Optimisation of floating matrix tablets and evaluation of their gastric residence time

International Journal of Pharmaceutics

Volumn 195, Issue 1-2, 2000, Pages 125-135

  Baumgartner, Saša ^a   Kristl, Julijana ^a   Vrečer, Franc ^b   Vodopivec, Polona ^b   Zorko, Bojan ^a  

^a UNIVERSITY OF LJUBLJANA   (Slovenia)

^b KRKA D D   (Slovenia)

Author keywords

Floating; Gastric residence time; Matrix; Non Fickian diffusion; Tablet

Indexed keywords

BARIUM SULFATE; BICARBONATE; CARBOXYMETHYLCELLULOSE; CETOSTEARYLIC ALCOHOL; CITRIC ACID; CROSCARMELLOSE SODIUM; DRUG ADDITIVE; HYDROCHLORIC ACID; HYDROXYPROPYLMETHYLCELLULOSE; MICROCRYSTALLINE CELLULOSE; PENTOXIFYLLINE; STARCH GLYCOLATE SODIUM;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CRUSHING STRENGTH; DOG; DRUG BIOAVAILABILITY; DRUG DIFFUSION; DRUG MEGADOSE; DRUG TRANSPORT; MATRIX TABLET; MEAN RESIDENCE TIME; NONHUMAN; PRIORITY JOURNAL; STOMACH; SUSTAINED DRUG RELEASE; TABLET COMPRESSION; TABLET FORMULATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; DELAYED-ACTION PREPARATIONS; DOGS; GASTROINTESTINAL TRANSIT; LACTOSE; METHYLCELLULOSE; OXAZINES; STOMACH; TABLETS; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 0033974459     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00378-6     Document Type: Article

References (19)

1. Baumgartner S., Šmid-Korbar J., Vrecer F., Kristl J. Physical and technological parameters influencing floating properties of matrix tablets based on cellulose ethers. S.T.P. Pharma Sci. 8:1998;182-187.
2. Cunningham J.G. Movements of the gastrointestinal tract. Cunningham J.G. Textbook of Veterinary Physiology. 2nd edition:1997;272-289 Saunders, Philadelphia.
3. Davis S.S. The design and evaluation of controlled release systems for the gastrointestinal tract. J. Control. Release. 2:1985;27-38.
4. Desai S., Bolton S. A floating controlled-release drug delivery system: in vitro-in vivo evaluation. Pharm. Res. 10:1993;1321-1325.
5. Deshpande A.A., Rhodes C.T., Shah N.H., Malick A.W. Controlled-release drug delivery systems for prolonged gastric residence: an overview. Drug Dev. Ind. Pharm. 22:1996;531-539.
6. Gerogiannis V.S., Rekkas D.M., Dallas P.P., Choulis N.H. Floating and swelling characteristics of various excipients used in controlled release technology. Drug Dev. Ind. Pharm. 19:1993;1061-1081.
7. Hwang S.J., Park H., Park K. Gastric retentive drug-delivery systems. Crit. Rev. Ther. Drug. 15:1998;243-284.
8. Jiménez-Castellanos M.R., Zia H., Rhodes C.T. Design and testing in vitro of a bioadhesive and floating drug delivery system for oral application. Int. J. Pharm. 105:1994;65-70.
9. Mitchell K., Ford J.L., Armstrong D.J., Elliott P.N.C., Rostron C., Hogan J.E. The influence of concentration on the release of drugs from gels an matrices containing Methocel® Int. J. Pharm. 100:1993;155-163.
10. Moës A.J. Gastroretentive dosage forms. Crit. Rev. Ther. Drug. 10:1993;143-195.
11. Oth M., Franz M., Timmermans J., Moes A. The bilayer floating capsule: a stomach-directed drug delivery system for Misoprostol. Pharm. Res. 9:1992;298-302.
12. Peppas N.A. Analysis of Fickian and non-Fickian drug release from polymers. Pharm. Acta Helv. 60:1985;110-111.
13. Peppas N.A., Wright S.L. Drug diffusion and binding in ionizable interpenetrating networks from poly(vinyl alcohol) and poly(acrylic acid). Eur. J. Pharm. Biopharm. 46:1998;15-29.
14. Rouge N., Cole E.T., Doelker E., Buri P. Screening of potentially floating excipients for minitablets. S.T.P. Pharma Sci. 7:1997;386-392.
15. Shah N., Zhang G., Apelian V., Zeng F., Infeld M.H., Malick A.W. Prediction of drug release from hydroxypropyl methylcellulose (HPMC) matrices: effect of polymer concentration. Pharm. Res. 10:1993;1693-1695.
16. Sheth P.R., Tossounian J.L. Sustained release pharmaceutical capsules. US Patent. 4, 126, 672:1978.
17. Timmermans J., Moës A.J. How well do floating dosage forms float? Int. J. Pharm. 62:1990;207-216.
18. Watanabe S., Kayano M., Ishino Y., Miyao K. Solid therapeutic preparation remaining in stomach. US Patent. 3, 976,764:1976.
19. Yang L., Fassihi R. Examination of drug solubility, polymer types, hydrodynamics and loading dose on drug release behaviour from a triple-layer asymmetric configuration delivery system. Int. J. Pharm. 155:1997;219-229.