Arginine at positions 13 or 70-71 in pocket 4 of HLA-DRB1 alleles is associated with susceptibility to tuberculoid leprosy

Journal of Experimental Medicine

Volumn 183, Issue 3, 1996, Pages 829-836

  Zerva, Loukia ^a   Cizman, Bojana ^a   Mehra, Navinder K ^b   Alahari, Souresh K ^c   Murali, Ramachandran ^a   Zmijewski, Chester M ^a   Kamoun, Malek ^a   Monos, Dimitri S ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; HLA DR ANTIGEN; HLA-DRB1 ANTIGEN; HLA DR1 ANTIGEN;

ALLELE; AMINO ACID SEQUENCE; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CHI SQUARE DISTRIBUTION; COMPARATIVE STUDY; GENE; GENETIC PREDISPOSITION; GENETICS; HISTOCOMPATIBILITY TEST; HUMAN; IMMUNOLOGY; MACROMOLECULE; MOLECULAR GENETICS; POLYMERASE CHAIN REACTION; PROTEIN CONFORMATION; REFERENCE VALUE; RISK FACTOR; TUBERCULOID LEPROSY; X RAY CRYSTALLOGRAPHY; AMINO ACID SUBSTITUTION; ANTIBODY SPECIFICITY; GENE ASSIGNMENT; GENETIC SUSCEPTIBILITY; HUMAN CELL; IMMUNE RESPONSE; LEPROMIN TEST; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL;

ALLELES; AMINO ACID SEQUENCE; ARGININE; CHI-SQUARE DISTRIBUTION; CRYSTALLOGRAPHY, X-RAY; GENES, MHC CLASS II; GENETIC PREDISPOSITION TO DISEASE; HISTOCOMPATIBILITY TESTING; HLA-DR ANTIGENS; HUMANS; LEPROSY, TUBERCULOID; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; PROTEIN CONFORMATION; REFERENCE VALUES; RISK FACTORS;

EID: 0029669947     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.3.829     Document Type: Article

References (46)

1. de Vries, R.R.P. 1992. HLA and disease: from epidemiology to immunotherapy. Eur. J. Clin. Invest. 22:1-8.
2. Hastings, R.C., T.P. Gillis, J.L. Krahenbuhl, and S.G. Franzblau. 1988. Leprosy. Clin. Microbiol. Rev. 1:330-348.
3. Cohn, Z.A., and G. Kaplan. 1991. Hansen's disease, cell-mediated immunity, and recombinant lymphokines. J. Infect. Dis. 163:1195-1200.
4. van Eden, W., R.R.P. de Vries, N.K. Mehra, M.C. Vaidya, J. D'Amaro, and J.J. van Rood. 1980. HLA segregation of tuberculoid leprosy: conformation of the DR2 marker. J. Infect. Dis. 141:693-701.
5. de Vries, R R.P., R.K. Mehra, M.C. Vaidya, M.D. Gupte, P. Meera Khan, and J.J. van Rood. 1980. HLA-liked control of susceptibility to tuberculoid leprosy and association with HLA-DR types. Tissue Antigens. 16:294-304.
6. Miyanaga, K., T. Juji, H. Maeda, S. Nakajima, and S Kobayashi. 1981. Tuberculoid leprosy and HLA in Japanese. Tissue Antigens 18:331-334.
7. Izumi, I., K. Sugiyama, Y. Matsumoto, and S. Ohkawa. 1982. Analysis of the immunogenetic background of Japanese leprosy patients by the HLA system. Vox Sang. 42:243-247.
8. Schauf, V., S. Ryan, D. Scollard, O. Jonasson, A. Brown, K. Nelson, T. Smith, and V. Vithayasai. 1985. Leprosy associated with HLA-DR2 and DQw1 in the population of northern Thailand. Tissue Antigens. 26:243-247.
9. Kim, S.J., I.H. Choi, S. Dahlberg, B. Nisperos, J.D. Kim, and J.A. Hansen. 1987. HLA and leprosy in Koreans. Tissue Antigens 29:146-153.
10. Mehra, N.K. 1990. Role of HLA linked factors in governing susceptibility to leprosy and tuberculosis. Trop. Med. Parasitol. 41:352-354.
11. Todd, J.R., B.C. West, and J.C. McDonald. 1990. Human leukocyte antigen and leprosy: study in northern Louisiana and review. Rev. Infect. Dis. 12:63-74.
12. van Eden, W., R.R.P. de Vries, J. D'Amaro, I. Schreuder, D.L. Leiker, and J.J. van Rood. 1982. HLA-DR associated genetic control of the type of leprosy in a population from Surinam. Hum. Immunol. 4:343-350.
13. van Eden, W., N.M. Gonzales, R.R.P. de Vries, J. Convit, and J.J. van Rood. 1985. HLA-linked control of predisposition to lepromatous leprosy. J. Infect. Dis. 151:9-14.
14. Rea, T.H , and P. Terasaki. 1980. HLA-DR antigens in tuberculoid and lepromatous leprosy. Lepr. Rev. 51:117-123.
15. Pollack, M.S., C. Ching, J. Panday, and E. Reichert. 1985. HLA antigen frequencies and HLA and Gm haplotype segregation in Filipino leprosy patients in Hawaii. Dis. Markers. 3: 119-129.
16. Ottenhoff, T.H.M., N.M. Gonzalez, R.R.P de Vries, J. Convit, and J.J. van Rood. 1984. Association of HLA specificity LB-E12 (MB1, DC1, MT1) with lepromatous leprosy in a Venezuelan population. Tissue Antigens. 24:25-29.
17. Rani, R., S.A. Zaheer, and R. Mukherjee. 1992. Do human leukocyte antigens have a role to play in differential manifestations of multibacillary leprosy: a study on multibacillary leprosy patients from North India. Tissue Antigens. 40:124-127.
18. Jorgensen, J.L., P.A. Reay, E.W. Ehrich, and M.M.A. Davis. 1992. Molecular components of T cell recognition. Annu. Rev. Immunol. 10:835-873.
19. Germain, R.N., and D.H. Margulies. 1993. The biochemistry and cell biology of antigen processing and presentation. Annu Rev. Immunol. 11:403-450.
20. Bjorkman, P.J., M.A. Saper, B. Samraoui, W.S. Bennett, J.L. Strominger, and D.C. Wiley. 1987. Structure of the human class I histocompatibihty antigen, HLA-A2. Nature (Lond.). 329.506-512.
21. Brown, J.H., T.S. Jardetzky, J.C. Gorga, L.J. Stern, R.G. Urban, J.L. Strominger, and D.C. Wiley. 1993. Three-dimensional structure of the human class II histocompatibility antigen HLA-DR1. Nature (Lond.). 364:33-39.
22. Hammer, J., B. Takacs, and F. Sinigaglia. 1993. Identification of a motif for HLA-DR1 binding peptides using M13 display libraries. J. Exp. Med. 176:1007-1013.
23. Sette, A., J. Sidney, C. Oseroff, M.F. del Guercio, S. Southwood, T. Arrhenius, M.F. Powell, S.M. Colon, F.C.A. Gaeta, and H.M. Grey. 1993. HLA-DR4w4 - binding motifs illustrate the biochemical basis of degeneracy and specificity in peptide - DR interactions. J. Immunol. 151:3163-3170.
24. Falk, K., O. Rotzschke, S. Stevanovic, G. Jung, and H.G. Rammensee. 1991. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature (Lond.). 351:290-296.
25. Rudensky, A.Y., P. Preston-Hurlburt, B.K. Al-Ramadi, J. Rothbard, and C.A. Janeway, Jr. 1992. Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs. Nature (Lond.). 359:429-431.
26. Chicz, R.M., R.G. Urban, W.S. Lane, J.C. Gorga, L.J. Stern, D.A.A. Vignali, and J.L. Strominger. 1992. Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size. Nature (Lond.). 358:764-768.
27. Stern, L.J., J.H. Brown, T.S. Jardetzky, J.C. Gorga, R.G. Urban, J.L. Strominger, and D.C. Wiley. 1994. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature (Lond.). 368:215-221.
28. Ridley, J., and W. Jopling. 1966. Classification of leprosy according to immunity: a five groups system. Int. J. Lepr. 34: 255-732.
29. Mehra, N.K., W. Verduijn, V. Taneja, J. Drabbels, S.P.N. Singh, and M.J. Giphart. 1991. Analysis of HLA-DR2-associated polymorphisms by oligonucleotide hybridization in an Asian Indian population. Hum. Immunol. 32:246-253.
30. Tiwari, J.L., and P.L. Terasaki. 1985. HLA and Disease Association. Springer Verlag, New York. 472 pp.
31. Kimura, A., and T. Sasazuki. 1992. Eleventh International Histocompatibility Workshop reference protocol for the HLA DNA-typing technique. In Proceedings of the 11th International Histocompatibility Workshop and Conference. K. Tsuji, M. Aizawa, and T. Sasazuki, editors. Oxford University Press, New York. 397-419.
32. Kimura, A., R.P. Dong, H. Harada, and T. Sasazuki. 1992. DNA typing of HLA class II genes in B-lymphoblastoid cell lines homozygous for HLA. In Proceedings of the 11th International Histocompatibility Workshop and Conference, Vol. I. K. Tsuji, M. Aizawa, and T. Sasazuki, editors. Oxford University Press, NY. 419-425.
33. Imanishi, T., T. Akaza, A. Kimura, K. Tokunaga, and T. Gojobori. 1992. Allele and haplotype frequencies for HLA and complement loci in various ethnic groups. In Proceedings of the 11th International Histocompatibility Workshop and Conference Vol I. K. Tsuji, M. Aizawa, and T. Sasazuki, editors. Oxford University Press, New York. 1166.
34. Mehra, N.K., A.G.M. Bouwens, A. Naipal, R. Rajalingam, Z. Grubic, V. Taneja, M.G.J. Tilanus, and M.J. Giphart. 1994. Asian Indian HLA-DR2-, DR4-, and DR52-related DR-DQ genotypes analyzed by polymerase chain reaction based nonradioactive oligonucleotide typing. Hum. Immunol. 39:202-210.
35. Nicholls, A., K.A. Sharp, and B. Honig. 1991. Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins. 11:281-296.
36. Karr, R.W., P. Panina-Bordignon, W.Y. Yu, and A. Lanzavecchia. 1991. Antigen-specific T cells with monogamous or promiscuous restriction patterns are sensitive to different HLA-DR beta chain substitutions. J. Immunol. 146:4242-4247.
37. Olson, R.R., M.T. De Magistris, A. Di Tommaso, and R.W. Karr. 1992. Mutations in the third, but not the first or second, hypervariable regions of DRB1*0101 eliminate DR1-restricted recognition of a pertussis toxin peptide. J. Immunol. 148:2703-2708.
38. Fu, X.T., C.P. Bono, S.L. Woulfe, C. Swearingen, N.L. Summers, F. Sinigaglia, A. Sette, B.D. Schwartz, and R.W. Karr. 1995. Pocket 4 of the HLA-DR (α, β1*0401) molecule is a major determinant of T cell recognition of peptide. J. Exp. Med. 181:915-926.
39. Nepom, G.T., P. Byers, C. Seyfried, L.A. Healey, K.R. Wilski, D. Stage, and B.S. Nepom. 1989. HLA genes associated with rheumatoid arthritis. Identification of susceptibility alleles using specific oligonucleotide probes. Arthritis Rheum. 32: 15-21.
40. Merryman, P.F., R.M. Crapper, S. Lee, P.K. Gregersen, and R.J. Winchester. 1989. Class II major histocompatibility complex gene sequences in rheumatoid arthritis. Arthritis Rheum. 32:251-258.
41. Hammer, J., F. Gallazzi, E. Bono, R.W. Karr, J. Guenot, P. Valsasnini, Z.A. Nagy, and F. Sinigaglia. 1995. Peptide binding specificity of HLA-DR4 molecules: Correlation with rheumatoid arthritis association. J. Exp. Med 181:1847-1855.
42. Richeldi, L., R. Sorrentino, and C. Saltini. 1993. HLA-DPB1 glutamate 69: a genetic marker of Beryllium disease. Science (Wash. DC). 262:242-244.
43. Nathenson, S.G., J. Geliebter, G.M. Pfaffenbach, and R.A. Zeff. 1986. Murine major histocompatibility complex class-I mutants. Annu. Rev. Immunol. 4:471-502.
44. Geluk, A., K.E. van Meijgaarden, A.A.M. Janson, J. Wouter Drijfhout, R.H. Meloen, R.R.P de Vries, and T.H.M. Ottenhoff. 1992. Functional analysis of DR17(DR3)-restricted mycobacterial T cell epitopes reveals DR17-binding motif and enables the design of allele-specific competitor peptides. J. Immunol. 149:2864-2871.
45. Malcherek, G., K. Falk, O. Rotzschke, H.G. Rammensee, S. Stevanovic, V. Gnau, G. Jung, and A. Melms. 1993. Natural peptide ligand motifs of two HLA molecules associated with myasthenia gravis. Int. Immunol. 5:1229-1237.
46. Rani, R., M.N. Fernandez-Vina, S.A. Zaheer, K.R. Beena, and P. Stastny. 1993. Study of HLA class II alleles by PCR oligotyping in leprosy patients from North India. Tissue Antigens. 42:133-137.