Tumor necrosis factor promoter polymorphism (TNF2) seems to protect against development of severe forms of leprosy in a pilot study in Brazilian patients [3]

International Journal of Leprosy and Other Mycobacterial Diseases

Volumn 68, Issue 3, 2000, Pages 325-327

  Santos, A R ^a   Almeda, A S ^a   Suffys, P N ^a   Moraes, M O ^a   Mattos, H J ^a   Nery, J A C ^a   Cabello, P H ^a   Sampaio, E P ^a   Sarno, E N ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

BRAZIL; CONTROLLED STUDY; DISEASE SEVERITY; GENETIC POLYMORPHISM; HUMAN; IMMUNOREACTIVITY; INFECTION RESISTANCE; LEPROSY; LETTER; MAJOR CLINICAL STUDY; PROMOTER REGION;

ALLELES; BRAZIL; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DNA, BACTERIAL; HUMANS; LEPROSY, TUBERCULOID; MYCOBACTERIUM LEPRAE; PILOT PROJECTS; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034479748     PISSN: 0148916X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Letter

References (15)

1. Tumor necrosis factor production in patients with leprosy
2. HLA and leprosy: A re-evaluation
3. Biologic therapy with TNF: Preclinical studies
4. Tumor necrosis factor-α is required in the protective immune response against Mycobacterium tuberculosis in mice
5. Tumor necrosis factor-alpha (TNF-α) synthesis is associated with the skin and peripheral nerve pathology of leprosy reversal reactions
6. The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection
7. Association of TNF2, a TNF-α promoter polymorphism, with septic shock susceptibility and mortality; a multicenter study
8. Classification of leprosy according to immunity; a five-group system
9. Tumor necrosis factor promoter polymorphism and susceptibility to lepromatous leprosy
10. Role of inflammatory cytokines in tissue injury in leprosy
11. Serum levels of tumor necrosis factor-alpha and interleukin-1β during leprosy reactional states
12. Tumor necrosis factor in leprosy patients
13. T cell independent granuloma formation in response to Mycobacterium avium-role of tumor necrosis factor-α and interferon-γ
14. An allelic polymorphism within the human tumor necrosis factor-α promoter region is strongly associated with HLAA1, B8 and DR3 alleles
15. Effects of a tumor necrosis factor (TNF-alpha) promoter base transition on transcriptional activity