The emerging role of metabolic regulation in the functioning of Toll-like receptors and the NOD-like receptor Nlrp3

FEBS Letters

Volumn 585, Issue 11, 2011, Pages 1568-1572

  Tannahill, Gillian M ^a   O'Neill, Luke A J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Glycolysis; HIF1 ; Insulin resistance; Metabolism; TLR

Indexed keywords

CRYOPYRIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLAMMASOME; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; SUPPRESSOR OF CYTOKINE SIGNALING; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4;

CELL MATURATION; CELL PROLIFERATION; CHRONIC INFLAMMATION; CITRIC ACID CYCLE; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GLYCOLYSIS; HUMAN; HYPERGLYCEMIA; INNATE IMMUNITY; INSULIN RELEASE; INSULIN RESISTANCE; MACROPHAGE ACTIVATION; METABOLIC DISORDER; METABOLIC REGULATION; MITOCHONDRIAL RESPIRATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW;

ANIMALS; CARRIER PROTEINS; DENDRITIC CELLS; GLYCOLYSIS; HUMANS; MACROPHAGES; MYELOID CELLS; TOLL-LIKE RECEPTORS;

EID: 79957579734     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2011.05.008     Document Type: Review

References (53)

1. S. Carpenter, and L.A. O'Neill Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins Biochem. J. 422 1 2009 1 10
2. A. Dunne Inflammasome activation: from inflammatory disease to infection Biochem. Soc. Trans. 39 2 2011 669 673
3. C.M. Krawczyk Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation Blood 115 23 2010 4742 4749
4. B. Vandanmagsar The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance Nat. Med. 17 2 2011 179 188
5. J. Jantsch Hypoxia and hypoxia-inducible factor-1 alpha modulate lipopolysaccharide-induced dendritic cell activation and function J. Immunol. 180 7 2008 4697 4705
6. D.N. Kellett 2-Deoxyglucose and inflammation J. Pharm. Pharmacol. 18 3 1966 199 200
7. A. Garedew, S.O. Henderson, and S. Moncada Activated macrophages utilize glycolytic ATP to maintain mitochondrial membrane potential and prevent apoptotic cell death Cell Death Differ. 17 10 2010 1540 1550
8. A. Garedew, and S. Moncada Mitochondrial dysfunction and HIF1alpha stabilization in inflammation J. Cell. Sci. 121 Pt 20 2008 3468 3475
9. J.C. Rodriguez-Prados Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation J. Immunol. 185 1 2010 605 614
10. S.Y. Kim Hypoxic stress up-regulates the expression of Toll-like receptor 4 in macrophages via hypoxia-inducible factor Immunology 129 4 2010 516 524
11. G.L. Semenza Regulation of oxygen homeostasis by hypoxia-inducible factor 1 Physiology (Bethesda) 24 2009 97 106
12. A.C. Epstein C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation Cell 107 1 2001 43 54 (Pubitemid 32972036)
13. P.H. Maxwell The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis Nature 399 6733 1999 271 275 (Pubitemid 29246458)
14. D. Lando Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch Science 295 5556 2002 858 861 (Pubitemid 34118367)
15. K.S. Hewitson Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family J. Biol. Chem. 277 29 2002 26351 26355 (Pubitemid 34967127)
16. K.L. Covello, and M.C. Simon HIFs, hypoxia, and vascular development Curr. Top. Dev. Biol. 62 2004 37 54 (Pubitemid 39752374)
17. T. Cramer HIF-1alpha is essential for myeloid cell-mediated inflammation Cell 112 5 2003 645 657 (Pubitemid 36331777)
18. C. Peyssonnaux Cutting edge: essential role of hypoxia inducible factor-1alpha in development of lipopolysaccharide-induced sepsis J. Immunol. 178 12 2007 7516 7519 (Pubitemid 46898018)
19. S.R. Walmsley Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity J. Exp. Med. 201 1 2005 105 115 (Pubitemid 40130088)
20. S. Frede Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB Biochem. J. 396 3 2006 517 527 (Pubitemid 44228166)
21. J. Rius NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha Nature 453 7196 2008 807 811 (Pubitemid 351793778)
22. D. Pchejetski The involvement of sphingosine kinase 1 in LPS-induced Toll-like receptor 4-mediated accumulation of HIF-1alpha protein, activation of ASK1 and production of the pro-inflammatory cytokine IL-6 Immunol. Cell. Biol. 89 2 2011 268 274
23. D. Wang, D. Malo, and S. Hekimi Elevated mitochondrial reactive oxygen species generation affects the immune response via hypoxia-inducible factor-1alpha in long-lived Mclk1+/- mouse mutants J. Immunol. 184 2 2010 582 590
24. K. Nishi LPS induces hypoxia-inducible factor 1 activation in macrophage-differentiated cells in a reactive oxygen species-dependent manner Antioxid. Redox Signal. 10 5 2008 983 995 (Pubitemid 351301367)
25. H. Lu, R.A. Forbes, and A. Verma Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis J. Biol. Chem. 277 26 2002 23111 23115 (Pubitemid 34952134)
26. S.Y. Jung Pyruvate promotes tumor angiogenesis through HIF-1-dependent PAI-1 expression Int. J. Oncol. 38 2 2011 571 576
27. F. Pistollato Hypoxia and succinate antagonize 2-deoxyglucose effects on glioblastoma Biochem. Pharmacol. 80 10 2010 1517 1527
28. M. Osada-Oka Glucose is necessary for stabilization of hypoxia-inducible factor-1alpha under hypoxia: contribution of the pentose phosphate pathway to this stabilization FEBS Lett. 584 14 2010 3073 3079
29. H.Y. Fang Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia Blood 114 4 2009 844 859
30. T. Oda Activation of hypoxia-inducible factor 1 during macrophage differentiation Am. J. Physiol. Cell Physiol. 291 1 2006 C104 C113
31. T. Cramer, and R.S. Johnson A novel role for the hypoxia inducible transcription factor HIF-1alpha: critical regulation of inflammatory cell function Cell Cycle 2 3 2003 192 193
32. A.P. Hollander Expression of hypoxia-inducible factor 1alpha by macrophages in the rheumatoid synovium: implications for targeting of therapeutic genes to the inflamed joint Arthr. Rheum. 44 7 2001 1540 1544 (Pubitemid 32642216)
33. C. Peyssonnaux HIF-1alpha expression regulates the bactericidal capacity of phagocytes J. Clin. Invest. 115 7 2005 1806 1815 (Pubitemid 40979719)
34. W. Shao The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock J. Biol. Chem. 282 50 2007 36321 36329
35. L. Franchi Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages Nat. Immunol. 7 6 2006 576 582 (Pubitemid 43797338)
36. S. Schenk, M. Saberi, and J.M. Olefsky Insulin sensitivity: modulation by nutrients and inflammation J. Clin. Invest. 118 9 2008 2992 3002
37. S.E. Shoelson, L. Herrero, and A. Naaz Obesity, inflammation, and insulin resistance Gastroenterology 132 6 2007 2169 2180 (Pubitemid 46693756)
38. S.P. Weisberg Obesity is associated with macrophage accumulation in adipose tissue J. Clin. Invest. 112 12 2003 1796 1808 (Pubitemid 38063703)
39. K.E. Wellen, and G.S. Hotamisligil Inflammation, stress, and diabetes J. Clin. Invest. 115 5 2005 1111 1119 (Pubitemid 40629025)
40. G.S. Hotamisligil Inflammation and metabolic disorders Nature 444 7121 2006 860 867 (Pubitemid 46024993)
41. H. Dominguez Metabolic and vascular effects of tumor necrosis factor-alpha blockade with etanercept in obese patients with type 2 diabetes J. Vasc. Res. 42 6 2005 517 525 (Pubitemid 41527607)
42. H. Wen Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling Nat. Immunol. 12 5 2011 408 415
43. J.A. Ehses Increased number of islet-associated macrophages in type 2 diabetes Diabetes 56 9 2007 2356 2370 (Pubitemid 47358243)
44. M.R. Dasu, S. Devaraj, and I. Jialal High glucose induces IL-1beta expression in human monocytes: mechanistic insights Am. J. Physiol. Endocrinol. Metab. 293 1 2007 E337 E346
45. K. Maedler Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets J. Clin. Invest. 110 6 2002 851 860
46. N. Shanmugam High glucose-induced expression of proinflammatory cytokine and chemokine genes in monocytic cells Diabetes 52 5 2003 1256 1264 (Pubitemid 36523365)
47. K. Maedler, and M.Y. Donath Beta-cells in type 2 diabetes: a loss of function and mass Horm. Res. 62 Suppl. 3 2004 67 73
48. K. Bendtzen Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans Science 232 4757 1986 1545 1547 (Pubitemid 16061563)
49. R. Zhou Thioredoxin-interacting protein links oxidative stress to inflammasome activation Nat. Immunol. 11 2 2010 136 140
50. S.L. Masters Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes Nat. Immunol. 11 10 2010 897 904
51. T.B. Koenen Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue Diabetes 60 2 2011 517 524
52. R. Stienstra The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity Cell. Metab. 12 6 2010 593 605
53. P. Lebrun, and E. Van Obberghen SOCS proteins causing trouble in insulin action Acta Physiol. (Oxf) 192 1 2008 29 36 (Pubitemid 350265362)