Preparation, in vitro and in vivo evaluation of stomach-specific metronidazole-loaded alginate beads as local anti-Helicobacter pylori therapy

Journal of Controlled Release

Volumn 119, Issue 2, 2007, Pages 207-214

  Ishak, Rania A H ^a   Awad, Gehanne A S ^a   Mortada, Nahed D ^a   Nour, Samia A K ^b  

^a Ain Shams University   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

Author keywords

Alginate beads; Floating drug delivery systems (FDDS); H. pylori clearance; Local delivery; Metronidazole; Sustained release

Indexed keywords

ANTIBIOTICS; DISEASE CONTROL; GELATION; NITROGEN COMPOUNDS;

CHITOSAN TREATED ALGINATE BEADS; DRUG ENTRAPMENT; FLOATING DRUG DELIVERY SYSTEMS (FDDS); METHYL CELLULOSE; METRONIDAZOLES; SUSTAINED RELEASE;

DRUG DELIVERY;

CARBOMER; CARRAGEENAN; MAGNESIUM STEARATE; METHYLCELLULOSE; METRONIDAZOLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL THERAPY; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; ERADICATION THERAPY; EXPERIMENTAL STUDY; GELATION; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; STOMACH; SUSPENSION;

ALGINATES; ANIMALS; ANTI-INFECTIVE AGENTS; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; GASTRIC MUCOSA; GLUCURONIC ACID; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HEXURONIC ACIDS; HUMANS; MALE; METRONIDAZOLE; MICE;

EID: 34248585771     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2007.02.012     Document Type: Article

References (35)

1. Wilson C.G., and Washington N. The stomach: its role in oral drug delivery. In: Rubinstein M.H. (Ed). Physiological Pharmaceutics: Biological Barriers to Drug Absorption (1989), Ellis Horwood, Chichester 47-70
2. R.C. Mamajek, E.S. Moyer, Drug-dispensing device and method, US Patent (1980) 4,207,890.
3. J. Urquhart, F. Theeuwes, Drug delivery system comprising a reservoir containing a plurality of tiny pills. US Patent (1984) 4,434,153.
4. Lehr C.M. Bioadhesion technologies for the delivery of peptide and protein drugs to the gastrointestinal tract. Crit. Rev. Ther. Drug Carr. Syst. 11 (1994) 119-160
5. Ponchel G., and Irache J.M. Specific and non-specific bioadhesive particulate systems for oral delivery to the gastrointestinal tract. Adv. Drug Deliv. Rev. 34 (1998) 191-219
6. L.J. Caldwell, C.R. Gardner, R.C. Cargill, Drug delivery device which can be retained in the stomach for a controlled period of time. US Patent (1988) 4,767,627.
7. Cargill R.I., Caldwell J., Engle K.J., Fix A., Porter P.A., and Gardner C.R. Controlled gastric emptying. I. Effects of physical properties on gastric residence times of non-disintegrating geometric shapes in beagle dogs. Pharm. Res. 5 8 (1988) 533-536
8. Davis S.S., Stockwell A.F., Taylor M.J., Hardy J.G., Whalley D.R., Wilson C.G., Bechgaard H., and Christensen F.N. The effect of density on the gastric emptying of single- and multiple-unit dosage forms. Pharm. Res. 3 (1986) 208-213
9. Deshpande A.A., Shah N.H., Rhodes C.T., and Malick W. Development of a novel controlled-release system for gastric retention. Pharm. Res. 14 (1997) 815-819
10. Singh B.N., and Kim K.H. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. J. Control. Release 63 (2000) 235-259
11. Iannucelli V., Coppi G., Bernabei M.T., and Cameroui R. Air compartment multiple-unit system for prolonged gastric residence, I: Formulation study. Int. J. Pharm. 174 (1998) 47-54
12. Whitehead L., Fell J.T., and Collett J.H. Preparation of a gastroretentive dosage form. Eur. J. Pharm. Sci. 4 (1996) S182
13. 2 gas-forming agents. Int. J. Pharm. 239 (2002) 81-91
14. Whitehead L., Collett J.H., and Fell J.T. Amoxicillin release from a floating dosage form based on alginates. Int. J. Pharm. 210 (2000) 45-49
15. Burton S., Washington N., Steele R.J.C., Masson R., and Feely L. Intragastric distribution of ion-exchange resins: a drug delivery system for the topical treatment of the gastric mucosa. J. Pharm. Pharmacol. 47 (1995) 901-906
16. Blaser M.J. Hypotheses on the pathogenesis and natural history of Helicobacter pylori-induced inflammation. Gastroenterology 102 (1992) 720-727
17. Liu Z., Lu W., Qian L., Zhang X., Zeng P., and Pan J. In vitro and in vivo studies on mucoadhesive microspheres of amoxicillin. J. Control. Release 102 (2005) 135-144
18. Sung J.J., Chung S.C., and Ling T.K. Antibacterial treatment of gastric ulcers associated with Helicobacter pylori. N. Engl. J. Med. 332 3 (1995) 139-142
19. Dollery C. Therapeutic Drugs. 2nd edition vol. 2 (1999), Churchill Livingstone, Edinburgh
20. Takka S., Ocak O.H., and Acartürk F. Formulation and investigation of nicardipine HCl-alginate gel beads with factorial design-based studies. Eur. J. Pharm. Sci. 6 3 (1998) 241-246
21. Cooreman M.P., Krausgrill P., and Hengels K.J. Local gastric and serum amoxicillin concentrations after different oral application forms. Antimicrob. Agents Chemother. 37 7 (1993) 1506-1509
22. Goodwin C.S., and Worsely B.W. Helicobacter pylori. Biology and Clinical Practice (1993), CRC Press, Boca Raton, NY 209-222
23. Sezer A.D., and Akbuga J. Release characteristics of chitosan-treated alginate beads, 1: Sustained release of a macromolecular drug from chitosan treated alginate beads. J. Microencapsul. 193 (1999) 197-203
24. Hari P.R., Chandy T., and Sharma C.P. Chitosan/calcium alginate microcapsules for intestinal delivery of nitrofurantoin. J. Microencapsul. 13 3 (1996) 319-329
25. Lim L.Y., and Wan L.S.C. Propranolol hydrochloride binding in calcium alginate beads. Drug Dev. Ind. Pharm. 23 10 (1997) 973-980
26. Aslani P., and Kennedy R.A. Effect of gelation conditions and dissolution media on the release of paracetamol from alginate gel beads. J. Microencapsul. 13 5 (1996) 601-614
27. Tønnesen H.H., and Karisen J. Alginate in drug delivery systems. Drug Dev. Ind. Pharm. 28 6 (2002) 621-630
28. www. medicinescomplete.com.
29. Zatz J.L., Berry J.J., and Alderman D.A. Viscosity-imparting agents in disperse systems. In: Lieberman H.A. (Ed). Pharmaceutical Dosage Forms: Disperse Systems. 2nd edition vol. 1 (1996), Marcel Dekker Inc., New York 300
30. Carbopol Water Soluble Resins, B.F. Goodrich Technical Brochure.
31. Huikari A., and Karlsson A. Viscosity stability of methyl cellulose solutions at different pH and temperature. Acta Pharm. Fenn. 984 (1989) 231-238
32. Shu X.Z., Zhu K.J., and Song W. Novel pH-sensitive citrate cross-linked chitosan film for drug controlled release. Int. J. Pharm. 212 1 (2001) 19-28
33. Mi F.L., Shyu S.S., Chen C.T., and Schoung J.Y. Porous chitosan microsphere for controlling the antigen release of Newcastle disease vaccine: preparation of antigen-adsorbed microsphere and in vitro release. Biomaterials 20 17 (1999) 1603-1612
34. Durig T., and Fassihi R. Mechanistic evaluation of binary effects of magnesium stearate and talc as dissolution retardants at 85% drug loading in an experimental extended-release formulation. J. Pharm. Sci. 86 10 (1997) 1092-1098
35. Whitehead L., Fell J.T., Collett J.H., Sharma H.L., and Smith A.-M. Floating dosage forms: an in vivo study demonstrating prolonged gastric retention. J. Control. Release 55 (1998) 3-12