Cytokine mRNA expression in leprosy: A possible role for interferon-γ and interleukin-12 in reactions (RR and ENL)

Scandinavian Journal of Immunology

Volumn 50, Issue 5, 1999, Pages 541-549

  Moraes, M O ^a   Sarno, E N ^a   Almeida, A S ^a   Saraiva, B C C ^a   Nery, J A C ^a   Martins, R C L ^a   Sampaio, E P ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; PERFORIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CYTOKINE PRODUCTION; ERYTHEMA NODOSUM LEPROSUM; GENE EXPRESSION; HUMAN; IMMUNE RESPONSE; INFLAMMATION; LEPROSY; MAJOR CLINICAL STUDY; MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSAL REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BASE SEQUENCE; CASE-CONTROL STUDIES; CYTOKINES; DNA PRIMERS; GENE EXPRESSION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERFERON TYPE II; INTERLEUKIN-12; LEPROSY; MEMBRANE GLYCOPROTEINS; POLYMERASE CHAIN REACTION; PORE FORMING CYTOTOXIC PROTEINS; RNA, MESSENGER;

EID: 0032741609     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1999.00622.x     Document Type: Article

References (37)

1. Verhagen CE, Wierenga EA, Buffing AAM, Chand MA, Faber WR, Das PK. Reversal reaction in borderline leprosy is associated with a polarized shift to type 1-like Mycobacterium leprae T cell reactivity in the lesional skin. A follow up study. J Immunol 1997;159:4474-83.
2. Cooper CL, Mueller C, Sinchaisri T et al. Analysis of naturally occurring delayed-type hypersensitivity reactions in leprosy by in situ hybridization. J Exp Med 1989;169:1565-81.
3. Yamamura M, Wang X, Ohmen JD et al. Cytokine patterns of immunologically mediated tissue damage. J Immunol 1992;149:1470-5.
4. Verhagen CE, Van der Pouw Kraan TCTM, Buffing AAM et al. Type 1- and type 2-like lesional skin-derived Mycobacterium leprae-responsive T cell clones are characterized by co-expression of IFNγ/TNFα and IL-4/IL-5/IL-13 respectively. J Immunol 1998;160:2380-7.
5. Ravisse P. Le diagnostic histophatologique de la lèpre et des réactions lépreuses. Acta Leprologica Genève 1986;4:267-76.
6. Sarno EN, Grau GE, Vieira LMM, Nery JAC. Serum levels of tumor necrosis factor-alpha and interleukin-1 β during leprosy reactional states. Clin Exp Immunol 1991;84:103-8.
7. Khanolkar-Young S, Rayment N, Brickell PM et al. Tumor necrosis factor-alpha (TNF-α) synthesis is associated with the skin and peripheral nerve pathology of leprosy reversal reactions. Clin Exp Immunol 1995;99:196-202.
8. Laal S, Bhutani LK, Nath I. Natural emergence of antigen-reactive T cells in lepromatous leprosy patients during erythema nodosum leprosum. Infect Immun 1985;50:887-92.
9. Sampaio EP, Moreira AL, Sarno EN, Malta AM, Kaplan G. Prolonged treatment with recombinant interferon γ induces erythema nodosum leprosum in lepromatous leprosy patients. J Exp Med 1992;175:1729-37.
10. Trinchieri G. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptative immunity. Annu Rev Immunol 1995;15:251-76.
11. Sieling PA, Wang XH, Gately MK et al. IL-12 regulates T helper type 1 cytokine responses in human infectious disease. J Immunol 1994;153:3639-47.
12. Libraty DH, Airan LE, Uyemura K et al. Interferon-γ differentially regulates interleukin-12 and interleukin-10 production in leprosy. J Clin Invest 1997;99:336-41.
13. Yamamura M, Uyemura U, Deans R et al. Defining protective responses to pathogens: Cytokine profiles in leprosy lesions. Science 1991;254:277-9.
14. Misra, N, Murtaza A, Walker B et al. Cytokine profile of circulating T cells of leprosy patients reflects both indiscriminate and polarized T-helper subsets: T-helper phenotype is stable and uninfluenced by related antigens of Mycobacterium leprae. Immunology 1995;86:97-103.
15. Ridley DS, Jopling WH. Classification of leprosy according to immunity: A five group system, Int J Lepr 1966;34:255-73.
16. Sampaio EP, Moraes MO, Nery JAC, Santos AR, Matos HC, Sarno EN. Pentoxifylline decreases in vivo and in vitro tumor necrosis factor (TNFα) production in lepromatous leprosy patients with erythema nodosum leprosum (ENL). Clin Exp Immunol 1998;111:300-8.
17. Ehlers S, Smith KA. Differentiation of T cell lymphokine gene expression: In vitro acquisition of T cell memory. J Exp Med 1991;173:25-36.
18. Sampaio EP, Sarno EN. Role of inflammatory cytokines in tissue injury in leprosy. Int J Lepr 1996;64:S69 74.
19. Nery JAC, Vieira LMM, Matos HJ, Gallo MEN, Sarno EN. Reactional states in multibacillary hansen disease patients during multidrug therapy. Rev Inst Med Trop São Paulo 1998;40:363-70.
20. Billiau A. Interferon-γ. Biology and role in pathogenesis. Adv Immunol 1996;62:61-129.
21. Ozmen L, Pericin M, Hakimi J et al. Interleukin 12, interferon γ, and tumor necrosis factor α are the key cytokines of the generalized Shwartzman reaction. J Exp Med 1994;180:907-15.
22. Laal S, Mishra RS, Nath I. Type 1 reactions in leprosy: Heterogeneity in T-cell functions related to the background leprosy type. Int J Lepr 1987;55:481-7.
23. Ottenhoff THM, Converse PJ, Gebre N, Wondimu A, Ehrenberg JP, Kiessling R. T cell responses to fractionated Mycobacterium leprae antigens in leprosy. The lepromatous nonresponder defect can be overcome in vitro by stimulation with fractionated M. leprae components. Eur J Immunol 1989;19:707-13.
24. + T cell clones from blood and skin lesions of leprosy patients. Identification of T-cell clones distinct from Th0, Th1 and Th2. Immunology 1995;84:585-94.
25. Matusevicius D, Kivisakk P, Navikas V, Soderstrom M, Fredrikson S, Link H. Interleukin-12 and perforin mRNA expression is augmented in blood mononuclear cells in multiple sclerosis. Scand J Immunol 1998;47:582-90.
26. + T cells via CD40 ligand. Proc Natl Acad Sci USA 1997;94:599-603.
27. Bucht A, Larsson P, Weisbrot L et al. Expression of interferon-gamma (IFN-gamma), IL-10, IL-12, and transforming growth factor-beta (TGF-beta) mRNA in synovial fluid cells from patients in the early and late phases of rheumatoid arthritis (RA). Clin Exp Immunol 1996;103:357-67.
28. McCabe RP, Secrist H, Botney M, Egan M, Peters MG. Cytokine mRNA expression in intestine from normal and inflammatory bowel disease patients. Clin Immunol Immunopathol 1993;66:52-8.
29. Rogge L, Barberis-Maino L, Biffi M et al. Selective expression of an interleukin-12 receptor component by human helper I cells. J Exp Med 1997;185:825-31.
30. Manetti R, Gerosa F, Giudizi MG et al. Interleukin 12 induces stable priming for interferon-γ (IFNγ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones. J Exp Med 1994;179:1273-83.
31. Stenger S, Mazzaccaro R, Uyemura K et al. Differential effects of cytolitic T cell subsets on intracellular infection. Science 1997;276:1684-7.
32. Stenger S, Hanson D, Teitelbaum R et al. An antimicrobial activity of cytolitic T cells mediated by granulysin. Science 1998;282:121-5.
33. Gérard C, Bruyns C, Marchant A et al. Interleukin 10 reduces the release of tumor necrosis factor and prevents lethality in experimental endotoxemia. J Exp Med 1993;177:547-50.
34. Rhoades KL, Cai S, Golub S, Economou JD. Granulocyte-macrophage colony stimulating factor and interleukin-4 differentially regulate the human tumor necrosis factor promoter region. Cell Immunol 1995;161:125-31.
35. Suk K, Erickson KL. Differential regulation of tumor necrosis factor-α mRNA degradation in macrophages by interleukin-4 and interferon-γ. Immunology 1996;87:551-8.
36. Xing Z, Gauldie J, Cox G et al. IL-6 is an antiinflammatory cytokine required for controlling local and systemic inflammatory responses. J Clin Invest 1998;101:311-20.
37. Rieckmann P, Albrecht M, Ehrenreich H, Weber T, Michael U. Semi-quantitative analysis of cytokine gene expression in blood and cerebrospinal fluid cells by reverse transcriptase polymerase chain reaction. Res Exp Med (Berl) 1995;195:17-29.