Optimization of a metformin effervescent floating tablet containing hydroxypropylmethylcellulose and stearic acid

Pharmazie

Volumn 65, Issue 2, 2010, Pages 97-101

  Rajab, Mazen ^a   Jouma, M ^a   Neubert, R H ^b   Dittgen, M ^a  

^a Damascus University   (Syrian Arab Republic)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BICARBONATE; CITRIC ACID; HYDROXYPROPYLMETHYLCELLULOSE; MAGNESIUM STEARATE; METFORMIN; METHYLCELLULOSE; STEARIC ACID;

ARTICLE; CONTROLLED DRUG RELEASE; DIFFUSION; DRUG SOLUBILITY; EFFERVESCENT TABLET; TABLET HARDNESS; TABLET MATRIX;

CALORIMETRY, DIFFERENTIAL SCANNING; DRUG COMPOUNDING; EXCIPIENTS; HARDNESS TESTS; HYPOGLYCEMIC AGENTS; KINETICS; LACTOSE; METFORMIN; METHYLCELLULOSE; POWDERS; REGRESSION ANALYSIS; SOLUBILITY; SPECTROPHOTOMETRY, ULTRAVIOLET; STEARIC ACIDS; TABLETS;

EID: 76149127009     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2010.9233     Document Type: Article

References (15)

1. Arora S, Ali J, Ahuja A, Khar RK, Baboota S (2005) Floating drug delivery systems: A review. AAPS Pharm Sci Tech 6: E372-E390.
2. Balan G, Timmins P, Greene DS, Marathe PH (2001) In vitro-in vivo correlation (IVIVC) models for metformin after administration of modified-release (MR) oral dosage forms to healthy human volunteers. J Pharm Sci 90: 1176-1185.
3. Basak SC, Rahman J, Ramaligam M (2007) Design and in vitro testing of a floatable gastroretentive tablet of metformin hydrochloride. Pharmazie 62: 145-148.
4. Catellani P, Vaona G, Plazzi P, Colombo P (1988) Compressed matrices: formulation and drug release kinetics. Acta Pharm Technol 34: 38-41.
5. Dave BS, Amin AF, Patel MM(2004) Gastroretentive drug delivery system of ranitidine hydrochloride: formulation and in vitro evaluation. AAPS Pharm Sci Tech 5: 77-82.
6. Efentakis M, Pagoni I, Vlachou M, Avgoustakis K (2007) Dimensional changes, gel layer evolution and drug release studies in hydrophilic matrices loaded with drugs of different solubility. Int J Pharm 339: 66-75.
7. Gambhire MN, Ambade KW, Kurmi SD, Kadam VJ, Jadhav KR (2007) Development and in vitro evaluation of an oral floating matrix tablet formulation of diltiazem hydrochloride. AAPS Pharm Sci Tech 8: E166-E174.
8. Patel DM, Patel NM, Pandya NN, Jogani PD (2007) Gastroretentive drug delivery system of carbamazepine: Formulation optimization using simplex lattice design: A technical note. AAPS Pharm Sci Tech 8: E82-E86.
9. Patel VF, Patel NM (2007a) Statistical evaluation of influence of viscosity and content of polymer on dipyridamole release from floating matrix tablets: A technical note. AAPS Pharm Sci Tech 8: E140-E144.
10. Patel VF, Patel NM (2007b) Statistical evaluation of influence of xanthan gum and guar gum blends on dipyridamole release from floating matrix tablets. Drug Dev Ind Pharm 33: 327-334.
11. Prajapati ST, Patel LD, Patel DM (2008) Gastric floating matrix tablets: Design and optimization using combination of polymers. Acta Pharm [Zagreb] 58: 221-229.
12. Rosa M, Zia H, Rhodes T (1994) Dosing and testing in-vitro of a bioadhesive and floating drug delivery system for oral application. Int J Pharm 105: 65-70.
13. Santos AFO, Basilio ID Jr, de Souza FS, Medeiros AFD, Pinto MF, de Santana DP, Macedo RO et al. (2008) Application of thermal analysis in study of binary mixtures with metformin. J Thermal Anal Calorim 93: 361-364.
14. Srivastava AK, Wadhwa S, Ridhurkar D, Mishra B (2005) Oral sustained delivery of atenolol from floating matrix tablets - formulation and in vitro evaluation. Drug Dev Ind Pharm 31: 367-374.
15. Streubel A, Siepmann J, Bodmeier R (2006) Drug delivery to the upper small intestine window using gastroretentive technologies. Curr Opin Pharmacol 6: 501-508.