression in epithelial and stromal compartment in non-small-cell lung cancer. Br J Cancer 2008; 99(9): 1476-83.
    • (2008) Br J Cancer , vol.99 , Issue.9 , pp. 1476-1483
    • Al-Saad, S.1    Al-Shibli, K.2    Donnem, T.3    Persson, M.4    Bremnes, R.M.5    Busund, L.T.6
  • 45
    • 54249140140 scopus 로고    scopus 로고
    • The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer
    • Nolan ME, Aranda V, Lee S, et al. The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer. Cancer Res 2008; 68(20): 8201-9.
    • (2008) Cancer Res , vol.68 , Issue.20 , pp. 8201-8209
    • Nolan, M.E.1    Aranda, V.2    Lee, S.3
  • 46
    • 33750505436 scopus 로고    scopus 로고
    • Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control
    • Aranda V, Haire T, Nolan ME, et al. Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nat Cell Biol 2006; 8(11): 1235-45.
    • (2006) Nat Cell Biol , vol.8 , Issue.11 , pp. 1235-1245
    • Aranda, V.1    Haire, T.2    Nolan, M.E.3
  • 47
    • 0344758986 scopus 로고    scopus 로고
    • Regulation of cell polarity and protrusion formation by targeting RhoA for degradation
    • Wang HR, Zhang Y, Ozdamar B, et al. Regulation of cell polarity and protrusion formation by targeting RhoA for degradation. Science 2003; 302(5651): 1775-9.
    • (2003) Science , vol.302 , Issue.5651 , pp. 1775-1779
    • Wang, H.R.1    Zhang, Y.2    Ozdamar, B.3
  • 48
    • 69549128378 scopus 로고    scopus 로고
    • A role for the TGFbeta- Par6 polarity pathway in breast cancer progression
    • Viloria-Petit AM, David L, Jia JY, et al. A role for the TGFbeta- Par6 polarity pathway in breast cancer progression. Proc Natl Acad Sci USA 2009; 106(33): 14028-33.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.33 , pp. 14028-33
    • Viloria-Petit, A.M.1    David, L.2    Jia, J.Y.3
  • 49
    • 67349198476 scopus 로고    scopus 로고
    • IQGAPs in cancer: A family of scaffold proteins underlying tumorigenesis
    • White CD, Brown MD, Sacks DB. IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis. FEBS Lett 2009; 583(12): 1817-24.
    • (2009) FEBS Lett , vol.583 , Issue.12 , pp. 1817-1824
    • White, C.D.1    Brown, M.D.2    Sacks, D.B.3
  • 50
    • 0030929148 scopus 로고    scopus 로고
    • IQGAP1, a Racand Cdc42-binding protein, directly binds and cross-links microfilaments
    • Bashour AM, Fullerton AT, Hart MJ, Bloom GS. IQGAP1, a Racand Cdc42-binding protein, directly binds and cross-links microfilaments. J Cell Biol 1997; 137(7): 1555-66.
    • (1997) J Cell Biol , vol.137 , Issue.7 , pp. 1555-1566
    • Bashour, A.M.1    Fullerton, A.T.2    Hart, M.J.3    Bloom, G.S.4
  • 51
    • 38149036613 scopus 로고    scopus 로고
    • IQGAP1 stimulates proliferation and enhances tumorigenesis of human breast epithelial cells
    • Jadeski L, Mataraza JM, Jeong HW, Li Z, Sacks DB. IQGAP1 stimulates proliferation and enhances tumorigenesis of human breast epithelial cells. J Biol Chem 2008; 283(2): 1008-17.
    • (2008) J Biol Chem , vol.283 , Issue.2 , pp. 1008-1017
    • Jadeski, L.1    Mataraza, J.M.2    Jeong, H.W.3    Li, Z.4    Sacks, D.B.5
  • 52
    • 0037039718 scopus 로고    scopus 로고
    • Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: Its overexpression in carcinomas and association with invasion fronts
    • Nabeshima K, Shimao Y, Inoue T, Koono M. Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: its overexpression in carcinomas and association with invasion fronts. Cancer Lett 2002; 176(1): 101-9.
    • (2002) Cancer Lett , vol.176 , Issue.1 , pp. 101-109
    • Nabeshima, K.1    Shimao, Y.2    Inoue, T.3    Koono, M.4
  • 53
    • 0034522264 scopus 로고    scopus 로고
    • Identification of cadherin-11 down-regulation as a common response of astrocytoma cells to transforming growth factor-alpha
    • Zhou R, Skalli O. Identification of cadherin-11 down-regulation as a common response of astrocytoma cells to transforming growth factor-alpha. Differentiation 2000; 66(4-5): 165-72.
    • (2000) Differentiation , vol.66 , Issue.4-5 , pp. 165-172
    • Zhou, R.1    Skalli, O.2
  • 54
    • 39749160439 scopus 로고    scopus 로고
    • Proteomic analysis of lasercaptured paraffin-embedded tissues: A molecular portrait of head and neck cancer progression
    • Patel V, Hood BL, Molinolo AA, et al. Proteomic analysis of lasercaptured paraffin-embedded tissues: a molecular portrait of head and neck cancer progression. Clin Cancer Res 2008; 14(4): 1002-14.
    • (2008) Clin Cancer Res , vol.14 , Issue.4 , pp. 1002-1014
    • Patel, V.1    Hood, B.L.2    Molinolo, A.A.3
  • 55
    • 24344491858 scopus 로고    scopus 로고
    • IQGAP1 is a scaffold for mitogenactivated protein kinase signaling
    • Roy M, Li Z, Sacks DB. IQGAP1 is a scaffold for mitogenactivated protein kinase signaling. Mol Cell Biol 2005; 25(18): 7940-52.
    • (2005) Mol Cell Biol , vol.25 , Issue.18 , pp. 7940-7952
    • Roy, M.1    Li, Z.2    Sacks, D.B.3
  • 56
    • 2342424547 scopus 로고    scopus 로고
    • IQGAP1 binds ERK2 and modulates its activity
    • Roy M, Li Z, Sacks DB. IQGAP1 binds ERK2 and modulates its activity. J Biol Chem 2004; 279(17): 17329-37.
    • (2004) J Biol Chem , vol.279 , Issue.17 , pp. 17329-37
    • Roy, M.1    Li, Z.2    Sacks, D.B.3
  • 57
    • 41549115361 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling: New (and old) players and new insights
    • Huang H, He X. Wnt/beta-catenin signaling: new (and old) players and new insights. Curr Opin Cell Biol 2008; 20(2): 119-25.
    • (2008) Curr Opin Cell Biol , vol.20 , Issue.2 , pp. 119-125
    • Huang, H.1    He, X.2
  • 58
    • 0036510761 scopus 로고    scopus 로고
    • IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin
    • Briggs MW, Li Z, Sacks DB. IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin. J Biol Chem 2002; 277(9): 7453-65.
    • (2002) J Biol Chem , vol.277 , Issue.9 , pp. 7453-7465
    • Briggs, M.W.1    Li, Z.2    Sacks, D.B.3
  • 59
    • 52149087696 scopus 로고    scopus 로고
    • IQGAP1 activates Tcf signal independent of Rac1 and Cdc42 in injury and repair of bronchial epithelial cells
    • Wang Y, Wang A, Wang F, et al. IQGAP1 activates Tcf signal independent of Rac1 and Cdc42 in injury and repair of bronchial epithelial cells. Exp Mol Pathol 2008; 85(2): 122-8.
    • (2008) Exp Mol Pathol , vol.85 , Issue.2 , pp. 122-128
    • Wang, Y.1    Wang, A.2    Wang, F.3
  • 60
    • 4043148481 scopus 로고    scopus 로고
    • IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation
    • Yamaoka-Tojo M, Ushio-Fukai M, Hilenski L, et al. IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation. Circ Res 2004; 95(3): 276-83.
    • (2004) Circ Res , vol.95 , Issue.3 , pp. 276-283
    • Yamaoka-Tojo, M.1    Ushio-Fukai, M.2    Hilenski, L.3
  • 61
    • 57349159403 scopus 로고    scopus 로고
    • IQGAP1-dependent signaling pathway regulates endothelial cell proliferation and angiogenesis
    • [Meyer RD, Sacks DB, Rahimi N. IQGAP1-dependent signaling pathway regulates endothelial cell proliferation and angiogenesis. PLoS One 2008; 3(12): e3848.
    • (2008) PLoS One , vol.3 , Issue.12
    • Meyer, R.D.1    Sacks, D.B.2    Rahimi, N.3
  • 62
    • 65549123466 scopus 로고    scopus 로고
    • Molecular mechanisms controlling Ecadherin expression in breast cancer
    • Baranwal S, Alahari SK. Molecular mechanisms controlling Ecadherin expression in breast cancer. Biochem Biophys Res Commun 2009; 384(1): 6-11.
    • (2009) Biochem Biophys Res Commun , vol.384 , Issue.1 , pp. 6-11
    • Baranwal, S.1    Alahari, S.K.2
  • 63
    • 0032493903 scopus 로고    scopus 로고
    • Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherinmediated cell-cell adhesion
    • Kuroda S, Fukata M, Nakagawa M, et al. Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherinmediated cell-cell adhesion. Science 1998; 281(5378): 832-5.
    • (1998) Science , vol.281 , Issue.5378 , pp. 832-835
    • Kuroda, S.1    Fukata, M.2    Nakagawa, M.3
  • 64
    • 0037847431 scopus 로고    scopus 로고
    • IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton
    • Briggs MW, Sacks DB. IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton. FEBS Lett 2003; 542(1-3): 7-11.
    • (2003) FEBS Lett , vol.542 , Issue.1-3 , pp. 7-11
    • Briggs, M.W.1    Sacks, D.B.2
  • 66
    • 59149105836 scopus 로고    scopus 로고
    • ADP-ribosylation factor 6 regulates glioma cell invasion through the IQ-domain GTPase-activating protein 1-Rac1-mediated pathway
    • Hu B, Shi B, Jarzynka MJ, Yiin JJ, D'Souza-Schorey C, Cheng SY. ADP-ribosylation factor 6 regulates glioma cell invasion through the IQ-domain GTPase-activating protein 1-Rac1-mediated pathway. Cancer Res 2009; 69(3): 794-801.
    • (2009) Cancer Res , vol.69 , Issue.3 , pp. 794-801
    • Hu, B.1    Shi, B.2    Jarzynka, M.J.3    Yiin, J.J.4    D'Souza-Schorey, C.5    Cheng, S.Y.6
  • 67
    • 0029784514 scopus 로고    scopus 로고
    • The Ras GTPase-activating-proteinrelated human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases
    • Brill S, Li S, Lyman CW, et al. The Ras GTPase-activating-proteinrelated human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases. Mol Cell Biol 1996; 16(9): 4869-78.
    • (1996) Mol Cell Biol , vol.16 , Issue.9 , pp. 4869-4878
    • Brill, S.1    Li, S.2    Lyman, C.W.3
  • 68
    • 39749108409 scopus 로고    scopus 로고
    • Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent
    • Schmidt VA, Chiariello CS, Capilla E, Miller F, Bahou WF. Development of hepatocellular carcinoma in Iqgap2-deficient mice is IQGAP1 dependent. Mol Cell Biol 2008; 28(5): 1489-502.
    • (2008) Mol Cell Biol , vol.28 , Issue.5 , pp. 1489-1502
    • Schmidt, V.A.1    Chiariello, C.S.2    Capilla, E.3    Miller, F.4    Bahou, W.F.5
  • 69
    • 48649099673 scopus 로고    scopus 로고
    • IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade
    • Nojima H, Adachi M, Matsui T, Okawa K, Tsukita S. IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade. Nat Cell Biol 2008; 10(8): 971-8.
    • (2008) Nat Cell Biol , vol.10 , Issue.8 , pp. 971-978
    • Nojima, H.1    Adachi, M.2    Matsui, T.3    Okawa, K.4    Tsukita, S.5
  • 70
    • 42349098965 scopus 로고    scopus 로고
    • The quest for the 1p36 tumor suppressor
    • Bagchi A, Mills AA. The quest for the 1p36 tumor suppressor. Cancer Res 2008; 68(8): 2551-6.
    • (2008) Cancer Res , vol.68 , Issue.8 , pp. 2551-2556
    • Bagchi, A.1    Mills, A.A.2
  • 71
    • 27544478385 scopus 로고    scopus 로고
    • Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth
    • Pante G, Thompson J, Lamballe F, et al. Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth. J Cell Biol 2005; 171(2): 337-48.
    • (2005) J Cell Biol , vol.171 , Issue.2 , pp. 337-348
    • Pante, G.1    Thompson, J.2    Lamballe, F.3
  • 72
    • 33646588346 scopus 로고    scopus 로고
    • Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation
    • Ferby I, Reschke M, Kudlacek O, et al. Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nat Med 2006; 12(5): 568-73.
    • (2006) Nat Med , vol.12 , Issue.5 , pp. 568-573
    • Ferby, I.1    Reschke, M.2    Kudlacek, O.3
  • 73
    • 77951061655 scopus 로고    scopus 로고
    • Mig-6 controls EGFR trafficking and suppresses gliomagenesis
    • Ying H, Zheng H, Scott K, et al. Mig-6 controls EGFR trafficking and suppresses gliomagenesis. Proc Natl Acad Sci USA 2010; 107(15): 6912-7.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.15 , pp. 6912-6917
    • Ying, H.1    Zheng, H.2    Scott, K.3
  • 74
    • 77950602115 scopus 로고    scopus 로고
    • Mitogen-inducible gene-6 is a negative regulator of epidermal growth factor receptor signaling in hepatocytes and human hepatocellular carcinoma
    • Reschke M, Ferby I, Stepniak E, et al. Mitogen-inducible gene-6 is a negative regulator of epidermal growth factor receptor signaling in hepatocytes and human hepatocellular carcinoma. Hepatology 2010; 51(4): 1383-90.
    • (2010) Hepatology , vol.51 , Issue.4 , pp. 1383-1390
    • Reschke, M.1    Ferby, I.2    Stepniak, E.3
  • 75
    • 66649098123 scopus 로고    scopus 로고
    • Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease
    • Jeong JW, Lee HS, Lee KY, et al. Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease. Proc Natl Acad Sci USA 2009; 106(21): 8677-82.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.21 , pp. 8677-8682
    • Jeong, J.W.1    Lee, H.S.2    Lee, K.Y.3
  • 76
    • 77954223151 scopus 로고    scopus 로고
    • The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression
    • Kim TH, Franco HL, Jung SY, et al. The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression. Oncogene 2010; 29(26): 3770-80.
    • (2010) Oncogene , vol.29 , Issue.26 , pp. 3770-3780
    • Kim, T.H.1    Franco, H.L.2    Jung, S.Y.3
  • 77
    • 0027235324 scopus 로고
    • A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42
    • Manser E, Leung T, Salihuddin H, Tan L, Lim L. A non-receptor tyrosine kinase that inhibits the GTPase activity of p21cdc42. Nature 1993; 363(6427): 364-7.
    • (1993) Nature , vol.363 , Issue.6427 , pp. 364-367
    • Manser, E.1    Leung, T.2    Salihuddin, H.3    Tan, L.4    Lim, L.5
  • 78
    • 0037155857 scopus 로고    scopus 로고
    • The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation
    • Lin Q, Lo CG, Cerione RA, Yang W. The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation. J Biol Chem 2002; 277(12): 10134-8.
    • (2002) J Biol Chem , vol.277 , Issue.12 , pp. 10134-10138
    • Lin, Q.1    Lo, C.G.2    Cerione, R.A.3    Yang, W.4
  • 79
    • 48949119348 scopus 로고    scopus 로고
    • TNK2 preserves epidermal growth factor receptor expression on the cell surface and enhances migration and invasion of human breast cancer cells
    • Howlin J, Rosenkvist J, Andersson T. TNK2 preserves epidermal growth factor receptor expression on the cell surface and enhances migration and invasion of human breast cancer cells. Breast Cancer Res 2008; 10(2): R36.
    • (2008) Breast Cancer Res , vol.10 , Issue.2
    • Howlin, J.1    Rosenkvist, J.2    Andersson, T.3
  • 80
    • 0034597599 scopus 로고    scopus 로고
    • Synaptojanin 2, a novel Rac1 effector that regulates clathrinmediated endocytosis
    • Malecz N, McCabe PC, Spaargaren C, Qiu R, Chuang Y, Symons M. Synaptojanin 2, a novel Rac1 effector that regulates clathrinmediated endocytosis. Curr Biol 2000; 10(21): 1383-6.
    • (2000) Curr Biol , vol.10 , Issue.21 , pp. 1383-1386
    • Malecz, N.1    McCabe, P.C.2    Spaargaren, C.3    Qiu, R.4    Chuang, Y.5    Symons, M.6
  • 82
    • 0040211565 scopus 로고    scopus 로고
    • Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation
    • Bock BC, Vacratsis PO, Qamirani E, Gallo KA. Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation. J Biol Chem 2000; 275(19): 14231-41.
    • (2000) J Biol Chem , vol.275 , Issue.19 , pp. 14231-14241
    • Bock, B.C.1    Vacratsis, P.O.2    Qamirani, E.3    Gallo, K.A.4
  • 83
    • 77955469972 scopus 로고    scopus 로고
    • MLK3 is critical for breast cancer cell migration and promotes a malignant phenotype in mammary epithelial cells
    • Chen J, Miller EM, Gallo KA. MLK3 is critical for breast cancer cell migration and promotes a malignant phenotype in mammary epithelial cells. Oncogene 2010; 29(31): 4399-411.
    • (2010) Oncogene , vol.29 , Issue.31 , pp. 4399-4411
    • Chen, J.1    Miller, E.M.2    Gallo, K.A.3
  • 84
    • 0024323584 scopus 로고
    • Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue
    • O'Brian C, Vogel VG, Singletary SE, Ward NE. Elevated protein kinase C expression in human breast tumor biopsies relative to normal breast tissue. Cancer Res 1989; 49(12): 3215-7.
    • (1989) Cancer Res , vol.49 , Issue.12 , pp. 3215-3217
    • O'Brian, C.1    Vogel, V.G.2    Singletary, S.E.3    Ward, N.E.4
  • 85
    • 0035836522 scopus 로고    scopus 로고
    • Interaction of protein kinase C isozymes with Rho GTPases
    • Slater SJ, Seiz JL, Stagliano BA, Stubbs CD. Interaction of protein kinase C isozymes with Rho GTPases. Biochemistry 2001; 40(14): 4437-45.
    • (2001) Biochemistry , vol.40 , Issue.14 , pp. 4437-4445
    • Slater, S.J.1    Seiz, J.L.2    Stagliano, B.A.3    Stubbs, C.D.4
  • 86
    • 0028903545 scopus 로고
    • MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype
    • Ways DK, Kukoly CA, deVente J, et al. MCF-7 breast cancer cells transfected with protein kinase C-alpha exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype. J Clin Invest 1995; 95(4): 1906-15.
    • (1995) J Clin Invest , vol.95 , Issue.4 , pp. 1906-1915
    • Ways, D.K.1    Kukoly, C.A.2    Devente, J.3
  • 87
    • 0033534687 scopus 로고    scopus 로고
    • Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway
    • Rizzo MA, Shome K, Vasudevan C, et al. Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway. J Biol Chem 1999; 274(2): 1131-9.
    • (1999) J Biol Chem , vol.274 , Issue.2 , pp. 1131-1139
    • Rizzo, M.A.1    Shome, K.2    Vasudevan, C.3
  • 88
    • 0035976615 scopus 로고    scopus 로고
    • Phosphatidic acid-mediated mitogenic activation of mTOR signaling
    • Fang Y, Vilella-Bach M, Bachmann R, Flanigan A, Chen J. Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science 2001; 294(5548): 1942-5.
    • (2001) Science , vol.294 , Issue.5548 , pp. 1942-1945
    • Fang, Y.1    Vilella-Bach, M.2    Bachmann, R.3    Flanigan, A.4    Chen, J.5
  • 89
    • 0037201951 scopus 로고    scopus 로고
    • Regulation of phospholipase D
    • Exton JH. Regulation of phospholipase D. FEBS Lett 2002; 531(1): 58-61.
    • (2002) FEBS Lett , vol.531 , Issue.1 , pp. 58-61
    • Exton, J.H.1
  • 90
    • 0000638944 scopus 로고    scopus 로고
    • Determination of interaction sites on the small G protein RhoA for phospholipase D
    • Bae CD, Min DS, Fleming IN, Exton JH. Determination of interaction sites on the small G protein RhoA for phospholipase D. J Biol Chem 1998; 273(19): 11596-604.
    • (1998) J Biol Chem , vol.273 , Issue.19 , pp. 11596-11604
    • Bae, C.D.1    Min, D.S.2    Fleming, I.N.3    Exton, J.H.4
  • 91
    • 0031105873 scopus 로고    scopus 로고
    • Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization
    • Colley WC, Sung TC, Roll R, et al. Phospholipase D2, a distinct phospholipase D isoform with novel regulatory properties that provokes cytoskeletal reorganization. Curr Biol 1997; 7(3): 191-201.
    • (1997) Curr Biol , vol.7 , Issue.3 , pp. 191-201
    • Colley, W.C.1    Sung, T.C.2    Roll, R.3
  • 92
    • 0035930933 scopus 로고    scopus 로고
    • Transformation of cells overexpressing a tyrosine kinase by phospholipase D1 and D2
    • Joseph T, Wooden R, Bryant A, Zhong M, Lu Z, Foster DA. Transformation of cells overexpressing a tyrosine kinase by phospholipase D1 and D2. Biochem Biophys Res Commun 2001; 289(5): 1019-24.
    • (2001) Biochem Biophys Res Commun , vol.289 , Issue.5 , pp. 1019-1024
    • Joseph, T.1    Wooden, R.2    Bryant, A.3    Zhong, M.4    Lu, Z.5    Foster, D.A.6
  • 94
    • 0036479114 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and NF-kappaB regulate motility of invasive MDA-MB-231 human breast cancer cells by the secretion of urokinase-type plasminogen activator
    • Sliva D, Rizzo MT, English D. Phosphatidylinositol 3-kinase and NF-kappaB regulate motility of invasive MDA-MB-231 human breast cancer cells by the secretion of urokinase-type plasminogen activator. J Biol Chem 2002; 277(5): 3150-7.
    • (2002) J Biol Chem , vol.277 , Issue.5 , pp. 3150-3157
    • Sliva, D.1    Rizzo, M.T.2    English, D.3
  • 95
    • 33845729059 scopus 로고    scopus 로고
    • The WASP-WAVE protein network: Connecting the membrane to the cytoskeleton
    • Takenawa T, Suetsugu S. The WASP-WAVE protein network: connecting the membrane to the cytoskeleton. Nat Rev Mol Cell Biol 2007; 8(1): 37-48.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , Issue.1 , pp. 37-48
    • Takenawa, T.1    Suetsugu, S.2
  • 96
    • 0034683671 scopus 로고    scopus 로고
    • Activation by Cdc42 and PIP(2) of Wiskott- Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex
    • Higgs HN, Pollard TD. Activation by Cdc42 and PIP(2) of Wiskott- Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex. J Cell Biol 2000; 150(6): 1311-20.
    • (2000) J Cell Biol , vol.150 , Issue.6 , pp. 1311-1320
    • Higgs, H.N.1    Pollard, T.D.2
  • 97
    • 0034683746 scopus 로고    scopus 로고
    • Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate
    • Rohatgi R, Ho HY, Kirschner MW. Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate. J Cell Biol 2000; 150(6): 1299-310.
    • (2000) J Cell Biol , vol.150 , Issue.6 , pp. 1299-1310
    • Rohatgi, R.1    Ho, H.Y.2    Kirschner, M.W.3
  • 98
    • 18544402891 scopus 로고    scopus 로고
    • Cdc42 is required for PIP(2)- induced actin polymerization and early development but not for cell viability
    • Chen F, Ma L, Parrini MC, et al. Cdc42 is required for PIP(2)- induced actin polymerization and early development but not for cell viability. Curr Biol 2000; 10(13): 758-65.
    • (2000) Curr Biol , vol.10 , Issue.13 , pp. 758-765
    • Chen, F.1    Ma, L.2    Parrini, M.C.3
  • 99
    • 0031972690 scopus 로고    scopus 로고
    • P140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase
    • Kobayashi K, Kuroda S, Fukata M, et al. p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase. J Biol Chem 1998; 273(1): 291-5.
    • (1998) J Biol Chem , vol.273 , Issue.1 , pp. 291-295
    • Kobayashi, K.1    Kuroda, S.2    Fukata, M.3
  • 100
    • 66449094672 scopus 로고    scopus 로고
    • Cyfip1 is a putative invasion suppressor in epithelial cancers
    • Silva JM, Ezhkova E, Silva J, et al. Cyfip1 is a putative invasion suppressor in epithelial cancers. Cell 2009; 137(6): 1047-61.
    • (2009) Cell , vol.137 , Issue.6 , pp. 1047-1061
    • Silva, J.M.1    Ezhkova, E.2    Silva, J.3
  • 102
    • 1042302005 scopus 로고    scopus 로고
    • The STATs of cancer--new molecular targets come of age
    • Yu H, Jove R. The STATs of cancer--new molecular targets come of age. Nat Rev Cancer 2004; 4(2): 97-105.
    • (2004) Nat Rev Cancer , vol.4 , Issue.2 , pp. 97-105
    • Yu, H.1    Jove, R.2
  • 103
    • 44849135184 scopus 로고    scopus 로고
    • Stat3 promotes metastatic progression of prostate cancer
    • Abdulghani J, Gu L, Dagvadorj A, et al. Stat3 promotes metastatic progression of prostate cancer. Am J Pathol 2008; 172(6): 1717-28.
    • (2008) Am J Pathol , vol.172 , Issue.6 , pp. 1717-1728
    • Abdulghani, J.1    Gu, L.2    Dagvadorj, A.3
  • 104
    • 0037243197 scopus 로고    scopus 로고
    • STAT5a activation mediates the epithelial to mesenchymal transition induced by oncogenic RhoA
    • Benitah SA, Valeron PF, Rui H, Lacal JC. STAT5a activation mediates the epithelial to mesenchymal transition induced by oncogenic RhoA. Mol Biol Cell 2003; 14(1): 40-53.
    • (2003) Mol Biol Cell , vol.14 , Issue.1 , pp. 40-53
    • Benitah, S.A.1    Valeron, P.F.2    Rui, H.3    Lacal, J.C.4
  • 105
    • 77952565165 scopus 로고    scopus 로고
    • Illuminating the ubiquitin/proteasome system
    • Salomons FA, Acs K, Dantuma NP. Illuminating the ubiquitin/proteasome system. Exp Cell Res 2010; 316(8): 1289-95.
    • (2010) Exp Cell Res , vol.316 , Issue.8 , pp. 1289-1295
    • Salomons, F.A.1    Acs, K.2    Dantuma, N.P.3
  • 106
    • 63649086487 scopus 로고    scopus 로고
    • Targeting the ubiquitin system in cancer therapy
    • Hoeller D, Dikic I. Targeting the ubiquitin system in cancer therapy. Nature 2009; 458(7237): 438-44.
    • (2009) Nature , vol.458 , Issue.7237 , pp. 438-444
    • Hoeller, D.1    Dikic, I.2
  • 107
    • 59149091922 scopus 로고    scopus 로고
    • Smad ubiquitination regulatory factor 2 promotes metastasis of breast cancer cells by enhancing migration and invasiveness
    • Jin C, Yang YA, Anver MR, Morris N, Wang X, Zhang YE. Smad ubiquitination regulatory factor 2 promotes metastasis of breast cancer cells by enhancing migration and invasiveness. Cancer Res 2009; 69(3): 735-40.
    • (2009) Cancer Res , vol.69 , Issue.3 , pp. 735-740
    • Jin, C.1    Yang, Y.A.2    Anver, M.R.3    Morris, N.4    Wang, X.5    Zhang, Y.E.6
  • 108
    • 54549088877 scopus 로고    scopus 로고
    • Rac activation and inactivation control plasticity of tumor cell movement
    • Sanz-Moreno V, Gadea G, Ahn J, et al. Rac activation and inactivation control plasticity of tumor cell movement. Cell 2008; 135(3): 510-23.
    • (2008) Cell , vol.135 , Issue.3 , pp. 510-523
    • Sanz-Moreno, V.1    Gadea, G.2    Ahn, J.3
  • 109
    • 33646864565 scopus 로고    scopus 로고
    • Staying in shape with formins
    • Faix J, Grosse R. Staying in shape with formins. Dev Cell 2006; 10(6): 693-706.
    • (2006) Dev Cell , vol.10 , Issue.6 , pp. 693-706
    • Faix, J.1    Grosse, R.2
  • 110
    • 77951587879 scopus 로고    scopus 로고
    • Forminlike 2 drives amoeboid invasive cell motility downstream of RhoC
    • Kitzing TM, Wang Y, Pertz O, Copeland JW, Grosse R. Forminlike 2 drives amoeboid invasive cell motility downstream of RhoC. Oncogene 2010; 29(16): 2441-8.
    • (2010) Oncogene , vol.29 , Issue.16 , pp. 2441-2448
    • Kitzing, T.M.1    Wang, Y.2    Pertz, O.3    Copeland, J.W.4    Grosse, R.5


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