Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction

PLoS Neglected Tropical Diseases

Volumn 2, Issue 5, 2008, Pages

  Misch, Elizabeth A ^a   Macdonald, Murdo ^b   Ranjit, Charnan ^b   Sapkota, Bishwa R ^b   Wells, Richard D ^a   Siddiqui, M Ruby ^c   Kaplan, Gillia ^c   Hawn, Thomas R ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b Anandaban Leprosy Hospital   (Nepal)

^c PUBLIC HEALTH RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOLEUCINE; SERINE; TOLL LIKE RECEPTOR 1;

ADAPTIVE IMMUNITY; ADULT; AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL CELL WALL; CELL STRAIN HEK293; CLINICAL FEATURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN CELL; IMMUNOREGULATION; INFECTION RISK; INFECTION SENSITIVITY; INNATE IMMUNITY; LEPROMATOUS LEPROSY; MAJOR CLINICAL STUDY; MALE; MYCOBACTERIUM LEPRAE; NEPAL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; REVERSAL REACTION; RISK REDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TH1 CELL; TUBERCULOID LEPROSY; CELL LINE; GENETICS; HAPLOTYPE; IMMUNOLOGY; LEPROSY; METABOLISM; MIDDLE AGED; MONONUCLEAR CELL; PHYSIOLOGY; POLYMERASE CHAIN REACTION;

ADULT; CELL LINE; FEMALE; HAPLOTYPES; HUMANS; IMMUNITY, INNATE; LEPROSY; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; MYCOBACTERIUM LEPRAE; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; TOLL-LIKE RECEPTOR 1;

EID: 48949118047     PISSN: None     EISSN: None     Source Type: Journal    
DOI: 10.1371/journal.pntd.0000231     Document Type: Article

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