Grape seed extract upregulates p21 (Cip1) through redox-mediated activation of ERK1/2 and posttranscriptional regulation leading to cell cycle arrest in colon carcinoma HT29 cells

Molecular Carcinogenesis

Volumn 50, Issue 7, 2011, Pages 553-562

  Kaur, Manjinder ^a   Tyagi, Alpna ^a   Singh, Rana P ^b   Sclafani, Robert A ^c,d   Agarwal, Rajesh ^a,d   Agarwal, Chapla ^a,d  

^a UNIVERSITY OF COLORADO   (United States)

^b JAWAHARLAL NEHRU UNIVERSITY   (India)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF COLORADO CANCER CENTER   (United States)

Author keywords

Chemoprevention; Cip1 p21; Colorectal cancer; Grape seed extract; Oxidative stress; Redox regulation

Indexed keywords

ACETYLCYSTEINE; CYCLIN DEPENDENT KINASE INHIBITOR 1; GLUTATHIONE; GRAPE SEED EXTRACT; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN P21; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL POPULATION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; GENETIC REGULATION; HUMAN; HUMAN CELL; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PHOSPHORYLATION; PREMEDICATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN STABILITY; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; UPREGULATION;

BASE SEQUENCE; BLOTTING, WESTERN; CELL CYCLE; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DNA PRIMERS; ENZYME ACTIVATION; GRAPE SEED EXTRACT; HT29 CELLS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; OXIDATION-REDUCTION; POLYMERASE CHAIN REACTION; RNA PROCESSING, POST-TRANSCRIPTIONAL; UP-REGULATION;

VITACEAE;

EID: 79958234549     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20739     Document Type: Article

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