Enforced expression of Bcl-2 selectively perturbs negative selection of dual reactive antibodies

Developmental Immunology

Volumn 8, Issue 3-4, 2001, Pages 223-234

  Notidis, E ^a   Hande, S ^a   Manser, T ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

B lymphocytes; Bcl 2; Clonal selection; Peripheral tolerance; Somatic hypermutation

Indexed keywords

4 AZOBENZENEARSONIC ACID; ANTIBODY; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCING CELL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; CONTROLLED STUDY; MEMORY CELL; MOUSE; MOUSE STRAIN; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALIA;

EID: 0035660720     PISSN: 10446672     EISSN: None     Source Type: Journal    
DOI: 10.1155/2001/83595     Document Type: Article

References (37)

1. Mutational drift and repertoire shift in the maturation of the immune response
2. Discriminating intrinsic and antigen-selected mutational hotspots in immunoglobulin V genes
3. Random mutagenesis of two CDR amino acids yields an unexpectedly high frequency of antibodies with increase affinity for both cognate antigen and autoantigen
4. Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells
5. Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice
6. In situ studies of the primary response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen driven B cell apoptosis in germinal centers as a mechanism for maintaining self tolerance
7. Single amino acid substitutions are sufficient to generate or enhance the specificity of two forms of an anti-Ars antibody variable region for DNA
8. Bcl-2 obstructs negative selection of autoreactive, hypermutated antibody V regions during memory B cell development
9. Overexpression of bcl-2 alters usage of mutational hot spots in germinal center B cells
10. Crossreactive B cells are present during a primary but not secondary response in BALB/c mice expressing a bcl-2 transgene
11. Germinal centers
12. Somatically mutated forms of a major anti-p-azophenylarsonate antibody variable region with dramatically reduced affinity for p-azophenylarsonate: By-products of an antigen driven immune response?
13. Evolution of antibody variable region structure during the immune response
14. Evolution of antibody structure during the immune response: The differentiative potential of a single B-lymphocyte
15. Regulation, timing and mechanism of antibody V-gene somatic hypermutation: Lessons from the arsonate system
16. 53, and Bax but not the survival gene bcl-2
17. bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation
18. H gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus
19. Characterization of anti-single-stranded DNA B cells in a non-autoimmune background
20. Soluble antigen can cause enhanced apoptosis of germinal-center B cells
21. The molecular genetics of the arsonate idiotypic system
22. Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighboring base sequences on mutagenesis
23. Affinity analysis of idiotype positive and idiotype negative Ars binding hybridoma proteins and Ars immune sera
24. Predicting regional mutability in antibody V genes based solely on di- and trinucleotide sequence composition
25. Recurrent somatic mutations in mouse antibodies to p-azophenylarsonate increase affinity for hapten
26. Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse
27. The influence of somatic mutation on clonal expansion
28. Antigen-induced B-cell death and elimination during germinal-center immune responses
29. Bcl-2 increases memory B cell recruitment but does not perturb selection in germinal centers
30. Di- and tri-nucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells
31. The role of bcl-2 in lymphoid differentiation and neoplastic transformation
32. L transgenic mice
33. The physiology of germinal centers
34. Bcl-x rather than Bcl-2 mediates CD40-dependent centrocyte survival in the germinal center
35. Altering the antibody repertoire via transgene homologous recombination: Evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation
36. The repertoire of somatic antibody mutants accumulating in the memory compartment after primary immunization is restricted through affinity maturation and mirrors that expressed in the secondary response
37. K genes encoded predominating antibody variable regions elicited in strain A mice by immunization with p-azophenylarsonate