Drug release kinetics and physicochemical characteristics of floating drug delivery systems

Expert Opinion on Drug Delivery

Volumn 8, Issue 7, 2011, Pages 891-903

  Adibkia, Khosro ^a   Hamedeyazdan, Sanaz ^a   Javadzadeh, Yousef ^b  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

buoyancy; drug release kinetics; effervescent and non effervescent systems; floating drug delivery systems

Indexed keywords

ACETOHYDROXAMIC ACID; ALGINIC ACID; AMOXICILLIN PLUS CLAVULANIC ACID; BENSERAZIDE PLUS LEVODOPA; CAPTOPRIL; CINNARIZINE; CIPROFLOXACIN; CLARITHROMYCIN; DIAZEPAM; FAMOTIDINE; FENOVERINE; FUROSEMIDE; MELATONIN; METFORMIN; METOPROLOL SUCCINATE; METRONIDAZOLE; MICROSPHERE; NIMODIPINE; NORFLOXACIN; NORVERAPAMIL; OFLOXACIN; POLYMER; PROPRANOLOL; RANITIDINE; ROSIGLITAZONE; SILYMARIN; VERAPAMIL;

CLINICAL ASSESSMENT; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG RELEASE; HUMAN; HYDRODYNAMICS; IN VIVO STUDY; INFORMATION RETRIEVAL; MEDICAL RESEARCH; PHARMACEUTICS; PHYSICAL CHEMISTRY; PREDICTION; REVIEW;

ANIMALS; DOSAGE FORMS; DRUG DELIVERY SYSTEMS; HUMANS; PHARMACOKINETICS; REPRODUCIBILITY OF RESULTS;

EID: 79959257965     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2011.574124     Document Type: Review

References (114)

1. Motlekar NA, Youan BB. The quest for non-invasive delivery of bioactive macromolecules: a focus on heparins. J Control Release 2006;113:91-101 (Pubitemid 43928148)
2. Bardonnet PL, Faivre V, Pugh WJ, et al. Gastroretentive dosage forms: overview and special case of Helicobacter pylori. J Control Release 2006;111:1-18 (Pubitemid 43289989)
3. Khobragade DS, Parshuramkar PR, Ujjainkar AP, et al. Conception and evaluation of sustained release polymeric matrix beads for enhanced gastric retention. Curr Drug Deliv 2009;6:249-54
4. Hu LD, Xing QB, Shang C, et al. Preparation of rosiglitazone maleate sustained-release floating microspheres for improved bioavailability. Pharmazie 2010;65:477-80
5. Klausner EA, Lavy E, Friedman M, et al. Expandable gastroretentive dosage forms. J Control Release 2003;90:143-62 (Pubitemid 36700451)
6. Tang YD, Venkatraman SS, Boey FY, et al. Sustained release of hydrophobic and hydrophilic drugs from a floating dosage form. Int J Pharm 2007;336:159-65 (Pubitemid 46566484)
7. Locatelli I, Nagelj Kovacic N, Mrhar A, et al. Gastric emptying of non-disintegrating solid drug delivery systems in fasted state: relevance to drug dissolution. Expert Opin Drug Deliv 2010;7:967-76
8. Moes AJ. Gastroretentive dosage forms. Crit Rev Ther Drug Carrier Syst 1993;10:143-95 (Pubitemid 23198886)
9. Javadzadeh Y, Hamedeyazdan S, Adibkia K, et al. Evaluation of drug release kinetics and physico-chemical characteristics of metronidazole floating beads based on calcium silicate and gas-forming agents. Pharm Dev Technol 2010;15:329-38
10. Asnaashari S, Khoei NS, Zarrintan MH, et al. Preparation and evaluation of novel metronidazole sustained release and floating matrix tablets. Pharm Dev Technol 30 April 2010. [Epub ahead of print]
11. Sungthongjeen S, Sriamornsak P, Puttipipatkhachorn S. Design and evaluation of floating multi-layer coated tablets based on gas formation. Eur J Pharm Biopharm 2008;69:255-63 (Pubitemid 351467157)
12. Singh BN, Kim KH. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. J Control Release 2000;63:235-59
13. Wurster DE, Alkhamis KA, Matheson LE. Prediction of the adsorption of diazepam by activated carbon in aqueous media. J Pharm Sci 2003;92:2008-16 (Pubitemid 37175631)
14. Patel A, Modasiya M, Shah D, et al. Development and in vivo floating behavior of verapamil HCl intragastric floating tablets. AAPS PharmSciTech 2009;10:310-15
15. Meka L, Kesavan B, Chinnala KM, et al. Preparation of a matrix type multiple-unit gastro retentive floating drug delivery system for captopril based on gas formation technique: in vitro evaluation. AAPS PharmSciTech 2008;9:612-19
16. Mayavanshi A, Gajjar S. Floating drug delivery systems to increase gastric retention of drugs: a review. Res J Pharm Tech 2008;1:345-48
17. Sevgi F, Kaynarsoy B, Ozyazici M, et al. A comparative histological study of alginate beads as a promising controlled release delivery for mefenamic acid. Pharm Dev Technol 2008;13:387-92
18. Streubel A, Siepmann J, Bodmeier R. Drug delivery to the upper small intestine window using gastroretentive technologies. Curr Opin Pharmacol 2006;6:501-8 (Pubitemid 44340666)
19. Arza RA, Gonugunta CS, Veerareddy PR. Formulation and evaluation of swellable and floating gastroretentive ciprofloxacin hydrochloride tablets. AAPS PharmSciTech 2009;10:220-6
20. Soppimath KS, Kulkarni AR, Rudzinski WE, et al. Microspheres as floating drug-delivery systems to increase gastric retention of drugs. Drug Metab Rev 2001;33:149-60 (Pubitemid 32703254)
21. Pathan SA, Iqbal Z, Sahani JK, et al. Buccoadhesive drug delivery systems-extensive review on recent patents. Recent Pat Drug Deliv Formul 2008;2:177-88
22. Davidovich-Pinhas M, Bianco-Peled H. Mucoadhesion: a review of characterization techniques. Expert Opin Drug Deliv 2010;7:259-71
23. Garse H, Vij M, Yamgar M, et al. Formulation and evaluation of a gastroretentive dosage form of labetalol hydrochloride. Arch Pharm Res 2010;33:405-10
24. Rajab M, Jouma M, Neubert RH, et al. Optimization of a metformin effervescent floating tablet containing hydroxypropylmethylcellulose and stearic acid. Pharmazie 2010;65:97-101
25. Sriamornsak P, Sungthongjeen S, Puttipipatkhachorn S. Use of pectin as a carrier for intragastric floating drug delivery: carbonate salt contained beads. Carbohydr Polymers 2007;67:436-45 (Pubitemid 44881126)
26. Jaimini M, Rana AC, Tanwar YS. Formulation and evaluation of famotidine floating tablets. Curr Drug Deliv 2007;4:51-5 (Pubitemid 46066414)
27. Dey N, Majumdar S, Rao M. Multiparticulate drug delivery systems for controlled release. Trop J Pharm Res 2008;7:1067-75
28. Shaji J, Chadawar V, Talwalkar P. Multiparticulate drug delivery system. Indian Pharm 2007;6:21-8
29. Tang ESK, Chan LW, Heng PWS. Coating of multiparticulates for sustained release. Am J Drug Deliv 2005;3:17-28 (Pubitemid 40542549)
30. Jimenezmartinez I, Quirinobarreda T, Villafuerterobles L. Sustained delivery of captopril from floating matrix tablets. Int J Pharm 2008;362:37-43
31. Bani-Jaber A, Al-Aani L, Alkhatib H, et al. Prolonged intragastric drug delivery mediated by eudragit- E-carrageenan polyelectrolyte matrix tablets. AAPS PharmSciTech 2011;12(1):354-61
32. Chavanpatil M, Jain P, Chaudhari S, et al. Development of sustained release gastroretentive drug delivery system for ofloxacin: in vitro and in vivo evaluation. Int J Pharm 2005;304:178-84 (Pubitemid 41427660)
33. Tadros MI. Controlled-release effervescent floating matrix tablets of ciprofloxacin hydrochloride: development, optimization and in vitro-in vivo evaluation in healthy human volunteers. Eur J Pharm Biopharm 2010;74:332-39
34. Dorozynski P, Jachowicz R, Kulinowski P, et al. The macromolecular polymers for the preparation of hydrodynamically balanced systems-methods of evaluation. Drug Dev Ind Pharm 2004;30:947-57 (Pubitemid 39453046)
35. Khattar D, Ahuja A, Khar RK. Hydrodynamically balanced systems as sustained release dosage forms for propranolol hydrochloride. Pharmazie 1990;45:356-8 (Pubitemid 20214267)
36. Jain SK, Agrawal GP, Jain NK. Floating microspheres as drug delivery system: newer approaches. Curr Drug Deliv 2008;5:220-3 (Pubitemid 351977886)
37. Sungthongjeen S, Paeratakul O, Limmatvapirat S, et al. Preparation and in vitro evaluation of a multiple-unit floating drug delivery system based on gas formation technique. Int J Pharm 2006;324:136-43 (Pubitemid 44528911)
38. Kumar KM, Shah MH, Ketkar A, et al. Effect of drug solubility and different excipients on floating behaviour and release from glyceryl monooleate matrices. Int J Pharm 2004;272:151-60 (Pubitemid 38293020)
39. Nakamichi K, Yasuura H, Fukui H, et al. Evaluation of a floating dosage form of nicardipine hydrochloride and hydroxypropylmethylcellulose acetate succinate prepared using a twin-screw extruder. Int J Pharm 2001;218:103-12 (Pubitemid 32406161)
40. Kuchekar BS, Boldhane SP. Development and optimization of metoprolol succinate gastroretentive drug delivery system. Acta Pharm 2010;60:415-25
41. Nama M, Gonugunta CSR, Reddy Veerareddy P. Formulation and evaluation of gastroretentive dosage forms of clarithromycin. AAPS PharmSciTech 2008;9:231-37
42. Ahuja G, Pathak K. Porous carriers for controlled/modulated drug delivery. Indian J Pharm Sci 2009;71:599-607
43. Sher P, Ingavle G, Ponrathnam S, et al. Modulation and optimization of drug release from uncoated low density porous carrier based delivery system. AAPS PharmSciTech 2009;10:547-58
44. Streubel A, Siepmann J, Bodmeier R. Floating microparticles based on low density foam powder. Int J Pharm 2002;241:279-92 (Pubitemid 34718029)
45. Jain S, Awasthi A, Jain N, et al. Calcium silicate based microspheres of repaglinide for gastroretentive floating drug delivery: preparation and in vitro characterization. J Control Release 2005;107:300-9 (Pubitemid 41316292)
46. Streubel A, Siepmann J, Bodmeier R. Floating matrix tablets based on low density foam powder: effects of formulation and processing parameters on drug release. Eur J Pharm Sci 2003;18:37-45 (Pubitemid 36120553)
47. Coppi G, Iannuccelli V, Cameroni R. Polysaccharide film-coating process for freely swellable hydrogels. Pharm Dev Technol 1998;3:347-53 (Pubitemid 28410362)
48. Park TG, Hoffman AS. Effect of temperature cycling on the activity and productivity of immobilized beta-galactosidase in a thermally reversible hydrogel bead reactor. Appl Biochem Biotechnol 1988;19:1-9
49. Murata Y, Sasaki N, Miyamoto E, et al. Use of floating alginate gel beads for stomach-specific drug delivery. Eur J Pharm Biopharm 2000;50:221-6
50. Rao KVR, Devi KP. Swelling controlled-release systems: recent developments and applications. Int J Pharm 1988;48:1-13
51. Han J, Zhou Z, Yin R, et al. Alginate-chitosan/hydroxyapatite polyelectrolyte complex porous scaffolds: preparation and characterization. Int J Biol Macromol 2010;46:199-205
52. Ma N, Xu L, Wang Q, et al. Development and evaluation of new sustained-release floating microspheres. Int J Pharm 2008;358:82-90
53. Singh B, Sharma V, Chauhan D. Gastroretentive floating sterculiaa alginate beads for use in antiulcer drug delivery. Chem Eng Res Des 2010;88:997-1012
54. Gholap SB, Banarjee SK, Gaikwad DD, et al. Hollow microsphere: a review. Int J Pharm Sci Rev Res 2010;1:74-9
55. Soppimath KS, Kulkarni AR, Aminabhavi TM. Development of hollow microspheres as floating controlled-release systems for cardiovascular drugs: preparation and release characteristics. Drug Dev Ind Pharm 2001;27:507-15 (Pubitemid 32803569)
56. Soppimath KS, Aminabhavi TM, Agnihotri SA, et al. Effect of coexcipients on drug release and floating property of nifedipine hollow microspheres: a novel gastro retentive drug delivery system. J Appl Polym Sci 2006;100:486-94
57. Junyaprasert VB, Pornsuwannapha S. Floating properties and release characteristics of hollow microspheres of acyclovir. Drug Deliv 2008;15:331-41
58. Basavaraj BV, Deveswaran R, Bharath S, et al. Hollow microspheres of diclofenac sodium - a gastroretentive controlled delivery system. Pak J Pharm Sci 2008;21:451-4
59. Sato Y, Kawashima Y, Takeuchi H, et al. Physicochemical properties to determine the buoyancy of hollow microspheres (microballoons) prepared by the emulsion solvent diffusion method. Eur J Pharm Biopharm 2003;55:297-304 (Pubitemid 36561556)
60. Sato Y, Kawashima Y, Takeuchi H, et al. In vitro evaluation of floating and drug releasing behaviors of hollow microspheres (microballoons) prepared by the emulsion solvent diffusion method. Eur J Pharm Biopharm 2004;57:235-43 (Pubitemid 38283699)
61. Parikh DC, Amin AF. In vitro and in vivo techniques to assess the performance of gastro-retentive drug delivery systems: a review. Expert Opin Drug Deliv 2008;5:951-65
62. Mudie DM, Amidon GL, Amidon GE. Physiological parameters for oral delivery and in vitro testing. Mol Pharm 7 Sep 2010. [Epub ahead of print]
63. Chen R-N, Ho H-O, Yu C-Y, et al. Development of swelling/floating gastroretentive drug delivery system based on a combination of hydroxyethyl cellulose and sodium carboxymethyl cellulose for Losartan and its clinical relevance in healthy volunteers with CYP2C9 polymorphism. Eur J Pharm Sci 2010;39:82-9
64. Sharma S, Pawar A. Low density multiparticulate system for pulsatile release of meloxicam. Int J Pharm 2006;313:150-58
65. Badve SS, Sher P, Korde A, et al. Development of hollow/porous calcium pectinate beads for floating-pulsatile drug delivery. Eur J Pharm Biopharm 2007;65:85-93 (Pubitemid 44827695)
66. Sriamornsak P, Asavapichayont P, Nunthanid J, et al. Wax-incorporated emulsion gel beads of calcium pectinate for intragastric floating drug delivery. AAPS PharmSciTech 2008;9:571-76
67. Li S. Effect of HPMC and Carbopol on the release and floating properties of gastric floating drug delivery system using factorial design. Int J Pharm 2003;253:13-22 (Pubitemid 36197827)
68. Baumgartner S, Kristl J, Vrecer F, et al. Optimisation of floating matrix tablets and evaluation of their gastric residence time. Int J Pharm 2000;195:125-35 (Pubitemid 30089497)
69. Sriamornsak P, Thirawong N, Puttipipatkhachorn S. Emulsion gel beads of calcium pectinate capable of floating on the gastric fluid: effect of some additives, hardening agent or coating on release behavior of metronidazole. Eur J Pharm Sci 2005;24:363-73 (Pubitemid 40283519)
70. Hilton AK, Deasy PB. In vitro and in vivo evaluation of an oral sustained-release floating dosage form of amoxycillin trihydrate. Int J Pharm 1992;86:79-48
71. Badhan AC, Mashru RC, Shah PP, et al. Development and evaluation of sustained release gastroretentive minimatrices for effective treatment of H. pylori infection. AAPS PharmSciTech 2009;10:459-67
72. Goole J, Deleuze P, Vanderbist F, et al. New levodopa sustained-release floating minitablets coated with insoluble acrylic polymer. Eur J Pharm Biopharm 2008;68:310-18
73. Jagdale SC, Agavekar AJ, Pandya SV, et al. Formulation and evaluation of gastroretentive drug delivery system of propranolol hydrochloride. AAPS PharmSciTech 2009;10:1071-79
74. Sawicki W. Pharmacokinetics of verapamil and norverapamil from controlled release floating pellets in humans. Eur J Pharm Biopharm 2002;53:29-35 (Pubitemid 34036995)
75. Jain S, Agrawal G, Jain N. A novel calcium silicate based microspheres of repaglinide: in vivo investigations. J Control Release 2006;113:111-16 (Pubitemid 43928144)
76. Goole J, Vangansbeke B, Pilcer G, et al. Pharmacoscintigraphic and pharmacokinetic evaluation on healthy human volunteers of sustained-release floating minitablets containing levodopa and carbidopa. Int J Pharm 2008;364:54-63
77. Zhao L, Yang X, Xu R, et al. Safety, tolerability and pharmacokinetics of phenoprolamine hydrochloride floating sustained-release tablets in healthy Chinese subjects. Int J Pharm 2009;377:99-104
78. Kakumanu VK, Arora VK, Bansal AK. Gastro-retentive dosage form for improving bioavailability of cefpodoxime proxetil in rats. Pharm Soc Japan 2008;128:439-45 (Pubitemid 351347236)
79. Sheth PR, Tossounian J. The hydrodynamically balanced system (HBS-) a novel drug delivery system for oral use. Drug Dev Ind Pharm 1984;10:313-39
80. Washington N, Washington C, Wilson CG, et al. What is Liquid Gaviscon? A comparison of four international formulations. Int J Pharm 1986;34:105-9 (Pubitemid 17216783)
81. Costa P, Sousa Lobo JM. Modeling and comparison of dissolution profiles. Eur J Pharm Sci 2001;13:123-33 (Pubitemid 32288781)
82. Wagner JG. Interpretation of percent dissolved-time plots derived from in vitro testing of conventional tablets and capsules. J Pharm Sci 1969;58:1253-7
83. Dash S, Murthy PN, Nath L, et al. Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm 2010;67:217-23
84. Siepmann J, Gopferich A. Mathematical modeling of bioerodible, polymeric drug delivery systems. Adv Drug Deliv Rev 2001;48:229-47 (Pubitemid 32434405)
85. Kanjickal DG, Lopina ST. Modeling of drug release from polymeric delivery systems-a review. Crit Rev Ther Drug Carrier Syst 2004;21:345-86 (Pubitemid 41647577)
86. Arifin DY, Lee LY, Wang CH. Mathematical modeling and simulation of drug release from microspheres: implications to drug delivery systems. Adv Drug Deliv Rev 2006;58:1274-325
87. Grassi M, Grassi G. Mathematical modelling and controlled drug delivery: matrix systems. Curr Drug Deliv 2005;2:97-116 (Pubitemid 40590925)
88. Barzegar-Jalali M, Adibkia K, Valizadeh H, et al. Kinetic analysis of drug release from nanoparticles. J Pharm Pharm Sci 2008;11:167-77
89. Mohammadi G, Barzegar-Jalali M, Valizadeh H, et al. Reciprocal powered time model for release kinetic analysis of ibuprofen solid dispersions in oleaster powder, microcrystalline cellulose and crospovidone. J Pharm Pharm Sci 2010;13:152-61
90. Barzegar-Jalali M, Dastmalchi S. Kinetic analysis of chlorpropamide dissolution from solid dispersions. Drug Dev Ind Pharm 2007;33:63-70 (Pubitemid 46034151)
91. Salsa T, Veiga F, Teixeira-Dias JJ, et al. Effect of polymer hydration on the kinetic release of drugs: a study of ibuprofen and ketoprofen in HPMC matrices. Drug Dev Ind Pharm 2003;29:289-97 (Pubitemid 36528619)
92. Papadopoulou V, Kosmidis K, Vlachou M, et al. On the use of the Weibull function for the discernment of drug release mechanisms. Int J Pharm 2006;309:44-50 (Pubitemid 43129463)
93. Ali J, Arora S, Ahuja A, et al. Formulation and development of hydrodynamically balanced system for metformin: In vitro and in vivo evaluation. Eur J Pharm Biopharm 2007;67:196-201 (Pubitemid 46991323)
94. Bandari S, Eaga CM, Thadishetty A, et al. Formulation and evaluation of multiple tablets as a biphasic gastroretentive floating drug delivery system for fenoverine. Acta Pharm 2010;60:89-97
95. Barmpalexis P, Kachrimanis K, Georgarakis E. Solid dispersions in the development of a nimodipine floating tablet formulation and optimization by artificial neural networks and genetic programming. Eur J Pharm Biopharm 2010;77(1):122-31
96. Bomma R, Swamy Naidu RA, Yamsani MR, et al. Development and evaluation of gastroretentive norfloxacin floating tablets. Acta Pharm 2009;59:211-21
97. Chavanpatil M, Jain P, Chaudhari S, et al. Novel sustained release, swellable and bioadhesive gastroretentive drug delivery system for ofloxacin. Int J Pharm 2006;316:86-92 (Pubitemid 43765689)
98. El-Gibaly I. Development and in vitro evaluation of novel floating chitosan microcapsules for oral use: comparison with non-floating chitosan microspheres. Int J Pharm 2002;249:7-21 (Pubitemid 35333428)
99. Elmowafy EM, Awad GAS, Mansour S, et al. Release mechanisms behind polysaccharides-based famotidine controlled release matrix tablets. AAPS PharmSciTech 2008;9:1230-39
100. Garg R, Gupta GD. Preparation and evaluation of gastroretentive floating tablets of Silymarin. Chem Pharm Bull (Tokyo) 2009;57:545-9
101. Ishak R, Awad G, Mortada N, et al. Preparation, in vitro and in vivo evaluation of stomach-specific metronidazole-loaded alginate beads as local anti-Helicobacter pylori therapy. J Control Release 2007;119:207-14 (Pubitemid 46754505)
102. Kerc J, Opara J. A new amoxicillin/ clavulanate therapeutic system: preparation, in vitro and pharmacokinetic evaluation. Int J Pharm 2007;335:106-13 (Pubitemid 46482868)
103. Lingam M, Ashok T, Venkateswarlu V, et al. Design and evaluation of a novel matrix type multiple units as biphasic gastroretentive drug delivery systems. AAPS PharmSciTech 2008;9:1253-61
104. Meka L, Kesavan B, Kalamata VN, et al. Design and evaluation of polymeric coated minitabletes as multiple unit gastroretentive floating drug delivery system for furosemide. L Pharm Sci 2009;98:2122-32
105. Mohan Kamila M, Mondal N, Kanta Ghosh L, et al. Multiunit floating drug delivery system of rosiglitazone maleate: development, characterization, statistical optimization of drug release and in vivo evaluation. AAPS PharmSciTech 2009;10:887-99
106. Nagarwal RC, Ridhurkar DN, Pandit JK. In vitro release kinetics and bioavailability of gastroretentive cinnarizine hydrochloride tablet. AAPS PharmSciTech 2010;11:294-303
107. Rajinikanth P, Mishra B. Floating in situ gelling system for stomach site-specific delivery of clarithromycin to eradicate H. pylori. J Control Release 2008;125:33-41 (Pubitemid 350198674)
108. Rajinikanth PS, Karunagaran LN, Balasubramaniam J, et al. Formulation and evaluation of clarithromycin microspheres for eradication of Helicobacter pylori. Chem Pharm Bull (Tokyo) 2008;56:1658-64
109. Rajinikanth PS, Mishra B. Preparation and in vitro characterization of gellan based floating beads of acetohydroxamic acid for eradication of H. pylori. Acta Pharm 2007;57:413-27
110. Rajinikanth PS, Mishra B. Stomach-site specific drug delivery system of clarithromycin for eradication of Helicobacter pylori. Chem Pharm Bull (Tokyo) 2009;57:1068-75
111. Shah M, Paradkar A. Cubic liquid crystalline glyceryl monooleate matrices for oral delivery of enzyme. Int J Pharm 2005;294:161-71 (Pubitemid 40462332)
112. Strubing S, Metz H, Mader K. Characterization of poly(vinyl acetate) based floating matrix tablets. J Control Release 2008;126:149-55
113. Xu X, Sun M, Zhi F, et al. Floating matrix dosage form for phenoporlamine hydrochloride based on gas forming agent: in vitro and in vivo evaluation in healthy volunteers. Int J Pharm 2006;310:139-45 (Pubitemid 43287977)
114. Rohith G, Sridhar BK, Srinatha A. Floating drug delivery of a locally acting H2-antagonist: an approach using an in situ gelling liquid formulation. Acta Pharm 2009;59:345-54