Low serum levels of cathelicidin LL-37 in leprosy

Acta Tropica

Volumn 117, Issue 1, 2011, Pages 56-59

  Matzner, Michael ^a   Al Samie, Abdul Rahim ^b   Winkler, Heide Maria ^a   Nemeth, Johannes ^a   Grasnek, Andreas ^a   Indra, Alexander ^c   Bieglmayer, Christian ^a   Winkler, Stefan ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Natl Leprosy Elimination Programme   (Yemen)

^c AUSTRIAN AGENCY FOR HEALTH AND FOOD SAFETY   (Austria)

Author keywords

Cathelicidin; Leprosy; M. leprae; Vitamin D3

Indexed keywords

CALCITRIOL; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; LEPROSTATIC AGENT;

ANTIMICROBIAL ACTIVITY; DISEASE CONTROL; DISEASE PREVALENCE; DISEASE TREATMENT; LEPROSY; SERUM;

ADULT; AGED; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; LEPROSY; MALE; MYCOBACTERIUM LEPRAE; YEMEN;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTIMICROBIAL CATIONIC PEPTIDES; CALCIFEDIOL; FEMALE; HUMANS; LEPROSY; MALE; MIDDLE AGED; SERUM; YEMEN; YOUNG ADULT;

YEMEN;

MYCOBACTERIUM LEPRAE;

EID: 78049458262     PISSN: 0001706X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.actatropica.2010.09.007     Document Type: Article

References (23)

1. Al Samie A.R., Al Qubati Y. Leprosy control in the Republic of Yemen: co-operation between government and non-government organizations, 1989-2003. Lepr. Rev. 2004, 75:164-170.
2. Fitness J., Floyd S., Warndorff D.K., Sichali L., Mwaungulu L., Crampin A.C., Fine P.E., Hill A.V. Large-scale candidate gene study of leprosy susceptibility in the Karonga district of northern Malawi. Am. J. Trop. Med. Hyg. 2004, 71:330-340.
3. Gibney K.B., MacGregor L., Leder K., Torresi J., Marshall C., Ebeling P.R., Biggs B.A. Vitamin D deficiency is associated with tuberculosis and latent tuberculosis infection in immigrants from sub-Saharan Africa. Clin. Infect. Dis. 2008, 46:443-446.
4. Gombart A.F., Bhan I., Borregaard N., Tamez H., Camargo C.A., Koeffler H.P., Thadhani R. Low plasma level of cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in patients undergoing hemodialysis. Clin. Infect. Dis. 2009, 48:418-424.
5. Karlsson J., Carlsson G., Ramme K.G., Hägglund H., Fadeel B., Nordenskjöld M., Henter J.I., Palmblad J., Pütsep K., Andersson M. Low plasma levels of the protein pro-LL-37 as an early indication of severe disease in patients with chronic neutropenia. Br. J. Haematol. 2007, 137:166-169.
6. Krutzik S.R., Hewison M., Liu P.T., Robles J.A., Stenger S., Adams J.S., Modlin R.L. IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway. J. Immunol. 2008, 181:7115-7120.
7. Lee H.M., Shin D.M., Choi D.K., Lee Z.W., Kim K.H., Yuk J.M., Kim C.D., Lee J.H., Jo E.K. Innate immune responses to Mycobacterium ulcerans via toll-like receptors and dectin-1 in human keratinocytes. Cell. Microbiol. 2009, 11:678-692.
8. Liu P.T., Stenger S., Tang D.H., Modlin R.L. Cutting edge: vitamin D-mediated human antimicrobial activity against Mycobacterium tuberculosis is dependent on the induction of cathelicidin. J. Immunol. 2007, 179:2060-2063.
9. Martineau A.R., Newton S.M., Wilkinson K.A., Kampmann B., Hall B.M., Nawroly N., Packe G.E., Davidson R.N., Griffiths C.J., Wilkinson R.J. Neutrophil-mediated innate immune resistance to mycobacteria. J. Clin. Invest. 2007, 117:1988-1994.
10. Martineau A.R., Wilkinson R.J., Wilkinson K.A., Newton S.M., Kampmann B., Hall B.M., Packe G.E., Davidson R.N., Eldridge S.M., Maunsell Z.J., Rainbow S.J., Berry J.L., Griffiths C.J. A single dose of vitamin D enhances immunity to mycobacteria. Am. J. Respir. Crit. Care Med. 2007, 176:208-213.
11. Nnoaham K.E., Clarke A. Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysis. Int. J. Epidemiol. 2001, 37:113-119.
12. Ochoa M.T., Stenger S., Sieling P.A., Thoma-Uszynski S., Sabet S., Cho S., Krensky A.M., Rollinghoff M., Nunes Sarno M.E., Burdick A.E., Rea T.H., Modlin R.L. T-cell release of granulysin contributes to host defense in leprosy. Nat. Med. 2001, 7:174-179.
13. Ong P.Y., Ohtake T., Brandt C., Strickland I., Boguniewicz M., Ganz T., Gallo R.L., Leung D.Y. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N. Engl. J. Med. 2002, 347:1151-1160.
14. Peyssonnaux C., Boutin A.T., Zinkernagel A.S., Datta V., Nizet V., Johnson R.S. Critical role of HIF-1alpha in keratinocyte defense against bacterial infection. J. Invest. Dermatol. 2008, 128:1964-1968.
15. Pütsep K., Carlsson G., Boman H.G., Andersson M. Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study. Lancet 2002, 360:1144-1149.
16. Rivas-Santiago B., Hernandez-Pando R., Carranza C., Juarez E., Contreras J.L., Aguilar-Leon D., Torres M., Sada E. Expression of cathelicidin LL-37 during Mycobacterium tuberculosis infection in human alveolar macrophages, monocytes, neutrophils, and epithelial cells. Infect. Immun. 2008, 76:935-941.
17. Roy S., Frodsham A., Saha B., Hazra S.K., Mascie-Taylor C.G., Hill A.V. Association of vitamin D receptor genotype with leprosy type. J. Infect. Dis. 1999, 179:187-191.
18. Stryjewski M.E., Hall R.P., Chu V.H., Kanafani Z.A., O'Riordan W.D., Weinstock M.S., Stienecker R.S., Streilein R., Dorschner R.A., Fowler V.G., Corey G.R., Gallo R.L. Expression of antimicrobial peptides in the normal and involved skin of patients with infective cellulites. J. Infect. Dis. 2007, 196:1425-1430.
19. UNAIDS, 2004. Report on the Global HIV/AIDS Epidemic. 4th Global Report. Geneva: UNAIDS. http://www.unaids.org/bangkok2004/GAR2004_html/GAR2004_00_en.htm.
20. Wahba A., Cohen H., Sheskin J. Neutrophil chemotactic responses in lepromatous leprosy: an in vitro study of 52 patients. Clin. Immunol. Immunopathol. 1980, 17:556-561.
21. Walker S.L., Lockwood D.N.J. The clinical and immunological features of leprosy. Br. Med. Bull. 2006, 77-78:103-121.
22. Weber G., Heilborn J.D., Chamorro Jimenez C.I., Hammarsjö A., Törma H., Ståhle M. Vitamin D induces the antimicrobial protein hCAP18 in human skin. J. Invest. Dermatol. 2005, 124:1080-1082.
23. World Health Organization Global leprosy situation. Weekly Epidemiol. Record 2008, 83:293-300.