메뉴 건너뛰기




Volumn 89, Issue 8, 2011, Pages 1302-1315

Cross-talk between cell cycle induction and mitochondrial dysfunction during oxidative stress and nerve growth factor withdrawal in differentiated PC12 cells

Author keywords

Akt, stress kinases; MAPK; NGF; P p27

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; FLAVOPIRIDOL; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NERVE GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; RETINOBLASTOMA PROTEIN; SELENOPROTEIN; SODIUM SELENITE;

EID: 79957793328     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22665     Document Type: Article
Times cited : (19)

References (60)
  • 1
    • 46749158750 scopus 로고    scopus 로고
    • The modular systems biology approach to investigate the control of apoptosis in Alzheimer's disease neurodegeneration
    • Alberghina L, Colangelo AM. 2006. The modular systems biology approach to investigate the control of apoptosis in Alzheimer's disease neurodegeneration. BMC Neurosci 7( Suppl 1): S2.
    • (2006) BMC Neurosci , vol.7 , Issue.SUPPL. 1
    • Alberghina, L.1    Colangelo, A.M.2
  • 3
    • 0031737550 scopus 로고    scopus 로고
    • Neuronal expression of cyclin dependent kinase inhibitors of the INK4 family in Alzheimer's disease
    • Arendt T HM, Gartner U. 1998. Neuronal expression of cyclin dependent kinase inhibitors of the INK4 family in Alzheimer's disease. J Neural Transm 105: 949-960.
    • (1998) J Neural Transm , vol.105 , pp. 949-960
    • Arendt, T.H.1    Gartner, U.2
  • 4
    • 0042197268 scopus 로고    scopus 로고
    • Are p27 and p21 cytoplasmic oncoproteins?
    • Blagosklonny MV. 2002. Are p27 and p21 cytoplasmic oncoproteins? Cell Cycle 1: 391-393.
    • (2002) Cell Cycle , vol.1 , pp. 391-393
    • Blagosklonny, M.V.1
  • 5
    • 77957122174 scopus 로고    scopus 로고
    • The engine driving the ship: metabolic steering of cell proliferation and death
    • Buchakjian MR, Kornbluth S. 2010. The engine driving the ship: metabolic steering of cell proliferation and death. Nat Rev Mol Cell Biol 11: 715-727.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 715-727
    • Buchakjian, M.R.1    Kornbluth, S.2
  • 6
    • 25444457320 scopus 로고    scopus 로고
    • Role of the cell cycle in the pathobiology of central nervous system trauma
    • Cernak I, Stoica B, Byrnes KR, Di Giovanni S, Faden AI. 2005. Role of the cell cycle in the pathobiology of central nervous system trauma. Cell Cycle 4: 1286-1293.
    • (2005) Cell Cycle , vol.4 , pp. 1286-1293
    • Cernak, I.1    Stoica, B.2    Byrnes, K.R.3    Di Giovanni, S.4    Faden, A.I.5
  • 7
    • 0037762690 scopus 로고    scopus 로고
    • Neurotrophins and their receptors: a convergence point for many signalling pathways
    • Chao MV. 2003. Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci 4: 299-309.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 299-309
    • Chao, M.V.1
  • 8
    • 60349084974 scopus 로고    scopus 로고
    • Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway
    • Chen L, Liu L, Yin J, Luo Y, Huang S. 2009. Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway. Int J Biochem Cell Biol 41: 1284-1295.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 1284-1295
    • Chen, L.1    Liu, L.2    Yin, J.3    Luo, Y.4    Huang, S.5
  • 12
    • 0032522924 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons
    • Crowder RJ, Freeman RS. 1998. Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. J Neurosci 18: 2933-2943.
    • (1998) J Neurosci , vol.18 , pp. 2933-2943
    • Crowder, R.J.1    Freeman, R.S.2
  • 13
    • 0030929913 scopus 로고    scopus 로고
    • Select alterations in protein kinases and phosphatases during apoptosis of differentiated PC12 cells
    • Davis PK, Dudek SM, Johnson GV. 1997. Select alterations in protein kinases and phosphatases during apoptosis of differentiated PC12 cells. J Neurochem 68: 2338-2347.
    • (1997) J Neurochem , vol.68 , pp. 2338-2347
    • Davis, P.K.1    Dudek, S.M.2    Johnson, G.V.3
  • 14
    • 0033606960 scopus 로고    scopus 로고
    • Caspase-induced proteolysis of the cyclin-dependent kinase inhibitor p27Kip1 mediates its anti-apoptotic activity
    • Eymin B, Sordet O, Droin N, Munsch B, Haugg M, Van de Craen M, Vandenabeele P, Solary E. 1999. Caspase-induced proteolysis of the cyclin-dependent kinase inhibitor p27Kip1 mediates its anti-apoptotic activity. Oncogene 18: 4839-4847.
    • (1999) Oncogene , vol.18 , pp. 4839-4847
    • Eymin, B.1    Sordet, O.2    Droin, N.3    Munsch, B.4    Haugg, M.5    Van de Craen, M.6    Vandenabeele, P.7    Solary, E.8
  • 15
    • 0029972440 scopus 로고    scopus 로고
    • Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support
    • Farinelli SE, Greene LA. 1996. Cell cycle blockers mimosine, ciclopirox, and deferoxamine prevent the death of PC12 cells and postmitotic sympathetic neurons after removal of trophic support. J Neurosci 16: 1150-1162.
    • (1996) J Neurosci , vol.16 , pp. 1150-1162
    • Farinelli, S.E.1    Greene, L.A.2
  • 16
    • 0028607141 scopus 로고
    • Proliferative inhibition by dominant-negative Ras rescues naive and neuronally differentiated PC12 cells from apoptotic death
    • Ferrari G, Greene LA. 1994. Proliferative inhibition by dominant-negative Ras rescues naive and neuronally differentiated PC12 cells from apoptotic death. EMBO J 13: 5922-5928.
    • (1994) EMBO J , vol.13 , pp. 5922-5928
    • Ferrari, G.1    Greene, L.A.2
  • 17
    • 0028324310 scopus 로고
    • Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of Cyclin D1 during programmed cell death
    • Freeman RS, Estus S, Johnson EMJr. 1994. Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of Cyclin D1 during programmed cell death. Neuron 12: 343-355.
    • (1994) Neuron , vol.12 , pp. 343-355
    • Freeman, R.S.1    Estus, S.2    Johnson Jr, E.M.3
  • 18
    • 0037047268 scopus 로고    scopus 로고
    • Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization
    • Fujita N, Sato S, Katayama K, Tsuruo T. 2002. Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. J Biol Chem 277: 28706-28713.
    • (2002) J Biol Chem , vol.277 , pp. 28706-28713
    • Fujita, N.1    Sato, S.2    Katayama, K.3    Tsuruo, T.4
  • 19
    • 0036550271 scopus 로고    scopus 로고
    • Kainate receptor-mediated apoptosis in primary cultures of cerebellar granule cells is attenuated by mitogen-activated protein and cyclin-dependent kinase inhibitors
    • Giardina SF, Beart PM. 2002. Kainate receptor-mediated apoptosis in primary cultures of cerebellar granule cells is attenuated by mitogen-activated protein and cyclin-dependent kinase inhibitors. Br J Pharmacol 135: 1733-1742.
    • (2002) Br J Pharmacol , vol.135 , pp. 1733-1742
    • Giardina, S.F.1    Beart, P.M.2
  • 20
    • 0033516567 scopus 로고    scopus 로고
    • Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F × DP, in β-amyloid-induced neuronal death
    • Giovanni A, Wirtz-Brugger F, Keramaris E, Slack R, Park DS. 1999. Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F × DP, in β-amyloid-induced neuronal death. J Biol Chem 274: 19011-19016.
    • (1999) J Biol Chem , vol.274 , pp. 19011-19016
    • Giovanni, A.1    Wirtz-Brugger, F.2    Keramaris, E.3    Slack, R.4    Park, D.S.5
  • 21
    • 0018085012 scopus 로고
    • Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium
    • Greene LA. 1978. Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium. J Cell Biol 78: 747-55.
    • (1978) J Cell Biol , vol.78 , pp. 747-755
    • Greene, L.A.1
  • 22
    • 0345704610 scopus 로고
    • Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor
    • Greene LA, Tischler AS. 1976. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci U S A 73: 2424-2428.
    • (1976) Proc Natl Acad Sci U S A , vol.73 , pp. 2424-2428
    • Greene, L.A.1    Tischler, A.S.2
  • 23
    • 0026468503 scopus 로고
    • Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation
    • Hempstead BL, Rabin SJ, Kaplan L, Reid S, Parada LF, Kaplan DR. 1992. Overexpression of the trk tyrosine kinase rapidly accelerates nerve growth factor-induced differentiation. Neuron 9: 883-896.
    • (1992) Neuron , vol.9 , pp. 883-896
    • Hempstead, B.L.1    Rabin, S.J.2    Kaplan, L.3    Reid, S.4    Parada, L.F.5    Kaplan, D.R.6
  • 24
    • 34247508686 scopus 로고    scopus 로고
    • Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?
    • Herrup K, Yang Y. 2007. Cell cycle regulation in the postmitotic neuron: oxymoron or new biology? Nat Rev Neurosci 8: 368-378.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 368-378
    • Herrup, K.1    Yang, Y.2
  • 25
    • 0037073753 scopus 로고    scopus 로고
    • Activation of the Rb/E2F1 pathway by the nonproliferative p38 MAPK during Fas (APO1/CD95)-mediated neuronal apoptosis
    • Hou ST, Xie X, Baggley A, Park DS, Chen G, Walker T. 2002. Activation of the Rb/E2F1 pathway by the nonproliferative p38 MAPK during Fas (APO1/CD95)-mediated neuronal apoptosis. J Biol Chem 277: 48764-48770.
    • (2002) J Biol Chem , vol.277 , pp. 48764-48770
    • Hou, S.T.1    Xie, X.2    Baggley, A.3    Park, D.S.4    Chen, G.5    Walker, T.6
  • 26
    • 13244249527 scopus 로고    scopus 로고
    • Why do neurons enter the cell cycle?
    • Kruman II. 2004. Why do neurons enter the cell cycle? Cell Cycle 3: 769-773.
    • (2004) Cell Cycle , vol.3 , pp. 769-773
    • Kruman, I.I.1
  • 28
    • 0032937879 scopus 로고    scopus 로고
    • Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death
    • Le-Niculescu H, Bonfoco E, Kasuya Y, Claret FX, Green DR, Karin M. 1999. Withdrawal of survival factors results in activation of the JNK pathway in neuronal cells leading to Fas ligand induction and cell death. Mol Cell Biol 19: 751-763.
    • (1999) Mol Cell Biol , vol.19 , pp. 751-763
    • Le-Niculescu, H.1    Bonfoco, E.2    Kasuya, Y.3    Claret, F.X.4    Green, D.R.5    Karin, M.6
  • 29
    • 0000203009 scopus 로고
    • Effects of mouse tumor transplantation on the nervous system
    • Levi-Montalcini R. 1952. Effects of mouse tumor transplantation on the nervous system. Ann N Y Acad Sci 55: 330-344.
    • (1952) Ann N Y Acad Sci , vol.55 , pp. 330-344
    • Levi-Montalcini, R.1
  • 30
    • 33750347347 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
    • Lin MT, Beal MF. 2006. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443: 787-795.
    • (2006) Nature , vol.443 , pp. 787-795
    • Lin, M.T.1    Beal, M.F.2
  • 31
    • 28444496362 scopus 로고    scopus 로고
    • Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in Drosophila
    • Mandal S, Guptan P, Owusu-Ansah E, Banerjee U. 2005. Mitochondrial regulation of cell cycle progression during development as revealed by the tenured mutation in Drosophila. Dev Cell 9: 843-854.
    • (2005) Dev Cell , vol.9 , pp. 843-854
    • Mandal, S.1    Guptan, P.2    Owusu-Ansah, E.3    Banerjee, U.4
  • 32
    • 0032692497 scopus 로고    scopus 로고
    • CEP-1347 (KT7515), an inhibitor of JNK activation, rescues sympathetic neurons and neuronally differentiated PC12 cells from death evoked by three distinct insults
    • Maroney AC, Finn JP, Bozyczko-Coyne D, O'Kane TM, Neff NT, Tolkovsky AM, Park DS, Yan CY, Troy CM, Greene LA. 1999. CEP-1347 (KT7515), an inhibitor of JNK activation, rescues sympathetic neurons and neuronally differentiated PC12 cells from death evoked by three distinct insults. J Neurochem 73: 1901-1912.
    • (1999) J Neurochem , vol.73 , pp. 1901-1912
    • Maroney, A.C.1    Finn, J.P.2    Bozyczko-Coyne, D.3    O'Kane, T.M.4    Neff, N.T.5    Tolkovsky, A.M.6    Park, D.S.7    Yan, C.Y.8    Troy, C.M.9    Greene, L.A.10
  • 33
    • 0034329742 scopus 로고    scopus 로고
    • Apoptosis in neurodegenerative disorders
    • Mattson MP. 2000. Apoptosis in neurodegenerative disorders. Nat Rev Mol Cell Biol 1: 120-129.
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 120-129
    • Mattson, M.P.1
  • 34
    • 0027071804 scopus 로고
    • Nerve growth factor withdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons
    • Mesner PW, Winters TR, Green SH. 1992. Nerve growth factor withdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons. J Cell Biol 119: 1669-1680.
    • (1992) J Cell Biol , vol.119 , pp. 1669-1680
    • Mesner, P.W.1    Winters, T.R.2    Green, S.H.3
  • 35
    • 0032578510 scopus 로고    scopus 로고
    • Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity
    • Murray B, Alessandrini A, Cole AJ, Yee AG, Furshpan EJ. 1998. Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity. Proc Natl Acad Sci U S A 95: 11975-11980.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 11975-11980
    • Murray, B.1    Alessandrini, A.2    Cole, A.J.3    Yee, A.G.4    Furshpan, E.J.5
  • 36
    • 0033570320 scopus 로고    scopus 로고
    • Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis
    • Padmanabhan J, Park DS, Greene LA, Shelanski ML. 1999. Role of cell cycle regulatory proteins in cerebellar granule neuron apoptosis. J Neurosci 19: 8747-8756.
    • (1999) J Neurosci , vol.19 , pp. 8747-8756
    • Padmanabhan, J.1    Park, D.S.2    Greene, L.A.3    Shelanski, M.L.4
  • 37
    • 0029913242 scopus 로고    scopus 로고
    • Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons
    • Park DS, Farinelli SE, Greene LA. 1996. Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons. J Biol Chem 271: 8161-8169.
    • (1996) J Biol Chem , vol.271 , pp. 8161-8169
    • Park, D.S.1    Farinelli, S.E.2    Greene, L.A.3
  • 38
    • 0030694346 scopus 로고    scopus 로고
    • Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons
    • Park DS, Levine B, Ferrari G, Greene LA. 1997a. Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons. J Neurosci 17: 8975-8983.
    • (1997) J Neurosci , vol.17 , pp. 8975-8983
    • Park, D.S.1    Levine, B.2    Ferrari, G.3    Greene, L.A.4
  • 39
    • 0031016498 scopus 로고    scopus 로고
    • G1/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis
    • Park DS, Morris EJ, Greene LA, Geller HM. 1997b. G1/S cell cycle blockers and inhibitors of cyclin-dependent kinases suppress camptothecin-induced neuronal apoptosis. J Neurosci 17: 1256-1270.
    • (1997) J Neurosci , vol.17 , pp. 1256-1270
    • Park, D.S.1    Morris, E.J.2    Greene, L.A.3    Geller, H.M.4
  • 41
    • 0033636761 scopus 로고    scopus 로고
    • Cell cycle regulators in neuronal death evoked by excitotoxic stress: implications for neurodegeneration and its treatment
    • Park DS, Obeidat A, Giovanni A, Greene LA. 2000. Cell cycle regulators in neuronal death evoked by excitotoxic stress: implications for neurodegeneration and its treatment. Neurobiol Aging 21: 771-781.
    • (2000) Neurobiol Aging , vol.21 , pp. 771-781
    • Park, D.S.1    Obeidat, A.2    Giovanni, A.3    Greene, L.A.4
  • 42
    • 0034723251 scopus 로고    scopus 로고
    • Selenite inhibits the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) through a thiol redox mechanism
    • Park HS, Park E, Kim MS, Ahn K, Kim IY, Choi EJ. 2000. Selenite inhibits the c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) through a thiol redox mechanism. J Biol Chem 275: 2527-2531.
    • (2000) J Biol Chem , vol.275 , pp. 2527-2531
    • Park, H.S.1    Park, E.2    Kim, M.S.3    Ahn, K.4    Kim, I.Y.5    Choi, E.J.6
  • 43
    • 7244243873 scopus 로고    scopus 로고
    • Regulation of Cu/Zn-superoxide dismutase expression via the phosphatidylinositol 3 kinase/Akt pathway and nuclear factor-kappaB
    • Rojo AI, Salinas M, Martin D, Perona R, Cuadrado A. 2004. Regulation of Cu/Zn-superoxide dismutase expression via the phosphatidylinositol 3 kinase/Akt pathway and nuclear factor-kappaB. J Neurosci 24: 7324-7334.
    • (2004) J Neurosci , vol.24 , pp. 7324-7334
    • Rojo, A.I.1    Salinas, M.2    Martin, D.3    Perona, R.4    Cuadrado, A.5
  • 44
    • 0024465402 scopus 로고
    • Cell cycle-specific action of nerve growth factor in PC12 cells: differentiation without proliferation
    • Rudkin BB, Lazarovici P, Levi BZ, Abe Y, Fujita K, Guroff G. 1989. Cell cycle-specific action of nerve growth factor in PC12 cells: differentiation without proliferation. EMBO J 8: 3319-3325.
    • (1989) EMBO J , vol.8 , pp. 3319-3325
    • Rudkin, B.B.1    Lazarovici, P.2    Levi, B.Z.3    Abe, Y.4    Fujita, K.5    Guroff, G.6
  • 46
    • 0034648063 scopus 로고    scopus 로고
    • Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons
    • Satoh T, Nakatsuka D, Watanabe Y, Nagata I, Kikuchi H, Namura S. 2000. Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons. Neurosci Lett 288: 163-166.
    • (2000) Neurosci Lett , vol.288 , pp. 163-166
    • Satoh, T.1    Nakatsuka, D.2    Watanabe, Y.3    Nagata, I.4    Kikuchi, H.5    Namura, S.6
  • 47
    • 0035055595 scopus 로고    scopus 로고
    • Mechanisms of action of flavopiridol
    • Sedlacek HH. 2001. Mechanisms of action of flavopiridol. Crit Rev Oncol Hematol 38: 139-170.
    • (2001) Crit Rev Oncol Hematol , vol.38 , pp. 139-170
    • Sedlacek, H.H.1
  • 50
    • 42449139803 scopus 로고    scopus 로고
    • Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells
    • Takada Y, Sethi G, Sung B, Aggarwal BB. 2008. Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells. Mol Pharmacol 73: 1549-1557.
    • (2008) Mol Pharmacol , vol.73 , pp. 1549-1557
    • Takada, Y.1    Sethi, G.2    Sung, B.3    Aggarwal, B.B.4
  • 52
    • 77953622082 scopus 로고    scopus 로고
    • Cyclin-C-dependent cell-cycle entry is required for activation of non-homologous end joining DNA repair in postmitotic neurons
    • Tomashevski A, Webster DR, Grammas P, Gorospe M, Kruman II. 2010. Cyclin-C-dependent cell-cycle entry is required for activation of non-homologous end joining DNA repair in postmitotic neurons. Cell Death Differ 17: 1189-1198.
    • (2010) Cell Death Differ , vol.17 , pp. 1189-1198
    • Tomashevski, A.1    Webster, D.R.2    Grammas, P.3    Gorospe, M.4    Kruman, I.I.5
  • 53
    • 1642538995 scopus 로고    scopus 로고
    • Inhibition of cell cycle pathway by flavopiridol promotes survival of cerebellar granule cells after an excitotoxic treatment
    • Verdaguer E, Jimenez A, Canudas AM, Jorda EG, Sureda FX, Pallas M, Camins A. 2004. Inhibition of cell cycle pathway by flavopiridol promotes survival of cerebellar granule cells after an excitotoxic treatment. J Pharmacol Exp Ther 308: 609-616.
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 609-616
    • Verdaguer, E.1    Jimenez, A.2    Canudas, A.M.3    Jorda, E.G.4    Sureda, F.X.5    Pallas, M.6    Camins, A.7
  • 54
    • 0031890109 scopus 로고    scopus 로고
    • Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: time course and modification by (-)-deprenyl
    • Wadia JS, Chalmers-Redman RM, Ju WJ, Carlile GW, Phillips JL, Fraser AD, Tatton WG. 1998. Mitochondrial membrane potential and nuclear changes in apoptosis caused by serum and nerve growth factor withdrawal: time course and modification by (-)-deprenyl. J Neurosci 18: 932-947.
    • (1998) J Neurosci , vol.18 , pp. 932-947
    • Wadia, J.S.1    Chalmers-Redman, R.M.2    Ju, W.J.3    Carlile, G.W.4    Phillips, J.L.5    Fraser, A.D.6    Tatton, W.G.7
  • 55
    • 0141726829 scopus 로고    scopus 로고
    • The concerted signaling of ERK1/2 and JNKs is essential for PC12 cell neuritogenesis and converges at the level of target proteins
    • Waetzig V, Herdegen T. 2003a. The concerted signaling of ERK1/2 and JNKs is essential for PC12 cell neuritogenesis and converges at the level of target proteins. Mol Cell Neurosci 24: 238-249.
    • (2003) Mol Cell Neurosci , vol.24 , pp. 238-249
    • Waetzig, V.1    Herdegen, T.2
  • 56
    • 0037414797 scopus 로고    scopus 로고
    • A single c-Jun N-terminal kinase isoform (JNK3-p54) is an effector in both neuronal differentiation and cell death
    • Waetzig V, Herdegen T. 2003b. A single c-Jun N-terminal kinase isoform (JNK3-p54) is an effector in both neuronal differentiation and cell death. J Biol Chem 278: 567-572.
    • (2003) J Biol Chem , vol.278 , pp. 567-572
    • Waetzig, V.1    Herdegen, T.2
  • 57
    • 0032527705 scopus 로고    scopus 로고
    • The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival
    • Wang X, Martindale JL, Liu Y, Holbrook NJ. 1998. The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem J 333: 291-300.
    • (1998) Biochem J , vol.333 , pp. 291-300
    • Wang, X.1    Martindale, J.L.2    Liu, Y.3    Holbrook, N.J.4
  • 58
    • 24044481621 scopus 로고    scopus 로고
    • Cell-cycle regulators are involved in transient cerebral ischemia induced neuronal apoptosis in female rats
    • Wen Y, Yang S, Liu R, Simpkins JW. 2005. Cell-cycle regulators are involved in transient cerebral ischemia induced neuronal apoptosis in female rats. FEBS Lett 579: 4591-4599.
    • (2005) FEBS Lett , vol.579 , pp. 4591-4599
    • Wen, Y.1    Yang, S.2    Liu, R.3    Simpkins, J.W.4
  • 59
  • 60
    • 0036371199 scopus 로고    scopus 로고
    • Selenite suppresses hydrogen peroxide-induced cell apoptosis through inhibition of ASK1/JNK and activation of PI3-K/Akt pathways
    • Yoon SO, Kim MM, Park SJ, Kim D, Chung J, Chung AS. 2002. Selenite suppresses hydrogen peroxide-induced cell apoptosis through inhibition of ASK1/JNK and activation of PI3-K/Akt pathways. FASEB J 16: 111-113.
    • (2002) FASEB J , vol.16 , pp. 111-113
    • Yoon, S.O.1    Kim, M.M.2    Park, S.J.3    Kim, D.4    Chung, J.5    Chung, A.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.