CNI-1493 inhibits Aβ production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease

Journal of Experimental Medicine

Volumn 205, Issue 7, 2008, Pages 1593-1599

  Bacher, Michael ^a   Dodel, Richard ^a   Aljabari, Bayan ^b   Keyvani, Kathy ^c   Marambaud, Philippe ^b   Kayed, Rakez ^d   Glabe, Charles ^d   Goertz, Nicole ^e   Hoppmann, Anne ^e   Sachser, Norbert ^e   Klotsche, Jens ^f   Schnell, Susanne ^g   Lewejohann, Lars ^e   Al Abed, Yousef ^b  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH   (United States)

^c UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF MÜNSTER   (Germany)

^f DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^g UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; PLACEBO; SECRETASE; SEMAPIMOD;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROTIC PLAQUE; BRAIN CORTEX; CELL ACTIVATION; COGNITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; GENE OVEREXPRESSION; HIPPOCAMPUS; IN VITRO STUDY; MALE; MAZE TEST; MENTAL DETERIORATION; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECOGNITION; SPATIAL MEMORY; TRANSGENIC MOUSE; TREATMENT DURATION; TREATMENT RESPONSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HIPPOCAMPUS; HUMANS; HYDRAZONES; MICE; MICE, TRANSGENIC; MICROGLIA; TIME FACTORS;

EID: 46949085484     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20060467     Document Type: Article

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