Cell-cycle regulators are involved in transient cerebral ischemia induced neuronal apoptosis in female rats

FEBS Letters

Volumn 579, Issue 21, 2005, Pages 4591-4599

  Wen, Yi ^a   Yang, Shaohua ^a   Liu, Ran ^a   Simpkins, James W ^a  

^a UNIVERSITY OF NORTH TEXAS   (United States)

Author keywords

Cdk 4 and BrdU; Cell cycle; Cyclin D1; Ischemia; Proliferating cell nuclear antigen; Retinoblastoma protein; Stroke

Indexed keywords

BROXURIDINE; CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLINE; DNA; RETINOBLASTOMA PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INJURY; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; FRONTAL CORTEX; MIDDLE CEREBRAL ARTERY OCCLUSION; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PARIETAL LOBE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; RAT; REGULATORY MECHANISM; REPERFUSION; SIGNAL TRANSDUCTION; TRANSIENT ISCHEMIC ATTACK; UPREGULATION;

ANIMALS; APOPTOSIS; BROMODEOXYURIDINE; CELL CYCLE; CELL CYCLE PROTEINS; ENZYME INHIBITORS; FEMALE; IN SITU NICK-END LABELING; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIC ATTACK, TRANSIENT; NEURONS; NEUROPROTECTIVE AGENTS; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; RETINOBLASTOMA PROTEIN;

EID: 24044481621     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2005.07.028     Document Type: Article

References (51)

1. M.D. Nguyen Cell cycle regulators in the neuronal death pathway of amyotrophic lateral sclerosis caused by mutant superoxide dismutase 1 J. Neurosci. 23 6 2003 2131 2140
2. I. Vincent, M. Rosado, and P. Davies Mitotic mechanisms in Alzheimer's disease? J. Cell. Biol. 132 3 1996 413 425
3. J.W. Husseman, D. Nochlin, and I. Vincent Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases Neurobiol. Aging 21 6 2000 815 828
4. O. Kranenburg, A.J. van der Eb, and A. Zantema Cyclin D1 is an essential mediator of apoptotic neuronal cell death Embo J. 15 1 1996 46 54
5. S. Timsit Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: a modulator of in vivo programmed cell death Eur. J. Neurosci. 11 1 1999 263 278
6. D.S. Park, S.E. Farinelli, and L.A. Greene Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons J. Biol. Chem. 271 14 1996 8161 8169
7. K. Johnson Inhibition of neuronal apoptosis by the cyclin-dependent kinase inhibitor GW8510: identification of 3′ substituted indolones as a scaffold for the development of neuroprotective drugs J. Neurochem. 93 3 2005 538 548
8. C.J. Sherr D-type cyclins Trends Biochem. Sci. 20 5 1995 187 190
9. J.Y. Wang, E.S. Knudsen, and P.J. Welch The retinoblastoma tumor suppressor protein Adv. Cancer Res. 64 1994 25 85
10. R.A. Weinberg The retinoblastoma protein and cell cycle control Cell 81 3 1995 323 330
11. E.Z. Longa Reversible middle cerebral artery occlusion without craniectomy in rats Stroke 20 1 1989 84 91
12. S.A. Menzies, J.T. Hoff, and A.L. Betz Middle cerebral artery occlusion in rats: a neurological and pathological evaluation of a reproducible model Neurosurgery 31 1 1992 100 106 Discussion 106-7
13. U. Dirnagl, C. Iadecola, and M.A. Moskowitz Pathobiology of ischaemic stroke: an integrated view Trends Neurosci. 22 9 1999 391 397
14. E.H. Lo, T. Dalkara, and M.A. Moskowitz Mechanisms, challenges and opportunities in stroke Nat. Rev. Neurosci. 4 5 2003 399 415
15. Z. Zheng, J.E. Lee, and M.A. Yenari Stroke: molecular mechanisms and potential targets for treatment Curr. Mol. Med. 3 4 2003 361 372
16. J.J. Velier Caspase-8 and caspase-3 are expressed by different populations of cortical neurons undergoing delayed cell death after focal stroke in the rat J. Neurosci. 19 14 1999 5932 5941
17. V.V. Didenko Caspase-3-dependent and -independent apoptosis in focal brain ischemia Mol. Med. 8 7 2002 347 352
18. K. Jin Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat Proc. Natl. Acad. Sci. USA 98 8 2001 4710 4715
19. W. Gu, T. Brannstrom, and P. Wester Cortical neurogenesis in adult rats after reversible photothrombotic stroke J. Cereb. Blood Flow Metab. 20 8 2000 1166 1173
20. J.W. Simpkins Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat J. Neurosurg. 87 5 1997 724 730
21. G. Paxinos Bregma, lambda and the interaural midpoint in stereotaxic surgery with rats of different sex, strain and weight J. Neurosci. Meth. 13 2 1985 139 143
22. Y. Gavrieli, Y. Sherman, and S.A. Ben-Sasson Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation J. Cell. Biol. 119 3 1992 493 501
23. Y. Wen Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats J. Biol. Chem. 279 21 2004 22684 22692
24. J.B. Bederson Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination Stroke 17 3 1986 472 476
25. Y. Wen Estrogen attenuates nuclear factor-kappa B activation induced by transient cerebral ischemia Brain Res. 1008 2 2004 147 154
26. D.W. Stacey Cyclin D1 serves as a cell cycle regulatory switch in actively proliferating cells Curr. Opin. Cell. Biol. 15 2 2003 158 163
27. R. Fotedar, and A. Fotedar Cell cycle control of DNA replication Prog. Cell Cycle Res. 1 1995 73 89
28. G. Zhu Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors J. Med. Chem. 46 11 2003 2027 2030
29. H. Park, M.S. Yeom, and S. Lee Loop flexibility and solvent dynamics as determinants for the selective inhibition of cyclin-dependent kinase 4: comparative molecular dynamics simulation studies of CDK2 and CDK4 Chembiochem 5 12 2004 1662 1672
30. T. Arendt Expression of the cyclin-dependent kinase inhibitor p16 in Alzheimer's disease Neuroreport 7 18 1996 3047 3049
31. T. Arendt, M. Holzer, and U. Gartner Neuronal expression of cycline dependent kinase inhibitors of the INK4 family in Alzheimer's disease J. Neural Transm. 105 8-9 1998 949 960
32. R. Bowser, and M.A. Smith Cell cycle proteins in Alzheimer's disease: plenty of wheels but no cycle J. Alzheimers Dis. 4 3 2002 249 254
33. E.Y. Lee Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation Genes Dev. 8 17 1994 2008 2021
34. M.R. al-Ubaidi Bilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoter J. Cell. Biol. 119 6 1992 1681 1687
35. R.M. Feddersen Disrupted cerebellar cortical development and progressive degeneration of Purkinje cells in SV40 T antigen transgenic mice Neuron 9 5 1992 955 966
36. D.S. Park Cyclin dependent kinase inhibitors and dominant negative cyclin dependent kinase 4 and 6 promote survival of NGF-deprived sympathetic neurons J. Neurosci. 17 23 1997 8975 8983
37. D.S. Park Cell cycle regulators in neuronal death evoked by excitotoxic stress: implications for neurodegeneration and its treatment Neurobiol. Aging 21 6 2000 771 781
38. A. Giovanni Involvement of cell cycle elements, cyclin-dependent kinases, pRb, and E2F x DP, in B-amyloid-induced neuronal death J. Biol. Chem. 274 27 1999 19011 19016
39. A. Giovanni E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3 J. Biol. Chem. 275 16 2000 11553 11560
40. A. Copani Mitotic signaling by beta-amyloid causes neuronal death Faseb J. 13 15 1999 2225 2234
41. J. Katchanov Mild cerebral ischemia induces loss of cyclin-dependent kinase inhibitors and activation of cell cycle machinery before delayed neuronal cell death J. Neurosci. 21 14 2001 5045 5053
42. Z. Nagy Cell cycle markers in the hippocampus in Alzheimer's disease Acta Neuropathol. (Berl.) 94 1 1997 6 15
43. Z. Nagy, M.M. Esiri, and A.D. Smith The cell division cycle and the pathophysiology of Alzheimer's disease Neuroscience 87 4 1998 731 739
44. J. Busser, D.S. Geldmacher, and K. Herrup Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer's disease brain J. Neurosci. 18 8 1998 2801 2807
45. H. Osuga Cyclin-dependent kinases as a therapeutic target for stroke Proc. Natl. Acad. Sci. USA 97 18 2000 10254 10259
46. F. Wang Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat J. Cereb. Blood Flow Metab. 22 2 2002 171 182
47. Y. Yang, D.S. Geldmacher, and K. Herrup DNA replication precedes neuronal cell death in Alzheimer's disease J. Neurosci. 21 8 2001 2661 2668
48. G. Battaglia Neurogenesis in cerebral heterotopia induced in rats by prenatal methylazoxymethanol treatment Cereb. Cortex 13 7 2003 736 748
49. C.M. Cooper-Kuhn, and H.G. Kuhn Is it all DNA repair? Methodological considerations for detecting neurogenesis in the adult brain Brain Res. Dev. Brain Res. 134 1-2 2002 13 21
50. A. Arvidsson, Z. Kokaia, and O. Lindvall N-methyl-d-aspartate receptor-mediated increase of neurogenesis in adult rat dentate gyrus following stroke Eur. J. Neurosci. 14 1 2001 10 18
51. E.A. Monaco III, and M.L. Vallano Cyclin-dependent kinase inhibitors: cancer killers to neuronal guardians Curr. Med. Chem. 10 5 2003 367 379