Association study of major risk single nucleotide polymorphisms in the common regulatory region of PARK2 and PACRG genes with leprosy in an Indian population

European Journal of Human Genetics

Volumn 14, Issue 4, 2006, Pages 438-442

  Malhotra, Dheeraj ^a   Darvishi, Katayoon ^a   Lohra, Manmohan ^b   Kumar, Himanshu ^a   Grover, Chander ^b   Sood, Soni ^b   Reddy, Belum S N ^b   Bamezai, Ramesh N K ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

^b MAULANA AZAD MEDICAL COLLEGE   (India)

Author keywords

Indian; PACRG; PARK2; SNP

Indexed keywords

LIGASE; PROTEIN PACRG; PROTEIN PARK2; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ALLELE; ARTICLE; BRAZIL; CONTROLLED STUDY; DOMINANT INHERITANCE; ETHNIC DIFFERENCE; FEMALE; GENE LOCUS; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HIGH RISK POPULATION; HUMAN; INDIAN; INFECTION RISK; LEPROSY; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RECESSIVE INHERITANCE; REGULATOR GENE; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE; VIET NAM;

ADOLESCENT; ADULT; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; INDIA; LEPROSY; MALE; MIDDLE AGED; MOLECULAR CHAPERONES; POLYMORPHISM, SINGLE NUCLEOTIDE; REGULATORY SEQUENCES, NUCLEIC ACID; UBIQUITIN-PROTEIN LIGASES;

EID: 33646170857     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/sj.ejhg.5201563     Document Type: Article

References (12)

1. World Health Organization: Leprosy. Global situation. Wkly Epidemiol Rec 2002; 77: 1-8.
2. Ridley DS, Jopling WH: Classification of leprosy according to immunity. A five group system. Int J Lepr Other Mycobact Dis 1966; 34: 255-273.
3. Chakravati MR, Vogel FA: A twin study on leprosy. in Becker PE, (ed): Topics in Human Genetics, Vol. 1. Stuttgart, Germany: Georg Thieme, 1973.
4. Shields ED, Russell DA, Pericak-Vance MA: Genetic epidemiology of the susceptibility to leprosy. J Clin Invest 1987; 79: 1139-1143.
5. Fitness J, Tosh K, Hill AV: Genetics of susceptibility to leprosy. Genes Immun 2002; 3: 441-453.
6. Siddiqui MR, Meisner S, Tosh K. et al: A major susceptibility locus for leprosy in India maps to chromosome 10p13. Nat Genet 2001; 27: 439-441.
7. Mira MT, Alcais A, Nguyen VT et al: Susceptibility to leprosy is associated with PARK2 and PACRG. Nature 2004; 427: 636-640.
8. Giasson BI, Lee VM: Parkin and the molecular pathways of Parkinson's disease. Neuron 2001; 31: 885-888.
9. Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R: A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. J Biol Chem 2003; 278: 51901-51910.
10. Schneider S, Roessli D, Excoffier L: Arlequin Version 2.000: A software for Population Genetics Data Analysis. Switzerland: Genetics and Biometry Laboratory, University of Geneva, (2000).
11. Schaid DJ, Rowland CM, Tines DE, Jacobson RM, Poland GA: Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet 2002; 70: 425-434.
12. Tosh K, Meisner S, Siddiqui MR et al: A region of chromosome 20 is linked to leprosy susceptibility in a South Indian population. J Infect Dis 2002; 186: 1190-1193.