-
1
-
-
46949085484
-
CNI-1493 inhibits Abeta production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease
-
Bacher M, Dodel R, Aljabari B, Keyvani K, Marambaud P, Kayed R, Glabe C, Goertz N, Hoppmann A, Sachser N, Klotsche J, Schnell S, Lewejohann L, Al-Abed Y (2008) CNI-1493 inhibits Abeta production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease. J Exp Med 205:1593-1599.
-
(2008)
J Exp Med
, vol.205
, pp. 1593-1599
-
-
Bacher, M.1
Dodel, R.2
Aljabari, B.3
Keyvani, K.4
Marambaud, P.5
Kayed, R.6
Glabe, C.7
Goertz, N.8
Hoppmann, A.9
Sachser, N.10
Klotsche, J.11
Schnell, S.12
Lewejohann, L.13
Al-Abed, Y.14
-
2
-
-
57149090475
-
Peripheral and central biodistribution of (111)In-labeled anti-beta-amyloid autoantibodies in a transgenic mouse model of Alzheimer's disease
-
Bacher M, Depboylu C, Du Y, Noelker C, Oertel WH, Behr T, Henriksen G, Behe M, Dodel R (2009) Peripheral and central biodistribution of (111)In-labeled anti-beta-amyloid autoantibodies in a transgenic mouse model of Alzheimer's disease. Neurosci Lett 449:240-245.
-
(2009)
Neurosci Lett
, vol.449
, pp. 240-245
-
-
Bacher, M.1
Depboylu, C.2
Du, Y.3
Noelker, C.4
Oertel, W.H.5
Behr, T.6
Henriksen, G.7
Behe, M.8
Dodel, R.9
-
3
-
-
0033835996
-
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
-
Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Lieber-burg I, Motter R, Nguyen M, Soriano F, Vasquez N, Weiss K, Welch B, Seubert P, Schenk D, Yednock T (2000) Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med 6:916-919.
-
(2000)
Nat Med
, vol.6
, pp. 916-919
-
-
Bard, F.1
Cannon, C.2
Barbour, R.3
Burke, R.L.4
Games, D.5
Grajeda, H.6
Guido, T.7
Hu, K.8
Huang, J.9
Johnson-Wood, K.10
Khan, K.11
Kholodenko, D.12
Lee, M.13
Lieber-Burg, I.14
Motter, R.15
Nguyen, M.16
Soriano, F.17
Vasquez, N.18
Weiss, K.19
Welch, B.20
Seubert, P.21
Schenk, D.22
Yednock, T.23
more..
-
4
-
-
67749122581
-
Neuroprotective Natural Antibodiestoassemblies Ofamyloido-genic Peptides Decrease With Normal Aging and Advancing Alzheimer's Disease
-
Britschgi M, Olin CE, Johns HT, Takeda-Uchimura Y, LeMieux MC, Ru-fibach K, Rajadas J, Zhang H, Tomooka B, Robinson WH, Clark CM, Fagan AM, Galasko DR, Holtzman DM, Jutel M, Kaye JA, Lemere CA, Leszek J, Li G, Peskind ER, Quinn JF, Yesavage JA, Ghiso JA, Wyss-Coray T (2009) Neuroprotective natural antibodiestoassemblies ofamyloido-genic peptides decrease with normal aging and advancing Alzheimer's disease. Proc Natl Acad Sci USA 106:12145-12150.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 12145-12150
-
-
Britschgi, M.1
Olin, C.E.2
Johns, H.T.3
Takeda-Uchimura, Y.4
Lemieux, M.C.5
Ru-Fibach, K.6
Rajadas, J.7
Zhang, H.8
Tomooka, B.9
Robinson, W.H.10
Clark, C.M.11
Fagan, A.M.12
Galasko, D.R.13
Holtzman, D.M.14
Jutel, M.15
Kaye, J.A.16
Lemere, C.A.17
Leszek, J.18
Li, G.19
Peskind, E.R.20
Quinn, J.F.21
Yesavage, J.A.22
Ghiso, J.A.23
Wyss-Coray, T.24
more..
-
5
-
-
0035877756
-
Early-onset amyloid deposition and cognitive deficits intransgenic mice expressing a double mutant form of amyloid precursor protein 695
-
Chishti MA, Yang DS, Janus C, Phinney AL, Horne P, Pearson J, Strome R, Zuker N, Loukides J, French J, Turner S, Lozza G, Grilli M, Kunicki S, Morissette C, Paquette J, Gervais F, Bergeron C, Fraser PE, Carlson GA, George-Hyslop PS, Westaway D (2001) Early-onset amyloid deposition and cognitive deficits intransgenic mice expressing a double mutant form of amyloid precursor protein 695. J Biol Chem 276:21562-21570.
-
(2001)
J Biol Chem
, vol.276
, pp. 21562-21570
-
-
Chishti, M.A.1
Yang, D.S.2
Janus, C.3
Phinney, A.L.4
Horne, P.5
Pearson, J.6
Strome, R.7
Zuker, N.8
Loukides, J.9
French, J.10
Turner, S.11
Lozza, G.12
Grilli, M.13
Kunicki, S.14
Morissette, C.15
Paquette, J.16
Gervais, F.17
Bergeron, C.18
Fraser, P.E.19
Carlson, G.A.20
George-Hyslop, P.S.21
Westaway, D.22
more..
-
6
-
-
16644379264
-
Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function
-
Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, Selkoe DJ, Ashe KH (2005) Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat Neurosci 8:79-84.
-
(2005)
Nat Neurosci
, vol.8
, pp. 79-84
-
-
Cleary, J.P.1
Walsh, D.M.2
Hofmeister, J.J.3
Shankar, G.M.4
Kuskowski, M.A.5
Selkoe, D.J.6
Ashe, K.H.7
-
7
-
-
0035902619
-
Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
-
DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM (2001) Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 98:8850-8855.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 8850-8855
-
-
Demattos, R.B.1
Bales, K.R.2
Cummins, D.J.3
Dodart, J.C.4
Paul, S.M.5
Holtzman, D.M.6
-
8
-
-
0037155581
-
Brain to plasma amyloid-beta efflux: A measure of brain amyloid burden in a mouse model of Alzheimer's disease
-
DeMattos RB, Bales KR, Cummins DJ, Paul SM, Holtzman DM (2002) Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science 295:2264-2267.
-
(2002)
Science
, vol.295
, pp. 2264-2267
-
-
Demattos, R.B.1
Bales, K.R.2
Cummins, D.J.3
Paul, S.M.4
Holtzman, D.M.5
-
9
-
-
0036240395
-
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model
-
Dodart JC, Bales KR, Gannon KS, Greene SJ, DeMattos RB, Mathis C, De-Long CA, Wu S, Wu X, Holtzman DM, Paul SM (2002) Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model. Nat Neurosci 5:452-457.
-
(2002)
Nat Neurosci
, vol.5
, pp. 452-457
-
-
Dodart, J.C.1
Bales, K.R.2
Gannon, K.S.3
Greene, S.J.4
Demattos, R.B.5
Mathis, C.6
De-Long, C.A.7
Wu, S.8
Wu, X.9
Holtzman, D.M.10
Paul, S.M.11
-
10
-
-
0036327185
-
Human antibodies against amyloid beta peptide: A potential treatment for Alzheimer's disease
-
Dodel R, Hampel H, Depboylu C, Lin S, Gao F, Schock S, Jäckel S, Wei X, Buerger K, Höft C, Hemmer B, Möller HJ, Farlow M, Oertel WH, Som-mer N, Du Y (2002) Human antibodies against amyloid beta peptide: a potential treatment for Alzheimer's disease. Ann Neurol 52:253-256.
-
(2002)
Ann Neurol
, vol.52
, pp. 253-256
-
-
Dodel, R.1
Hampel, H.2
Depboylu, C.3
Lin, S.4
Gao, F.5
Schock, S.6
Jäckel, S.7
Wei, X.8
Buerger, K.9
Höft, C.10
Hemmer, B.11
Möller, H.J.12
Farlow, M.13
Oertel, W.H.14
Som-Mer, N.15
Du, Y.16
-
11
-
-
77949962484
-
Intravenous immunoglobulins as a treatment for Alzheimer's disease: Rationale and current evidence
-
Dodel R, Neff F, Noelker C, Pul R, Du Y, Bacher M, Oertel W (2010) Intravenous immunoglobulins as a treatment for Alzheimer's disease: rationale and current evidence. Drugs 70:513-528.
-
(2010)
Drugs
, vol.70
, pp. 513-528
-
-
Dodel, R.1
Neff, F.2
Noelker, C.3
Pul, R.4
Du, Y.5
Bacher, M.6
Oertel, W.7
-
12
-
-
4644275963
-
Intravenous immuno-globulins containing antibodies against beta-amyloid for the treatment of Alzheimer's disease
-
Dodel RC, Du Y, Depboylu C, Hampel H, Frölich L, Haag A, Hemmeter U, Paulsen S, Teipel SJ, Brettschneider S, Spottke A, Nölker C, Möller HJ, Wei X, Farlow M, Sommer N, Oertel WH (2004) Intravenous immuno-globulins containing antibodies against beta-amyloid for the treatment of Alzheimer's disease. J Neurol Neurosurg Psychiatry 75:1472-1474.
-
(2004)
J Neurol Neurosurg Psychiatry
, vol.75
, pp. 1472-1474
-
-
Dodel, R.C.1
Du, Y.2
Depboylu, C.3
Hampel, H.4
Frölich, L.5
Haag, A.6
Hemmeter, U.7
Paulsen, S.8
Teipel, S.J.9
Brettschneider, S.10
Spottke, A.11
Nölker, C.12
Möller, H.J.13
Wei, X.14
Farlow, M.15
Sommer, N.16
Oertel, W.H.17
-
13
-
-
0035845614
-
Reduced levels of amyloid beta-peptide antibody in Alzheimer disease
-
Du Y, Dodel R, Hampel H, Buerger K, Lin S, Eastwood B, Bales K, Gao F, Moeller HJ, Oertel W, Farlow M, Paul S (2001) Reduced levels of amyloid beta-peptide antibody in Alzheimer disease. Neurology 57:801-805.
-
(2001)
Neurology
, vol.57
, pp. 801-805
-
-
Du, Y.1
Dodel, R.2
Hampel, H.3
Buerger, K.4
Lin, S.5
Eastwood, B.6
Bales, K.7
Gao, F.8
Moeller, H.J.9
Oertel, W.10
Farlow, M.11
Paul, S.12
-
14
-
-
0041320819
-
Human anti-beta-amyloid antibodies block beta-amyloid fibril formation and prevent beta-amyloid-induced neuro-toxicity
-
Du Y, Wei X, Dodel R, Sommer N, Hampel H, Gao F, Ma Z, Zhao L, Oertel WH, Farlow M (2003) Human anti-beta-amyloid antibodies block beta-amyloid fibril formation and prevent beta-amyloid-induced neuro-toxicity. Brain 126:1935-1939.
-
(2003)
Brain
, vol.126
, pp. 1935-1939
-
-
Du, Y.1
Wei, X.2
Dodel, R.3
Sommer, N.4
Hampel, H.5
Gao, F.6
Ma, Z.7
Zhao, L.8
Oertel, W.H.9
Farlow, M.10
-
15
-
-
57649148788
-
Structural classification of toxic amyloid oligomers
-
Glabe CG (2008) Structural classification of toxic amyloid oligomers. J Biol Chem 283:29639-29643.
-
(2008)
J Biol Chem
, vol.283
, pp. 29639-29643
-
-
Glabe, C.G.1
-
16
-
-
25444462744
-
Impaired visuospatial recognition memory but normal object novelty detection and relative familiarity judgments in adult mice expressing the APPswe Alzheimer's disease mutation
-
Hale G, Good M (2005) Impaired visuospatial recognition memory but normal object novelty detection and relative familiarity judgments in adult mice expressing the APPswe Alzheimer's disease mutation. Behav Neurosci 119:884-891.
-
(2005)
Behav Neurosci
, vol.119
, pp. 884-891
-
-
Hale, G.1
Good, M.2
-
17
-
-
0036853548
-
Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease
-
Hock C, Konietzko U, Papassotiropoulos A, Wollmer A, Streffer J, von Rotz RC, Davey G, Moritz E, Nitsch RM (2002) Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease. Nat Med 8:1270-1275.
-
(2002)
Nat Med
, vol.8
, pp. 1270-1275
-
-
Hock, C.1
Konietzko, U.2
Papassotiropoulos, A.3
Wollmer, A.4
Streffer, J.5
von Rotz, R.C.6
Davey, G.7
Moritz, E.8
Nitsch, R.M.9
-
18
-
-
47149112621
-
Long-term effects of Abeta42 immunisation in Alzheimer's disease: Follow-up of a randomised, placebo-controlled phase I trial
-
Holmes C, Boche D, Wilkinson D, Yadegarfar G, Hopkins V, Bayer A, Jones RW, Bullock R, Love S, Neal JW, Zotova E, Nicoll JA (2008) Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet 372:216-223.
-
(2008)
Lancet
, vol.372
, pp. 216-223
-
-
Holmes, C.1
Boche, D.2
Wilkinson, D.3
Yadegarfar, G.4
Hopkins, V.5
Bayer, A.6
Jones, R.W.7
Bullock, R.8
Love, S.9
Neal, J.W.10
Zotova, E.11
Nicoll, J.A.12
-
19
-
-
0029742199
-
Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
-
Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G (1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274:99-102.
-
(1996)
Science
, vol.274
, pp. 99-102
-
-
Hsiao, K.1
Chapman, P.2
Nilsen, S.3
Eckman, C.4
Harigaya, Y.5
Younkin, S.6
Yang, F.7
Cole, G.8
-
20
-
-
0035866345
-
The level of MHC class I expression on murine adenocarcinoma can change the antitumor effector mechanism of immunocytokine therapy
-
Imboden M, Murphy KR, Rakhmilevich AL, Neal ZC, Xiang R, Reisfeld RA, Gillies SD, Sondel PM (2001) The level of MHC class I expression on murine adenocarcinoma can change the antitumor effector mechanism of immunocytokine therapy. Cancer Res 61:1500-1507.
-
(2001)
Cancer Res
, vol.61
, pp. 1500-1507
-
-
Imboden, M.1
Murphy, K.R.2
Rakhmilevich, A.L.3
Neal, Z.C.4
Xiang, R.5
Reisfeld, R.A.6
Gillies, S.D.7
Sondel, P.M.8
-
21
-
-
24044465136
-
Novel Src homology 3 domain-binding motifs identified from proteomic screen ofaPro-rich region
-
Jia CY, Nie J, Wu C, Li C, Li SS (2005) Novel Src homology 3 domain-binding motifs identified from proteomic screen ofaPro-rich region. Mol Cell Proteomics 4:1155-1166.
-
(2005)
Mol Cell Proteomics
, vol.4
, pp. 1155-1166
-
-
Jia, C.Y.1
Nie, J.2
Wu, C.3
Li, C.4
Li, S.S.5
-
22
-
-
33644862462
-
Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface
-
Kaether C, Schmitt S, Willem M, Haass C (2006) Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface. Traffic 7:408-415.
-
(2006)
Traffic
, vol.7
, pp. 408-415
-
-
Kaether, C.1
Schmitt, S.2
Willem, M.3
Haass, C.4
-
23
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG (2003) Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300:486-489.
-
(2003)
Science
, vol.300
, pp. 486-489
-
-
Kayed, R.1
Head, E.2
Thompson, J.L.3
McIntire, T.M.4
Milton, S.C.5
Cotman, C.W.6
Glabe, C.G.7
-
24
-
-
36749079289
-
Linking folding with aggregation in Alzheimer's beta-amyloid peptides
-
Khandogin J, Brooks CL 3rd (2007) Linking folding with aggregation in Alzheimer's beta-amyloid peptides. Proc Natl Acad Sci U S A 104: 16880-16885.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 16880-16885
-
-
Khandogin, J.1
Brooks, C.L.2
-
25
-
-
21044453723
-
Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo
-
Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ (2005) Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med 11:556-561.
-
(2005)
Nat Med
, vol.11
, pp. 556-561
-
-
Klyubin, I.1
Walsh, D.M.2
Lemere, C.A.3
Cullen, W.K.4
Shankar, G.M.5
Betts, V.6
Spooner, E.T.7
Jiang, L.8
Anwyl, R.9
Selkoe, D.J.10
Rowan, M.J.11
-
26
-
-
33645038471
-
A specific amyloid-beta protein assembly in the brain impairs memory
-
Lesné S, Koh MT, Kotiline kL, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH (2006) A specific amyloid-beta protein assembly in the brain impairs memory. Nature 440:352-357.
-
(2006)
Nature
, vol.440
, pp. 352-357
-
-
Lesné, S.1
Koh, M.T.2
Kotiline, K.L.3
Kayed, R.4
Glabe, C.G.5
Yang, A.6
Gallagher, M.7
Ashe, K.H.8
-
27
-
-
17644412057
-
Working memory impairment in a transgenic amyloid precursor protein TgCRND8 mouse model of Alzheimer's disease
-
Lovasic L, Bauschke H, Janus C (2005) Working memory impairment in a transgenic amyloid precursor protein TgCRND8 mouse model of Alzheimer's disease. Genes Brain Behav 4:197-208.
-
(2005)
Genes Brain Behav
, vol.4
, pp. 197-208
-
-
Lovasic, L.1
Bauschke, H.2
Janus, C.3
-
28
-
-
77953518555
-
Alzheimer's disease: Clinical trials and drug development
-
Mangialasche F, Solomon A, Winblad B, Mecocci P, Kivipelto M (2010) Alzheimer's disease: clinical trials and drug development. Lancet Neurol 9:702-716.
-
(2010)
Lancet Neurol
, vol.9
, pp. 702-716
-
-
Mangialasche, F.1
Solomon, A.2
Winblad, B.3
Mecocci, P.4
Kivipelto, M.5
-
29
-
-
0036852750
-
Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillo-genesis
-
McLaurin J, Cecal R, Kierstead ME, Tian X, Phinney AL, Manea M, French JE, Lambermon MH, Darabie AA, Brown ME, Janus C, Chishti MA, Horne P, Westaway D, Fraser PE, Mount HT, Przybylski M, St George-Hyslop P (2002) Therapeutically effective antibodies against amyloid-beta peptide target amyloid-beta residues 4-10 and inhibit cytotoxicity and fibrillo-genesis. Nat Med 8:1263-1269.
-
(2002)
Nat Med
, vol.8
, pp. 1263-1269
-
-
McLaurin, J.1
Cecal, R.2
Kierstead, M.E.3
Tian, X.4
Phinney, A.L.5
Manea, M.6
French, J.E.7
Lambermon, M.H.8
Darabie, A.A.9
Brown, M.E.10
Janus, C.11
Chishti, M.A.12
Horne, P.13
Westaway, D.14
Fraser, P.E.15
Mount, H.T.16
Przybylski, M.17
George-Hyslop, P.18
-
30
-
-
0035964312
-
Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: Implications for the pathogenesis and treatment of Alzheimer's disease
-
Monsonego A, Maron R, Zota V, Selkoe DJ, Weiner HL (2001) Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease. Proc Natl Acad Sci U S A 98:10273-10278.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 10273-10278
-
-
Monsonego, A.1
Maron, R.2
Zota, V.3
Selkoe, D.J.4
Weiner, H.L.5
-
31
-
-
84984755327
-
A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
-
Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW (2000) A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 408: 982-985.
-
(2000)
Nature
, vol.408
, pp. 982-985
-
-
Morgan, D.1
Diamond, D.M.2
Gottschall, P.E.3
Ugen, K.E.4
Dickey, C.5
Hardy, J.6
Duff, K.7
Jantzen, P.8
Dicarlo, G.9
Wilcock, D.10
Connor, K.11
Hatcher, J.12
Hope, C.13
Gordon, M.14
Arendash, G.W.15
-
32
-
-
0037168655
-
A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR
-
Petkova AT, Ishii Y, Balbach JJ, Antzutkin ON, Leapman RD, Delaglio F, Tycko R (2002) A structural model for Alzheimer's beta -amyloid fibrils based on experimental constraints from solid state NMR. Proc Natl Acad Sci U S A 99:16742-16747.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 16742-16747
-
-
Petkova, A.T.1
Ishii, Y.2
Balbach, J.J.3
Antzutkin, O.N.4
Leapman, R.D.5
Delaglio, F.6
Tycko, R.7
-
33
-
-
12244249201
-
Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils
-
Petkova AT, Leapman RD, Guo Z, Yau WM, Mattson MP, Tycko R (2005) Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils. Science 307:262-265.
-
(2005)
Science
, vol.307
, pp. 262-265
-
-
Petkova, A.T.1
Leapman, R.D.2
Guo, Z.3
Yau, W.M.4
Mattson, M.P.5
Tycko, R.6
-
34
-
-
33746593662
-
Alzheimer's disease beta-amyloid peptides are released in association with exosomes
-
Rajendran L, Honsho M, Zahn TR, Keller P, Geiger KD, Verkade P, Simons K (2006) Alzheimer's disease beta-amyloid peptides are released in association with exosomes. Proc Natl Acad Sci USA 103:11172-11177.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 11172-11177
-
-
Rajendran, L.1
Honsho, M.2
Zahn, T.R.3
Keller, P.4
Geiger, K.D.5
Verkade, P.6
Simons, K.7
-
35
-
-
70049083865
-
18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease
-
Relkin NR, Szabo P, Adamiak B, Burgut T, Monthe C, Lent RW, Younkin S, Younkin L, Schiff R, Weksler ME (2009) 18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease. Neurobiol Aging 30:1728-1736.
-
(2009)
Neurobiol Aging
, vol.30
, pp. 1728-1736
-
-
Relkin, N.R.1
Szabo, P.2
Adamiak, B.3
Burgut, T.4
Monthe, C.5
Lent, R.W.6
Younkin, S.7
Younkin, L.8
Schiff, R.9
Weksler, M.E.10
-
36
-
-
77649189880
-
APP transgenic mice: The effect of active and passive immunotherapy in cognitive tasks
-
Roskam S, Neff F, Schwarting R, Bacher M, Dodel R (2010) APP transgenic mice: the effect of active and passive immunotherapy in cognitive tasks. Neurosci Biobehav Rev 34:487-499.
-
(2010)
Neurosci Biobehav Rev
, vol.34
, pp. 487-499
-
-
Roskam, S.1
Neff, F.2
Schwarting, R.3
Bacher, M.4
Dodel, R.5
-
37
-
-
0033536163
-
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, Kholodenko D, Lee M, Liao Z, Lieberburg I, Motter R, Mutter L, Soriano F, Shopp G, Vasquez N, Vandevert C, Walker S, Wogulis M, Yednock T, Games D, Seubert P (1999) Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400:173-177.
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
Gordon, G.4
Grajeda, H.5
Guido, T.6
Hu, K.7
Huang, J.8
Johnson-Wood, K.9
Khan, K.10
Kholodenko, D.11
Lee, M.12
Liao, Z.13
Lieberburg, I.14
Motter, R.15
Mutter, L.16
Soriano, F.17
Shopp, G.18
Vasquez, N.19
Vandevert, C.20
Walker, S.21
Wogulis, M.22
Yednock, T.23
Games, D.24
Seubert, P.25
more..
-
38
-
-
7944233158
-
Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases
-
Selkoe DJ (2004) Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases. Nat Cell Biol 6:1054-1061.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 1054-1061
-
-
Selkoe, D.J.1
-
39
-
-
49149124343
-
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
-
Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ (2008) Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med 14:837-842.
-
(2008)
Nat Med
, vol.14
, pp. 837-842
-
-
Shankar, G.M.1
Li, S.2
Mehta, T.H.3
Garcia-Munoz, A.4
Shepardson, N.E.5
Smith, I.6
Brett, F.M.7
Farrell, M.A.8
Rowan, M.J.9
Lemere, C.A.10
Regan, C.M.11
Walsh, D.M.12
Sabatini, B.L.13
Selkoe, D.J.14
-
41
-
-
0011444914
-
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
-
Sturchler-Pierrat C, Abramowski D, Duke M, Wiederhold KH, Mistl C, Roth-acher S, Ledermann B, Burki K, Frey P, Paganetti PA, Waridel C, Calhoun ME, Jucker M, Probst A, Staufenbiel M, Sommer B (1997) Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc Natl Acad Sci USA 94:13287-13292.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 13287-13292
-
-
Sturchler-Pierrat, C.1
Abramowski, D.2
Duke, M.3
Wiederhold, K.H.4
Mistl, C.5
Roth-Acher, S.6
Ledermann, B.7
Burki, K.8
Frey, P.9
Paganetti, P.A.10
Waridel, C.11
Calhoun, M.E.12
Jucker, M.13
Probst, A.14
Staufenbiel, M.15
Sommer, B.16
-
42
-
-
41949107347
-
Autoantibody-catalyzed hydrolysis of amyloid beta peptide
-
Taguchi H, Planque S, Nishiyama Y, Symersky J, Boivin S, Szabo P, Friedland RP, Ramsland PA, Edmundson AB, Weksler ME, Paul S (2008) Autoantibody-catalyzed hydrolysis of amyloid beta peptide. J Biol Chem 283:4714-4722.
-
(2008)
J Biol Chem
, vol.283
, pp. 4714-4722
-
-
Taguchi, H.1
Planque, S.2
Nishiyama, Y.3
Symersky, J.4
Boivin, S.5
Szabo, P.6
Friedland, R.P.7
Ramsland, P.A.8
Edmundson, A.B.9
Weksler, M.E.10
Paul, S.11
-
43
-
-
68149162581
-
Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction
-
Tomic JL, Pensalfini A, Head E, Glabe CG (2009) Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction. Neurobiol Dis 35:352-358.
-
(2009)
Neurobiol Dis
, vol.35
, pp. 352-358
-
-
Tomic, J.L.1
Pensalfini, A.2
Head, E.3
Glabe, C.G.4
-
44
-
-
33645505550
-
Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: A potent role for trimers
-
Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ (2006) Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. J Physiol 572:477-492.
-
(2006)
J Physiol
, vol.572
, pp. 477-492
-
-
Townsend, M.1
Shankar, G.M.2
Mehta, T.3
Walsh, D.M.4
Selkoe, D.J.5
-
45
-
-
14944378094
-
Certain inhibitors of synthetic amyloid jS-peptide (Aβ) fibrillogenesis block oligomerization of natural Aβ and thereby rescue long-term potentiation
-
Walsh DM, Townsend M, Podlisny MB, Shankar GM, Fadeeva JV, El Agnaf O, Hartley DM, Selkoe DJ (2005) Certain inhibitors of synthetic amyloid jS-peptide (Aβ) fibrillogenesis block oligomerization of natural Aβ and thereby rescue long-term potentiation. J Neurosci 25:2455-2462.
-
(2005)
J Neurosci
, vol.25
, pp. 2455-2462
-
-
Walsh, D.M.1
Townsend, M.2
Podlisny, M.B.3
Shankar, G.M.4
Fadeeva, J.V.5
El-Agnaf, O.6
Hartley, D.M.7
Selkoe, D.J.8
-
46
-
-
0036085702
-
Patients with Alzheimer disease have lower levels of serum anti-amyloid peptide antibodies than healthy elderly individuals
-
Weksler ME, Relkin N, Turkenich R, LaRusse S, Zhou L, Szabo P (2002) Patients with Alzheimer disease have lower levels of serum anti-amyloid peptide antibodies than healthy elderly individuals. Exp Gerontol 37:943-948.
-
(2002)
Exp Gerontol
, vol.37
, pp. 943-948
-
-
Weksler, M.E.1
Relkin, N.2
Turkenich, R.3
Larusse, S.4
Zhou, L.5
Szabo, P.6
|