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Volumn 272, Issue 3 16-3, 1997, Pages

MEK1 is required for PDGF-induced ERK activation and DNA synthesis in tracheal myocytes

Author keywords

extracellular signal regulated kinase; mitogen activated protein kinase; mitogen activated protein kinase extracellular signal regulated kinase; PD 98059; platelet derived growth factor; Raf 1; signal transduction; Src

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE;

EID: 0030956451     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1997.272.3.l558     Document Type: Article
Times cited : (79)

References (57)
  • 1
    • 0027080533 scopus 로고
    • Activating transcription factor-2 DNA-binding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated protein kinases
    • Abdel-Hafiz, H., L. Heasley, J. Kyriakis, J. Avruch, D. Kroll, G. Johnson, and J. Hoeffler. Activating transcription factor-2 DNA-binding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated protein kinases. Mol. Endocrinol. 6: 2079-2089, 1992.
    • (1992) Mol. Endocrinol. , vol.6 , pp. 2079-2089
    • Abdel-Hafiz, H.1    Heasley, L.2    Kyriakis, J.3    Avruch, J.4    Kroll, D.5    Johnson, G.6    Hoeffler, J.7
  • 2
    • 0028535220 scopus 로고
    • Hydrogen peroxide stimulates MAP kinase activation in bovine tracheal myocytes: Implications for human airway disease
    • Abe, M., T.-S. O. Chao, J. Solway, M. R. Rosner, and M. Hershenson. Hydrogen peroxide stimulates MAP kinase activation in bovine tracheal myocytes: implications for human airway disease. Am. J. Respir. Cell Mol. Biol. 11: 577-585, 1994.
    • (1994) Am. J. Respir. Cell Mol. Biol. , vol.11 , pp. 577-585
    • Abe, M.1    Chao, T.-S.O.2    Solway, J.3    Rosner, M.R.4    Hershenson, M.5
  • 3
    • 0025283763 scopus 로고
    • Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinases from Swiss 3T3 cells
    • Ahn, N. G., J. E. Weiel, C. P. Chan, and E. G. Krebs. Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinases from Swiss 3T3 cells. J. Biol. Chem. 265: 11487-11494, 1990.
    • (1990) J. Biol. Chem. , vol.265 , pp. 11487-11494
    • Ahn, N.G.1    Weiel, J.E.2    Chan, C.P.3    Krebs, E.G.4
  • 4
    • 0025120244 scopus 로고
    • Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase
    • Anderson, N. G., J. L. Maller, N. K. Tonks, and T. W. Sturgill. Requirement for integration of signals from two distinct phosphorylation pathways for activation of MAP kinase. Nature 343: 651-653, 1990.
    • (1990) Nature , vol.343 , pp. 651-653
    • Anderson, N.G.1    Maller, J.L.2    Tonks, N.K.3    Sturgill, T.W.4
  • 5
    • 0028879873 scopus 로고    scopus 로고
    • Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src
    • Barone, M. V., and S. A. Courtneidge. Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src. Nature 378: 509-512, 1996.
    • (1996) Nature , vol.378 , pp. 509-512
    • Barone, M.V.1    Courtneidge, S.A.2
  • 7
    • 0026596576 scopus 로고
    • Serum-, TPA-and Ras-induced expression from Ap-1/Ets-driven promoters requires raf-1 kinase
    • Bruder, J. T., G. Heidecker, and U. R. Rapp. Serum-, TPA-and Ras-induced expression from Ap-1/Ets-driven promoters requires raf-1 kinase. Genes Dev. 6: 545-556, 1992.
    • (1992) Genes Dev. , vol.6 , pp. 545-556
    • Bruder, J.T.1    Heidecker, G.2    Rapp, U.R.3
  • 8
    • 0027331715 scopus 로고
    • V-raf confers CSF-1 independent growth to a macrophage cell line and leads to immediate early gene expression without MAP kinase activation
    • Buscher, D., P. Sbarba, R. Hipskind, U. Rapp, E. R. Stanley, and M. Baccarini. V-raf confers CSF-1 independent growth to a macrophage cell line and leads to immediate early gene expression without MAP kinase activation. Oncogene 8: 3323-3332, 1993.
    • (1993) Oncogene , vol.8 , pp. 3323-3332
    • Buscher, D.1    Sbarba, P.2    Hipskind, R.3    Rapp, U.4    Stanley, E.R.5    Baccarini, M.6
  • 9
    • 0026757051 scopus 로고
    • Activation of MAP kinases by calcium-dependent and calcium-independent pathways: Stimulation by thapsigargin and EGF
    • Chao, T.-S. O., K. L. Byron, K.-M. Lee, M. Villereal, and M. R. Rosner. Activation of MAP kinases by calcium-dependent and calcium-independent pathways: stimulation by thapsigargin and EGF. J. Biol. Chem. 267: 19876-19883, 1992.
    • (1992) J. Biol. Chem. , vol.267 , pp. 19876-19883
    • Chao, T.-S.O.1    Byron, K.L.2    Lee, K.-M.3    Villereal, M.4    Rosner, M.R.5
  • 10
    • 0028239183 scopus 로고
    • Differential raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters and calcium
    • Chao, T.-S. O., D. A. Foster, U. Rapp, and M. R. Rosner. Differential raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters and calcium. J. Biol. Chem. 269: 7337-7341, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 7337-7341
    • Chao, T.-S.O.1    Foster, D.A.2    Rapp, U.3    Rosner, M.R.4
  • 11
    • 0027361017 scopus 로고
    • Phosphorylation of the c-Fos transrepression domain by MAP kinase and 90-kDa ribosomal S6 kinase
    • Chen, R., C. Abate, and J. Blenis. Phosphorylation of the c-Fos transrepression domain by MAP kinase and 90-kDa ribosomal S6 kinase. Proc. Natl. Acad. Sci. USA 90: 10952-10956, 1993.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10952-10956
    • Chen, R.1    Abate, C.2    Blenis, J.3
  • 12
    • 0028047598 scopus 로고
    • junB promoter regulation: Ras mediated transactivation by c-Ets-1 and c-Ets-2
    • Coffer, P., M. de Jonge, A. Mettouchi, J. Ghysdael, and W. Kruijer. junB promoter regulation: Ras mediated transactivation by c-Ets-1 and c-Ets-2. Oncogene 9: 911-921, 1994.
    • (1994) Oncogene , vol.9 , pp. 911-921
    • Coffer, P.1    De Jonge, M.2    Mettouchi, A.3    Ghysdael, J.4    Kruijer, W.5
  • 13
    • 0022081671 scopus 로고
    • Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation
    • Courtneidge, S. A. Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation. EMBO J. 4: 1471-1477, 1985.
    • (1985) EMBO J. , vol.4 , pp. 1471-1477
    • Courtneidge, S.A.1
  • 14
    • 0028228616 scopus 로고
    • Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH/3T3 cells
    • Cowley, S., H. Paterson, P. Kemp, and C. Marshall. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH/3T3 cells. Cell 77: 841-852, 1994.
    • (1994) Cell , vol.77 , pp. 841-852
    • Cowley, S.1    Paterson, H.2    Kemp, P.3    Marshall, C.4
  • 16
    • 0026539931 scopus 로고
    • The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product
    • Crews, C. M., A. Alessandrini, and R. L. Erikson. The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. Science 258: 478-480, 1992.
    • (1992) Science , vol.258 , pp. 478-480
    • Crews, C.M.1    Alessandrini, A.2    Erikson, R.L.3
  • 18
    • 0026460077 scopus 로고
    • Angiotensin II stimulates the pp44 and pp42 MAP kinases in cultured rat aortic smooth muscle cells
    • Duff, J., B. Berk, and M. Corson. Angiotensin II stimulates the pp44 and pp42 MAP kinases in cultured rat aortic smooth muscle cells. Biochem. Biophys. Res. Commun. 188: 257-264, 1992.
    • (1992) Biochem. Biophys. Res. Commun. , vol.188 , pp. 257-264
    • Duff, J.1    Berk, B.2    Corson, M.3
  • 19
    • 0025258896 scopus 로고
    • Identification by mass spectrometry of threonine 97 in bovine myelin basic protein as a specific phosphorylation site for mitogen-activated protein kinase
    • Erickson, A. K., D. M. Payne, P. A. Martino, A. J. Rossomando, J. Shabanowitz, M. J. Weber, D. F. Hunt, and T. W. Sturgill. Identification by mass spectrometry of threonine 97 in bovine myelin basic protein as a specific phosphorylation site for mitogen-activated protein kinase. J. Biol. Chem. 265: 19728-19735, 1990.
    • (1990) J. Biol. Chem. , vol.265 , pp. 19728-19735
    • Erickson, A.K.1    Payne, D.M.2    Martino, P.A.3    Rossomando, A.J.4    Shabanowitz, J.5    Weber, M.J.6    Hunt, D.F.7    Sturgill, T.W.8
  • 20
    • 0026701092 scopus 로고
    • MAP kinase activation resulting from selective oncogene expression in NIH3T3 and rat 1a cells
    • Gallego, C., S. Gupta, L. Heasley, N.-X. Qian, and G. Johnson. MAP kinase activation resulting from selective oncogene expression in NIH3T3 and rat 1a cells. Proc. Natl. Acad. Sci. USA 89: 7355-7359, 1992.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 7355-7359
    • Gallego, C.1    Gupta, S.2    Heasley, L.3    Qian, N.-X.4    Johnson, G.5
  • 21
    • 0027225936 scopus 로고
    • Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus
    • Gonzalez, F. A., A. Seth, D. L. Raden, D. S. Bowman, F. S. Fay, and R. J. Davis. Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus. J. Cell Biol. 122: 1089-1101, 1993.
    • (1993) J. Cell Biol. , vol.122 , pp. 1089-1101
    • Gonzalez, F.A.1    Seth, A.2    Raden, D.L.3    Bowman, D.S.4    Fay, F.S.5    Davis, R.J.6
  • 22
    • 0027263039 scopus 로고
    • Direct evidence for tyrosine and threonine phosphorylation and activation of mitogen-activated protein kinase by vasopressin in cultured rat vascular smooth muscle cells
    • Granot, Y., E. Erikson, H. Fridman, V. Van Putten, B. Williams, R. Schrier, and J. Mailer. Direct evidence for tyrosine and threonine phosphorylation and activation of mitogen-activated protein kinase by vasopressin in cultured rat vascular smooth muscle cells. J. Biol. Chem. 268: 9564-9569, 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 9564-9569
    • Granot, Y.1    Erikson, E.2    Fridman, H.3    Van Putten, V.4    Williams, B.5    Schrier, R.6    Mailer, J.7
  • 23
    • 0028108504 scopus 로고
    • Regulation of Fra-1 and Fra-2 phosphorylation differs during the cell cycle of fibroblasts and phosphorylation in vitro by MAP kinase affects DNA binding activity
    • Gruda, M. C., K. Kovary, R. Metz, and R. Bravo. Regulation of Fra-1 and Fra-2 phosphorylation differs during the cell cycle of fibroblasts and phosphorylation in vitro by MAP kinase affects DNA binding activity. Oncogene 9: 2537-2547, 1994.
    • (1994) Oncogene , vol.9 , pp. 2537-2547
    • Gruda, M.C.1    Kovary, K.2    Metz, R.3    Bravo, R.4
  • 24
    • 0015911409 scopus 로고
    • Hyperplasia of bronchial muscle in asthma
    • Heard, B., and S. Hossain. Hyperplasia of bronchial muscle in asthma. J. Pathol. 110: 319-331, 1973.
    • (1973) J. Pathol. , vol.110 , pp. 319-331
    • Heard, B.1    Hossain, S.2
  • 26
    • 0029162759 scopus 로고
    • Histamine antagonizes serotonin and growth factor-induced MAP kinase activation in bovine tracheal smooth muscle cells
    • Hershenson, M. B., T.-S. O. Chao, M. K. Abe, M. D. Kelleher, J. Solway, and M. R. Rosner. Histamine antagonizes serotonin and growth factor-induced MAP kinase activation in bovine tracheal smooth muscle cells. J. Biol. Chem. 270: 19908-19913, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 19908-19913
    • Hershenson, M.B.1    Chao, T.-S.O.2    Abe, M.K.3    Kelleher, M.D.4    Solway, J.5    Rosner, M.R.6
  • 28
    • 0028567874 scopus 로고
    • Constitutive activation of Mek1 by mutation of serine phosphorylation sites
    • Huang, W., and R. L. Erikson. Constitutive activation of Mek1 by mutation of serine phosphorylation sites. Proc. Natl. Acad. Sci. USA 91: 8960-8963, 1994.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 8960-8963
    • Huang, W.1    Erikson, R.L.2
  • 29
    • 0024578295 scopus 로고
    • The mechanics of airway narrowing in asthma
    • James, A., P. Pare, and J. Hogg. The mechanics of airway narrowing in asthma. Am. Rev. Respir. Dis. 139: 242-246, 1989.
    • (1989) Am. Rev. Respir. Dis. , vol.139 , pp. 242-246
    • James, A.1    Pare, P.2    Hogg, J.3
  • 30
    • 0028967220 scopus 로고
    • SAP1a is a nuclear target of signaling cascades involving ERKs
    • Janknecht, R., W. H. Ernst, and A. Nordheim. SAP1a is a nuclear target of signaling cascades involving ERKs. Oncogene 10: 1209-1216, 1995.
    • (1995) Oncogene , vol.10 , pp. 1209-1216
    • Janknecht, R.1    Ernst, W.H.2    Nordheim, A.3
  • 31
    • 0027425113 scopus 로고
    • Activation of ternary complex factor elk-1 by MAP kinases
    • Janknecht, R., W. H. Ernst, V. Pingoud, and A. Nordheim. Activation of ternary complex factor elk-1 by MAP kinases. EMBO J. 12: 5097-5104, 1993.
    • (1993) EMBO J. , vol.12 , pp. 5097-5104
    • Janknecht, R.1    Ernst, W.H.2    Pingoud, V.3    Nordheim, A.4
  • 33
    • 0026455122 scopus 로고
    • Endothelin-1 stimulates tyrosine phosphorylation and MAP kinase activity in cultured vascular smooth muscle cells
    • Koide, M., Y. Kawahara, T. Tsuda, Y. Ishida, K. Shii, and M. Yokoyama. Endothelin-1 stimulates tyrosine phosphorylation and MAP kinase activity in cultured vascular smooth muscle cells. J. Hypertens. 10: 1173-1182, 1992.
    • (1992) J. Hypertens. , vol.10 , pp. 1173-1182
    • Koide, M.1    Kawahara, Y.2    Tsuda, T.3    Ishida, Y.4    Shii, K.5    Yokoyama, M.6
  • 34
    • 0028028073 scopus 로고
    • Novel mechanism of C/EBPB (NF-M) transcriptional control: Activation through derepression
    • Kowenz-Leutz, E., G. Twamley, S. Ansieau, and A. Leutz. Novel mechanism of C/EBPB (NF-M) transcriptional control: activation through derepression. Genes Dev. 8: 2781-2791, 1994.
    • (1994) Genes Dev. , vol.8 , pp. 2781-2791
    • Kowenz-Leutz, E.1    Twamley, G.2    Ansieau, S.3    Leutz, A.4
  • 38
    • 0026068743 scopus 로고
    • Defective regulation of mitogen-activated protein kinase activity in a 3T3 cell variant mitogenically nonresponsive to tetradecanoyl phorbol acetate
    • L'Allemain, G., T. W. Sturgill, and M. J. Weber. Defective regulation of mitogen-activated protein kinase activity in a 3T3 cell variant mitogenically nonresponsive to tetradecanoyl phorbol acetate. Mol. Cell. Biol. 11: 1002-1008, 1991.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 1002-1008
    • L'Allemain, G.1    Sturgill, T.W.2    Weber, M.J.3
  • 39
    • 0027283659 scopus 로고
    • Growth factors induce nuclear translocation of MAP kinases (p42 mapk and p44 mapk) but not of their activator MAP kinase kinase (p45 mapkk) in fibroblasts
    • Lenormond, P., C. Sardet, G. Pages, G. L'Allemain, A. Brunet, and J. Pouyssegur. Growth factors induce nuclear translocation of MAP kinases (p42 mapk and p44 mapk) but not of their activator MAP kinase kinase (p45 mapkk) in fibroblasts. J. Cell Biol. 122: 1079-1088, 1993.
    • (1993) J. Cell Biol. , vol.122 , pp. 1079-1088
    • Lenormond, P.1    Sardet, C.2    Pages, G.3    L'Allemain, G.4    Brunet, A.5    Pouyssegur, J.6
  • 43
    • 0027095797 scopus 로고
    • Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44 mapk
    • Meloche, S., G. Pages, and J. Pouyssegur. Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44 mapk. Mol. Biol. Cell 3: 63-71, 1992.
    • (1992) Mol. Biol. Cell , vol.3 , pp. 63-71
    • Meloche, S.1    Pages, G.2    Pouyssegur, J.3
  • 44
    • 0026720523 scopus 로고
    • Biphasic and synergistic activation of p44 mapk (ERK1) by growth factors: Correlation between late phase activation and mitogenicity
    • Meloche, S., K. Seuwen, G. Pages, and J. Pouyssegur. Biphasic and synergistic activation of p44 mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity. Mol. Endocrinol. 6: 845-854, 1992.
    • (1992) Mol. Endocrinol. , vol.6 , pp. 845-854
    • Meloche, S.1    Seuwen, K.2    Pages, G.3    Pouyssegur, J.4
  • 45
    • 26844487020 scopus 로고
    • Repeated allergen inhalations induce DNA synthesis in airway smooth muscle and epithelial cells in vivo
    • Panettieri, R. A., R. K. Murray, G. Bilgen, and J. G. Martin. Repeated allergen inhalations induce DNA synthesis in airway smooth muscle and epithelial cells in vivo (Abstract). Am. J. Respir. Crit. Care Med. 149: A303, 1994.
    • (1994) Am. J. Respir. Crit. Care Med. , vol.149
    • Panettieri, R.A.1    Murray, R.K.2    Bilgen, G.3    Martin, J.G.4
  • 46
    • 0029034774 scopus 로고
    • Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor
    • Pang, L., T. Sawada, S. J. Decker, and A. R. Saltiel. Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J. Biol. Chem. 270: 13585-13588, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 13585-13588
    • Pang, L.1    Sawada, T.2    Decker, S.J.3    Saltiel, A.R.4
  • 48
    • 0028294622 scopus 로고
    • 1 receptor regulation of cyclic AMP synthesis controls growth factor stimulation of raf activity
    • 1 receptor regulation of cyclic AMP synthesis controls growth factor stimulation of raf activity. Mol. Cell. Biol. 14: 2343-2351, 1994.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 2343-2351
    • Russell, M.1    Winitz, S.2    Johnson, G.L.3
  • 49
    • 0027385030 scopus 로고
    • Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase
    • Samuels, M. L., M. J. Weber, J. M. Bishop, and M. McMahon. Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase. Mol. Cell. Biol. 13: 6241-6252, 1993.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 6241-6252
    • Samuels, M.L.1    Weber, M.J.2    Bishop, J.M.3    McMahon, M.4
  • 50
    • 0026375221 scopus 로고
    • Structural changes in the airways of sensitized Brown Norway rats after antigen challenge
    • Sapienza, S., T. Du, D. H. Eidelman, N. S. Wang, and J. G. Martin. Structural changes in the airways of sensitized Brown Norway rats after antigen challenge. Am. Rev. Respir. Dis. 144: 423-427, 1991.
    • (1991) Am. Rev. Respir. Dis. , vol.144 , pp. 423-427
    • Sapienza, S.1    Du, T.2    Eidelman, D.H.3    Wang, N.S.4    Martin, J.G.5
  • 51
    • 0026343730 scopus 로고
    • 2-terminal domain of c-Myc increases transactivation of gene expression
    • 2-terminal domain of c-Myc increases transactivation of gene expression. J. Biol. Chem. 266: 23521-23524, 1991.
    • (1991) J. Biol. Chem. , vol.266 , pp. 23521-23524
    • Seth, A.1    Alvarez, E.2    Gupta, S.3    Davis, R.J.4
  • 52
    • 0028241533 scopus 로고
    • Activation of raf as a result of recruitment to the plasma membrane
    • Stokoe, D., S. G. Macdonald, K. Cadwallader, M. Symons, and J. F. Hancock. Activation of raf as a result of recruitment to the plasma membrane. Science 264: 1463-1467, 1994.
    • (1994) Science , vol.264 , pp. 1463-1467
    • Stokoe, D.1    Macdonald, S.G.2    Cadwallader, K.3    Symons, M.4    Hancock, J.F.5
  • 53
    • 0028864350 scopus 로고
    • Preferential involvement of MEK1 in the tumor necrosis factor-alpha-induced activation of p42mapk/erk2 in mouse macrophages
    • Winston, B. W., L. K. Remigio, and D. W. Riches. Preferential involvement of MEK1 in the tumor necrosis factor-alpha-induced activation of p42mapk/erk2 in mouse macrophages. J. Biol. Chem. 270: 27391-27394, 1995.
    • (1995) J. Biol. Chem. , vol.270 , pp. 27391-27394
    • Winston, B.W.1    Remigio, L.K.2    Riches, D.W.3
  • 54
    • 0026523559 scopus 로고
    • Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK
    • Wood, K. W., C. Sarnecki, R. M. Roberts, and J. Blenis. Ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Cell 68: 1041-1050, 1992.
    • (1992) Cell , vol.68 , pp. 1041-1050
    • Wood, K.W.1    Sarnecki, C.2    Roberts, R.M.3    Blenis, J.4
  • 55
    • 0021273449 scopus 로고
    • The shape of the dose-response curve to histamine in asthmatic and normal subjects
    • Woolcock, A. J., C. M. Salome, and K. Yan. The shape of the dose-response curve to histamine in asthmatic and normal subjects. Am. Rev. Respir. Dis. 130: 71-75, 1984.
    • (1984) Am. Rev. Respir. Dis. , vol.130 , pp. 71-75
    • Woolcock, A.J.1    Salome, C.M.2    Yan, K.3
  • 56
    • 0030062094 scopus 로고    scopus 로고
    • Selective activation of MEK1 but not MEK2 by A-raf from epidermal growth factor-stimulated HeLa cells
    • Wu, X., S. J. Noh, G. Zhou, J. E. Dixon, and K. L. Guan. Selective activation of MEK1 but not MEK2 by A-raf from epidermal growth factor-stimulated HeLa cells. J. Biol. Chem. 271: 3265-3271, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 3265-3271
    • Wu, X.1    Noh, S.J.2    Zhou, G.3    Dixon, J.E.4    Guan, K.L.5
  • 57
    • 0028308224 scopus 로고
    • Identification of 2 serine residues of MEKl that are differentially phosphorylated during activation by raf and MEK kinase
    • Yan, M., and D. J. Templeton. Identification of 2 serine residues of MEKl that are differentially phosphorylated during activation by raf and MEK kinase. J. Biol. Chem. 269: 19067-19073, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 19067-19073
    • Yan, M.1    Templeton, D.J.2


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