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Volumn 6, Issue 5, 2011, Pages 533-549

Leprosy susceptibility: Genetic variations regulate innate and adaptive immunity, and disease outcome

Author keywords

autophagy; cytokines; genetics; granuloma; infectious; leprosy; lipid bodies; population; SNPs; TNF; vitamin D

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 23; LEUKOTRIENE A4 HYDROLASE; LIPOXIN A; MANNOSE RECEPTOR; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR; VITAMIN D; VITAMIN D RECEPTOR;

EID: 79956078781     PISSN: 17460913     EISSN: 17460921     Source Type: Journal    
DOI: 10.2217/fmb.11.39     Document Type: Review
Times cited : (85)

References (154)
  • 3
    • 70549103951 scopus 로고    scopus 로고
    • Comparative genomic and phylogeographic analysis of Mycobacterium leprae
    • Monot M, Honoré N, Garnier T et al.: Comparative genomic and phylogeographic analysis of Mycobacterium leprae. Nat. Genet. 41(12), 1282-1289 (2009).
    • (2009) Nat. Genet. , vol.41 , Issue.12 , pp. 1282-1289
    • Monot, M.1    Honoré, N.2    Garnier, T.3
  • 4
    • 78650491780 scopus 로고    scopus 로고
    • Mycobacterium leprae: Genes, pseudogenes and genetic diversity
    • Singh P, Cole ST: Mycobacterium leprae: Genes, pseudogenes and genetic diversity. Future Microbiol. 6(1), 57-71 (2011).
    • (2011) Future Microbiol. , vol.6 , Issue.1 , pp. 57-71
    • Singh, P.1    Cole, S.T.2
  • 5
    • 79952372516 scopus 로고    scopus 로고
    • Mycobacterium leprae - host-cell interactions and genetic determinants in leprosy: An overview
    • Pinheiro RO SJ, Sarno EM, Sampaio EP: Mycobacterium leprae - host-cell interactions and genetic determinants in leprosy: An overview Future Microbiol. 6(2), 217-230 (2011).
    • (2011) Future Microbiol. , vol.6 , Issue.2 , pp. 217-230
    • Pinheiro, R.O.S.J.1    Sarno, E.M.2    Sampaio, E.P.3
  • 6
    • 0013931934 scopus 로고
    • Classification of leprosy according to immunity. A five-group system
    • Ridley DS, Jopling WH: Classification of leprosy according to immunity. A five-group system. Int. J. Lepr. Other Mycobact. Dis. 34, 255-273 (1966).
    • (1966) Int. J. Lepr. Other Mycobact. Dis. , vol.34 , pp. 255-273
    • Ridley, D.S.1    Jopling, W.H.2
  • 11
    • 0023914891 scopus 로고
    • Detection of major genes for susceptibility to leprosy and its subtypes in a Caribbean island: Desirade island
    • Seminal paper that describes the results of complex segregation analysis developed in families of a Caribbean island. Results suggested that different genes could control susceptibility to leprosy per se
    • Abel L, Demenais F: Detection of major genes for susceptibility to leprosy and its subtypes in a Caribbean island: Desirade island. Am. J. Hum. Genet. 42(2), 256-266 (1988). n Seminal paper that describes the results of complex segregation analysis developed in families of a Caribbean island. Results suggested that different genes could control susceptibility to leprosy per se.
    • (1988) Am. J. Hum. Genet. , vol.42 , Issue.2 , pp. 256-266
    • Abel, L.1    Demenais, F.2
  • 12
    • 0013804028 scopus 로고
    • The genetics of resistance to leprosy
    • Beiguelman B: The genetics of resistance to leprosy. Int. J. Lepr. 33(4), 808-812 (1965).
    • (1965) Int. J. Lepr. , vol.33 , Issue.4 , pp. 808-812
    • Beiguelman, B.1
  • 13
    • 0014169280 scopus 로고
    • Leprosy and genetics. A review of past research with remarks concerning future investigations
    • Beiguelman B: Leprosy and genetics. A review of past research with remarks concerning future investigations. Bull. World Health Organ. 37(3), 461-476 (1967).
    • (1967) Bull. World Health Organ. , vol.37 , Issue.3 , pp. 461-476
    • Beiguelman, B.1
  • 14
    • 0014346106 scopus 로고
    • Some remarks on the genetics of leprosy resistance
    • Beiguelman B: Some remarks on the genetics of leprosy resistance. Acta Genet. Med. Gemellol. (Roma) 17(4), 584-594 (1968).
    • (1968) Acta Genet. Med. Gemellol. (Roma) , vol.17 , Issue.4 , pp. 584-594
    • Beiguelman, B.1
  • 16
    • 77951923057 scopus 로고    scopus 로고
    • A major gene controls leprosy susceptibility in a hyperendemic isolated population from north of Brazil
    • Lazaro FP, Werneck RI, Mackert CC et al.: A major gene controls leprosy susceptibility in a hyperendemic isolated population from north of Brazil. J. Infect. Dis. 201(10), 1598-1605 (2010).
    • (2010) J. Infect. Dis. , vol.201 , Issue.10 , pp. 1598-1605
    • Lazaro, F.P.1    Werneck, R.I.2    Mackert, C.C.3
  • 17
    • 0032820204 scopus 로고    scopus 로고
    • The natural resistance-associated macrophage protein and susceptibility to intracellular pathogens
    • DOI 10.1016/S1286-4579(99)80010-0
    • Bellamy R: The natural resistance-associated macrophage protein and susceptibility to intracellular pathogens. Microbes Infect. 1(1), 23-27 (1999). (Pubitemid 29364908)
    • (1999) Microbes and Infection , vol.1 , Issue.1 , pp. 23-27
    • Bellamy, R.1
  • 18
    • 0027211744 scopus 로고
    • High-resolution linkage map in the vicinity of the host resistance locus Bcg
    • DOI 10.1006/geno.1993.1244
    • Malo D, Vidal SM, Hu J, Skamene E, Gros PL: High-resolution linkage map in the vicinity of the host resistance locus BCG. Genomics 16(3), 655-663 (1993). (Pubitemid 23183485)
    • (1993) Genomics , vol.16 , Issue.3 , pp. 655-663
    • Malo, D.1    Vidal, S.M.2    Hu, J.3    Skamene, E.4    Gros, P.5
  • 19
    • 0027262167 scopus 로고
    • Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg
    • DOI 10.1016/0092-8674(93)90135-D
    • Vidal SM, Malo D, Vogan K, Skamene E, Gros P: Natural resistance to infection with intracellular parasites: Isolation of a candidate for BCG. Cell 73(3), 469-485 (1993). (Pubitemid 23143347)
    • (1993) Cell , vol.73 , Issue.3 , pp. 469-485
    • Vidal, S.M.1    Malo, D.2    Vogan, K.3    Skamene, E.4    Gros, P.5
  • 20
    • 0030069824 scopus 로고    scopus 로고
    • Bactericidal activities of combinations of new drugs against Mycobacterium leprae in nude mice
    • Ji B, Perani EG, Petinom C, Grosset JH: Bactericidal activities of combinations of new drugs against Mycobacterium leprae in nude mice. Antimicrob. Agents Chemother. 40(2), 393-399 (1996). (Pubitemid 26049353)
    • (1996) Antimicrobial Agents and Chemotherapy , vol.40 , Issue.2 , pp. 393-399
    • Ji, B.1    Perani, E.G.2    Petinom, C.3    Grosset, J.H.4
  • 22
    • 79951552532 scopus 로고    scopus 로고
    • Host resistance to malaria: Using mouse models to explore the host response
    • Longley R, Smith C, Fortin A et al.: Host resistance to malaria: Using mouse models to explore the host response. Mamm. Genome 22(1-2), 32-42 (2011).
    • (2011) Mamm. Genome , vol.22 , Issue.1-2 , pp. 32-42
    • Longley, R.1    Smith, C.2    Fortin, A.3
  • 25
    • 0038007126 scopus 로고    scopus 로고
    • Missense mutations of the interleukin-12 receptor beta 1(IL12RB1) and interferon-gamma receptor 1 (IFNGR1) genes are not associated with susceptibility to lepromatous leprosy in Korea
    • DOI 10.1007/s00251-003-0573-x
    • Lee SB, Kim BC, Jin SH et al.: Missense mutations of the interleukin-12 receptor b 1 (IL12RB1) and interferon-g receptor 1 (IFNGR1) genes are not associated with susceptibility to lepromatous leprosy in Korea. Immunogenetics 55(3), 177-181 (2003). (Pubitemid 36819365)
    • (2003) Immunogenetics , vol.55 , Issue.3 , pp. 177-181
    • Lee, S.-B.1    Kim, B.C.2    Jin, S.H.3    Park, Y.-G.4    Kim, S.-K.5    Kang, T.-J.6    Chae, G.-T.7
  • 28
    • 44149110322 scopus 로고    scopus 로고
    • IFNG +874T/A, IL10 -1082G/A and TNF -308G/A polymorphisms in association with tuberculosis susceptibility: A meta-analysis study
    • Pacheco AG, Cardoso CC, Moraes MO: IFNG +874T/A, IL10 -1082G/A and TNF -308G/A polymorphisms in association with tuberculosis susceptibility: A meta-analysis study. Hum. Genet. 123(5), 477-484 (2008).
    • (2008) Hum. Genet. , vol.123 , Issue.5 , pp. 477-484
    • Pacheco, A.G.1    Cardoso, C.C.2    Moraes, M.O.3
  • 29
    • 61849147420 scopus 로고    scopus 로고
    • Genetic, epidemiological and biological analysis of interleukin-10 promoter single-nucleotide polymorphisms suggests a definitive role for -819C/T in leprosy susceptibility
    • Pereira AC, Brito-de-Souza VN, Cardoso CC et al.: Genetic, epidemiological and biological analysis of interleukin-10 promoter single-nucleotide polymorphisms suggests a definitive role for -819C/T in leprosy susceptibility. Genes Immun. 10(2), 174-180 (2009).
    • (2009) Genes Immun. , vol.10 , Issue.2 , pp. 174-180
    • Pereira, A.C.1    Brito-de-Souza, V.N.2    Cardoso, C.C.3
  • 30
    • 78049421645 scopus 로고    scopus 로고
    • IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among Brazilians
    • Cardoso CC, Pereira AC, Brito-de-Souza VN et al.: IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among Brazilians. Hum. Genet. 128(5), 481-490 (2010).
    • (2010) Hum. Genet. , vol.128 , Issue.5 , pp. 481-490
    • Cardoso, C.C.1    Pereira, A.C.2    Brito-de-Souza, V.N.3
  • 31
    • 48949118047 scopus 로고    scopus 로고
    • Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction
    • Misch EA, Macdonald M, Ranjit C et al.: Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction. PLoS Negl. Trop. Dis. 2(5), E231 (2008).
    • (2008) PLoS Negl. Trop. Dis. , vol.2 , Issue.5
    • Misch, E.A.1    Macdonald, M.2    Ranjit, C.3
  • 32
    • 77950954449 scopus 로고    scopus 로고
    • Common polymorphisms in the NOD2 gene region are associated with leprosy and its reactive states
    • Berrington WR, Macdonald M, Khadge S et al.: Common polymorphisms in the NOD2 gene region are associated with leprosy and its reactive states. J. Infect. Dis. 201(9), 1422-1435 (2010).
    • (2010) J. Infect. Dis. , vol.201 , Issue.9 , pp. 1422-1435
    • Berrington, W.R.1    Macdonald, M.2    Khadge, S.3
  • 33
    • 77956610643 scopus 로고    scopus 로고
    • Association of TNF, MBL, and VDR polymorphisms with leprosy phenotypes
    • Sapkota BR, Macdonald M, Berrington WR et al.: Association of TNF, MBL, and VDR polymorphisms with leprosy phenotypes. Hum. Immunol. 71(10), 992-998 (2010).
    • (2010) Hum. Immunol. , vol.71 , Issue.10 , pp. 992-998
    • Sapkota, B.R.1    Macdonald, M.2    Berrington, W.R.3
  • 37
    • 77957232770 scopus 로고    scopus 로고
    • Mycobacterium leprae downregulates the expression of PHEX in Schwann cells and osteoblasts
    • Silva SR, Tempone AJ, Silva TP et al.: Mycobacterium leprae downregulates the expression of PHEX in Schwann cells and osteoblasts. Mem. Inst. Oswaldo Cruz. 105(5), 627-632 (2010).
    • (2010) Mem. Inst. Oswaldo Cruz. , vol.105 , Issue.5 , pp. 627-632
    • Silva, S.R.1    Tempone, A.J.2    Silva, T.P.3
  • 40
    • 77957654090 scopus 로고    scopus 로고
    • Leprosy and the adaptation of human Toll-like receptor 1
    • Wong SH, Gochhait S, Malhotra D et al.: Leprosy and the adaptation of human Toll-like receptor 1. PLoS Pathog. 6, E1000979 (2010).
    • (2010) PLoS Pathog. , vol.6
    • Wong, S.H.1    Gochhait, S.2    Malhotra, D.3
  • 41
    • 33645224419 scopus 로고    scopus 로고
    • Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
    • Liu PT, Stenger S, Li H et al.: Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science 311(5768), 1770-1773 (2006).
    • (2006) Science , vol.311 , Issue.5768 , pp. 1770-1773
    • Liu, P.T.1    Stenger, S.2    Li, H.3
  • 42
    • 41949101594 scopus 로고    scopus 로고
    • Toll-like receptors control autophagy
    • DOI 10.1038/emboj.2008.31, PII EMBOJ200831
    • Delgado MA, Elmaoued RA, Davis AS, Kyei G, Deretic V: Toll-like receptors control autophagy. EMBO J. 27(7), 1110-1121 (2008). (Pubitemid 351508141)
    • (2008) EMBO Journal , vol.27 , Issue.7 , pp. 1110-1121
    • Delgado, M.A.1    Elmaoued, R.A.2    Davis, A.S.3    Kyei, G.4    Deretic, V.5
  • 43
    • 78651077774 scopus 로고    scopus 로고
    • Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling
    • Shin DM, Yuk JM, Lee HM et al.: Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling. Cell Microbiol. 12(11), 1648-1665 (2010).
    • (2010) Cell Microbiol. , vol.12 , Issue.11 , pp. 1648-1665
    • Shin, D.M.1    Yuk, J.M.2    Lee, H.M.3
  • 44
    • 74049127960 scopus 로고    scopus 로고
    • Genomewide association study of leprosy
    • nn Describes the first genome-wide association study in leprosy, which confirmed previous associations and described the effect of new genes such as NOD2 and LRRK2 in leprosy susceptibility
    • Zhang FR, Huang W, Chen SM et al.: Genomewide association study of leprosy. N. Engl. J. Med. 361(27), 2609-2618 (2009). nn Describes the first genome-wide association study in leprosy, which confirmed previous associations and described the effect of new genes such as NOD2 and LRRK2 in leprosy susceptibility.
    • (2009) N. Engl. J. Med. , vol.361 , Issue.27 , pp. 2609-2618
    • Zhang, F.R.1    Huang, W.2    Chen, S.M.3
  • 45
    • 77950954449 scopus 로고    scopus 로고
    • Common polymorphisms in the NOD2 gene region are associated with leprosy and its reactive states
    • Berrington WR, Macdonald M, Khadge S et al.: Common polymorphisms in the NOD2 gene region are associated with leprosy and its reactive states. J. Infect. Dis. 201(9), 1422-1435 (2010).
    • (2010) J. Infect. Dis. , vol.201 , Issue.9 , pp. 1422-1435
    • Berrington, W.R.1    Macdonald, M.2    Khadge, S.3
  • 46
    • 41149087158 scopus 로고    scopus 로고
    • Leprosy as a genetic model for susceptibility to common infectious diseases
    • Alter A, Alcais A, Abel L, Schurr E: Leprosy as a genetic model for susceptibility to common infectious diseases. Hum. Genet. 123(3), 227-235 (2008).
    • (2008) Hum. Genet. , vol.123 , Issue.3 , pp. 227-235
    • Alter, A.1    Alcais, A.2    Abel, L.3    Schurr, E.4
  • 47
    • 73849151394 scopus 로고    scopus 로고
    • NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
    • Cooney R, Baker J, Brain O et al.: NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat. Med. 16(1), 90-97 (2010).
    • (2010) Nat. Med. , vol.16 , Issue.1 , pp. 90-97
    • Cooney, R.1    Baker, J.2    Brain, O.3
  • 48
    • 70349672696 scopus 로고    scopus 로고
    • Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains
    • Intemann CD, Thye T, Niemann S et al.: Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains. PLoS Pathog. 5(9), E1000577 (2009).
    • (2009) PLoS Pathog. , vol.5 , Issue.9
    • Intemann, C.D.1    Thye, T.2    Niemann, S.3
  • 49
    • 74049118029 scopus 로고    scopus 로고
    • A common genetic fingerprint in leprosy and Crohn's disease?
    • Schurr E, Gros P: A common genetic fingerprint in leprosy and Crohn's disease? N. Engl. J. Med. 361(27), 2666-2668 (2009).
    • (2009) N. Engl. J. Med. , vol.361 , Issue.27 , pp. 2666-2668
    • Schurr, E.1    Gros, P.2
  • 50
    • 77951073629 scopus 로고    scopus 로고
    • NOD2 and Toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis
    • Ferwerda G, Girardin SE, Kullberg BJ et al.: NOD2 and Toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis. PLoS Pathog. 1(3), 279-285 (2005).
    • (2005) PLoS Pathog. , vol.1 , Issue.3 , pp. 279-285
    • Ferwerda, G.1    Girardin, S.E.2    Kullberg, B.J.3
  • 51
    • 37749012084 scopus 로고    scopus 로고
    • Nod1 and Nod2 in innate immunity and human inflammatory disorders
    • Le Bourhis L, Benko S, Girardin SE: Nod1 and Nod2 in innate immunity and human inflammatory disorders. Biochem. Soc. Trans. 35(Pt 6), 1479-1484 (2007).
    • (2007) Biochem. Soc. Trans. , vol.35 , Issue.PART 6 , pp. 1479-1484
    • Le Bourhis, L.1    Benko, S.2    Girardin, S.E.3
  • 54
    • 65549153845 scopus 로고    scopus 로고
    • C-type lectins and phagocytosis
    • Kerrigan AM, Brown GD: C-type lectins and phagocytosis. Immunobiology 214(7), 562-575 (2009).
    • (2009) Immunobiology , vol.214 , Issue.7 , pp. 562-575
    • Kerrigan, A.M.1    Brown, G.D.2
  • 55
    • 77949261482 scopus 로고    scopus 로고
    • Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility
    • Alter A, de Léséleuc L, Van Thuc N et al.: Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility. Hum. Genet. 127(3), 337-348 (2010).
    • (2010) Hum. Genet. , vol.127 , Issue.3 , pp. 337-348
    • Alter, A.1    De Léséleuc, L.2    Van Thuc, N.3
  • 56
    • 79851480892 scopus 로고    scopus 로고
    • DC-SIGN (CD209) Promoter -336 A/G polymorphism is associated with dengue hemorrhagic fever and correlated to DC-SIGN expression and immune augmentation
    • Wang L, Chen RF, Liu JW et al.: DC-SIGN (CD209) Promoter -336 A/G polymorphism is associated with dengue hemorrhagic fever and correlated to DC-SIGN expression and immune augmentation. PLoS Negl. Trop. Dis. 5(1), E934 (2011).
    • (2011) PLoS Negl. Trop. Dis. , vol.5 , Issue.1
    • Wang, L.1    Chen, R.F.2    Liu, J.W.3
  • 58
    • 78449236734 scopus 로고    scopus 로고
    • Mycobacterium leprae phenolglycolipid-1 expressed by engineered M. bovis BCG modulates early interaction with human phagocytes
    • Tabouret G, Astarie-Dequeker C, Demangel C et al.: Mycobacterium leprae phenolglycolipid-1 expressed by engineered M. bovis BCG modulates early interaction with human phagocytes. PLoS Pathog. 6(10), E1001159 (2010).
    • (2010) PLoS Pathog. , vol.6 , Issue.10
    • Tabouret, G.1    Astarie-Dequeker, C.2    Demangel, C.3
  • 59
    • 79551554942 scopus 로고    scopus 로고
    • SLC11A1 (NRAMP1) polymorphisms and tuberculosis susceptibility: Updated systematic review and meta-analysis
    • Li X, Yang Y, Zhou F et al.: SLC11A1 (NRAMP1) polymorphisms and tuberculosis susceptibility: Updated systematic review and meta-analysis. PLoS One, 6(1), E15831 (2011).
    • (2011) PLoS One , vol.6 , Issue.1
    • Li, X.1    Yang, Y.2    Zhou, F.3
  • 61
    • 78049458262 scopus 로고    scopus 로고
    • Low serum levels of cathelicidin LL-37 in leprosy
    • Matzner M, Al Samie AR, Winkler HM et al.: Low serum levels of cathelicidin LL-37 in leprosy. Acta Trop. 117(1), 56-59 (2011).
    • (2011) Acta Trop. , vol.117 , Issue.1 , pp. 56-59
    • Matzner, M.1    Al Samie, A.R.2    Winkler, H.M.3
  • 62
    • 58149182886 scopus 로고    scopus 로고
    • IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway
    • Krutzik SR, Hewison M, Liu PT et al.: IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway. J. Immunol. 181(10), 7115-7120 (2008).
    • (2008) J. Immunol. , vol.181 , Issue.10 , pp. 7115-7120
    • Krutzik, S.R.1    Hewison, M.2    Liu, P.T.3
  • 63
    • 72649097644 scopus 로고    scopus 로고
    • Divergence of macrophage phagocytic and antimicrobial programs in leprosy
    • Montoya D, Cruz D, Teles RM et al.: Divergence of macrophage phagocytic and antimicrobial programs in leprosy. Cell Host Microbe 6(4), 343-353 (2009).
    • (2009) Cell Host Microbe , vol.6 , Issue.4 , pp. 343-353
    • Montoya, D.1    Cruz, D.2    Teles, R.M.3
  • 68
    • 33748585986 scopus 로고    scopus 로고
    • Interaction of TaqI polymorphism at exon 9 of the vitamin D receptor gene with the negative lepromin response may favor the occurrence of leprosy
    • DOI 10.1111/j.1574-695X.2006.00128.x
    • Goulart LR, Ferreira FR, Goulart IM: Interaction of TaqI polymorphism at exon 9 of the vitamin D receptor gene with the negative lepromin response may favor the occurrence of leprosy. FEMS Immunol. Med. Microbiol. 48(1), 91-98 (2006). (Pubitemid 44379224)
    • (2006) FEMS Immunology and Medical Microbiology , vol.48 , Issue.1 , pp. 91-98
    • Goulart, L.R.1    Ferreira, F.R.2    Goulart, I.M.B.3
  • 69
    • 77956610643 scopus 로고    scopus 로고
    • Association of TNF, MBL, and VDR polymorphisms with leprosy phenotypes
    • Sapkota BR, Macdonald M, Berrington WR et al.: Association of TNF, MBL, and VDR polymorphisms with leprosy phenotypes. Hum. Immunol. 71(10), 992-998 (2010).
    • (2010) Hum. Immunol. , vol.71 , Issue.10 , pp. 992-998
    • Sapkota, B.R.1    Macdonald, M.2    Berrington, W.R.3
  • 70
    • 68649115023 scopus 로고    scopus 로고
    • SNP 668C (-44) alters a NF-kB1 putative binding site in non-coding strand of human b-defensin 1 (DEFB1) and is associated with lepromatous leprosy
    • Prado-Montes de Oca E, Velarde-Felix JS, Rios-Tostado JJ, Picos-Cardenas VJ, Figuera LE: SNP 668C (-44) alters a NF-kB1 putative binding site in non-coding strand of human b-defensin 1 (DEFB1) and is associated with lepromatous leprosy. Infect. Genet. Evol. 9(4), 617-625 (2009).
    • (2009) Infect. Genet. Evol. , vol.9 , Issue.4 , pp. 617-625
    • Prado-Montes De Oca, E.1    Velarde-Felix, J.S.2    Rios-Tostado, J.J.3    Picos-Cardenas, V.J.4    Figuera, L.E.5
  • 71
    • 33646170857 scopus 로고    scopus 로고
    • Association study of major risk single nucleotide polymorphisms in the common regulatory region of PARK2 and PACRG genes with leprosy in an Indian population
    • Malhotra D, Darvishi K, Lohra M et al.: Association study of major risk single nucleotide polymorphisms in the common regulatory region of PARK2 and PACRG genes with leprosy in an Indian population. Eur. J. Hum. Genet. 14(4), 438-442 (2005).
    • (2005) Eur. J. Hum. Genet. , vol.14 , Issue.4 , pp. 438-442
    • Malhotra, D.1    Darvishi, K.2    Lohra, M.3
  • 72
    • 70350689923 scopus 로고    scopus 로고
    • Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release
    • Links parkin to one of the apoptosis pathways since it shows that parkin associates with mitochondria and inhibits cytochrome c release
    • Berger AK, Cortese GP, Amodeo KD, Weihofen A, Letai A, LaVoie MJ: Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release. Hum. Mol. Genet. 18(22), 4317-4328 (2009). n Links parkin to one of the apoptosis pathways since it shows that parkin associates with mitochondria and inhibits cytochrome c release.
    • (2009) Hum. Mol. Genet. , vol.18 , Issue.22 , pp. 4317-4328
    • Berger, A.K.1    Cortese, G.P.2    Amodeo, K.D.3    Weihofen, A.4    Letai, A.5    LaVoie, M.J.6
  • 73
    • 78649653044 scopus 로고    scopus 로고
    • Parkin mono-ubiquitinates Bcl-2 and regulates autophagy
    • Chen D, Gao F, Li B et al.: Parkin mono-ubiquitinates Bcl-2 and regulates autophagy. J. Biol. Chem. 285(49), 38214-38223 (2010).
    • (2010) J. Biol. Chem. , vol.285 , Issue.49 , pp. 38214-38223
    • Chen, D.1    Gao, F.2    Li, B.3
  • 75
    • 75949098487 scopus 로고    scopus 로고
    • PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
    • Vives-Bauza C, Zhou C, Huang Y et al.: PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc. Natl Acad. Sci. USA 107(1), 378-383 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , Issue.1 , pp. 378-383
    • Vives-Bauza, C.1    Zhou, C.2    Huang, Y.3
  • 76
    • 77951256153 scopus 로고    scopus 로고
    • Autophagy in infection
    • Deretic V: Autophagy in infection. Curr. Opin. Cell Biol. 22(2), 252-262 (2010).
    • (2010) Curr. Opin. Cell Biol. , vol.22 , Issue.2 , pp. 252-262
    • Deretic, V.1
  • 77
    • 79953147165 scopus 로고    scopus 로고
    • Ancient ubiquitous protein 1 (AUP1) localizes to lipid droplets and binds the E2 ubiquitin conjugase G2 (UBE2G2) via its G2 binding region
    • Spandl J, Lohmann D, Kuerschner L, Moessinger C, Thiele C: Ancient ubiquitous protein 1 (AUP1) localizes to lipid droplets and binds the E2 ubiquitin conjugase G2 (UBE2G2) via its G2 binding region. J. Biol. Chem. 286(7), 5599-5606 (2011).
    • (2011) J. Biol. Chem. , vol.286 , Issue.7 , pp. 5599-5606
    • Spandl, J.1    Lohmann, D.2    Kuerschner, L.3    Moessinger, C.4    Thiele, C.5
  • 78
    • 77649128120 scopus 로고    scopus 로고
    • The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans
    • nn The authors used a zebrafish model and found a clear role for the lta4h gene in severe susceptibility to Mycobacterium marinum infection. Further investigations showed an association between the human LTA4H gene and susceptibility to TB and multibacillary leprosy
    • Tobin DM, Vary JC, Ray JP et al.: The lta4h locus modulates susceptibility to mycobacterial infection in zebrafish and humans. Cell 140(5), 717-730 (2010). nn The authors used a zebrafish model and found a clear role for the lta4h gene in severe susceptibility to Mycobacterium marinum infection. Further investigations showed an association between the human LTA4H gene and susceptibility to TB and multibacillary leprosy.
    • (2010) Cell , vol.140 , Issue.5 , pp. 717-730
    • Tobin, D.M.1    Vary, J.C.2    Ray, J.P.3
  • 79
    • 58149296186 scopus 로고    scopus 로고
    • Lipid mediators in innate immunity against tuberculosis: Opposing roles of PGE2 and LXA4 in the induction of macrophage death
    • Chen M, Divangahi M, Gan H et al.: Lipid mediators in innate immunity against tuberculosis: Opposing roles of PGE2 and LXA4 in the induction of macrophage death. J. Exp. Med. 205(12), 2791-2801 (2008).
    • (2008) J. Exp. Med. , vol.205 , Issue.12 , pp. 2791-2801
    • Chen, M.1    Divangahi, M.2    Gan, H.3
  • 80
    • 48749091598 scopus 로고    scopus 로고
    • Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy
    • Cruz D, Watson AD, Miller CS et al.: Host-derived oxidized phospholipids and HDL regulate innate immunity in human leprosy. J. Clin. Invest. 118(8), 2917-2928 (2008).
    • (2008) J. Clin. Invest. , vol.118 , Issue.8 , pp. 2917-2928
    • Cruz, D.1    Watson, A.D.2    Miller, C.S.3
  • 81
    • 77956930778 scopus 로고    scopus 로고
    • Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism
    • Kim MJ, Wainwright HC, Locketz M et al.: Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism. EMBO Mol. Med. 2(7), 258-274 (2010).
    • (2010) EMBO Mol. Med. , vol.2 , Issue.7 , pp. 258-274
    • Kim, M.J.1    Wainwright, H.C.2    Locketz, M.3
  • 82
    • 77649106927 scopus 로고    scopus 로고
    • Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis
    • nn Describes the induction of lipid droplets in cells infected with Mycobacterium leprae and describes the lipid droplets as intracellular sites for the synthesis of eicosanoids such as PGE2
    • Mattos KA, D'Avila H, Rodrigues LS et al.: Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis. J. Leuk. Biol. 87(3), 371-384 (2010). nn Describes the induction of lipid droplets in cells infected with Mycobacterium leprae and describes the lipid droplets as intracellular sites for the synthesis of eicosanoids such as PGE2.
    • (2010) J. Leuk. Biol. , vol.87 , Issue.3 , pp. 371-384
    • Mattos, K.A.1    D'Avila, H.2    Rodrigues, L.S.3
  • 83
    • 78651466240 scopus 로고    scopus 로고
    • Modulation of lipid droplets by Mycobacterium leprae in Schwann cells: A putative mechanism for host lipid acquisition and bacterial survival in phagosomes
    • Mattos KA, Lara FA, Oliveira VGC et al.: Modulation of lipid droplets by Mycobacterium leprae in Schwann cells: A putative mechanism for host lipid acquisition and bacterial survival in phagosomes. Cell. Microbiol. 13(2), 259-273 (2011).
    • (2011) Cell. Microbiol. , vol.13 , Issue.2 , pp. 259-273
    • Mattos, K.A.1    Lara, F.A.2    Oliveira, V.G.C.3
  • 84
    • 0029560642 scopus 로고
    • 2 are associated with the absence of Th 1 cells and in vitro T cell suppression in lepromatous leprosy
    • DOI 10.1016/0165-2478(95)02455-7
    • Misra N, Selvakumar M, Singh S et al.: Monocyte derived IL 10 and PGE2 are associated with the absence of Th 1 cells and in vitro T cell suppression in lepromatous leprosy. Immunol. Lett. 48(2), 123-128 (1995). (Pubitemid 26014798)
    • (1995) Immunology Letters , vol.48 , Issue.2 , pp. 123-128
    • Misra, N.1    Selvakumar, M.2    Singh, S.3    Bharadwaj, M.4    Ramesh, V.5    Misra, R.S.6    Nath, I.7
  • 85
    • 54249109973 scopus 로고    scopus 로고
    • Expression of adipose differentiation-related protein (ADRP) and perilipin in macrophages infected with Mycobacterium leprae
    • Tanigawa K, Suzuki K, Nakamura K et al.: Expression of adipose differentiation-related protein (ADRP) and perilipin in macrophages infected with Mycobacterium leprae. FEMS Microbiol. Lett. 289(1), 72-79 (2008).
    • (2008) FEMS Microbiol. Lett. , vol.289 , Issue.1 , pp. 72-79
    • Tanigawa, K.1    Suzuki, K.2    Nakamura, K.3
  • 86
    • 65949095803 scopus 로고    scopus 로고
    • Autophagy regulates lipid metabolism
    • Singh R, Kaushik S, Wang Y et al.: Autophagy regulates lipid metabolism. Nature 458(7242), 1131-1135 (2009).
    • (2009) Nature , vol.458 , Issue.7242 , pp. 1131-1135
    • Singh, R.1    Kaushik, S.2    Wang, Y.3
  • 87
    • 42149094416 scopus 로고    scopus 로고
    • Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis
    • DOI 10.1111/j.1462-5822.2008.01133.x
    • Tobin DM, Ramakrishnan L: Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis. Cell. Microbiol. 10(5), 1027-1039 (2008). (Pubitemid 351540503)
    • (2008) Cellular Microbiology , vol.10 , Issue.5 , pp. 1027-1039
    • Tobin, D.M.1    Ramakrishnan, L.2
  • 88
    • 33746705745 scopus 로고    scopus 로고
    • Development of leprosy and type 1 leprosy reactions after treatment with infliximab: A report of 2 cases
    • Scollard DM, Joyce MP, Gillis TP: Development of leprosy and type 1 leprosy reactions after treatment with infliximab: A report of 2 cases. Clin. Infect. Dis. 43(2), E19-E22 (2006).
    • (2006) Clin. Infect. Dis. , vol.43 , Issue.2
    • Scollard, D.M.1    Joyce, M.P.2    Gillis, T.P.3
  • 89
    • 65349093399 scopus 로고    scopus 로고
    • Lymphotoxin - A and TNF have essential but independent roles in the evolution of the granulomatous response in experimental leprosy
    • Hagge DA, Saunders BM, Ebenezer GJ et al.: Lymphotoxin-a and TNF have essential but independent roles in the evolution of the granulomatous response in experimental leprosy. Am. J. Pathol. 174(4), 1379-1389 (2009).
    • (2009) Am. J. Pathol. , vol.174 , Issue.4 , pp. 1379-1389
    • Hagge, D.A.1    Saunders, B.M.2    Ebenezer, G.J.3
  • 93
    • 67349185555 scopus 로고    scopus 로고
    • Influence of TNF and IL10 gene polymorphisms in the immunopathogenesis of leprosy in the south of Brazil
    • Franceschi DSA, Mazini PS, Rudnick CCC et al.: Influence of TNF and IL10 gene polymorphisms in the immunopathogenesis of leprosy in the south of Brazil. Int. J. Infect. Dis. 13(4), 493-498 (2009).
    • (2009) Int. J. Infect. Dis. , vol.13 , Issue.4 , pp. 493-498
    • Franceschi, D.S.A.1    Mazini, P.S.2    Rudnick, C.C.C.3
  • 94
    • 0034479748 scopus 로고    scopus 로고
    • Tumor necrosis factor promoter polymorphism (TNF2) seems to protect against development of severe forms of leprosy in a pilot study in Brazilian patients
    • Santos AR, Almeida AS, Suffys PN et al.: Tumor necrosis factor promoter polymorphism (TNF2) seems to protect against development of severe forms of leprosy in a pilot study in Brazilian patients. Int. J. Lepr. Other Mycobact. Dis. 68(3), 325-327
    • Int. J. Lepr. Other Mycobact. Dis. , vol.68 , Issue.3 , pp. 325-327
    • Santos, A.R.1    Almeida, A.S.2    Suffys, P.N.3
  • 95
    • 79956159649 scopus 로고    scopus 로고
    • TNF -308G>A single nucleotide polymorphism is associated with leprosy among Brazilians: A genetic epidemiology assessment, meta-analysis and functional study
    • (In press)
    • Cardoso CC, Pereira AC, Brito-de-Souza VN et al.: TNF -308G>A single nucleotide polymorphism is associated with leprosy among Brazilians: A genetic epidemiology assessment, meta-analysis and functional study. J. Infect. Dis. (2011) (In press).
    • (2011) J. Infect. Dis.
    • Cardoso, C.C.1    Pereira, A.C.2    Brito-de-Souza, V.N.3
  • 96
    • 0035090042 scopus 로고    scopus 로고
    • Tumor necrosis factor-α promoter polymorphism TNF2 is associated with a stronger delayed-type hypersensivity reaction in the skin of borderline tuberculoid leprosy patients
    • DOI 10.1007/s002510000295
    • Moraes MO, Duppre NC, Suffys PN et al.: Tumor necrosis factor-alpha promoter polymorphism TNF2 is associated with a stronger delayed-type hypersensitivity reaction in the skin of borderline tuberculoid leprosy patients. Immunogenetics 53(1), 45-47 (2001). (Pubitemid 32209412)
    • (2001) Immunogenetics , vol.53 , Issue.1 , pp. 45-47
    • Moraes, M.O.1    Duppre, N.C.2    Suffys, P.N.3    Santos, A.R.4    Almeida, A.S.5    Nery, J.A.C.6    Sampaio, E.P.7    Sarno, E.N.8
  • 97
    • 1842483836 scopus 로고    scopus 로고
    • Allele-specific repression of lymphotoxin-α by activated B cell factor-1
    • DOI 10.1038/ng1331
    • Knight JC, Keating BJ, Kwiatkowski DP: Allele-specific repression of lymphotoxin-a by activated B cell factor-1. Nat. Genet. 36(4), 394-399 (2004). (Pubitemid 38437263)
    • (2004) Nature Genetics , vol.36 , Issue.4 , pp. 394-399
    • Knight, J.C.1    Keating, B.J.2    Kwiatkowski, D.P.3
  • 98
    • 70349989030 scopus 로고    scopus 로고
    • Genetic deficiencies of innate immune signalling in human infectious disease
    • van de Vosse E, van Dissel JT, Ottenhoff TH: Genetic deficiencies of innate immune signalling in human infectious disease. Lancet Infect. Dis. 9(11), 688-698 (2009).
    • (2009) Lancet Infect. Dis. , vol.9 , Issue.11 , pp. 688-698
    • Van De Vosse, E.1    Van Dissel, J.T.2    Ottenhoff, T.H.3
  • 99
    • 57149144518 scopus 로고    scopus 로고
    • The genetic heterogeneity of mendelian susceptibility to mycobacterial diseases
    • Al-Muhsen S, Casanova J-L: The genetic heterogeneity of mendelian susceptibility to mycobacterial diseases. J. Allergy Clin. Immunol. 122(6), 1043-1051 (2008).
    • (2008) J. Allergy Clin. Immunol. , vol.122 , Issue.6 , pp. 1043-1051
    • Al-Muhsen, S.1    Casanova, J-.L.2
  • 101
    • 0033787711 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the first intron of the human IFN-g gene: Absolute correlation with a polymorphic CA microsatellite marker of high IFN g production
    • Pravica V, Perrey C, Stevens A, Lee J-H, Hutchinson IV: A single nucleotide polymorphism in the first intron of the human IFN-g gene: Absolute correlation with a polymorphic CA microsatellite marker of high IFN g production. Hum. Immunol. 61(9), 863-866 (2000).
    • (2000) Hum. Immunol. , vol.61 , Issue.9 , pp. 863-866
    • Pravica, V.1    Perrey, C.2    Stevens, A.3    Lee, J-.H.4    Hutchinson, I.V.5
  • 104
    • 44149110322 scopus 로고    scopus 로고
    • IFNG+874T/A, IL10-1082G/A and TNF-308G/A polymorphisms in association with tuberculosis susceptibility: A meta-analysis study
    • Pacheco A, Cardoso C, Moraes M: IFNG+874T/A, IL10-1082G/A and TNF-308G/A polymorphisms in association with tuberculosis susceptibility: A meta-analysis study. Hum. Genet. 123(5), 477-484 (2008).
    • (2008) Hum. Genet. , vol.123 , Issue.5 , pp. 477-484
    • Pacheco, A.1    Cardoso, C.2    Moraes, M.3
  • 105
    • 78049421645 scopus 로고    scopus 로고
    • IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among Brazilians
    • Cardoso C, Pereira A, Brito-de-Souza V et al.: IFNG +874 T>A single nucleotide polymorphism is associated with leprosy among Brazilians. Hum. Genet. 128(5), 481-490 (2010).
    • (2010) Hum. Genet. , vol.128 , Issue.5 , pp. 481-490
    • Cardoso, C.1    Pereira, A.2    Brito-de-Souza, V.3
  • 109
    • 38349100266 scopus 로고    scopus 로고
    • Variation analysis and gene annotation of eight MHC haplotypes: The MHC Haplotype Project
    • Horton R, Gibson R, Coggill P et al.: Variation analysis and gene annotation of eight MHC haplotypes: The MHC Haplotype Project. Immunogenetics 60(1), 1-18 (2008).
    • (2008) Immunogenetics , vol.60 , Issue.1 , pp. 1-18
    • Horton, R.1    Gibson, R.2    Coggill, P.3
  • 110
    • 0018140646 scopus 로고
    • Major transplantation antigens in host responses to infection
    • Zinkernagel R: Major transplantation antigens in host responses to infection. Hosp. Pract. 13(7), 83-92 (1978). (Pubitemid 8386725)
    • (1978) Hospital Practice , vol.13 , Issue.7 , pp. 83-92
    • Zinkernagel, R.M.1
  • 111
    • 0038504920 scopus 로고    scopus 로고
    • Segregation of HLA/TNF region is linked to leprosy clinical spectrum in families displaying mixed leprosy subtypes
    • DOI 10.1038/sj.gene.6363911
    • Mira MT, Alcais A, di Pietrantonio T et al.: Segregation of HLA/TNF region is linked to leprosy clinical spectrum in families displaying mixed leprosy subtypes. Genes Immun. 4(1), 67-73 (2003). (Pubitemid 38967576)
    • (2003) Genes and Immunity , vol.4 , Issue.1 , pp. 67-73
    • Mira, M.T.1    Alcais, A.2    Di Pietrantonio, T.3    Thuc, N.V.4    Phuong, M.C.5    Abel, L.6    Schurr, E.7
  • 112
    • 77957654090 scopus 로고    scopus 로고
    • Leprosy and the adaptation of human Toll-like receptor 1
    • Wong SH, Gochhait S, Malhotra D et al.: Leprosy and the adaptation of human Toll-like receptor 1. PLoS Pathog. 6, E1000979 (2010).
    • (2010) PLoS Pathog. , vol.6
    • Wong, S.H.1    Gochhait, S.2    Malhotra, D.3
  • 114
    • 0023225995 scopus 로고
    • HLA and leprosy in Koreans
    • Kim SJ CI, Dahlberg S, Nisperos B, Kim JD, Hansen JA: HLA and leprosy in Koreans. Tissue Antigens 29(3), 146-153 (1987). (Pubitemid 17078581)
    • (1987) Tissue Antigens , vol.29 , Issue.3 , pp. 146-153
    • Kim, S.J.1    Choi, I.H.2    Dahlberg, S.3
  • 115
    • 1642354132 scopus 로고    scopus 로고
    • HLA associations in leprosy patients from Mumbai, India
    • Shankarkumar U: HLA associations in leprosy patients from Mumbai, India. Lepr. Rev. 75(1), 79-85 (2004). (Pubitemid 38374525)
    • (2004) Leprosy Review , vol.75 , Issue.1 , pp. 79-85
    • Shankarkumar, U.1
  • 116
    • 54049150355 scopus 로고    scopus 로고
    • Association between killer-cell immunoglobulin-like receptor genotypes and leprosy in Brazil
    • Franceschi DS, Mazini PS, Rudnick CC et al.: Association between killer-cell immunoglobulin-like receptor genotypes and leprosy in Brazil. Tissue Antigens 72(5), 478-482 (2008).
    • (2008) Tissue Antigens , vol.72 , Issue.5 , pp. 478-482
    • Franceschi, D.S.1    Mazini, P.S.2    Rudnick, C.C.3
  • 117
    • 0035851354 scopus 로고    scopus 로고
    • T cell responses to major membrane protein II (MMP II) of Mycobacterium leprae are restricted by HLA-DR molecules in patients with leprosy
    • DOI 10.1016/S0264-410X(01)00354-1, PII S0264410X01003541
    • Ohyama H, Matsushita S, Nishimura F et al.: T cell responses to major membrane protein II (MMP II) of Mycobacterium leprae are restricted by HLA-DR molecules in patients with leprosy. Vaccine 20(3-4), 475-482 (2001). (Pubitemid 32973791)
    • (2001) Vaccine , vol.20 , Issue.3-4 , pp. 475-482
    • Ohyama, H.1    Matsushita, S.2    Nishimura, F.3    Kato, N.4    Hatano, K.5    Takashiba, S.6    Murayama, Y.7
  • 119
  • 120
    • 0018953892 scopus 로고
    • HLA-linked control of susceptibility to tuberculoid leprosy and association with HLA-DR types
    • de Vries RR, Mehra NK, Vaidya MC, Gupte MD, Meera Khan P, Van Rood JJ: HLA-linked control of susceptibility to tuberculoid leprosy and association with HLA-DR types. Tissue Antigens 16(4), 294-304 (1980). (Pubitemid 10024294)
    • (1980) Tissue Antigens , vol.16 , Issue.4 , pp. 294-304
    • De Vries, R.R.P.1    Mehra, N.K.2    Vaidya, M.C.3
  • 121
    • 0023878138 scopus 로고
    • The HLA association of lepromatous leprosy and borderline lepromatous leprosy in Turkey. A preliminary study
    • Cem Mat M, Yazici H, Ozbakir F, Tüzün Y: The HLA association of lepromatous leprosy and borderline lepromatous leprosy in Turkey. A preliminary study. Int. J. Dermatol. 27(4), 246-247 (1988).
    • (1988) Int. J. Dermatol. , vol.27 , Issue.4 , pp. 246-247
    • Cem Mat, M.1    Yazici, H.2    Ozbakir, F.3    Tüzün, Y.4
  • 122
    • 0022350837 scopus 로고
    • Leprosy associated with HLA-DR2 and DQw1 in the population of northern Thailand
    • Schauf V, Ryan S, Scollard D et al.: Leprosy associated with HLA-DR2 and DQw1 in the population of northern Thailand. Tissue Antigens 26(4), 243-247 (1985). (Pubitemid 16232252)
    • (1985) Tissue Antigens , vol.26 , Issue.4 , pp. 243-247
    • Schauf, V.1    Ryan, S.2    Scollard, D.3
  • 125
    • 0027362134 scopus 로고
    • Study of HLA class II alleles by PCR oligotyping in leprosy patients from North India
    • Rani R, Fernandez-Vina MA, Zaheer SA, Beena KR, Stastny P: Study of HLA class II alleles by PCR oligotyping in leprosy patients from north India. Tissue Antigens 42(3), 133-137 (1993). (Pubitemid 23295481)
    • (1993) Tissue Antigens , vol.42 , Issue.3 , pp. 133-137
    • Rani, R.1    Fernandez-Vina, M.A.2    Zaheer, S.A.3    Beena, K.R.4    Stastny, P.5
  • 126
    • 34247249484 scopus 로고    scopus 로고
    • Immunogenetics of mycobacterial infections in the North Indian population
    • DOI 10.1111/j.1399-0039.2006.77311.x
    • Singh M, Balamurugan A, Katoch K, Sharma SK, Mehra NK: Immunogenetics of mycobacterial infections in the North Indian population. Tissue Antigens 69, 228-230 (2007). (Pubitemid 46625887)
    • (2007) Tissue Antigens , vol.69 , Issue.SUPPL. 1 , pp. 228-230
    • Singh, M.1    Balamurugan, A.2    Katoch, K.3    Sharma, S.K.4    Mehra, N.K.5
  • 129
    • 0029669947 scopus 로고    scopus 로고
    • Arginine at positions 13 or 70-71 in pocket 4 of HLA-DRB1 alleles is associated with susceptibility to tuberculoid leprosy
    • Zerva L, Cizman B, Mehra NK et al.: Arginine at positions 13 or 70-71 in pocket 4 of HLA-DRB1 alleles is associated with susceptibility to tuberculoid leprosy. J. Exp. Med. 183(3), 829-836 (1996).
    • (1996) J. Exp. Med. , vol.183 , Issue.3 , pp. 829-836
    • Zerva, L.1    Cizman, B.2    Mehra, N.K.3
  • 130
    • 0036280904 scopus 로고    scopus 로고
    • Associations between human leukocyte antigens and leprosy in the Turkish population
    • DOI 10.1046/j.1365-2230.2002.01004.x
    • Koçak M, Balci M, Pençe B, Kundakçi N: Associations between human leukocyte antigens and leprosy in the Turkish population. Clin. Exp. Dermatol. 27(3), 235-239 (2002). (Pubitemid 34639290)
    • (2002) Clinical and Experimental Dermatology , vol.27 , Issue.3 , pp. 235-239
    • Kocak, M.1    Balci, M.2    Pence, B.3    Kundakci, N.4
  • 131
    • 61449102631 scopus 로고    scopus 로고
    • Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D
    • Ramagopalan SV, Maugeri NJ, Handunnetthi L et al.: Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D. PLoS Genet. 5(2), E1000369 (2009).
    • (2009) PLoS Genet. , vol.5 , Issue.2
    • Ramagopalan, S.V.1    Maugeri, N.J.2    Handunnetthi, L.3
  • 133
    • 0027971331 scopus 로고
    • Cytokine patterns at the site of mycobacterial infection
    • Sieling PA, Modlin RL: Cytokine patterns at the site of mycobacterial infection. Immunobiology 191(4-5), 378-387 (1994). (Pubitemid 24331463)
    • (1994) Immunobiology , vol.191 , Issue.4-5 , pp. 378-387
    • Sieling, P.A.1    Modlin, R.L.2
  • 139
    • 70349845465 scopus 로고    scopus 로고
    • Implications of high level pseudogene transcription in Mycobacterium leprae
    • Williams DL, Slayden RA, Amin A et al.: Implications of high level pseudogene transcription in Mycobacterium leprae. BMC Genomics 10, 397 (2009).
    • (2009) BMC Genomics , vol.10 , pp. 397
    • Williams, D.L.1    Slayden, R.A.2    Amin, A.3
  • 140
    • 78649531935 scopus 로고    scopus 로고
    • Whole-genome expression analysis of Mycobacterium leprae and its clinical application
    • Akama T, Suzuki K, Tanigawa K et al.: Whole-genome expression analysis of Mycobacterium leprae and its clinical application. Jpn J. Infect. Dis. 63(6), 387-392 (2010).
    • (2010) Jpn J. Infect. Dis. , vol.63 , Issue.6 , pp. 387-392
    • Akama, T.1    Suzuki, K.2    Tanigawa, K.3
  • 142
    • 74749085722 scopus 로고    scopus 로고
    • Adjusting to a new home: Mycobacterium tuberculosis gene expression in response to an intracellular lifestyle
    • Stokes RW, Waddell SJ: Adjusting to a new home: Mycobacterium tuberculosis gene expression in response to an intracellular lifestyle. Future Microbiol. 4(10), 1317-1335 (2009).
    • (2009) Future Microbiol. , vol.4 , Issue.10 , pp. 1317-1335
    • Stokes, R.W.1    Waddell, S.J.2
  • 143
    • 21544435993 scopus 로고    scopus 로고
    • Insights into regulation of human Schwann cell proliferation by Erk1/2 via a MEK-independent and p56Lck-dependent pathway from leprosy bacilli
    • DOI 10.1073/pnas.0501196102
    • Tapinos N, Rambukkana A: Insights into regulation of human Schwann cell proliferation by Erk1/2 via a MEK-independent and p56Lck-dependent pathway from leprosy bacilli. Proc. Natl Acad. Sci. USA 102(26), 9188-9193 (2005). (Pubitemid 40923539)
    • (2005) Proceedings of the National Academy of Sciences of the United States of America , vol.102 , Issue.26 , pp. 9188-9193
    • Tapinos, N.1    Rambukkana, A.2
  • 144
    • 0030899672 scopus 로고    scopus 로고
    • Neural targeting of Mycobacterium leprae mediated by the G domain of the laminin-α2 chain
    • DOI 10.1016/S0092-8674(00)81927-3
    • Rambukkana A, Salzer JL, Yurchenco PD, Tuomanen EI: Neural targeting of Mycobacterium leprae mediated by the G domain of the laminin-a2 chain. Cell 88(6), 811-821 (1997). (Pubitemid 27164269)
    • (1997) Cell , vol.88 , Issue.6 , pp. 811-821
    • Rambukkana, A.1    Salzer, J.L.2    Yurchenco, P.D.3    Tuomanen, E.I.4
  • 145
    • 77649119986 scopus 로고    scopus 로고
    • TB: Screening for responses to a vile visitor
    • Behr M, Schurr E, Gros P: TB: Screening for responses to a vile visitor. Cell 140(5) 615-618 (2010).
    • (2010) Cell , vol.140 , Issue.5 , pp. 615-618
    • Behr, M.1    Schurr, E.2    Gros, P.3
  • 146
    • 77954219746 scopus 로고    scopus 로고
    • Seropositivity to anti-phenolic glycolipid-I in leprosy cases, contacts and no known contacts of leprosy in an endemic and a non-endemic area in northeast Brazil
    • Frota CC, Freitas MV, Foss NT et al.: Seropositivity to anti-phenolic glycolipid-I in leprosy cases, contacts and no known contacts of leprosy in an endemic and a non-endemic area in northeast Brazil. Trans. R Soc. Trop. Med. Hyg. 104(7), 490-495 (2010).
    • (2010) Trans. R Soc. Trop. Med. Hyg. , vol.104 , Issue.7 , pp. 490-495
    • Frota, C.C.1    Freitas, M.V.2    Foss, N.T.3
  • 147
    • 77950616102 scopus 로고    scopus 로고
    • Penitentiary or penthouse condo: The tuberculous granuloma from the microbe's point of view
    • Paige C, Bishai WR: Penitentiary or penthouse condo: The tuberculous granuloma from the microbe's point of view. Cell. Microbiol. 12(3), 301-309 (2010).
    • (2010) Cell. Microbiol. , vol.12 , Issue.3 , pp. 301-309
    • Paige, C.1    Bishai, W.R.2
  • 151
    • 67650486394 scopus 로고    scopus 로고
    • Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions
    • Schuring RP, Hamann L, Faber WR et al.: Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions. J. Infect. Dis. 199(12), 1816-1819 (2009).
    • (2009) J. Infect. Dis. , vol.199 , Issue.12 , pp. 1816-1819
    • Schuring, R.P.1    Hamann, L.2    Faber, W.R.3
  • 153
    • 33847209550 scopus 로고    scopus 로고
    • Human genetics of infectious diseases: A unified theory
    • Casanova JL, Abel L: Human genetics of infectious diseases: A unified theory. EMBO J. 26(4), 915-922 (2007).
    • (2007) EMBO J. , vol.26 , Issue.4 , pp. 915-922
    • Casanova, J.L.1    Abel, L.2
  • 154
    • 73349113553 scopus 로고    scopus 로고
    • Genetic polymorphisms of infectious diseases in case-control studies
    • Pacheco AG, Moraes MO: Genetic polymorphisms of infectious diseases in case-control studies. Dis. Markers. 27(3), 173-186 (2009).
    • (2009) Dis. Markers. , vol.27 , Issue.3 , pp. 173-186
    • Pacheco, A.G.1    Moraes, M.O.2


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