Candidate genes and neuropsychological phenotypes in children with ADHD: Review of association studies

Journal of Psychiatry and Neuroscience

Volumn 34, Issue 2, 2009, Pages 88-101

  Kebir, Oussama ^a   Tabbane, Karim ^a   Sengupta, Sarojini ^b   Joober, Ridha ^b  

^a RAZI HOSPITAL   (Tunisia)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME A; BRAIN DERIVED NEUROTROPHIC FACTOR; CATECHOL METHYLTRANSFERASE; DOPAMINE 4 RECEPTOR; DOPAMINE 5 RECEPTOR; DOPAMINE BETA MONOOXYGENASE; DOPAMINE TRANSPORTER; DOPAMINE TRANSPORTER 1; IONOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; TRYPTOPHAN HYDROXYLASE 2; UNCLASSIFIED DRUG;

ATTENTION DEFICIT DISORDER; COGNITION; CONCEPTUAL FRAMEWORK; EVIDENCE BASED MEDICINE; GENE FREQUENCY; GENE FUNCTION; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC CORRELATION; GENETIC HETEROGENEITY; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; MEDLINE; NEUROPSYCHOLOGICAL TEST; NONHUMAN; PHENOTYPE; REACTION TIME; REVIEW; SAMPLE SIZE; SYSTEMATIC REVIEW; CHILD; GENETICS; META ANALYSIS; PSYCHOLOGICAL ASPECT;

ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; GENE FREQUENCY; GENOME-WIDE ASSOCIATION STUDY; HUMANS;

EID: 65649137370     PISSN: 11804882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (126)

1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington: The Association; 1994.
2. Biederman J, Faraone SV. Attention-deficit hyperactivity disorder. Lancet 2005;366:237-48.
3. Faraone SV, Perlis RH, Doyle AE, et al. Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry 2005; 57:1313-23.
4. Waldman ID, Gizer IR. The genetics of attention deficit hyperactivity disorder. Clin Psychol Rev 2006;26:396-432.
5. Castellanos FX, Tannock R. Neuroscience of attention-deficit/ hyperactivity disorder: the search for endophenotypes. Nat Rev Neurosci 2002;3:617-28.
6. Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 2003;160: 636-45.
7. Waldman ID. Statistical approaches to complex phenotypes: evaluating neuropsychological endophenotypes for attentiondeficit/hyperactivity disorder. Biol Psychiatry 2005;57:1347-56.
8. Barkley RA. Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol Bull 1997;121:65-94.
9. Willcutt EG, Doyle AE, Nigg JT, et al. Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review. Biol Psychiatry 2005;57:1336-46.
10. Sergeant JA. Modeling attention-deficit/hyperactivity disorder: a critical appraisal of the cognitive-energetic model. Biol Psychiatry 2005;57:1248-55.
11. Andreou P, Neale BM, Chen WAI, et al. Reaction time performance in ADHD: improvement under fast-incentive condition and familial effects. Psychol Med 2007;37:1703-15.
12. Sonuga-Barke EJS. Causal models of attention-deficit/hyperactivity disorder: from common simple deficits to multiple developmental pathways. Biol Psychiatry 2005;57:1231-8.
13. Holmes J, Hever T, Hewitt L, et al. A pilot twin study of psychological measures of attention deficit hyperactivity disorder. Behav Genet 2002;32:389-95.
14. Myles-Worsley M, Coon H. Genetic and developmental factors in spontaneous selective attention: a study of normal twins. Psychiatry Res 1997;71:163-74.
15. Murphy KR, Barkley RA. Parents of children with attentiondeficit/ hyperactivity disorder: psychological and attentional impairment. Am J Orthopsychiatry 1996;66:93-102.
16. Asarnow RF, Nuechterlein KH, Subotnik KL, et al. Neurocognitive impairments in nonpsychotic parents of children with schizophrenia and attention-deficit/hyperactivity disorder: the University of California, Los Angeles Family Study. Arch Gen Psychiatry 2002; 59:1053-60.
17. Doyle AE, Willcutt EG, Seidman LJ, et al. Attention-deficit/ hyperactivity disorder endophenotypes. Biol Psychiatry 2005; 57:1324-35.
18. Groot AS, de Sonneville LM, Stins JF, et al. Familial influences on sustained attention and inhibition in preschoolers. J Child Psychol Psychiatry 2004;45:306-14.
19. Nigg JT, Blaskey LG, Stawicki JA, et al. Evaluating the endophenotype model of ADHD neuropsychological deficit: results for parents and siblings of children with ADHD combined and inattentive subtypes. J Abnorm Psychol 2004;113:614-25.
20. Schachar RJ, Chen S, Logan GD, et al. Evidence for an error monitoring deficit in attention deficit hyperactivity disorder. J Abnorm Child Psychol 2004;32:285-93.
21. Kuntsi J, Stevenson J. Psychological mechanisms in hyperactivity: II. The role of genetic factors. J Child Psychol Psychiatry 2001;42:211-9.
22. Pennington BF, Bennetto L, McAleer O, et al. Executive functions and working memory: theoretical and measurement issues. In: Lyon GR, Krasnegor NA, editors. Attention, memory and executive function. Baltimore (MD): Paul H. Brooks; 1996. p. 327-48.
23. Seidman LJ, Biederman J, Monuteaux MC, et al. Neuropsychological functioning in nonreferred siblings of children with attention deficit/ hyperactivity disorder. J Abnorm Psychol 2000; 109:252-65.
24. Swan GE, Carmelli D. Evidence for genetic mediation of executive control: a study of aging male twins. J Gerontol B Psychol Sci Soc Sci 2002;57:P133-43.
25. Ando J, Ono Y, Wright MJ. Genetic structure of spatial and verbal working memory. Behav Genet 2001;31:615-24.
26. Stins JF, van Baal GC, Polderman TJ, et al. Heritability of Stroop and flanker performance in 12-year old children. BMC Neurosci 2004;5:49.
27. Fan J, Wu Y, Fossella JA, et al. Assessing the heritability of attentional networks. BMC Neurosci 2001;2:14.
28. Cooper H, Hedges L. The handbook of research synthesis. New York (NY): Russel Sage Foundation; 1994.
29. Petronis A, Van Tol HH, Lichter JB, et al. The D4 dopamine receptor gene maps on 11p proximal to HRAS. Genomics 1993;18:161-3.
30. Li D, Sham PC, Owen MJ, et al. Meta-analysis shows significant association between dopamine system genes and attention deficit hyperactivity disorder (ADHD). Hum Mol Genet 2006;15:2276-84.
31. Asghari V, Sanyal S, Buchwaldt S, et al. Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants. J Neurochem 1995;65:1157-65.
32. Swanson J, Oosterlaan J, Murias M, et al. Attention deficit/ hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention. Proc Natl Acad Sci U S A 2000;97:4754-9.
33. Manor I, Tyano S, Eisenberg J, et al. The short DRD4 repeats confer risk to attention deficit hyperactivity disorder in a family-based design and impair performance on a continuous performance test (TOVA). Mol Psychiatry 2002;7:790-4.
34. Bellgrove MA, Hawi Z, Lowe N, et al. DRD4 gene variants and sustained attention in attention deficit hyperactivity disorder (ADHD): effects of associated alleles at the VNTR and -521 SNP. Am J Med Genet B Neuropsychiatr Genet 2005;136B:81-6.
35. Johnson KA, Kelly SP, Robertson IH. Absence of the 7-repeat variant of the DRD4 VNTR is associated with drifting sustained attention in children with ADHD but not in controls. Am J Med Genet B Neuropsychiatr Genet. In press.
36. Langley K, Marshall L, van der Bree M, et al. Association of the dopamine D4 receptor gene 7-repeat allele with neuropsychological test performance of children with ADHD. Am J Psychiatry 2004; 161:133-8.
37. Kieling C, Roman T, Doyle AE, et al. Association between DRD4 gene and performance of children with ADHD in a test of sustained attention. Biol Psychiatry 2006;60:1163-5.
38. Barkley RA, Smith KM, Fisher M, et al. An examination of the behavioral and neuropsychological correlates of three ADHD candidate gene polymorphisms (DRD47+, DBH Taq1 A2, and DAT1 40 bp VNTR) in hyperactive and normal children followed to adulthood. Am J Med Genet B Neuropsychiatr Genet 2006;141B:487-98.
39. Oh KS, Shin DW, Oh GT, et al. Dopamine transporter genotype influences the attention deficit in Korean boys with ADHD. Yonsei Med J 2003;44:787-92.
40. Loo SK, Specter E, Smolen A, et al. Functional effects of the DAT1 polymorphism on EEG measures in ADHD. J Am Acad Child Adolesc Psychiatry 2003;42:986-93.
41. Bellgrove MA, Hawi Z, Kirley A, et al. Dissecting the attention deficit hyperactivity disorder (ADHD) phenotype: sustained attention, response variability and spatial attentional asymmetries in relation to dopamine transporter (DAT1) genotype. Neuropsychologia 2005;43:1847-57.
42. Bellgrove MA, Hawi Z, Kirley A, et al. Association between dopamine transporter (DAT1) genotype, left-side inattention, and an enhanced response to methylphenidate in attention-deficit hyperactivity disorder. Neuropsychopharmacology 2005;30:2290-7.
43. Wohl M, Boni C, Asch M, et al. Lack of association of the dopamine transporter gene in a French ADHD sample. Am J Med Genet B Neuropsychiatr Genet 2008;147B:1509-10.
44. Karama S, Grizenko N, Sonuga-Barke EJS, et al. Dopamine transporter 3'UTR VNTR genotype is a marker of performance on executive function tasks in children with ADHD. BMC Psychiatry 2008; 8:45.
45. Eisenberg J, Mei-Tal G, Steinberg A, et al. Haplotype relative risk study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD): association of the highenzyme activity Val allele with ADHD impulsive-hyperactive phenotype. Am J Med Genet 1999;88:497-502.
46. Mills S, Langley K, Van den Bree M, et al. No evidence of association between catechol-O-methyltransferase (COMT) Val158Met genotype and performance on neuropsychological tasks in children with ADHD: a case-control study. BMC Psychiatry 2004;4:15.
47. Taerk E, Grizenko N, Ben Amor L, et al. Catechol-Omethyltransferase (COMT) Val108/158Met polymorphism does not modulate executive function in children with ADHD. BMC Med Genet 2004;5:30.
48. Bellgrove MA, Domschke K, Hawi Z, et al. The methionine allele of the COMT polymorphism impairs prefrontal cognition in children and adolescents with ADHD. Exp Brain Res 2005;163:352-60.
49. Bellgrove MA, Mattingley JB, Hawi Z, et al. Impaired temporal resolution of visual attention and dopamine beta hydroxylase genotype in attention-deficit/hyperactivity disorder. Biol Psychiatry 2006;60:1039-45.
50. Bellgrove MA, Hawi Z, Gill M, et al. The cognitive genetics of attention deficit hyperactivity disorder (ADHD): sustained attention as a candidate phenotype. Cortex 2006;42:838-45.
51. Vandenbergh DJ, Persico AM, Hawkins AL, et al. Human dopamine transporter gene maps to chromosome 5p15.3 and displays a VNTR. Genomics 1992;14:1104-6.
52. Doucette-Stamm LA, Blakely DJ, Tian J, et al. Population genetic study of the human dopamine transporter gene (DAT1). Genet Epidemiol 1995;12:303-8.
53. Mitchell RJ, Howlett S, Earl L, et al. Distribution of the 3′ VNTR polymorphism in the human dopamine transporter gene in world populations. Hum Biol 2000;72:295-304.
54. Heinz A, Goldman D, Jones DW, et al. Genotype influences in vivo dopamine transporter availability in human striatum. Neuropsychopharmacology 2000;22:133-9.
55. Cheon KA, Ryu YH, Kim JW, et al. The homozygosity for 10-repeat allele at dopamine transporter gene and dopamine transporter density in Korean children with attention deficit hyperactivity disorder: relating to treatment response to methylphenidate. Eur Neuropsychopharmacol 2005;15:95-101.
56. Krause KH, Dresel SH, Krause J, et al. The dopamine transporter and neuroimaging in attention deficit hyperactivity disorder. Neurosci Biobehav Rev 2003;27:605-13.
57. Garris PA, Wightman RM. Different kinetics govern dopaminergic transmission in the amygdala, prefrontal cortex, and striatum: an in vivo voltammetric study. J Neurosci 1994;14:442-50.
58. Carter CS, Krener P, Chaderjian M, et al. Asymmetrical visual-spatial attentional performance in ADHD: evidence for a right hemispheric deficit. Biol Psychiatry 1995;37:789-97.
59. Nigg JT, Swanson JM, Hinshaw SP. Covert visual spatial attention in boys with attention deficit hyperactivity disorder: lateral effects, methylphenidate response, and results for parents. Neuropsychologia 1997;35:165-76.
60. McDonald S, Bennett KM, Chambers H, et al. Covert orienting and focusing of attention in children with attention deficit hyperactivity disorder. Neuropsychologia 1999;37:345-56.
61. Lachman HM, Papolos DF, Saito T, et al. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 1996;6:243-50.
62. Sesack SR, Hawrylak VA, Guido MA, et al. Cellular and subcellular localization of the dopamine transporter in rat cortex. Adv Pharmacol 1998;42:171-4.
63. Dougherty DD, Bonab AA, Spencer TJ, et al. Dopamine transporter density in patients with attention deficit hyperactivity disorder. Lancet 1999;354:2132-3.
64. Lewis DA, Melchitzky DS, Sesack SR, et al. Dopamine transporter immunoreactivity in monkey cerebral cortex: regional, laminar, and ultrastructural localization. J Comp Neurol 2001;432:119-36.
65. Moron JA, Brockington A, Wise RA, et al. Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines. J Neurosci 2002;22:389-95.
66. Barnett JH, Jones PB, Robbins TW, et al. Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls. Mol Psychiatry 2007;12:502-9.
67. Arnsten AFT. Catecholamine modulation of prefrontal cortical cognitive function. Trends Cogn Sci 1998;2:436-47.
68. Craig SP, Buckle VJ, Lamouroux A, et al. Localization of the human dopamine beta hydroxylase (DBH) gene to chromosome 9q34. Cytogenet Cell Genet 1988;48:48-50.
69. Gaspar P, Berger B, Febvret A, et al. Catecholamine innervation of the human cerebral cortex as revealed by comparative immunohistochemistry of tyrosine hydroxylase and dopamine-betahydroxylase. J Comp Neurol 1989;279:249-71.
70. Zabetian CP, Anderson GM, Buxbaum SG, et al. A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus. Am J Hum Genet 2001;68:515-22.
71. Hollingsworth DE, McAuliffe SP, Knowlton BJ. Temporal allocation of visual attention in adult attention deficit hyperactivity disorder. J Cogn Neurosci 2001;13:298-305.
72. Li CS, Lin WH, Chang HL, et al. A psychophysical measure of attention deficit in children with attention-deficit/hyperactivity disorder. J Abnorm Psychol 2004;113:228-36.
73. Kieling C, Genro JP, Hutz MH, et al. The -1021 C/T DBH polymorphism is associated with neuropsychological performance among children and adolescents with ADHD. Am J Med Genet B Neuropsychiatr Genet 2008;147B:485-90.
74. Manor I, Tyano S, Mel E, et al. Family-based and association studies of monoamine oxidase A and attention deficit hyperactivity disorder (ADHD): preferential transmission of the long promoter-region repeat and its association with impaired performance on a continuous performance test (TOVA). Mol Psychiatry 2002;7:626-32.
75. Sabol SZ, Hu S, Hamer D. A functional polymorphism in the monoamine oxidase A gene promoter. Hum Genet 1998;103:273-9.
76. Manuck SB, Flory JD, Ferrell RE, et al. A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity. Psychiatry Res 2000;95:9-23.
77. Sonuga-Barke EJ, Brookes KJ, Buitelaar J, et al. Intelligence in DSM-IV combined type attention-deficit/hyperactivity disorder is not predicted by either dopamine receptor/transporter genes or other previously identified risk alleles for attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 2008;147:316-9.
78. Maher BS, Marazita ML, Ferrell RE, et al. Dopamine system genes and attention deficit hyperactivity disorder: a meta-analysis. Psychiatr Genet 2002;12:207-15.
79. Lowe N, Kirley A, Hawi Z, et al. Joint analysis of DRD5 marker concludes association with ADHD confined to the predominantly inattentive and combined subtypes. Am J Hum Genet 2004;74:348-56.
80. Manor I, Corbex M, Eisenberg J, et al. Association of the dopamine D5 receptor with attention deficit hyperactivity disorder (ADHD) and scores on a continuous performance test (TOVA). Am J Med Genet B Neuropsychiatr Genet 2004;127B:73-7.
81. Comings DE, Gade-Andavolu R, Gonzalez N, et al. Additive effect of three noradrenergic genes (ADRA2a, ADRA2C, DBH) on attention-deficit hyperactivity disorder and learning disabilities in Tourette syndrome subjects. Clin Genet 1999;55:160-72.
82. Xu C, Schachar R, Tannok W, et al. Linkage study of the alpha2A adrenergic receptor in attention-deficit hyperactivity disorder families. Am J Med Genet 2001;105:159-62.
83. Comings DE, Gonzalez NS, Cheng Li SC, et al. A "line item" approach to the identification of genes involved in polygenic behavioral disorders: the adrenergic alpha2A (ADRA2A) gene. Am J Med Genet B Neuropsychiatr Genet 2003;118B:110-4.
84. Roman T, Schmitz M, Polanczyk GV, et al. Further evidence for the association between attention deficit/hyperactivity disorder and the dopamine-beta-hydroxylase gene. Am J Med Genet 2002; 114:154-8.
85. Park L, Nigg JT, Waldman ID, et al. Association and linkage of alpha-2A adrenergic receptor gene polymorphisms with childhood ADHD. Mol Psychiatry 2005;10:572-80.
86. Waldman ID, Nigg JT, Gizer IR, et al. The adrenergic receptor α-2A gene (ADRA2A) and neuropsychological executive functions as putative endophenotype for childhood ADHD. Cogn Affect Behav Neurosci 2006;6:18-30.
87. Smalley SL, Kustanovich V, Minassian SL, et al. Genetic linkage of attention-deficit/hyperactivity disorder on chromosome 16p13, in a region implicated in autism. Am J Hum Genet 2002;71:959-63.
88. Turic D, Langley K, Mills S, et al. Follow-up of genetic linkage findings on chromosome 16p13: evidence of association of N-methyl-D-aspartate glutamate receptor 2A gene polymorphism with ADHD. Mol Psychiatry 2004;9:169-73.
89. Adams J, Crosbie J, Ickowicz A, et al. Glutamate receptor, ionotropic, N-methyl D-aspartate 2A (GRIN2A) gene as a positional candidate for attention-deficit/hyperactivity disorder in the 16p13 region. Mol Psychiatry 2004;9:494-9.
90. Zill P, Büttner A, Eisenmenger W, et al. Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims. Biol Psychiatry 2004; 56:581-6.
91. Zill P, Baghai TC, Zwanzger P, et al. SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression. Mol Psychiatry 2004;9:1030-6.
92. Sheehan K, Lowe N, Kirley A, et al. Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD. Mol Psychiatry 2005; 10:944-9.
93. Walitza S, Renner TJ, Dempfle A, et al. Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder. Mol Psychiatry 2005;10:1126-32.
94. Brookes K, Xu X, Chen W, et al. The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry 2006;11:934-53.
95. Manor I, Laiba E, Eisenberg J, et al. Association between trypotphan hydroxylase 2, performance on a continuance performance test and response to methylphenidate in ADHD participants. Am J Med Genet B Neuropsychiatr Genet 2008;47B:1501-8.
96. Egan MF, Kojima M, Callicott JH, et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003;112:257-69.
97. Kent L, Green E, Hawi Z, et al. Association of the paternally transmitted copy of common Valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene with susceptibility to ADHD. Mol Psychiatry 2005;10:939-43.
98. Friedel S, Horro FF, Wermter AK, et al. Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 2005;132B:96-9.
99. Lee J, Laurin N, Crosbie J, et al. Association study of the brain-derived neurotropic factor (BDNF) gene in attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 2007;144B: 976-81.
100. Schimmelmann BG, Friedel S, Dempfle A, et al. No evidence for preferential transmission of common valine allele of the Val66Met polymorphism of the brain-derived neurotrophic factor gene (BDNF) in ADHD. J Neural Transm 2007;114:523-6.
101. Xu X, Mill J, Zhou K, et al. Family-based association study between brain-derived neurotrophic factor gene polymorphisms and attention deficit hyperactivity disorder in UK and Taiwanese samples. Am J Med Genet B Neuropsychiatr Genet 2007;144B:83-6.
102. Ribasés M, Hervás A, Ramos-Quiroga JA, et al. Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder. Biol Psychiatry 2008;63:935-45.
103. Mill J, Caspi A, Williams BS, et al. Prediction of heterogeneity in intelligence and adult prognosis by genetic polymorphisms in the dopamine system among children with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry 2006;63:462-9.
104. Genro JP, Roman T, Zeni CP, et al. No association between dopaminergic polymorphisms and intelligence variability in attention-deficit/ hyperactivity disorder. Mol Psychiatry 2006; 11:1066-7.
105. Szatmari P, Maziade M, Zwaigenbaum L, et al. Informative phenotypes for genetic studies of psychiatric disorders. Am J Med Genet B Neuropsychiatr Genet 2007;144B:581-8.
106. Kuntsi J, Andreou P, Ma J, et al. Testing assumptions for endophenotype studies in ADHD: reliability and validity of tasks in a general population sample. BMC Psychiatry 2005;5:40.
107. Klein C, Wendling K, Huettner P, et al. Intra-subject variability in attention-deficit hyperactivity disorder. Biol Psychiatry 2006;60: 1088-97.
108. Fried PA, Watkinson B, Gray R. Differential effects on cognitive functioning in 13- to 16-year-olds prenatally exposed to cigarettes and marihuana. Neurotoxicol Teratol 2003;25:427-36.
109. Julvez J, Ribas-Fito N, Torrent M, et al. Maternal smoking habits and cognitive development of children at age 4 years in a population-based birth cohort. Int J Epidemiol 2007;36:825-32.
110. Doyle AE, Faraone SV, Seidman LJ, et al. Are endophenotypes based on measures of executive functions useful for molecular genetic studies of ADHD. J Child Psychol Psychiatry 2005; 46:774-803.
111. Davidson MC, Amso D, Anderson LC, et al. Development of cognitive control and executive functions from 4 to 13 years: evidence from manipulations of memory, inhibition, and task switching. Neuropsychologia 2006;44:2037-78.
112. Denckla MB. A theory and model of executive function: A neuropsychological perspective. In: Lyon GR, Krasnegor NA, editors. Attention, memory and executive function (ch. 15). Baltimore (MD): Paul H. Brooks; 1996. p. 263-78.
113. Carlsson A, Winblad B. Influence of age and time interval between death and autopsy on dopamine and 3-methoxytyramine levels in human basal ganglia. J Neural Transm 1976;38:271-6.
114. Lee JJ, Chang CK, Liu IM, et al. Changes in endogenous monoamines in aged rats. Clin Exp Pharmacol Physiol 2001;28:285-9.
115. Venero JL, Machado A, Cano J. Turnover of dopamine and serotonin and their metabolites in the striatum of aged rats. J Neurochem 1991;56:1940-8.
116. Galva MD, Bondiolotti GP, Olasmaa M, et al. Effect of aging on lazabemide binding, monoamine oxidase activity and monoamine metabolites in human frontal cortex. J Neural Transm Gen Sect 1995; 101:83-94.
117. Meng SZ, Ozawa Y, Itoh M, et al. Developmental and age related changes of dopamine transporter, and dopamine D1 and D2 receptors in human basal ganglia. Brain Res 1999;843:136-44.
118. Biederman J, Mick E, Faraone SV, et al. Influence of gender on attention deficit hyperactivity disorder in children referred to a psychiatric clinic. Am J Psychiatry 2002;159:36-42.
119. Gogos JA, Morgan M, Luine V, et al. Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci U S A 1998;95:9991-6.
120. Qian Q, Wang Y, Zhou R, et al. Family-based and case-control association studies of catechol-O-methyltransferase in attention deficit hyperactivity disorder suggest genetic sexual dimorphism. Am J Med Genet B Neuropsychiatr Genet 2003;118:103-9.
121. Brandon CL, Marinelli M, White FJ. Adolescent exposure to methylphenidate alters the activity of rat midbrain dopamine neurons. Biol Psychiatry 2003;54:1338-44.
122. Willcutt EG, Pennington BF. Comorbidity of reading disability and attention-deficit/hyperactivity disorder: differences by gender and subtype. J Learn Disabil 2000;33:179-91.
123. Abecasis GR, Cardon LR, Cookson WO. A general test of association for quantitative traits in nuclear families. Am J Hum Genet 2000;66:279-92.
124. Waldman ID, Robinson BF, Rowe DC. A logistic regression based extension of the TDT for continuous and categorical traits. Ann Hum Genet 1999;63:329-40.
125. Flint J, Munafo MR. The endophenotype concept in psychiatric genetics. Psychol Med 2007;37:163-80.
126. Kuntsi J, Neale BM, Chen W, et al. The IMAGE project: methodological issues for the moleculargenetic analysis of ADHD. Behav Brain Funct 2006;2:27.