Enforced expression of the apoptosis inhibitor Bcl-2 ablates tolerance induction in DNA-reactive B cells through a novel mechanism

Journal of Autoimmunity

Volumn 37, Issue 1, 2011, Pages 18-27

  Wang, Ying Hua ^a   Yan, Yi ^a   Rice, Jeffrey S ^b   Volpe, Bruce T ^c   Diamond, Betty ^a  

^a FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Anti DNA antibodies; Apoptosis; Bcl 2; Receptor editing

Indexed keywords

DNA; PROTEIN BCL 2; RAG1 PROTEIN; RAG2 PROTEIN;

ADOPTIVE IMMUNOTHERAPY; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; CELL POPULATION; CONTROLLED STUDY; FEMALE; GERMINAL CENTER; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN;

ANIMALS; ANTIBODIES, ANTINUCLEAR; APOPTOSIS; AUTOANTIGENS; AUTOIMMUNITY; B-LYMPHOCYTES; DNA; DNA-BINDING PROTEINS; EPITOPES; FEMALE; GENE EXPRESSION REGULATION; IMMUNE TOLERANCE; IMMUNIZATION; IMMUNOLOGIC MEMORY; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MOLECULAR MIMICRY; PEPTIDES; PROTO-ONCOGENE PROTEINS C-BCL-2; SPLEEN;

EID: 79958075127     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2011.03.002     Document Type: Article

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