Functional effects of the DAT1 polymorphism on EEG measures in ADHD

Journal of the American Academy of Child and Adolescent Psychiatry

Volumn 42, Issue 8, 2003, Pages 986-993

  Loo, Sandra K ^a,d   Specter, Elaine ^c   Smolen, Andrew ^b   Hopper, Christian ^c   Teale, Peter D ^c   Reite, Martin L ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Attention deficit hyperactivity disorder; Dopamine transporter gene; Electroencephalography; Methylphenidate

Indexed keywords

DOPAMINE TRANSPORTER; METHYLPHENIDATE; PLACEBO; CARRIER PROTEIN; CENTRAL STIMULANT AGENT; MEMBRANE PROTEIN; NERVE PROTEIN; SLC6A3 PROTEIN, HUMAN;

ALERTNESS; ALLELE; ARTICLE; ATTENTION DEFICIT DISORDER; BRAIN REGION; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ELECTROENCEPHALOGRAM; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MENTAL PERFORMANCE; PRIORITY JOURNAL; ADOLESCENT; CHILD; COGNITIVE DEFECT; ELECTROENCEPHALOGRAPHY; FEMALE; GENETICS; MALE; NEUROPSYCHOLOGICAL TEST; RANDOMIZED CONTROLLED TRIAL;

ADOLESCENT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CENTRAL NERVOUS SYSTEM STIMULANTS; CHILD; COGNITION DISORDERS; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOUBLE-BLIND METHOD; ELECTROENCEPHALOGRAPHY; FEMALE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; METHYLPHENIDATE; NERVE TISSUE PROTEINS; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, GENETIC;

EID: 0041328649     PISSN: 08908567     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CHI.0000046890.27264.88     Document Type: Article

References (51)

1. Amara S, Kuhar M (1993), Neurotransmitter transporters: recent progress. Annu Rev Neurosci 16:73-93
2. American Psychiatric Association (1994), Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington DC: American Psychiatric Association
3. Barr CL, Xu C, Kroft J et al (2001), Haplotype study of three polymorphisms at the dopamine transporter locus confirm linkage to attention-deficit/hyperactivity disorder. Biol Psychiatry 49:333-339
4. Biederman J, Munir K, Knee D et al (1986), A family study of patients with Attention Deficit Disorder and normal controls. J Psychiatry Res 148:263-274
5. Chabot RJ, Merkin H, Wood LM, Davenport TL, Serfontein G (1996), Sensitivity and specificity of QEEG in children with attention deficit or specific developmental learning disorders. Clin Electroencephalogr 27:26-34
6. Chabot RJ, Serfontein G (1996), Quantitative electroencephalographic profiles of children with attention deficit disorder. Biol Psychiatry 40:951-963
7. Clarke AR, Barry RJ, McCarthy R, Selikowitz M (1998), EEG analysis in Attention-Deficit/Hyperactivity Disorder: a comparative study of two subtypes. Psychiatry Res 81:19-29
8. Clarke AR, Barry RJ, McCarthy R, Selikowitz M (2001), Age and sex effects in the EEG: differences in two subtypes of attention-deficit/hyperactivity disorder. Clin Neurophysiol 112:815-826
9. Clarke AR, Barry RJ, McCarthy R, Selikowitz M (2002), EEG differences between good and poor responders to methylphenidate and dexamphetamine in children with attention-deficit/hyperactivity disorder. Clin Neurophysiol 113:194-205
10. Cohen J (1988), Statistical Power Analyses for the Behavioral Sciences, 2nd ed. Hillsdale, NJ: Erlbaum
11. Cook EH Jr, Stein MA, Krasowski MD et al (1995), Association of attention-deficit disorder and the dopamine transporter gene. Am J Hum Genet 56:993-998
12. Daly G, Hawi Z, Fitzgerald M, Gill M (1999), Mapping susceptibility loci in attention deficit hyperactivity disorder: preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children. Mol Psychiatry 4:192-196
13. Dougherty DD, Bonab AA, Spencer TJ, Rauch SL, Madras BK, Fischman AJ (1999), Dopamine transporter density in patients with attention deficit hyperactivity disorder. Lancet 354:2132-2133
14. El-Sayed E, Larsson JO, Persson HE, Rydelius PA (2002), Altered cortical activity in children with attention-deficit/hyperactiviry disorder during attentional load task. J Am Acad Child Adolesc Psychiatry 41:811-819
15. Gelernter J, Vandenbergh D, Kruger SD et al (1995), The dopamine transporter protein gene (SLC6A3): primary linkage mapping and linkage studies in Tourette syndrome. Genomics 30:459-463
16. Gill M, Daly G, Heron S, Hawi Z, Fitzgerald M (1997), Confirmation of association between attention deficit hyperactivity disorder and a dopamine transporter polymorphism. Mol Psychiatry 2:311-313
17. Gillis JJ, Gilger JW, Pennington BF, Defries JC (1992), Attention Deficit Disorder in reading disabled twins: evidence for a genetic aetiology. J Abnorm Child Psychol 20:303-315
18. Giros B, Jaber M, Jones SR, Wightman RM, Caron MG (1996), Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking dopamine transporter. Nature 379:606-612
19. Gomez CM, Vazquez M, Vaquero E, Lopez-Mendoza D, Cardoso MJ (1998), Frequency analysis of the EEG during spatial selective attention. Int J Neurosci 95:17-32
20. Heinz A, Goldman D, Jones DW et al (2000), Genotype influences in vivo dopamine transporter availability in human striatum. Neuropsychopharmacology 22:133-139
21. Hjorth B (1975), An on-line transformation of EEG scalp potentials into orthogonal source derivations. Electroencephalogr Clin Neurophysiol 39:526-530
22. Holmes J, Payton A, Barrett JH et al (2000), A family-based and case-control association study of the dopamine D4 receptor gene and dopamine transporter gene in attention deficit hyperactivity disorder. Mol Psychiatry 5:523-530
23. Jacobsen LK, Staley JK, Zoghbi SS et al (2000), Prediction of dopamine transporter binding availability by genotype: a preliminary report. Am J Psychiatry 157:1700-1703
24. Janzen T, Graap K, Stephanson S, Marshall W, Fitzsimmons G (1995), Differences in baseline EEG measures for ADD and normally achieving preadolescent males. Biofeedback Self Regul 20:65-82
25. Jonkman LM, Kemner C, Verbaten MN et al (1997), Effects of methylphenidate on event-related potentials and performance of attention-deficit hyperactivity disorder children in auditory and visual selective attention tasks. Biol Psychiatry 41:690-702
26. Kaufman J, Birmaher B, Brent D et al (1997), Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36:980-988
27. Kuperman S, Johnson B, Arndt S, Lindgren S, Wolraich M (1996), Quantitative EEG differences in a nonclinical sample of children with ADHD and undifferentiated ADD [see comments]. J Am Acad Child Adolesc Psychiatry 35:1009-1017
28. Lazzaro I, Gordon E, Whitmont S et al (1998), Quantified EEG activity in adolescent attention deficit hyperactivity disorder. Clin Electroencephalogr 29:37-42
29. Loo S, Teale P, Reite M (1999), EEG correlates of psychostimulant effects among children with ADHD: a preliminary report. Biol Psychiatry 45:1657-1660
30. Lubar JF, White JN Jr, Swartwood MO, Swartwood JN (1999), Methylphenidate effects on global and complex measures of EEG Pediatr Neurol 21:633-637
31. Mann CA, Lubar JF, Zimmerman AW, Miller CA, Muenchen RA (1992), Quantitative analysis of EEG in boys with attention-deficit-hyperactivity disorder: controlled study with clinical implications. Pediatr Neurol 8:30-36
32. Monastra VJ, Lubar JF, Linden M (2001), The development of a quantitative electroencephalographic scanning process for attention deficit-hyperactivity disorder: reliability and validity studies. Neuropsychology 15:136-144
33. Monastra VJ, Lubar JF, Linden M et al (1999), Assessing attention deficit hyperactivity disorder via quantitative electroencephalography: an initial validation study. Neuropsychology 13:424-433
34. Palmer CG, Bailey JN, Ramsey C et al (1999), No evidence of linkage or linkage disequilibrium between DAT1 and attention deficit hyperactivity disorder in a large sample. Psychiatr Genet 9:157-160
35. Roman T, Schmitz M, Polanczyk G, Eizirik M, Rohde LA, Hutz MH (2001), Attention-deficit hyperactivity disorder: a study of association with both the dopamine transporter gene and the dopamine D4 receptor gene. Am J Med Genet 105:471-478
36. Satterfield JH, Schell AM, Backs RW, Hidaka KC (1984), A cross-sectional and longitudinal study of age effects of electrophysiological measures in hyperactive and normal children. Biol Psychiatry 19:973-990
37. Statistical Package for the Social Sciences (SPSS), version 10.1. Chicago, www.spss.com
38. Stassen HH, Bomben G, Hell D (1998), Familial brain wave patterns: study of a 12-sib family. Pychiatr Genet 8:141-153
39. Swanson J, Oosterlaan J, Murias M et al (2000a), Attention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention. Proc Natl Acad Sci USA 97:4754-4759
40. Swanson JM, Flodman P, Kennedy J et al (2000b), Dopamine genes and ADHD. Neurosci Biobehav Rev 24:21-25
41. Swartwood MO, Swartwood JN, Lubar JF, Timmerman DL, Zimmerman AW, Muenchen (1998), Methylphenidate effects on EEG, behavior, and performance in boys with ADHD. Pediatr Neurol 18:244-250
42. Todd RD, Neuman RJ, Lobos EA, Jong YJ, Reich W, Heath AC (2001), Lack of association of dopamine D4 receptor gene polymorphisms with ADHD subtypes in a population sample of twins. Am J Med Genet 105:432-438
43. van Baal GC, de Geus EJ, Boomsma DI (1998), Genetic influences on EEG coherence in 5-year-old twins. Behav Genet 28:9-19
44. van Beijsterveldt CE, Molenaar PC, de Geus EJ, Boomsma DI (1996), Heritability of human brain functioning as assessed by electroencephalography. Am J Hum Genet 58:562-573
45. Vandenbergh DJ, Persico AM, Hawkins AL et al (1992), Human dopamine transporter gene (DAT1) maps to chromosome 5p15.3 and displays a VNTR. Genomics 14:1104-1100
46. Vazquez Marrufo M, Vaquero E, Cardoso MJ, Gomez CM (2001), Temporal evolution of alpha and beta bands during visual spatial attention. Brain Res Cogn Brain Res 12:315-320
47. Verbaten MN, Overtoom CC, Koelega HS et al (1994), Methylphenidate influences on both early and late ERP waves of ADHD children in a continuous performance test. J Abnorm Child Pychol 22:561-578
48. Waldman ID, Rowe DC, Abramowitz A et al (1998), Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity. Am J Hum Genet 63:1767-1776
49. Winsberg BG, Comings DE (1999), Association of the dopamine transporter gene (DAT1) with poor methylphenidate response [see comments]. J Am Acad Child Adolesc Psychiatry 38:1474-1477
50. Winsberg BG, Javitt DC, Silipo GS (1997), Electrophysiological indices of information processing in methylphenidate responders. Biol Psychiatry 42:434-445
51. Zhuang X, Ousting RS, Jones SR et al (2001), Hyperactivity and impaired response habituation in hyperdopaminergic mice. Proc Natl Acad Sci USA 98:1982-1987