Regulated overexpression of the survival factor bcl-2 in CHO cells increases viable cell density in batch culture and decreases DNA release in extended fixed-bed cultivation

Cytotechnology

Volumn 32, Issue 1, 2000, Pages 45-61

  Fussenegger, Martin ^a   Fassnacht, Dieter ^b   Schwartz, Regine ^b   Zanghi, James A ^a   Graf, Michael ^a   Bailey, James E ^a   Pörtner, Ralf ^b  

^a ETH ZURICH   (Switzerland)

^b HAMBURG UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

Apoptosis; Bcl 2; Fixed bed reactor; Regulated gene expression

Indexed keywords

BATCH CELL CULTURE; CELL DENSITY; CHO CELL; CULTURE MEDIUM; DNA; FIXED BED REACTOR; GENE OVEREXPRESSION; GENETIC LINKAGE; GLYCOPROTEIN; HETEROLOGOUS PRODUCT; HYBRIDOMA CELL CULTURE; PROTEIN BCL 2; SERUM; TETRACYCLINE;

EID: 0033974023     PISSN: 09209069     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008168522385     Document Type: Article

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