PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys

Nature Neuroscience

Volumn 9, Issue 8, 2006, Pages 1050-1056

  Nader, Michael A ^a   Morgan, Drake ^a,b   Gage, H Donald ^a   Nader, Susan H ^a   Calhoun, Tonya L ^a   Buchheimer, Nancy ^a   Ehrenkaufer, Richard ^a   Mach, Robert H ^a,c  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COCAINE; DOPAMINE; DOPAMINE 2 RECEPTOR;

ABSTINENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; APPARATUS; ARTICLE; COCAINE DEPENDENCE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOPAMINERGIC NERVE CELL; DOPAMINERGIC TRANSMISSION; IMAGE ANALYSIS; MACACA; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REINFORCEMENT; RISK FACTOR;

ANIMALS; BEHAVIOR, ADDICTIVE; BEHAVIOR, ANIMAL; BRAIN; COCAINE; FOOD; GABA MODULATORS; HUMANS; LORAZEPAM; MACACA MULATTA; MALE; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, DOPAMINE D2; REINFORCEMENT (PSYCHOLOGY); SELF ADMINISTRATION; TIME FACTORS;

EID: 33747619663     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn1737     Document Type: Article

References (47)

1. Neuroscience of Psychoactive Substance Use and Dependence. (World Health Organization, Geneva, Switzerland, 2004).
2. 2003 National Survey on Drug Use and Health (NSDUH). (US Department of Health and Human Services, National Institute on Drug Abuse, Rockville, Maryland, 2004).
3. O'Brien, M.S. & Anthony, J.C. Risk of becoming cocaine dependent: epidemiological estimates for the United States, 2000-2001. Neuropsychopharmacology 30, 1006-1018 (2005).
4. Emergency Department Trends From The Drug Abuse Warning Network: Final Estimates 1994-2001. (US Department of Health and Human Services, National Institute on Drug Abuse, Rockville, Maryland, 2002).
5. Mello, N.K. & Negus, S.S. Preclinical evaluation of pharmacotherapies for treatment of cocaine and opioid abuse using drug self-administration procedures. Neuropsychopharmacology 14, 375-424 (1996).
6. Leshner, A.I. Vulnerability to addiction: new research opportunities. Am. J. Med. Genet. 96, 590-591 (2000).
7. Leshner, A.I. Addiction is a brain disease, and it matters. Science 278, 45-47 (1997).
8. Griffith, R.R., Bigelow, G.E. & Henningfield, J.E. Similarities in animal and human drug-taking behavior. in Advances in Substance Abuse Vol. 1 (ed. Mello, N.K.) 1-90 (JAI Press, Greenwich, Connecticut, 1980).
9. Spealman, R.D. & Goldberg, S.R. Drug self-administration by laboratory animals: control by schedules of reinforcement. Annu. Rev. Pharmacol. Toxicol. 18, 313-339 (1978).
10. Woolverton, W.L. & Nader, M.A. Experimental evaluation of the reinforcing effects of drugs. in Testing and Evaluation of Drugs of Abuse (eds. Adler, M.W. & Cowan, A.) 165-192 (Wiley-Liss, New York, 1990).
11. Reith, M.E., Sershen, H. & Lajtha, A. Saturable [3H]cocaine binding in central nervous system of mouse. Life Sci. 27, 1055-1062 (1980).
12. 3H]cocaine binding sites in caudate-putamen. J. Pharmacol. Exp. Ther. 251, 131-141 (1989).
13. Blum, K., Cull, J.C., Braverman, E.R. & Comings, D.E. Reward deficiency syndrome. Am. Sci. 84, 132-145 (1996).
14. Nader, M.A. & Czoty, P.W. PET imaging of dopamine D2 receptors in monkey models of cocaine abuse: genetic predisposition versus environmental modulation. Am. J. Psychiatry 162, 1473-1482 (2005).
15. Volkow, N.D. et al. Prediction of reinforcing responses to psychostimulants in humans by brain dopamine D2 receptor levels. Am. J. Psychiatry 156, 1440-1443 (1999).
16. Morgan, D. et al. Social dominance in monkeys: dopamine D2 receptors and cocaine self-administration. Nat. Neurosci. 5, 169-174 (2002).
17. Volkow, N.D. et al. Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers. Synapse 14, 169-177 (1993).
18. Martinez, D. et al. Cocaine dependence and D2 receptor availability in the functional subdivisions of the striatum: relationship with cocaine-seeking behavior. Neuropsychopharmacology 29, 1190-1202 (2004).
19. Dackis, C. & O'Brien, C. Neurobiology of addiction: treatment and public policy ramifications. Nat. Neurosci. 8, 1431-1436 (2005).
20. Mach, R.H. et al. Comparison of two fluorine-18 labeled benzamide derivatives that bind reversibly to dopamine D2 receptor: in vitro binding studies and positron emission tomography. Synapse 24, 322-333 (1996).
21. Mach, R.H. et al. Use of positron emission tomography to study the dynamics of psychostimulant-induced dopamine release. Pharmacol. Biochem. Behav. 57, 477-486 (1997).
22. Dewey, S.L. et al. GABAergic inhibition of endogenous dopamine release measured in vivo with 11C-raclopride and positron emission tomography. J. Neurosci. 12, 3773-3780 (1992).
23. Nader, M.A. et al. PET imaging of dopamine D2 receptors with [18F] fluoroclebopride in monkeys: effects of isoflurane- and ketamine-induced anesthesia. Neuropsychopharmacology 21, 589-596 (1999).
24. Logan, J. et al. Graphical analysis of reversible radioligand binding from time-activity measurements applied to [N-11C-methyl]-cocaine PET studies in human subjects. J. Cereb. Blood Flow Metab. 10, 740-747 (1990).
25. Hietala, J., Kuoppamaki, M., Nagren, K., Lehikoinen, P. & Syvalahti, E. Effects of lorazepam administration on striatal dopamine D2 receptor binding characteristics in man - a positron emission tomography study. Psychopharmacology (Berl.) 132, 361-365 (1997).
26. Zernig, G., Wakonigg, G., Madlung, E., Haring, C. & Saria, A. Do vertical shifts in dose-response rate-relationships in operant conditioning procedures indicate "sensitization" to "drug wanting"? Psychopharmacology (Berl.) 171, 349-351 (2004).
27. Laruelle, M. et al. Imaging D2 receptor occupancy by endogenous dopamine in humans. Neuropsychopharmacology 17, 162-174 (1997).
28. Kalivas, P.W. & Duffy, P. Similar effects of daily cocaine and stress on mesocorticolimbic dopamine neurotransmission in the rat. Biol. Psychiatry 25, 913-928 (1989).
29. Piazza, P.V. & Le Moal, M. The role of stress in drug self-administration. Trends Pharmacol. Sci. 19, 67-74 (1998).
30. Goeders, N.E. Stress and cocaine addiction. J. Pharmacol. Exp. Ther. 301, 785-789 (2002).
31. Volkow, N.D. & Folwer, J.S. Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex. Cereb. Cortex 10, 318-325 (2000).
32. Bradberry, C.W. Acute and chronic dopamine dynamics in a nonhuman primate model of recreational cocaine use. J. Neurosci. 20, 7109-7115 (2000).
33. Moore, R., Vinsant, S.L., Nader, M.A., Porrino, L.J. & Friedman, D.P. Effect of cocaine self-administration on dopamine D2 receptors in rhesus monkeys. Synapse 30, 88-96 (1998).
34. Nader, M.A. et al. Effects of cocaine self-administration on striatal dopamine systems in rhesus monkeys: initial and chronic exposure. Neuropsychopharmacology 27, 35-46 (2002).
35. Robinson, T.E. & Berridge, K.C. The neural basis of drug craving: an incentive-sensitization theory of addiction. Brain Res. Brain Res. Rev. 18, 247-291 (1993).
36. Piazza, P.V., Deminiere, J.-M., Le Moal, M. & Simon, H. Factors that predict individual vulnerability to amphetamine self-administration. Science 245, 1511-1513 (1989).
37. Koob, G.F. & Le Moal, M. Plasticity of reward neurocircuitry and the 'dark side' of drug addiction. Nat. Neurosci. 8, 1442-1444 (2005).
38. Grigson, P.S. & Twining, R.C. Cocaine-induced suppression of saccharin intake: a model of drug-induced devaluation of natural rewards. Behav. Neurosci. 116, 321-333 (2002).
39. Ahmed, S.H. & Koob, G.F. Transition from moderate to excessive drug intake: change in hedonic set point. Science 282, 298-300 (1998).
40. Calabresi, P., De Murtas, M. & Bernardi, G. The neostriatum beyond the motor function: experimental and clinical evidence. Neuroscience 78, 39-60 (1997).
41. Piazza, P.V., Deroche-Gamonent, V., Rouge-Pont, F. & Le Moal, M. Vertical shifts in self-administration dose-response functions predict a drug-vulnerable phenotype predisposed to addiction. J. Neurosci. 20, 4226-4232 (2000).
42. Volkow, N.D. et al. Effects of chronic cocaine abuse on postsynaptic dopamine receptors. Am. J. Psychiatry 147, 719-724 (1990).
43. Czoty, P.W., Gage, H.D. & Nader, M.A. PET imaging of striatal dopamine D2 receptors in nonhuman primates: increases in availability produced by chronic raclopride treatment. Synapse 58, 215-219 (2005).
44. Dewey, S.L. et al. Serotonergic modulation of striatal dopamine measured with positron emission tomography (PET) and in vivo microdialysis. J. Neurosci. 15, 821-829 (1995).
45. Mach, R.H. et al. The use of [18F]4-fluorobenzyl iodide (FBI) in PET radio-tracer synthesis: model alkylation studies and its application in the design of dopamine D1 and D2 receptor-based imaging agents. Nucl. Med. Biol. 20, 777-794 (1993).
46. Mach, R.H. et al. 18F-labeled benzamides for studying the dopamine D2 receptor with positron emission tomography. J. Med. Chem. 36, 3707-3720 (1993).
47. Mintun, M.A., Raichle, M.E., Kilbourn, M.R., Wooten, G.F. & Welch, M.J. A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann. Neurol. 15, 217-227 (1984).