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Volumn 118, Issue 8, 2008, Pages 2896-2907

B cell receptor revision diminishes the autoreactive B cell response after antigen activation in mice

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; B LYMPHOCYTE RECEPTOR; INTERLEUKIN 7 RECEPTOR; NUCLEIC ACID BINDING PROTEIN;

EID: 48749089721     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI35618     Document Type: Article
Times cited : (39)

References (65)
  • 1
    • 0020977755 scopus 로고
    • Cellular mechanisms of immunologic tolerance
    • Nossal, G.J. 1983. Cellular mechanisms of immunologic tolerance. Annu. Rev. Immunol. 1:33-62.
    • (1983) Annu. Rev. Immunol , vol.1 , pp. 33-62
    • Nossal, G.J.1
  • 2
    • 0029965138 scopus 로고    scopus 로고
    • Balancing immunity and tolerance: Deleting and tuning lymphocyte repertoires
    • Goodnow, C.C. 1996. Balancing immunity and tolerance: deleting and tuning lymphocyte repertoires. Proc. Natl. Acad. Sci. U. S. A. 93:2264-2271.
    • (1996) Proc. Natl. Acad. Sci. U. S. A , vol.93 , pp. 2264-2271
    • Goodnow, C.C.1
  • 3
    • 0027532192 scopus 로고
    • B lymphocytes may escape tolerance by revising their antigen receptors
    • Radic, M.Z., Erikson, J., Litwin, S., and Weigert, M. 1993. B lymphocytes may escape tolerance by revising their antigen receptors. J. Exp. Med. 177:1165-1173.
    • (1993) J. Exp. Med , vol.177 , pp. 1165-1173
    • Radic, M.Z.1    Erikson, J.2    Litwin, S.3    Weigert, M.4
  • 4
    • 0027478391 scopus 로고
    • Receptor editing in self-reactive bone marrow B cells
    • Tiegs, S.L., Russell, D.M., and Nemazee, D. 1993. Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177:1009-1020.
    • (1993) J. Exp. Med , vol.177 , pp. 1009-1020
    • Tiegs, S.L.1    Russell, D.M.2    Nemazee, D.3
  • 5
    • 0025368647 scopus 로고
    • The need for central and peripheral tolerance in the B cell repertoire
    • Goodnow, C.C., Adelstein, S., and Basten, A. 1990. The need for central and peripheral tolerance in the B cell repertoire. Science. 248:1373-1379.
    • (1990) Science , vol.248 , pp. 1373-1379
    • Goodnow, C.C.1    Adelstein, S.2    Basten, A.3
  • 6
    • 21244498502 scopus 로고    scopus 로고
    • Low-affinity, Smith antigen-specific B cells are tolerized by dendritic cells and macrophages
    • Kilmon, M.A., Rutan, J.A., Clarke, S.H., and Vilen, B.J. 2005. Low-affinity, Smith antigen-specific B cells are tolerized by dendritic cells and macrophages. J. Immunol. 175:37-41.
    • (2005) J. Immunol , vol.175 , pp. 37-41
    • Kilmon, M.A.1    Rutan, J.A.2    Clarke, S.H.3    Vilen, B.J.4
  • 7
    • 33748467673 scopus 로고    scopus 로고
    • Selective dysregulation of the FcgammaIIB receptor on memory B cells in SLE
    • Mackay, M., et al. 2006. Selective dysregulation of the FcgammaIIB receptor on memory B cells in SLE. J. Exp. Med. 203:2157-2164.
    • (2006) J. Exp. Med , vol.203 , pp. 2157-2164
    • Mackay, M.1
  • 8
    • 0030460833 scopus 로고    scopus 로고
    • Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells
    • Han, S., Zheng, B., Schatz, D.G., Spanopoulou, E., and Kelsoe, G. 1996. Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells. Science. 274:2094-2097.
    • (1996) Science , vol.274 , pp. 2094-2097
    • Han, S.1    Zheng, B.2    Schatz, D.G.3    Spanopoulou, E.4    Kelsoe, G.5
  • 9
    • 0030475466 scopus 로고    scopus 로고
    • Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells
    • Hikida, M., et al. 1996. Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells. Science. 274:2092-2094.
    • (1996) Science , vol.274 , pp. 2092-2094
    • Hikida, M.1
  • 10
    • 0028785538 scopus 로고
    • In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance
    • Han, S., Zheng, B., Dal Porto, J., and Kelsoe, G. 1995. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance. J. Exp. Med. 182:1635-1644.
    • (1995) J. Exp. Med , vol.182 , pp. 1635-1644
    • Han, S.1    Zheng, B.2    Dal Porto, J.3    Kelsoe, G.4
  • 11
    • 0036098150 scopus 로고    scopus 로고
    • Expression of recombination activating genes 1 and 2 in peripheral B cells of patients with systemic lupus erythematosus
    • Girschick, H.J., Grammer, A.C., Nanki, T., Vazquez, E., and Lipsky, P.E. 2002. Expression of recombination activating genes 1 and 2 in peripheral B cells of patients with systemic lupus erythematosus. Arthritis Rheum. 46:1255-1263.
    • (2002) Arthritis Rheum , vol.46 , pp. 1255-1263
    • Girschick, H.J.1    Grammer, A.C.2    Nanki, T.3    Vazquez, E.4    Lipsky, P.E.5
  • 12
    • 33645127890 scopus 로고    scopus 로고
    • Analysis of RAG expression by peripheral blood CD5+ and CD5- B cells of patients with childhood systemic lupus erythematosus
    • Morbach, H., Singh, S.K., Faber, C., Lipsky, P.E., and Girschick, H.J. 2006. Analysis of RAG expression by peripheral blood CD5+ and CD5- B cells of patients with childhood systemic lupus erythematosus. Ann. Rheum. Dis. 65:482-487.
    • (2006) Ann. Rheum. Dis , vol.65 , pp. 482-487
    • Morbach, H.1    Singh, S.K.2    Faber, C.3    Lipsky, P.E.4    Girschick, H.J.5
  • 13
    • 0034767872 scopus 로고    scopus 로고
    • Expression of recombination-activating genes and terminal deoxynucleotidyl transferase and secondary rearrangement of immunoglobulin kappa light chains in rheumatoid arthritis synovial tissue
    • Zhang, Z., Wu, X., Limbaugh, B.H., and Bridges, S.L., Jr. 2001. Expression of recombination-activating genes and terminal deoxynucleotidyl transferase and secondary rearrangement of immunoglobulin kappa light chains in rheumatoid arthritis synovial tissue. Arthritis Rheum. 44:2275-2284.
    • (2001) Arthritis Rheum , vol.44 , pp. 2275-2284
    • Zhang, Z.1    Wu, X.2    Limbaugh, B.H.3    Bridges Jr., S.L.4
  • 14
    • 0035173472 scopus 로고    scopus 로고
    • RAG1 and RAG2 expression by B cell subsets from human tonsil and peripheral blood
    • Girschick, H.J., Grammer, A.C., Nanki, T., Mayo, M., and Lipsky, P.E. 2001. RAG1 and RAG2 expression by B cell subsets from human tonsil and peripheral blood. J. Immunol. 166:377-386.
    • (2001) J. Immunol , vol.166 , pp. 377-386
    • Girschick, H.J.1    Grammer, A.C.2    Nanki, T.3    Mayo, M.4    Lipsky, P.E.5
  • 15
    • 0032490679 scopus 로고    scopus 로고
    • Immunization with a peptide surrogate for double-stranded DNA (dsDNA) induces autoantibody production and renal immunoglobulin deposition
    • Putterman, C., and Diamond, B. 1998. Immunization with a peptide surrogate for double-stranded DNA (dsDNA) induces autoantibody production and renal immunoglobulin deposition. J. Exp. Med. 188:29-38.
    • (1998) J. Exp. Med , vol.188 , pp. 29-38
    • Putterman, C.1    Diamond, B.2
  • 18
    • 0035253574 scopus 로고    scopus 로고
    • T cell studies in a peptide-induced model of systemic lupus erythematosus
    • Khalil, M., Inaba, K., Steinman, R., Ravetch, J., and Diamond, B. 2001. T cell studies in a peptide-induced model of systemic lupus erythematosus. J. Immunol. 166:1667-1674.
    • (2001) J. Immunol , vol.166 , pp. 1667-1674
    • Khalil, M.1    Inaba, K.2    Steinman, R.3    Ravetch, J.4    Diamond, B.5
  • 19
    • 0038675204 scopus 로고    scopus 로고
    • Extrafollicular antibody responses
    • MacLennan, I.C., et al. 2003. Extrafollicular antibody responses. Immunol. Rev. 194:8-18.
    • (2003) Immunol. Rev , vol.194 , pp. 8-18
    • MacLennan, I.C.1
  • 20
    • 33645856486 scopus 로고    scopus 로고
    • Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation
    • Paus, D., et al. 2006. Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation. J. Exp. Med. 203:1081-1091.
    • (2006) J. Exp. Med , vol.203 , pp. 1081-1091
    • Paus, D.1
  • 21
    • 14944362858 scopus 로고    scopus 로고
    • Regulation of plasma-cell development
    • Shapiro-Shelef, M., and Calame, K. 2005. Regulation of plasma-cell development. Nat. Rev. Immunol. 5:230-242.
    • (2005) Nat. Rev. Immunol , vol.5 , pp. 230-242
    • Shapiro-Shelef, M.1    Calame, K.2
  • 22
    • 33745113481 scopus 로고    scopus 로고
    • Transcription factors that regulate memory in humoral responses
    • Calame, K. 2006. Transcription factors that regulate memory in humoral responses. Immunol. Rev. 211:269-279.
    • (2006) Immunol. Rev , vol.211 , pp. 269-279
    • Calame, K.1
  • 23
    • 34548383012 scopus 로고    scopus 로고
    • New markers for murine memory B cells that define mutated and unmutated subsets
    • Anderson, S.M., Tomayko, M.M., Ahuja, A., Haberman, A.M., and Shlomchik, M.J. 2007. New markers for murine memory B cells that define mutated and unmutated subsets. J. Exp. Med. 204:2103-2114.
    • (2007) J. Exp. Med , vol.204 , pp. 2103-2114
    • Anderson, S.M.1    Tomayko, M.M.2    Ahuja, A.3    Haberman, A.M.4    Shlomchik, M.J.5
  • 24
    • 0034599971 scopus 로고    scopus 로고
    • Antigen-specific B cell memory: Expression and replenishment of a novel b220(-) memory b cell compartment
    • McHeyzer-Williams, L.J., Cool, M., and McHeyzer-Williams, M.G. 2000. Antigen-specific B cell memory: expression and replenishment of a novel b220(-) memory b cell compartment. J. Exp. Med. 191:1149-1166.
    • (2000) J. Exp. Med , vol.191 , pp. 1149-1166
    • McHeyzer-Williams, L.J.1    Cool, M.2    McHeyzer-Williams, M.G.3
  • 25
    • 0025852445 scopus 로고
    • A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene
    • Kitamura, D., Roes, J., Kühn, R., and Rajewsky, K. 1991. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature. 350:423-426.
    • (1991) Nature , vol.350 , pp. 423-426
    • Kitamura, D.1    Roes, J.2    Kühn, R.3    Rajewsky, K.4
  • 26
    • 0031872205 scopus 로고    scopus 로고
    • Expression of recombination activating genes in germinal center B cells: Involvement of interleukin 7 (IL-7) and the IL-7 receptor
    • Hikida, M., et al. 1998. Expression of recombination activating genes in germinal center B cells: involvement of interleukin 7 (IL-7) and the IL-7 receptor. J. Exp. Med. 188:365-372.
    • (1998) J. Exp. Med , vol.188 , pp. 365-372
    • Hikida, M.1
  • 27
    • 0029151210 scopus 로고
    • Immunoglobulin recombinase gene activity is modulated reciprocally by interleukin 7 and CD19 in B cell progenitors
    • Billips, L.G., et al. 1995. Immunoglobulin recombinase gene activity is modulated reciprocally by interleukin 7 and CD19 in B cell progenitors. J. Exp. Med. 182:973-982.
    • (1995) J. Exp. Med , vol.182 , pp. 973-982
    • Billips, L.G.1
  • 28
    • 0032913081 scopus 로고    scopus 로고
    • Activation of the recombination activating gene 1 (RAG-1) transcript in bone marrow of senescent C57BL/6 mice by recombinant interleukin-7
    • Ben-Yehuda, A., et al. 1999. Activation of the recombination activating gene 1 (RAG-1) transcript in bone marrow of senescent C57BL/6 mice by recombinant interleukin-7. J. Gerontol. A Biol. Sci. Med. Sci. 54:B143-B148.
    • (1999) J. Gerontol. A Biol. Sci. Med. Sci , vol.54
    • Ben-Yehuda, A.1
  • 29
    • 0034968595 scopus 로고    scopus 로고
    • Control of chromatin accessibility for V(D)J recombination by interleukin-7
    • Huang, J., and Muegge, K. 2001. Control of chromatin accessibility for V(D)J recombination by interleukin-7. J. Leukoc. Biol. 69:907-911.
    • (2001) J. Leukoc. Biol , vol.69 , pp. 907-911
    • Huang, J.1    Muegge, K.2
  • 30
    • 0031025419 scopus 로고    scopus 로고
    • A transgenic T cell receptor restores thymocyte differentiation in interleukin-7 receptor alpha chain-deficient mice
    • Crompton, T., Outram, S.V., Buckland, J., and Owen, M.J. 1997. A transgenic T cell receptor restores thymocyte differentiation in interleukin-7 receptor alpha chain-deficient mice. Eur. J. Immunol. 27:100-104.
    • (1997) Eur. J. Immunol , vol.27 , pp. 100-104
    • Crompton, T.1    Outram, S.V.2    Buckland, J.3    Owen, M.J.4
  • 31
    • 0034332403 scopus 로고    scopus 로고
    • Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo
    • Schluns, K.S., Kieper, W.C., Jameson, S.C., and Lefrancois, L. 2000. Interleukin-7 mediates the homeostasis of naive and memory CD8 T cells in vivo. Nat. Immunol. 1:426-432.
    • (2000) Nat. Immunol , vol.1 , pp. 426-432
    • Schluns, K.S.1    Kieper, W.C.2    Jameson, S.C.3    Lefrancois, L.4
  • 32
    • 0347281680 scopus 로고    scopus 로고
    • Interleukin 7 regulates the survival and generation of memory CD4 cells
    • Kondrack, R.M., et al. 2003. Interleukin 7 regulates the survival and generation of memory CD4 cells. J. Exp. Med. 198:1797-1806.
    • (2003) J. Exp. Med , vol.198 , pp. 1797-1806
    • Kondrack, R.M.1
  • 33
    • 0036498562 scopus 로고    scopus 로고
    • Positive effects of glucocorticoids on T cell function by up-regulation of IL-7 receptor alpha
    • Franchimont, D., et al. 2002. Positive effects of glucocorticoids on T cell function by up-regulation of IL-7 receptor alpha. J. Immunol. 168:2212-2218.
    • (2002) J. Immunol , vol.168 , pp. 2212-2218
    • Franchimont, D.1
  • 34
    • 18344411790 scopus 로고    scopus 로고
    • Antigen receptor engagement turns off the V(D)J recombination machinery in human tonsil B cells
    • Meffre, E., et al. 1998. Antigen receptor engagement turns off the V(D)J recombination machinery in human tonsil B cells. J. Exp. Med. 188:765-772.
    • (1998) J. Exp. Med , vol.188 , pp. 765-772
    • Meffre, E.1
  • 35
    • 0034163580 scopus 로고    scopus 로고
    • Molecular analysis of the autoantibody response in peptide-induced autoimmunity
    • Putterman, C., Deocharan, B., and Diamond, B. 2000. Molecular analysis of the autoantibody response in peptide-induced autoimmunity. J. Immunol. 164:2542-2549.
    • (2000) J. Immunol , vol.164 , pp. 2542-2549
    • Putterman, C.1    Deocharan, B.2    Diamond, B.3
  • 36
    • 0033806726 scopus 로고    scopus 로고
    • Peptide mimic of phosphorylcholine, a dominant epitope found on Streptococcus pneumoniae
    • Harris, S.L., Park, M.K., Nahm, M.H., and Diamond, B. 2000. Peptide mimic of phosphorylcholine, a dominant epitope found on Streptococcus pneumoniae. Infect. Immun. 68:5778-5784.
    • (2000) Infect. Immun , vol.68 , pp. 5778-5784
    • Harris, S.L.1    Park, M.K.2    Nahm, M.H.3    Diamond, B.4
  • 37
    • 0029059370 scopus 로고
    • Soluble antigen can cause enhanced apoptosis of germinal-centre B cells
    • Pulendran, B., Kannourakis, G., Nouri, S., Smith, K.G., and Nossal, G.J. 1995. Soluble antigen can cause enhanced apoptosis of germinal-centre B cells. Nature. 375:331-334.
    • (1995) Nature , vol.375 , pp. 331-334
    • Pulendran, B.1    Kannourakis, G.2    Nouri, S.3    Smith, K.G.4    Nossal, G.J.5
  • 38
    • 0029014435 scopus 로고
    • Antigen-induced B-cell death and elimination during germinal-centre immune responses
    • Shokat, K.M., and Goodnow, C.C. 1995. Antigen-induced B-cell death and elimination during germinal-centre immune responses. Nature. 375:334-338.
    • (1995) Nature , vol.375 , pp. 334-338
    • Shokat, K.M.1    Goodnow, C.C.2
  • 39
    • 0024455288 scopus 로고
    • Induction of self-tolerance in mature peripheral B lymphocytes
    • Goodnow, C.C., Crosbie, J., Jorgensen, H., Brink, R.A., and Basten, A. 1989. Induction of self-tolerance in mature peripheral B lymphocytes. Nature. 342:385-391.
    • (1989) Nature , vol.342 , pp. 385-391
    • Goodnow, C.C.1    Crosbie, J.2    Jorgensen, H.3    Brink, R.A.4    Basten, A.5
  • 40
    • 0026041119 scopus 로고
    • Peripheral deletion of self-reactive B cells
    • Russell, D.M., et al. 1991. Peripheral deletion of self-reactive B cells. Nature. 354:308-311.
    • (1991) Nature , vol.354 , pp. 308-311
    • Russell, D.M.1
  • 41
    • 33344465620 scopus 로고    scopus 로고
    • A checkpoint for autoreactivity in human IgM+ memory B cell development
    • Tsuiji, M., et al. 2006. A checkpoint for autoreactivity in human IgM+ memory B cell development. J. Exp. Med. 203:393-400.
    • (2006) J. Exp. Med , vol.203 , pp. 393-400
    • Tsuiji, M.1
  • 42
    • 32044454695 scopus 로고    scopus 로고
    • B cell tolerance checkpoints that restrict pathways of antigen-driven differentiation
    • William, J., Euler, C., Primarolo, N., and Shlomchik, M.J. 2006. B cell tolerance checkpoints that restrict pathways of antigen-driven differentiation. J. Immunol. 176:2142-2151.
    • (2006) J. Immunol , vol.176 , pp. 2142-2151
    • William, J.1    Euler, C.2    Primarolo, N.3    Shlomchik, M.J.4
  • 43
    • 30744437153 scopus 로고    scopus 로고
    • Early preplasma cells define a tolerance checkpoint for autoreactive B cells
    • Culton, D.A., et al. 2006. Early preplasma cells define a tolerance checkpoint for autoreactive B cells. J. Immunol. 176:790-802.
    • (2006) J. Immunol , vol.176 , pp. 790-802
    • Culton, D.A.1
  • 44
    • 0342740028 scopus 로고
    • Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity
    • Diamond, B., and Scharff, M.D. 1984. Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity. Proc. Natl. Acad. Sci. U. S. A. 81:5841-5844.
    • (1984) Proc. Natl. Acad. Sci. U. S. A , vol.81 , pp. 5841-5844
    • Diamond, B.1    Scharff, M.D.2
  • 45
    • 0029933460 scopus 로고    scopus 로고
    • Pathogenic autoantibodies are routinely generated during the response to foreign antigen: A paradigm for autoimmune disease
    • Ray, S.K., Putterman, C., and Diamond, B. 1996. Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune disease. Proc. Natl. Acad. Sci. U. S. A. 93:2019-2024.
    • (1996) Proc. Natl. Acad. Sci. U. S. A , vol.93 , pp. 2019-2024
    • Ray, S.K.1    Putterman, C.2    Diamond, B.3
  • 46
    • 0032811233 scopus 로고    scopus 로고
    • Cross-reactive B cells are present during a primary but not secondary response in BALB/c mice expressing a bcl-2 transgene
    • Kuo, P., Bynoe, M., and Diamond, B. 1999. Cross-reactive B cells are present during a primary but not secondary response in BALB/c mice expressing a bcl-2 transgene. Mol. Immunol. 36:471-479.
    • (1999) Mol. Immunol , vol.36 , pp. 471-479
    • Kuo, P.1    Bynoe, M.2    Diamond, B.3
  • 47
    • 0026052840 scopus 로고
    • Tolerance susceptibility of newly generating memory B cells
    • Linton, P.J., Rudie, A., and Klinman, N.R. 1991. Tolerance susceptibility of newly generating memory B cells. J. Immunol. 146:4099-4104.
    • (1991) J. Immunol , vol.146 , pp. 4099-4104
    • Linton, P.J.1    Rudie, A.2    Klinman, N.R.3
  • 49
    • 0034684650 scopus 로고    scopus 로고
    • Antigen-independent appearance of recombination activating gene (RAG)-positive bone marrow B cells in the spleens of immunized mice
    • Gartner, F., Alt, F.W., Monroe, R.J., and Seidl, K.J. 2000. Antigen-independent appearance of recombination activating gene (RAG)-positive bone marrow B cells in the spleens of immunized mice. J. Exp. Med. 192:1745-1754.
    • (2000) J. Exp. Med , vol.192 , pp. 1745-1754
    • Gartner, F.1    Alt, F.W.2    Monroe, R.J.3    Seidl, K.J.4
  • 50
    • 0034686433 scopus 로고    scopus 로고
    • Immunization and infection change the number of recombination activating gene (RAG)-expressing B cells in the periphery by altering immature lymphocyte production
    • Nagaoka, H., Gonzalez-Aseguinolaza, G., Tsuji, M., and Nussenzweig, M.C. 2000. Immunization and infection change the number of recombination activating gene (RAG)-expressing B cells in the periphery by altering immature lymphocyte production. J. Exp. Med. 191:2113-2120.
    • (2000) J. Exp. Med , vol.191 , pp. 2113-2120
    • Nagaoka, H.1    Gonzalez-Aseguinolaza, G.2    Tsuji, M.3    Nussenzweig, M.C.4
  • 51
    • 0034608480 scopus 로고    scopus 로고
    • Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes
    • Wilson, P.C., et al. 2000. Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes. J. Exp. Med. 191:1881-1894.
    • (2000) J. Exp. Med , vol.191 , pp. 1881-1894
    • Wilson, P.C.1
  • 52
    • 0035353180 scopus 로고    scopus 로고
    • Localization of recombination activating gene 1/green fluorescent protein (RAG1/GFP) expression in secondary lymphoid organs after immunization with T-dependent antigens in rag1/gfp knockin mice
    • Igarashi, H., et al. 2001. Localization of recombination activating gene 1/green fluorescent protein (RAG1/GFP) expression in secondary lymphoid organs after immunization with T-dependent antigens in rag1/gfp knockin mice. Blood. 97:2680-2687.
    • (2001) Blood , vol.97 , pp. 2680-2687
    • Igarashi, H.1
  • 53
    • 0037079710 scopus 로고    scopus 로고
    • Expression of the recombination-activating genes in extrafollicular lymphocytes but no apparent reinduction in germinal center reactions in human tonsils
    • Meru, N., Jung, A., Baumann, I., and Niedobitek, G. 2002. Expression of the recombination-activating genes in extrafollicular lymphocytes but no apparent reinduction in germinal center reactions in human tonsils. Blood. 99:531-537.
    • (2002) Blood , vol.99 , pp. 531-537
    • Meru, N.1    Jung, A.2    Baumann, I.3    Niedobitek, G.4
  • 54
    • 0030803748 scopus 로고    scopus 로고
    • V(D)J recombination in mature B cells: A mechanism for altering antibody responses
    • Papavasiliou, F., et al. 1997. V(D)J recombination in mature B cells: a mechanism for altering antibody responses. Science. 278:298-301.
    • (1997) Science , vol.278 , pp. 298-301
    • Papavasiliou, F.1
  • 55
    • 17844376528 scopus 로고    scopus 로고
    • Expression of RAGs in peripheral B cells outside germinal centers is associated with the expression of CD5
    • Hillion, S., Saraux, A., Youinou, P., and Jamin, C. 2005. Expression of RAGs in peripheral B cells outside germinal centers is associated with the expression of CD5. J. Immunol. 174:5553-5561.
    • (2005) J. Immunol , vol.174 , pp. 5553-5561
    • Hillion, S.1    Saraux, A.2    Youinou, P.3    Jamin, C.4
  • 56
    • 0030764978 scopus 로고    scopus 로고
    • V(D)J recombinase activity in a subset of germinal center B lymphocytes
    • Han, S., et al. 1997. V(D)J recombinase activity in a subset of germinal center B lymphocytes. Science. 278:301-305.
    • (1997) Science , vol.278 , pp. 301-305
    • Han, S.1
  • 57
    • 0032537732 scopus 로고    scopus 로고
    • V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigenreceptor signalling
    • Hertz, M., Kouskoff, V., Nakamura, T., and Nemazee, D. 1998. V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigenreceptor signalling. Nature. 394:292-295.
    • (1998) Nature , vol.394 , pp. 292-295
    • Hertz, M.1    Kouskoff, V.2    Nakamura, T.3    Nemazee, D.4
  • 58
    • 0033549813 scopus 로고    scopus 로고
    • Continued RAG expression in late stages of B cell development and no apparent reinduction after immunization
    • Yu, W., et al. 1999. Continued RAG expression in late stages of B cell development and no apparent reinduction after immunization. Nature. 400:682-687.
    • (1999) Nature , vol.400 , pp. 682-687
    • Yu, W.1
  • 59
    • 0033180183 scopus 로고    scopus 로고
    • RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues
    • Monroe, R.J., et al. 1999. RAG2:GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues. Immunity. 11:201-212.
    • (1999) Immunity , vol.11 , pp. 201-212
    • Monroe, R.J.1
  • 60
    • 0032740593 scopus 로고    scopus 로고
    • Cutting edge: Absence of expression of RAG1 in peritoneal B-1 cells detected by knocking into RAG1 locus with green fluorescent protein gene
    • Kuwata, N., Igarashi, H., Ohmura, T., Aizawa, S., and Sakaguchi, N. 1999. Cutting edge: absence of expression of RAG1 in peritoneal B-1 cells detected by knocking into RAG1 locus with green fluorescent protein gene. J. Immunol. 163:6355-6359.
    • (1999) J. Immunol , vol.163 , pp. 6355-6359
    • Kuwata, N.1    Igarashi, H.2    Ohmura, T.3    Aizawa, S.4    Sakaguchi, N.5
  • 61
    • 33846895443 scopus 로고    scopus 로고
    • The PI3K p110delta is required for down-regulation of RAG expression in immature B cells
    • Llorian, M., Stamataki, Z., Hill, S., Turner, M., and Martensson, I.L. 2007. The PI3K p110delta is required for down-regulation of RAG expression in immature B cells. J. Immunol. 178:1981-1985.
    • (2007) J. Immunol , vol.178 , pp. 1981-1985
    • Llorian, M.1    Stamataki, Z.2    Hill, S.3    Turner, M.4    Martensson, I.L.5
  • 62
    • 34248216554 scopus 로고    scopus 로고
    • Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection
    • Verkoczy, L., et al. 2007. Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection. J. Immunol. 178:6332-6341.
    • (2007) J. Immunol , vol.178 , pp. 6332-6341
    • Verkoczy, L.1
  • 63
    • 0027533532 scopus 로고
    • Soluble antigen profoundly reduces memory B-cell numbers even when given after challenge immunization
    • Nossal, G.J., Karvelas, M., and Pulendran, B. 1993. Soluble antigen profoundly reduces memory B-cell numbers even when given after challenge immunization. Proc. Natl. Acad. Sci. U. S. A. 90:3088-3092.
    • (1993) Proc. Natl. Acad. Sci. U. S. A , vol.90 , pp. 3088-3092
    • Nossal, G.J.1    Karvelas, M.2    Pulendran, B.3
  • 64
    • 0038558209 scopus 로고    scopus 로고
    • Expression of a targeted lambda 1 light chain gene is developmentally regulated and independent of Ig kappa rearrangements
    • Oberdoerffer, P., Novobrantseva, T.I., and Rajewsky, K. 2003. Expression of a targeted lambda 1 light chain gene is developmentally regulated and independent of Ig kappa rearrangements. J. Exp. Med. 197:1165- 1172.
    • (2003) J. Exp. Med , vol.197 , pp. 1165-1172
    • Oberdoerffer, P.1    Novobrantseva, T.I.2    Rajewsky, K.3
  • 65
    • 0027398107 scopus 로고
    • Optimization of primers for cloning libraries of mouse immunoglobulin genes using the polymerase chain reaction
    • Kettleborough, C.A., Saldanha, J., Ansell, K.H., and Bendig, M.M. 1993. Optimization of primers for cloning libraries of mouse immunoglobulin genes using the polymerase chain reaction. Eur. J. Immunol. 23:206-211.
    • (1993) Eur. J. Immunol , vol.23 , pp. 206-211
    • Kettleborough, C.A.1    Saldanha, J.2    Ansell, K.H.3    Bendig, M.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.