Role of oxidative stress and MAPK signaling in reference moist smokeless tobacco-induced HOK-16B cell death

Toxicology Letters

Volumn 195, Issue 1, 2010, Pages 23-30

  Mitchell, Clint ^b   Joyce, Andrew R ^b   Piper, John T ^a   McKallip, Robert J ^a   Fariss, Marc W ^a  

^a Altria Client Services   (United States)

^b Scientific Division   (United States)

Author keywords

MAPK pathways, Oral keratinocyte, Oxidative stress, Smokeless tobacco, Iron, Antioxidants

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; DEFEROXAMINE; IRON; IRON CHELATE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; SMOKELESS TOBACCO EXTRACT; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; TOXIC SUBSTANCE; UNCLASSIFIED DRUG; 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID; ASCORBIC ACID; CHROMAN DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; TROLOX C;

ARTICLE; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; EXTRACELLULAR SPACE; HUMAN; HUMAN CELL; IN VITRO STUDY; KERATINOCYTE; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOKELESS TOBACCO; TOXICITY TESTING; CELL LINE; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION REGULATION; METABOLISM; PHYSIOLOGY; TIME;

NICOTIANA TABACUM;

ASCORBIC ACID; CELL DEATH; CELL LINE; CHROMANS; DEFEROXAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HUMANS; KERATINOCYTES; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; OXIDATIVE STRESS; TIME FACTORS; TOBACCO, SMOKELESS;

EID: 77951898666     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.02.020     Document Type: Article

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