Development and in vivo floating behavior of verapamil HCL intragastric floating tablets

AAPS PharmSciTech

Volumn 10, Issue 1, 2009, Pages 310-315

  Patel, Anand ^a   Modasiya, Moin ^a   Shah, Dushyant ^a   Patel, Vishnu ^a  

^a APMC College of Pharmaceutical Education and Research   (India)

Author keywords

Intragastric floating tablet; Sustained release; Verapamil hydrochloride

Indexed keywords

BICARBONATE; CARBOMER; CITRIC ACID; HYDROXYPROPYLMETHYLCELLULOSE; VERAPAMIL; XANTHAN; ACRYLIC ACID DERIVATIVE; ACRYLIC ACID RESIN; BACTERIAL POLYSACCHARIDE; CALCIUM CHANNEL BLOCKING AGENT; CARBOPOL 940; DRUG DERIVATIVE; METHYLCELLULOSE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; GEL; HUMIDITY; IN VITRO STUDY; IN VIVO STUDY; LINEAR REGRESSION ANALYSIS; MATRIX TABLET; NONHUMAN; TABLET COMPRESSION; TABLET PROPERTY; TEMPERATURE; X RAY ANALYSIS; ANIMAL; CHEMICAL MODEL; CHEMISTRY; DELAYED RELEASE FORMULATION; EVALUATION; MALE; METABOLISM; ORAL DRUG ADMINISTRATION; RADIOGRAPHY; SOLUBILITY; STATISTICAL MODEL; STOMACH; TABLET;

ACRYLATES; ACRYLIC RESINS; ADMINISTRATION, ORAL; ANIMALS; CALCIUM CHANNEL BLOCKERS; CHEMISTRY, PHARMACEUTICAL; CITRIC ACID; DELAYED-ACTION PREPARATIONS; DOGS; DRUG COMPOUNDING; DRUG STABILITY; GELS; HUMIDITY; LINEAR MODELS; MALE; METHYLCELLULOSE; MODELS, CHEMICAL; POLYSACCHARIDES, BACTERIAL; SODIUM BICARBONATE; SOLUBILITY; STOMACH; TABLETS; TEMPERATURE; VERAPAMIL;

EID: 67549151413     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-009-9210-9     Document Type: Article

References (21)

1. W. Zhenping, Y. Zhanfeng, and B. Dianzhou. Design and evalvation of a two-layer floating tablet for gastric-retention using cisalpine as a model drug. Drug Dev. Ind. Pharm. 27(5):469-474 (2001).
2. A. Streobel, J. Siepmann, and R. Bodmeier. Gastroretentive drug delivery systems. Expert Opinion on Drug Delivery. 3(2):217-233 (2006).
3. G. Ponchel, and J. M. Irache. Specific and non-specific bioadhesive particulate system for oral delivery to the GI tract. Adv. Drug Del. Rev. 34:191-219 (1998).
4. A. A. Deshpande, N. H. Shah, C. T. Rhodes, and W. Malick. Development of a novel controlled release system for gastric retention. Pharm. Res. 14:815-819 (1997).
5. S. S. Davis, A. F. Stockwell, M. J. Taylor, et al. The effect of density on the gastric emptying of single and multiple unit dosage forms. Pharm. Res. 3:208-213 (1986).
6. J. Urguhart, F. Theeuwes, inventors. Alza Corporation, assignee. Drug delivery system comprising a reservoir containing a plurality of tiny pills. US patent 4 434 153. February 28, 1994.
7. R. C. Mamajek, E. S. Moyer. Inventors. Mc Nei lab, Inc, assignee. Drug dispensing device and method. US Patent 4 207 890. June 17, 1980.
8. J. A. Fix, R. Cargill, and K. Engle. Controlled gastric emptying, III: Gastric residence time of a non disintegrating geometric shape in human volunteers. Pharm. Res. 10:1087-1089 (1993).
9. F. Kedzierewicz, P. Thouvenot, J. Lemut, A. Etinine, and M. Hoffonan. Evaluation of peroral silicone dosage forms in humans by gamma-scintigraphy. J. Control Release. 58:195-205 (1999).
10. R. Groning, and G. Heun. Dosage forms with controlled gastrointestinal passage-studies on the absorption of nitrofurantoin. Int. J. Pharm. 56:111-116 (1989).
11. A. K. Bansal. Gastric-retention: A means to address regional variability in intestinal drug absorption (Drug Delivery). Pharma Techno. 1-20 (2003).
12. D. McTavish, and S. E. M. Verapamil. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension. Drugs. 38(1):19-76 (1989).
13. H. A. Klein, and E. KapIinsky. Digitalis and verapamil in atrial fibrillation and flutter. Is VP now the preferred agent? Drugs. 31:185 (1986).
14. M. Rosa, H. Zia, and T. Rhodes. Dosing and testing in vitro of a bioadhesive and floating drug delivery system for oral application. Int. J. Pharm. 105:65-70 (1994).
15. P. Dorozynski, R. Jachowicz, P. Kulinowski, S. Kwiecinski, K. Szybinski, T. Skorka, and A. Jasinski. The polymers for the preparation of hydrodynamically balanced systems - methods of evaluation. Drug Dev. Ind. Pharm. 30(9):947-957 (2004).
16. B. R. Mathews. Regulatory aspects of stability testing in Europe. Drug Dev. Ind. Pharm. 25:831-856 (1999).
17. N. Tomoya, K. Shin-ichi, S. Yasushi, and K. Masayuki. Preparation of floating drug delivery system by plasma technique. Chem. Pharm. Bull. 54(4):514-518 (2006).
18. B.S. Dave, A. F. Amin, and M. M. Patel. Gastroretentive drug delivery system of ranitidine hydrochloride: Formulation and in vitro evaluation. AAPS PharmSciTech. 5(2):34 (2004).
19. F. Mamoru, A. Nicholas, and W. James. Floating hot-melt extruded tablets for gastroretentive controlled drug release system. J. Control Release. 115:121-129 (2006).
20. R. Ziyaur, A. Mushir, and R. K. Khar. Design and evaluation of bilayer floating tablets of captopri. Acta. Pharm. 56:49-57 (2006).
21. R. Korsmeyer, R. Gurny, and N. Peppas. Mechanisms of solute release from porous hydrophilic polymers. Int. J. Pharm. 15:25-35 (1983).