Extracorporeal liver support based on primary human liver cells and albumin dialysis - Treatment of a patient with primary graft non-function

Journal of Hepatology

Volumn 39, Issue 4, 2003, Pages 649-653

  Sauer, Igor M ^a   Zeilinger, Katrin ^a   Pless, Gesine ^a   Kardassis, Dimitrios ^a   Theruvath, Tom ^a   Pascher, Andreas ^a   Goetz, Max ^a   Neuhaus, Peter ^a   Gerlach, Joerg C ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Case report; Liver transplantation; Modular extracorporeal liver support; Primary human liver cells; Primary non function

Indexed keywords

AMMONIA; BILIRUBIN;

ADULT; AMMONIA BLOOD LEVEL; ARTICLE; BILIRUBIN BLOOD LEVEL; BIOREACTOR; CADAVER DONOR; CASE REPORT; COMA; DETOXIFICATION; FEMALE; GRAFT FAILURE; HEMODIALYSIS; HUMAN; HUMAN CELL; KIDNEY FUNCTION; LIVER TRANSPLANTATION; NEUROLOGY; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; URINE VOLUME;

EID: 0141674782     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(03)00348-9     Document Type: Article

References (16)

1. Stange J, Hassanein TI, Mehta R, Mitzner SR, Bartlett RH. The molecular adsorbents recycling system as a liver support system based on albumin dialysis: a summary of preclinical investigations, prospective, randomized, controlled clinical trial, and clinical experience from 19 centers. Artif Organs 2002;26:103-110.
2. Allen JW, Hassanein T, Bhatia SN. Advances in bioartificial liver devices. Hepatology 2001;34:447-455.
3. Tsiaoussis J, Newsome PN, Nelson LJ, Hayes PC, Plevris JN. Which hepatocyte will it be? Hepatocyte choice for bioartificial liver support systems. Liver Transpl 2001;7:2-10.
4. Annual Report/Eurotransplant International Foundation - Leiden: Annual report 2002/Guido G. Persijn and Bernard Cohen CIP-Gegevens Koninklijke Bibliotheek, Den Haag ISBN 90-71658-21-X: 28-29. http://www.eurotransplant.nl/members/files/annual_report/AR2002.pdf
5. Gerlach JC, Botsch M, Kardassis D, Lemmens P, Schoen M, Janke J, et al. Experimental evaluation of a cell module for hybrid liver support. Int J Artif Org 2001;24:793-798.
6. Sauer IM, Obermayer N, Kardassis D, Theruvath T, Gerlach JC. Development of a hybrid liver support system. Ann N Y Acad Sci 2001;944:308-319.
7. Sauer IM, Zeilinger K, Obermayer N, Pless G, Pascher A, Mieder T, et al. Primary human liver cells as source for modular extracorporeal liver support - a preliminary report. Int J Artif Org 2002;25:1001-1005.
8. Gerlach JC, Brombacher J, Kloppel K, Schnoy N, Neuhaus P. Comparison of four methods for mass hepatocyte isolation from pig and human livers. Transplantation 1994;57:1318-1322.
9. Strasberg SM, Howard TK, Molmenti EP, Hertl H. Selecting the donor liver: risk factors for poor function after orthotopic liver transplantation. Hepatology 1994;20:829-838.
10. Ferenci P, Lockwood A, Mullen K, Tarter R, Weissenborn K, Blei AT. Hepatic encephalopathy - definition, nomenclature, diagnosis, and quantification: final report of the working party at the 11th World Congresses of Gastroenterology, Vienna, 1998. Hepatology 2002;35:716-721.
11. Kreymann B, Seige M, Schweigart U, Kopp KF, Classen M. Albumin dialysis: effective removal of copper in a patient with fulminant Wilson disease and successful bridging to liver transplantation: a new possibility for the elimination of protein-bound toxins. J Hepatol 1999;31:1080-1085.
12. Ash SR, Blake DE, Carr DJ, Harker KD. Push-pull sorbent based pheresis for treatment of acute hepatic failure: the BioLogic-detoxifier/plasma filter System. ASAIO J 1998;44:129-139.
13. Sauer IM, Kardassis D, Zeillinger K, Pascher A, Gruenwald A, Pless G, et al. Clinical extracorporeal hybrid liver support - phase I study with primary porcine liver cells. Xenotransplantation 2003; in press.
14. Alwayn IPJ, Robson SC. Understanding and preventing the coagulation disorders associated with xenograft rejection. Graft 2000;4:50-53.
15. Hammer C. Xenotransplantation for liver therapy or: can porcine hepatocytes generate physiological functions sufficient for a human patient in ALF? Int J Artif Org 2002;25:1019-1028.
16. Sauer IM, Gerlach JC. Modular extracorporeal liver support. Artif Org 2002;26:703-706.