Accumulation of DNA damage and cell death after fractionated irradiation

Radiation Research

Volumn 175, Issue 6, 2011, Pages 708-718

  Řezáčova, Martina ^a   Rudolfová, Gabriela ^a   Tichý, Aleś ^a,b   Bač Ková, Alena ^c   Mutná, Darina ^a   Havelek, Radim ^a   Vávrová, Jiřina ^b   Odrážka, Karel ^d   Lukášová, Emilie ^c   Kozubek, Stanislav ^c  

^a CHARLES UNIVERSITY   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

^c INSTITUTE OF BIOPHYSICS   (Czech Republic)

^d Pardubice Regional Hospital   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

CHECKPOINT KINASE 1; CYCLIN B1; HISTONE H2AX; PROTEIN P53;

APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER RADIOTHERAPY; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL DEATH; CELL GROWTH; CELL ISOLATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOUBLE STRANDED DNA BREAK; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; LYMPHATIC LEUKEMIA; LYMPHOCYTE; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; SENESCENCE; SKIN FIBROBLAST;

APOPTOSIS; CELL AGING; CELL PROLIFERATION; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DOSE FRACTIONATION; FIBROBLASTS; HUMANS; LEUKEMIA, LYMPHOID; LYMPHOCYTES; TUMOR CELLS, CULTURED;

EID: 79957619987     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RR2478.1     Document Type: Article

References (52)

1. M. Baumann and C. Petersen, TaCP and NTCP: a basic introduction. Rays 30, 99-104 (2005).
2. H. R. Withers and H. D. Thames, Dose fractionation and volume effects in normal tissues and tumors. Am. J. Clin. Oncol. 11, 313-329 (1988).
3. J. Chen, J. van de Gein and T. Goffman, Extra lethal damage due to residual incompletely repaired sublethal damage in hyperfractionated and continuous radiation treatment. Med. Phys. 18, 488-496 (1991).
4. J. Y. Ostashevsky, Cell recovery kinetics for split-dose, multifractionated and continuous irradiation in the DSB model. Int. J. Radiat. Biol. 63, 47-58 (1993). (Pubitemid 23025130)
5. B. A. Rupnow, A. D. Murtha, M. A. Alarcon, A. J. Giaccia and S. J. Knox, Direct evidence that apoptosis enhances tumor responses to fractionated radiotherapy. Cancer Res. 58, 1779-1784 (1998). (Pubitemid 28217445)
6. J. D. Down, A. Boudewijn, R. van Os, H. D. Thames and R. E. Ploemacher, Variations in radiation sensitivity and repair among different hematopoietic stem cells subsets following fractionated irradiation. Blood 86, 122-127 (1995).
7. S. S. Qutob, A. S. Multanio, S. Pathak, J. P. McNamee, P. V. Bellier, Q. Y. Liu and C. E. Ng, Fractionated Xradiation treatment can elicit an inducible-like radioprotective response that is not dependent on the intrinsic cellular X-radiation resistance/sensitivity. Radiat. Res. 166, 590-599 (2006). (Pubitemid 44477712)
8. K. K. Ang, H. D. Thames Jr., A. J. van der Kogel and E. van der Schueren, Is the rate of repair of radiation-induced sublethal damage in rat spinal cord dependent on the size of dose per fraction? Int. J. Radiat. Oncol. Biol. Phys. 13, 557-562 (1987). (Pubitemid 17069651)
9. I. Pogribny, I. Koturbash, V. Tryndyak, D. Hudson, S. M. Stevenson, O. Sedelnikova, W. Bonner and O. Kovalchuk, Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus. Mol. Cancer Res. 3, 553-561 (2005). (Pubitemid 41567274)
10. C. E. Rube, A. Fricke, J. Wendorf, A. Stutzel, M. Kuhne, M. F. Ong, P. Lipp and C. Rube, Accumulation of double-strand breaks in normal tissues after fractionated irradiation. Int. J. Radiat. Oncol. Biol. Phys. 76, 1206-1213 (2010).
11. M. A. Kuefner, S. Grudzenski, S. A. Schwab, M. Wiederseiner, M. Heckmann, W. Bautz, M. Lobrich and M. Uder, DNA double-strand breaks and their repair in blood lymphocytes of patients undergoing angiographic procedures. Invest. Radiol. 44, 440-446 (2009).
12. C. J. Bakkenist and M. B. Kastan, DNA damage activities ATM through intermolecular autophosphorylation and dimmer association. Nature 421, 499-506 (2003). (Pubitemid 36168436)
13. J. Bartek and J. Lukas, Damage alert. Nature 421, 486-488 (2003).
14. H. Hoeijmakers, Genome maintenance mechanisms for preventing cancer. Nature 411, 366-374 (2001).
15. Y. Shiloh, ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer 3, 155-168 (2003). (Pubitemid 37328868)
16. P. Rogakou, C. Bonn, C. Redon and W. M. Bonner, Megabase chromatin domains involved in DNA double-strand breaks in vivo. J. Cell Biol. 146, 458-462 (1999).
17. O. Fernandez-Capetillo, A. Lee, M. Nussenzweig and A. Nussenzweig, H2AX: the histone guardian of the genome. DNA Repair 3, 959-967 (2004). (Pubitemid 38997938)
18. C. Lukas, J. Falck, J. Bartkova, J. Bartek and J. Lukas, Distinct spatiotemporal dynamics of mammalian Checkpoint regulators induced by DNA damage. Nat. Cell Biol. 5, 255-260 (2003). (Pubitemid 36322254)
19. C. Lukas, F. Melander, M. Stuck, J. Falck, S. Bekker-Jensen, M. Goldberg, Y. Lerenthal, P. S. Jackson, J. Bartek and J. Lukas, MDC1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J. 23, 2674-2683 (2004). (Pubitemid 38988238)
20. N. Mailand, S. Bekker-Jensen, H. Faustrup, F. Melander, J. Bartek, C. Lukas and J. Lukas, RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell 131, 1-14 (2008).
21. A. T. Noon, A. Shibata, N. Rief, M. Lobrich, G. S. Steward, P. A. Jeggo and A. A. Goodarzi, 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nat. Cell Biol. 12, 177-184 (2010).
22. A. Goodarzi, P. Jeggo and M. Lobrich, The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax. DNA Repair 9, 1273-1282 (2010).
23. S. V. Costes, I. Chiolo, J. M. Pluth, M. H. Barcellos-Hoff and B. Jakob, Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization. Mutat. Res. 704, 78-87 (2010).
24. S. Bekker-Jensen, C. Lukas, R. Kitagawa, F. Melander, M. B. Kastan, J. Bartek and J. Lukas, Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J. Cell Biol. 173, 195-206 (2006).
25. J. Bakkenist and M. B. Kastan, Initiating cellular stress responses. Cell 118, 9-17 (2004). (Pubitemid 38902810)
26. J. Lukas and J. Bartek, Cell division: the heart of the cycle. Nature 432, 564-567 (2004).
27. H. Chehab, A. Malikzay, E. S. Stavridi and T. D. Halozonetis, Phosphorylation of serine 20 mediates stabilization of human p53 in response to DNA damage. Proc. Natl. Acad. Sci. USA 96, 13777-13782 (1999).
28. S. J. Kuerbitz, B. S. Plunkett, W. V. Walsh and M. B. Kastan, Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl. Acad. Sci. USA 89, 7491-7495 (1992).
29. R. G. Syljuasen, S. Bekker-Jensen, J. Bartek and J. Lukas, Adaptation to ionizing radiation-induced G2 checkpoint occurs in human cells and depends on checkpoint kinase 1 and Polo-like kinase 1. Cancer Res. 66, 10253-10257 (2006). (Pubitemid 44799740)
30. P. Toczyski, D. J. Galgoczy and L. H. Hartwell, CDC5 and ChII control adaptation to the yeast DNA damage checkpoint. Cell 90, 1097-1106 (1997). (Pubitemid 27408523)
31. J. Bartek and J. Lukas, DNA damage checkpoints: from initiation to recovery or adaptation. Curr. Opinion Cell Biol. 19, 238-254 (2007).
32. D. Adams, Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence. Mol. Cell 36, 2-14 (2009).
33. M. Braig and C. A. Schmitt, Oncogene-induced senescence: Putting the breaks on tumor development. Cancer Res. 66, 2881-2884 (2006).
34. M. Falk, E. Lukásová, B. Gabrielová, V. Ondr?ej and S. Kozubek, Chromatin dynamics during DSB repair. Biochim. Biophys. Acta 1773, 1534-1545 (2007). (Pubitemid 47498611)
35. M. Rezácová, A. Tichý, J. Vávrová, D. Vokurková and E. Lukásová, Is defect in phosphorylation of NBS1 responsible for high radiosensitivity of T-lymphocyte leukemia cells MOLT-4? Leukemia Res. 32, 1259-1267 (2008).
36. F. Debacq-Chainiaux, J. D. Erusalimskx, J. Campisi and O. Toussaint, Protocols to detect senescence-associated betagalactosidase (SA-b-gal) activity, a biomarker of senescent cells in culture and in vivo. Nat. Protocols 4, 1798-1806 (2009).
37. M. Kozubek, S. Kozubek, E. Lukásová, E. Bártová, M. Skalńková and A. Jergová, High resolution cytometry of FISH dots in interphase cell nuclei. Cytometry 36, 279-293 (1999). (Pubitemid 29344463)
38. M. Kozubek, S. Kozubek, E. Lukásová, A. Marecková, E. Bártová, M. Skalńková, Pa. Matula, Pe. Matula, P. Jersová and I. Koutná, Combined confocal and wide-field high resolution cytometry of fluorescent in situ hybridization-stained cells. Cytometry 45, 1-12 (2001). (Pubitemid 32807918)
39. T. Ozaki, M. Naka, M. Takada, M. Tada, S. Sakiyama and A. Nakagawara, Deletion of the COOH-terminal region of p73alpha enhances both its transactivation function and DNAbinding activity but inhibits induction of apoptosis in mammalian cells. Cancer Res. 59, 5902-5907 (1999). (Pubitemid 30004948)
40. J. Pines and T. Hunter, Human cyclins A and B1 are differentially located in the cell and undergo cell cycledependent nuclear transport. J. Cell Biol. 115, 1-17 (1991). (Pubitemid 21909889)
41. F. Toyoshima, T. Moriguchi, A Wada, M. Fukuda and E. Nishida, Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint. EMBO J. 17, 2728-2735 (1998). (Pubitemid 28227119)
42. M. Castedo, J-L. Perfettini, T. Roumier, A. Valent, H. Raslova, K. Yakushijin, D. Horne, J. Feunteun, G. Lenoir and G. Kroemer, Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy. Oncogene 23, 4362-4370 (2004). (Pubitemid 38850415)
43. M. Castedo, J-L. Perfettini, T. Roumier, A. Valent, H. Raslova, K. Yakushijin, D. Horne, J. Feunteun, G. Lenoir and G. Kroemer, Cell death by mitotic catastrophe: a molecular definition. Oncogene 23, 2825-2837 (2004). (Pubitemid 38638845)
44. Z. Han, W. Wei, S. Dunaway, J. W. Darnowski, P. Calabresi, J. Sedivy, E. A. Hendrickson, K. V. Balan, P. Pantazis and J. H. Wyche, Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin. J. Biol. Chem. 277, 17154-17160 (2002). (Pubitemid 34967748)
45. C. A. Schmitt, Cellular senescence and cancer treatment. Biochim. Biophys. Acta 1775, 5-20 (2007). (Pubitemid 44881196)
46. M. Dimitrijevic-Bussod, V. S. Balzaretti-Maggi and D. M. Gadbois, Extracellular matrix and radiation G1 cell cycle arrest in human fibroblasts. Cancer Res. 59, 4843-4847 (1999). (Pubitemid 29472886)
47. A. Di Leonardo, S. P. Linke, K. Clarkin and G. M. Wahl, DNA damage triggers a prolonged p53-dependent G1 arrest and longterm induction of Cip1 in normal human fibroblasts. Genes Dev. 8, 2540-2551 (1994). (Pubitemid 24347245)
48. B. Herskind, S. M. Bentzen, J. Overgaard, M. Overgaard, M. Bamberg and H. P. Rodemann, Differentiation state of skin fibroblasts cultures versus risk of subcutaneous fibrosis after radiotherapy. Radiother. Oncol. 47, 263-269 (1998). (Pubitemid 28293647)
49. L. Hakenjos, M. Bamberg and H. P. Rodemann, TGF-b1- mediated alterations of rat lung fibroblasts differentiation resulting in the radiation-induced phenotype. Int. J. Radiat. Biol. 76, 503-509 (1961).
50. P. Dumont, M. Burton, Q. M. Chen, E. S. Gonos, C. Frippiat, J. B. Mazarati, F. Eliaers, J. Remacle and O. Toussaint, Induction of replicative senescence biomarkers by sublethal oxidative stress in normal human fibroblasts. Free Radic. Biol. Med. 28, 361-373 (2000). (Pubitemid 30110651)
51. O. Toussaint, E. E. Medrano and T. von Zglinicki, Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp. Gerontol. 35, 927-945 (2000).
52. H. Jiang, H. C. Reinhardt, J. Bártková, J. Tommiska, C. Blomqvist, H. Nevanlinna, J. Bá rtek, M. B. Yaffe and M. T. Hemann, The combined status of ATM and p53 link tumor development with therapeutic response. Genes Dev. 23, 1895- 1909 (2010).