Biological implications of Mycobacterium leprae gene expression during infection

Journal of Molecular Microbiology and Biotechnology

Volumn 8, Issue 1, 2004, Pages 58-72

  Williams, Diana L ^a,b   Torrero, Marina ^b   Wheeler, Paul R ^c   Truman, Richard W ^a   Yoder, Mark ^d   Morrison, Norman ^d   Bishai, William R ^d   Gillis, Thomas P ^a  

^a LOUISIANA STATE UNIVERSITY   (United States)

^b LOUISIANA STATE UNIVERSITY   (United States)

^c VETERINARY LABORATORIES AGENCY   (United Kingdom)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DNA array; Gene expression; Leprosy; Mycobacterium leprae; Mycobacterium tuberculosis; Reverse transcriptase polymerase chain reaction RNA; Transcriptome; Virulence

Indexed keywords

BACTERIAL DNA; FATTY ACID; IRON; PROTEIN SECA; SCAVENGER; SECRETORY PROTEIN; SIGMA FACTOR;

ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; CATABOLISM; CELL DIVISION; CONTROLLED STUDY; DNA MICROARRAY; DNA REPLICATION; ENERGY YIELD; FOOT PAD; GENE CONTROL; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENETIC CODE; GENETIC TRANSCRIPTION; HUMAN; IRON STORAGE; IRON TRANSPORT; LEPROSY; MOLECULAR RECOGNITION; MOUSE; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; NUDE MOUSE; OPEN READING FRAME; PROTEIN METABOLISM; PROTEIN SECRETION; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UNINDEXED SEQUENCE;

ANIMALS; COMPUTATIONAL BIOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; GENOME, BACTERIAL; HUMANS; LEPROSY; MICE; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

LETHRINIDAE; MUS MUSCULUS; MYCOBACTERIUM LEPRAE; MYCOBACTERIUM TUBERCULOSIS;

EID: 16344371628     PISSN: 14641801     EISSN: None     Source Type: Journal    
DOI: 10.1159/000082081     Document Type: Article

References (59)

1. Abou-Zeid C, Ratliff TL, Wiker HG, Harboe M, Bennedsen J, Rook GA: Characterization of fibronectin-binding antigens released by Mycobacterium tuberculosis and Mycobacterium bovis BCG. Infect Immun 1988;56:3046-3051.
2. Armitige LY, Jagannath C, Wanger AR, Norris SJ: Disruption of the genes encoding antigen 85A and antigen 85B of Mycobacterium tuberculosis H37Rv: Effect on growth in culture and in macrophages. Infect Immun 2000;68:767-778.
3. Arruda S, Bomfim G, Knights R, Huima-Byron T, Riley LW: Cloning of a M. tuberculosis DNA fragment associated with entry and survival inside cells. Science 1993;261:1454-1457.
4. Aung H, Toossi Z, Wisnieski JJ, Wallis RS, Culp LA, Phillips NB, et al: Induction of monocyte expression of tumor necrosis factor alpha by the 30-kD alpha antigen of Mycobacterium tuberculosis and synergism with fibronectin. J Clin Invest 1996;98:1261-1268.
5. Avarbock AD, Salem J, Li LS, Wang ZM, Rubin H: Cloning and characterization of a bifunctional RelA/SpoT homolog from Mycobacterium tuberculosis. Gene 1999;233:261-269.
6. Beckwith J, Ferro-Novick S: Genetic studies on protein export in bacteria. Curr Top Microbiol Immunol 1986;125:5-27.
7. Belisle JT, Vissa VD, Sievert T, Takayama K, Brennan PJ, Besra GS: Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis. Science 1997;276:420-1422.
8. Braunstein M, Brown AM, Kurtz S, Jacobs WR Jr: Two nonredundant SecA homologs function in mycobacteria. J Bacteriol 2001;183:6979-6990.
9. Braunstein M, Espinosa BJ, Chan J, Belisle JT, Jacobs WR Jr: SecA2 functions in the secretion of superoxide dismutatse A and in the virulence of Mycobacterium tuberculosis. Mol Microbiol 2003;48:453-464.
10. Brosch R, Grodon SV, Eiglmeier K, Garnier T, Cole ST: Comparative genomics of the leprosy and tubercule bacilli. Res Microbiol 2000;151:135-142.
11. Casali N, Koniecny M, Schmidy MS, Riley LW: Invasion activity of a Mycobacterium tuberculosis peptide presented by the Escherichia coli AIDA autotransporter. Infect Immun 2002;70:6846-6852.
12. Cashel M, Gentry GR, Hernandez VJ, Vinella D: The stringent response; in Neidhardt FC (ed): Escherichia coli and Salmonella: Cellular and Molecular Biology. Washington, ASM Press, 1996, p 1458.
13. Chan J, Fan XD, Hunter SW, Brennan PJ, Bloom BR: Lipoarrabinomannan, a possible virulence factor involved in persistence of Mycobacterium tuberculosis within macrophages. Infect Immun 1991;59:1755-1761.
14. Chitale S, Ehrt S, Kawamura I, Fujimura T, Shimono N, Anand N, Lu S, Cohen-Gould L, Riley LW: Recombinant Mycobacterium tuberculosis protein associated with mammalian cell entry. Cell Microbiol 2001;3:247-254.
15. Collins D, Gicquel B: Genetics of mycobacterial virulence; in Hatfull G, Jacobs W (eds): Molecular Genetics of Mycobacteria. Washington, ASM Press, 2002, pp 265-268.
16. Cole ST, Eiglmeier K, Parkhill J, James KD, Thomson NR, Wheeler PR, et al: Massive gene decay in the leprosy bacillus. Nature 2001;409:1007-1011.
17. DeVoss JJ, Rutter K, Schroder G, Barry CE 3rd: Iron acquisition and metabolism by mycobacteria. J Bacteriol 1999;181:4443-4451.
18. Eiglmeier K, Parkhill J, Honore N, Garnier T, Tekaia F, Telenti A, Klatser P, James KD, Thomson NR, Whealer PR, Churcher C, Harris D, Mungall K, Barrell BG, Lole ST: The decaying genome of Mycobacterium leprae. Lepr Rev 2001;72:387-398.
19. Franzblau SG: Drug susceptibility testing of Mycobacterium leprae in the BACTEC 460 system. Antimicrob Agents Chemother 1989;33:2115-2117.
20. Gingeras TR, Rosenow C: Studying microbial genomes with high-density oligonucleotide arrays. ASM News 2000;66:463-469.
21. Gomez M, Smith I: Determinants of mycobacterial gene expression; in Hatfull GF, Jacobs WR Jr (eds): Molecular Genetics of Mycobacteria. Washington, ASM Press, 1994, pp 111-129.
22. Haile Y, Caugant DA, Bjune G, Wiker HG: Mycobacterium tuberculosis mammalian cell entry operon (nice) homologs in Mycobacterium other than tuberculosis (MOTT). FEMS Immunol Med Microbiol 2002;33:125-132.
23. Kaushal D, Schroeder BG, Tyagi S, Yoshimatsu T, Scott C, Ko C, et al: Reduced immunopathology and mortality despite tissue persistence in a Mycobacterium tuberculosis mutant lacking alternative sigma factor, SigH. Proc Natl Acad Sci USA 2002;99:8330-8335.
24. Klann AG, Belanger AE, Abanes-DeMello A, Lee JY, Hatfull GF: Characterization of the dnaG locus in Mycobacterium smegmatis reveals linkage of DNA replication and cell division. J Bacteriol 1998;180:65-72.
25. Krahenbuhl J, Adams LB: The role of the macrophage in resistance to the leprosy bacillus: in Swilling BS, Eisenstein TK (eds): Macrophage-Pathogens Interactions. New York, Dekker, Inc, 1994, pp 281-302.
26. Krogh A, Larsson B, von Heijne G, Sonnhammer EL: (2001) Predicting transmembrane protein topology with a hidden Markov model: Application to complete genomes. J Mol Biol 2001;305:567-580.
27. Lee YN, Colston MJ: Measurement of ATP generation and decay in Mycobacterium leprac in vitro. J Gen Microbiol 1985;131:3331-3337.
28. Lewis KN, Liao R, Guinn KM, Hickey MJ, Smith S, Behr MA, Sherman DR: Deletion of RD1 from Mycobacterium tuberculosis mimics bacille Calmette-Guerin attenuation. J Infect Dis 2003;1876:117-123.
29. Li Z, Kelly F, Collins DM, Rouse D, Morris S: Expression of katG in Mycobacterium tuberculosis is associated with its growth and persistence in mice and guinea pigs. J Infect Dis 1998;177:1030-1035.
30. Manganelli R, Dubnau E, Tyagi S, Kramer FR, Smith I: Differential expression of 10 sigma factor genes in Mycobacterium tuberculosis. Mol Microbiol 1999;31:715-724.
31. Manganelli R, Voskuil MI, Schoolnik GK, Dubnau E, Gomez M, Smith I: Role of the extracytoplasmic-function sigma factor sigma (H) in Mycobacterium tuberculosis global gene expression. Mol Microbiol 2002;45:365-374.
32. Marques MA, Chitale S, Brennan PJ, Pessolani MC: Mapping and identification of the major cell wall-associated components of Mycobacterium leprae. Infect Immun 1998;66:2625-2631.
33. McKinney JD, Honer zu Bentrup K, Munoz-Elias EJ, Miczak A, Chen B, Chan WT, Swenson D, Sacchettini JC, Jacobs WR Jr, Russell DG: Persistence of M. tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase. Nature 2000;406:735-738.
34. Modlin R, Gebhard JF, Taylor CR, Rea TH: T lymphocyte subsets in the skin lesions of patients with leprosy. J Acad Dermatol 1983;8:182-189.
35. Neill MA, Klebanoff SJ: The effect of phenolic glycolipid-1 from Mycobacterium leprae on the antimicrobial activity of human macrophages. J Exp Med 1988;67:30-42.
36. Nielsen H, Engelbrecht J, Brunak S, von Heijne G: Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites. Protein Eng 1997;10:1-6.
37. Pfaltzgraff RE, Bryceson A: Clinical leprosy; in Hastings RC (ed): Leprosy. Edinburgh, Churchill Livingstone, 1985, pp 134-176.
38. Primm TP, Andersen SJ, Mizrahi V, Avarbock D, Rubin H, Barry CE 3rd: The stringent response of Mycobacterium tuberculosis is required for long-term survival. J Bacteriol 2002;182:4889-4898.
39. Quadri LE, Sello J, Keating TA, Weinreb PH, Walsh CT: Identification of a Mycobacterium tuberculosis gene cluster encoding the biosynthetic enzymes for assembly of the virulence-conferring siderophore mycobactin. Chem Biol 1998;5:631-645.
40. Raman S, Song T, Puyang X, Bardarov S, Jacobs WR Jr, Husson RN: The alternative sigma factor SigH regulates major components of oxidative and heat stress responses in Mycobacterium tuberculosis. J Bacteriol 2001;183:6119-6125.
41. Rees RF: The microbiology of leprosy; in Hastings RC (ed): Leprosy. Edinburgh, Churchill Livingstone, 1985, pp 36-28.
42. Reeve I, Hummell D, Nelson N, Voss J: Overexpression, purification, and site-directed spin labeling of the Nramp metal transporter from Mycobacterium leprae. Proc Natl Acad Sci USA 2002;99:8608-8613.
43. Schlesinger LS, Bellinger-Kawahara CG, Payne NR, Horwitz MA: Phagocytosis of Mycobacterium tuberculosis is mediated by human monocyte complement receptors and complement component C3. J Immunol 1990;144:2771-2780.
44. Schnappinger D, Ehrt S, Voskuil MI, Liu Y, Mangan JA, Monahan IM, et al: Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: Insights into the phagosomal environment. J Exp Med 2003;198:693-704.
45. Schorey JS, Li Q, McCourt DW, Bong-Mastek M, Clark-Curtiss JE, Ratliff TL, Brown EJ: A Mycobacterium leprae gene encoding a fibronectin-binding protein is used for efficient invasion of epithelial cells and Schwann cells. Infect Immun 1995;63:2652-2756.
46. Sibley LD, Krahenbuhl JL, Franzblau SG: Intracellular fate of Mycobacterium leprae in normal and activated mouse macrophages. Infect Immun 1987;55:680-685.
47. Sibley LD, Krahenbuhl JL: Defective activation of granuloma macrophages from Mycobacterium leprae-infected nude mice. J Leukoc Biol 1988;43:60.
48. Smith I: Mycobacterium tuberculosis pathogenesis and molecular determinants of virulence. Clin Microbiol Rev 2003;16:463-496.
49. Sonnenberg MG, Belisle JT: Definition of Mycobacterium tuberculosis culture filtrate proteins by two-dimensional polyacrylamide gel electrophoresis, N-terminal amino acid sequencing, and electroscopy mass spectrometry. Infect Immun 1997;65:4515-4524.
50. Talaat AM, Lyons R, Howard ST, Johnston SA: The temporal expression profile of Mycobacterium tuberculosis infection in mice. Proc Natl Acad Sci USA 2004;101:4602-4607.
51. The Wellcome Trust Sanger Institute: Massive gene decay in the leprosy bacillus. 2001. http://www.sanger.ac.uk/Projects/M_leprae/.
52. The Wellcome Trust Sanger Institute: Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. 1998. http://www.sanger.ac.uk/Projects/M_tuberculosis/.
53. Truman RW, Krahenbuhl JL: Viable M. leprae as a research agent. Int J Lepr Other Mycobact Dis 2001;69:1-12.
54. Wheeler PR: Catabolic pathways for glucose, glycerol and 6-phosphogluconate in Mycobacterium leprae grown in armadillo tissues. J Gen Microbiol 1983;129:1481-1495.
55. Wiker HG, Harboe M: The antigen 85 complex: A major secretion product of Mycobacterium tuberculosis. Microbiol Rev 1992;56:648-651.
56. Wilson TM, deLisle GW, Collins DM: Effect of inhA and katG on isoniazid resistance and virulence of Mycobacterium bovis. Mol Microbiol 1995;15:1009-1115.
57. Williams DL, Oby-Robinson S, Pittman TL, Scollard DM: Purification of Mycobacterium leprae RNA for gene expression analysis directly from biopsy specimens of leprosy patients. Biotechniques 2003;35:534-541.
58. Wittman A, Heinisch L, Scherlitz-Hofmann I, Stoiber T, Ankel-Fuchs I, Mollmann U: Catecholates and mixed catecholate hydroxamates as artificial siderophores for mycobacteria. Biometals 2004;17:53-64.
59. World Health Organization: Leprosy elimination project: Status report. 2003. http://www.who.int/lep/Reports/s20042.pdf.