Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Butturini, Elena ^a,b   Cavalieri, Elisabetta ^a   de Prati, Alessandra Carcereri ^a   Darra, Elena ^a   Rigo, Antonella ^c   Shoji, Kazuo ^a,b   Murayama, Norie ^b   Yamazaki, Hiroshi ^b   Watanabe, Yasuo ^b   Suzuki, Hisanori ^a   Mariotto, Sofia ^a  

^a UNIVERSITY OF VERONA   (Italy)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF VERONA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONYL DERIVATIVE; COSTUNOLIDE; CYSTEINE; DEHYDROCOSTUS LACTONE; GLUTATHIONE; GLUTATHIONE DERIVATIVE; GLUTATHIONE ETHYLENE ESTER; INTERLEUKIN 6; JANUS KINASE 1; JANUS KINASE 2; PROTEIN KINASE TYK2; STAT3 PROTEIN; UNCLASSIFIED DRUG; LACTONE; PRIMER DNA; REACTIVE OXYGEN METABOLITE; SESQUITERPENE;

ARTICLE; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; FEMALE; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MICHAEL ADDITION; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; OXIDATION REDUCTION REACTION; PROTEIN DNA BINDING; PROTEIN PROCESSING; PROTEIN SYNTHESIS INHIBITION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TRANSCRIPTION TERMINATION; GEL MOBILITY SHIFT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; TUMOR CELL LINE; WESTERN BLOTTING;

BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA PRIMERS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GLUTATHIONE; HUMANS; LACTONES; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; REACTIVE OXYGEN SPECIES; SESQUITERPENES; STAT3 TRANSCRIPTION FACTOR;

EID: 79956191110     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020174     Document Type: Article

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