A sesquiterpene, dehydrocostus lactone, inhibits the expression of inducible nitric oxide synthase and TNF-α in LPS-activated macrophages

Planta Medica

Volumn 65, Issue 2, 1999, Pages 104-108

  Lee, Hwa Jin ^a   Kim, Nam Yi ^a   Jang, Mi Kyung ^a   Son, Haeng Ja ^a   Kim, Kyung Mi ^b   Sohn, Dong Hwan ^b   Lee, Soo Hwan ^c   Ryu, Jae Ha ^a  

^a Sookmyung Women's University   (South Korea)

^b Wonkwang University School of Medicine   (South Korea)

^c Ajou University School of Medicine   (South Korea)

Author keywords

Compositae; Dehydrocostus lactone; Nitric oxide synthase; Saussureo lappa; Sesquiterpene lactone; Tumor necrosis factor

Indexed keywords

DEHYDROCOSTUS LACTONE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; SAUSSUREA LAPPA EXTRACT; SESQUITERPENE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME INHIBITOR INTERACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME MECHANISM; IMMUNOBLOTTING; INTRAPERITONEAL DRUG ADMINISTRATION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PLANT ROOT; PROTEIN EXPRESSION; SEPTIC SHOCK;

ANIMALS; CELL LINE; ENZYME INHIBITORS; LACTONES; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MICE; MICE, INBRED ICR; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; SESQUITERPENES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033029852     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1999-13968     Document Type: Article

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