Formulation and evaluation of a gastroretentive dosage form of labetalol hydrochloride

Archives of Pharmacal Research

Volumn 33, Issue 3, 2010, Pages 405-410

  Garse, Harshal ^a   Vij, Mohit ^a   Yamgar, Manohar ^a   Kadam, Vilasrao ^a   Hirlekar, Rajashree ^a  

^a BHARATI VIDYAPEETH S COLLEGE OF PHARMACY   (India)

Author keywords

Floating behaviour; Hydroxypropylmethyl cellulose and poloxamer; Labetalol hydrochloride; Non effervescent floating tablets; Sustained release

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE; LABETALOL; POLOXAMER; ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIHYPERTENSIVE AGENT; DRUG DERIVATIVE; METHYLCELLULOSE; WATER; WETTING AGENT;

ARTICLE; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG RELEASE; DRUG RETENTION; DRUG SCREENING; IN VITRO STUDY; TABLET FORMULATION; CHEMISTRY; DELAYED RELEASE FORMULATION; EVALUATION; KINETICS; METHODOLOGY; OSMOLARITY; PH; PHARMACEUTICS; SOLUBILITY; TABLET;

ADRENERGIC ANTAGONISTS; ANTIHYPERTENSIVE AGENTS; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; HYDROGEN-ION CONCENTRATION; KINETICS; LABETALOL; METHYLCELLULOSE; OSMOLAR CONCENTRATION; POLOXAMER; SOLUBILITY; TABLETS; TECHNOLOGY, PHARMACEUTICAL; WATER; WETTING AGENTS;

EID: 77953624573     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-010-0309-z     Document Type: Article

References (12)

1. Ansel, H., Stoklosa, M., Pharmaceutical Calculations, 11th edn, Lippincott, Williams and Wilkins, Baltimore, MD, pp. 178-180, (2001).
2. Arora S., Ali J., Ahuja A., Khar R. K., and Baboota S., Floatimg drug dellivery systems: A Review. AAPS PharmSciTech, 6, 47 (2005).
3. Baumgartner, S., Smid-Korber, J., Vreces, F., and Kristl, J., Physical and technological parameters influencing floating properties of matrix tablets based on cellulose ethers. STP Pharma. Sciences, 8, 182-187 (1998).
4. Dollery, C., Therapeutic drugs. Volume 1, IInd edition, Churchill Livingstone, L1-L3 (1999).
5. Gutierrez-Rocca, J., Omidian, H., and Shah, K., Progresses in gastroretentive drug delivery. Pharm. Tech., 152-156 (2003).
6. nd edition, Revised and expanded, CBS Publishers Delhi, pp. 1-42, (2004).
7. Martes, L., In: Handbook of Analytical Chemistry (eds) Mcgraw Hill, New York, pp. 329, (1963).
8. Nur, A. O. and Zhang, J. S., Captopril floating and/or bioadhesive tablets: design and release kinetics. Drug Dev. Ind. Pharm., 26, 965-969 (2000).
9. Rosa, M., Zia, H., and Rhodes, T., Dosing and testing in-vitro of a bioadhesive and floating drug delivery system for oral application. Int. J. Pharm., 105, 65-70 (1994).
10. Srivastava, A. K., Wadhwa, S., Ridhurkar, D., and Mishra, B., Oral sustained delivery of atenolol from floating matrix tablets formulation and in vitro evaluation. Drug Dev. Ind. Pharm., 31, 367-374 (2005).
11. Timmermans, J. and Moes, A. J., How well does floating dosage forms float. Int. J. Pharm., 62, 207-216 (1990).
12. Wu, W., Zhou, Q., Zhang, H. B., Ma, G. D., Fu, C. D., Studies on Nimodipine sustained release tablet capable of floating on gastric fluids with prolonged gastric resident time. Yao Xue Xue Bao., 32, 786-790 (1997).