Deleted in liver cancer 1 controls cell migration through a dia1-dependent signaling pathway

Cancer Research

Volumn 68, Issue 21, 2008, Pages 8743-8751

  Holeiter, Gerlinde ^a   Heering, Johanna ^a   Erlmann, Patrik ^a   Schmid, Simone ^a   Jähne, Ruth ^a   Olayioye, Monilola A ^a  

^a UNIVERSITY OF STUTTGART   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CYTOSOL RECEPTOR; DLC1 PROTEIN; DLC2 PROTEIN; RHO FACTOR; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHO KINASE; RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CONTROL; CELL LOSS; CELL MIGRATION; CELL MOTILITY; CELL TRANSFORMATION; CELLULAR DISTRIBUTION; CHEMOTAXIS; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOSKELETON; CYTOSOL; CYTOSOLIC FRACTION; DOWN REGULATION; EMBRYO; ENZYMATIC ASSAY; ENZYME ACTIVITY; FEMALE; FOCAL ADHESION; GENE DELETION; GENE EXPRESSION; GENE LOSS; GENE SILENCING; HUMAN; HUMAN CELL; LIVER CELL; METASTASIS; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE; STRESS FIBER; TUMOR SUPPRESSOR GENE; WOUND HEALING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BASE SEQUENCE; CELL LINE; CELL MOVEMENT; DNA PRIMERS; GUANOSINE TRIPHOSPHATE; HUMANS; MICROSCOPY, FLUORESCENCE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 55349116044     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-08-0984     Document Type: Article

References (41)

1. Ridley AJ, Schwartz MA, Burridge K, et al. Cell migration: integrating signals from front to back. Science 2003;302:1704-9.
2. Jaffe AB, Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 2005;21:247-69.
3. Ridley AJ. Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking. Trends Cell Biol 2006;16:522-9.
4. Homma Y, Emori Y. A dual functional signal mediator showing RhoGAP and phospholipase C-δ stimulating activities. EMBO J 1995;14:286-91.
5. Ching YP, Wong CM, Chan SF, et al. Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma. J Biol Chem 2003;278:10824-30.
6. Wong CM, Lee JM, Ching YP, et al. Genetic and epigenetic alterations of DLC-1 gene in hepatocellular carcinoma. Cancer Res 2003;63:7646-51.
7. Yuan BZ, Miller MJ, Keck CL, et al. Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP. Cancer Res 1998;58:2196-9.
8. Durkin ME, Yuan BZ, Zhou X, et al. DLC-1: a Rho GTPase-activating protein and tumour suppressor. J Cell Mol Med 2007;11:1185-207.
9. Yuan BZ, Zhou X, Durkin ME, et al. DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity. Oncogene 2003;22:445-50.
10. Yuan BZ, Jefferson AM, Baldwin KT, et al. DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas. Oncogene 2004;23:1405-11.
11. Zhou X, Thorgeirsson SS, Popescu NC. Restoration of DLC-1 gene expression induces apoptosis and inhibits both cell growth and tumorigenicity in human hepatocellular carcinoma cells. Oncogene 2004;23:1308-13.
12. Ng IO, Liang ZD, Cao L, Lee TK. DLC-1 is deleted in primary hepatocellular carcinoma and exerts inhibitory effects on the proliferation of hepatoma cell lines with deleted DLC-1. Cancer Res 2000;60:6581-4.
13. Sekimata M, Kabuyama Y, Emori Y, Homma Y. Morphological changes and detachment of adherent cells induced by p122, a GTPase-activating protein for Rho. J Biol Chem 1999;274:17757-62.
14. Wong CM, Yam JW, Ching YP, et al. Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma. Cancer Res 2005;65:8861-8.
15. Goodison S, Yuan J, Sloan D, et al. The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells. Cancer Res 2005;65:6042-53.
16. Leung TH, Ching YP, Yam JW, et al. Deleted in liver cancer 2 (DLC2) suppresses cell transformation by means of inhibition of RhoA activity. Proc Natl Acad Sci U S A 2005;102:15207-12.
17. Malliri A, Collard JG. Role of Rho-family proteins in cell adhesion and cancer. Curr Opin Cell Biol 2003;15:583-9.
18. Sahai E, Marshall CJ. RHO-GTPases and cancer. Nat Rev Cancer 2002;2:133-42.
19. Fritz G, Brachetti C, Bahlmann F, et al. Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters. Br J Cancer 2002;87:635-44.
20. Kamai T, Arai K, Tsujii T, et al. Overexpression of RhoA mRNA is associated with advanced stage in testicular germ cell tumour. BJU Int 2001;87:227-31.
21. van Golen KL, Wu ZF, Qiao XT, et al. RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype. Cancer Res 2000;60:5832-8.
22. Clark EA, Golub TR, Lander ES, Hynes RO. Genomic analysis of metastasis reveals an essential role for RhoC. Nature 2000;406:532-5.
23. Yamaguchi H, Lorenz M, Kempiak S, et al. Molecular mechanisms of invadopodium formation: the role of the N-WASP-Arp2/3 complex pathway and cofilin. J Cell Biol 2005;168:441-52.
24. Simpson KJ, Dugan AS, Mercurio AM. Functional analysis of the contribution of RhoA and RhoC GTPases to invasive breast carcinoma. Cancer Res 2004;64:8694-701.
25. Yoshizaki H, Ohba Y, Kurokawa K, et al. Activity of Rho-family GTPases during cell division as visualized with FRET-based probes. J Cell Biol 2003;162:223-32.
26. Posern G, Treisman R. Actin' together: serum response factor, its cofactors and the link to signal transduction. Trends Cell Biol 2006;16:588-96.
27. Kawai K, Yamaga M, Iwamae Y, et al. A PLCy(1)-binding protein, p122RhoGAP, is localized in focal adhesions. Biochem Soc Trans 2004;32:1107-9.
28. Qian X, Li G, Asmussen HK, et al. Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities. Proc Natl Acad Sci U S A 2007;104:9012-7.
29. Liao YC, Si L, deVere White RW, Lo SH. The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1. J Cell Biol 2007;176:43-9.
30. Yam JW, Ko FC, Chan CY, et al. Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression. Cancer Res 2006;66:8367-72.
31. Yamana N, Arakawa Y, Nishino T, et al. The RhomDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src. Mol Cell Biol 2006;26:6844-58.
32. Lo SH. Tensin. Int J Biochem Cell Biol 2004;36:31-4.
33. Ng DC, Chan SF, Kok KH, et al. Mitochondrial targeting of growth suppressor protein DLC2 through the START domain. FEBS Lett 2006;580:191-8.
34. Healy KD, Hodgson L, Kim TY, et al. DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms. Mol Carcinog 2008;47:326-37.
35. Wheeler AP, Ridley AJ. Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility. Exp Cell Res 2004;301:43-9.
36. Besson A, Gurian-West M, Schmidt A, et al. p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev 2004;18:862-76.
37. Sahai E, Olson MF, Marshall CJ. Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility. EMBO J 2001;20:755-66.
38. Pertz O, Hodgson L, Klemke RL, Hahn KM. Spatiotemporal dynamics of RhoA activity in migrating cells. Nature 2006;440:1069-72.
39. Goulimari P, Kitzing TM, Knieling H, et al. Ga12/ 13 is essential for directed cell migration and localized Rho-Dia1 function. J Biol Chem 2005;280:42242-51.
40. Kurokawa K, Matsuda M. Localized RhoA activation as a requirement for the induction of membrane ruffling. Mol Biol Cell 2005;16:4294-303.
41. Sahai E, Marshall CJ. Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis. Nat Cell Biol 2003;5:711-9.