Therapeutic plasma proteins - application of proteomics in process optimization, validation, and analysis of the final product

Electrophoresis

Volumn 32, Issue 10, 2011, Pages 1104-1117

  Gaso Sokac, Dajana ^a   Kovac, Spomenka ^a   Clifton, James ^b   Josic, Djuro ^b,c,d  

^a JOSIP JURAJ STROSSMAYER UNIVERSITY OF OSIJEK   (Croatia)

^b BROWN UNIVERSITY   (United States)

^c University of Rijeka   (Croatia)

^d RHODE ISLAND HOSPITAL   (United States)

Author keywords

Plasma proteins; Process optimization; Proteomics; Quality control

Indexed keywords

MOLECULAR BIOLOGY; PROCESS CONTROL; PROTEINS;

IN-PROCESS; OPTIMIZATION ANALYSIS; OPTIMIZATIONS VALIDATION; PLASMA PROTEIN; PROCESS ANALYSIS; PROCESS OPTIMISATION; PROCESS VALIDATION; PROTEOMIC TECHNOLOGIES; PROTEOMICS; THERAPEUTIC PROTEIN;

OPTIMIZATION;

A1 AT; ANTITHROMBIN III; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 9; CHOLINESTERASE; FRESH FROZEN PLASMA; HUMAN SERUM ALBUMIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; PLASMA PROTEIN; PROTHROMBIN COMPLEX; RECOMBINANT BLOOD CLOTTING FACTOR 7A; RECOMBINANT BLOOD CLOTTING FACTOR 8; SERINE PROTEINASE INHIBITOR; THROMBIN; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

AFFINITY CHROMATOGRAPHY; AMINO ACID SEQUENCE; CRYOPRECIPITATION; DEEP VEIN THROMBOSIS; DRUG IMPURITY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; ENZYME MECHANISM; GLYCOBIOLOGY; GLYCOSYLATION; HEMOPHILIA A; HEMOPHILIA B; HEMOSTASIS; HIGH THROUGHPUT SCREENING; HUMAN; IMMUNOMODULATION; LIQUID CHROMATOGRAPHY; LUNG EMPHYSEMA; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEOMICS; QUALITY CONTROL; QUANTITATIVE ANALYSIS; REVIEW; RISK FACTOR; SEPARATION TECHNIQUE; STRUCTURE ANALYSIS; TUNING CURVE; VALIDATION PROCESS; VIRUS INFECTION; WORKFLOW;

EID: 79955589084     PISSN: 01730835     EISSN: 15222683     Source Type: Journal    
DOI: 10.1002/elps.201000641     Document Type: Review

References (163)

1. Stadler, M., Gruber, G., Kannicht, C., Biesert, L., Radomski, K. U., Suhartono, H., Pock, K., Neisser-Svae, A., Weinberger, J., Roemisch, J., Svae, T. E., Biologicals 2006, 34, 281-288.
2. Buchacher, A., Iberer, G., Biotechnol. J. 2006, 1, 148-163.
3. Josic, Dj., Kannicht, C., Löster, K., Pock, K., Iberer, G., Buchacher, A., Haemophilia 2001, 7, 250-257.
4. Lion, N., Tissot, J.-D., Exp. Rev. Proteomics 2008, 5, 375-379.
5. Josic, D., Kovac, S., Biotechnol. J. 2008, 3, 496-509.
6. Rose, K., Bougueleret, L., Baussant, T., Bohm, G., Botti, P., Colinge, J., Cusin, I., Proteomics 2004, 4, 2125-2150.
7. Kovac, S., Yang, X., Huang, F., Hixson, D., Josic, D., J. Chromatogr. A 2008, 1194, 38-47.
8. Thiele, T., Steil, L., Völker, U., Greinacher, A., BioDrugs 2007, 21, 179-193.
9. Liumbruno, G., D'Amici, G. M., Grazzini, G., Zolla, L., J. Proteomics 2008, 71, 34-45.
10. Brigulla, M., Thiele, T., Scharf, C., Breitner-Ruddock, S., Venz, S., Völker, U., Greinacker, A., Transfusion 2006, 46, 377-385.
11. D'Amici, G. M., Timperio, A. M., Gevi, F., Grazzini, G., Zolla, L., Electrophoresis 2010, 31, 2730-2739.
12. Clifton, J., Huang, F., Gaso-Sokac, D., Brilliant, K., Hixson, D., Josic, D., J. Proteomics 2010, 73, 678-688.
13. Grupta, P., Lee, K. H., Trends Biotechnol. 2007, 25, 324-330.
14. Gaso Sokac, D., Kovac, S., Josic, D., Food Technol. Biotechnol. 2010, 48, 284-295.
15. Josic, D., Buchacher, A., Kannicht, C., Lim, Y.-P., Löster, K., Pock, K., Robinson, S., Schwinn, H., Stadler, M., Vox Sang. 1999, 77, 90-99.
16. Solheim, B. G., Seghatchian, J., Transfusion Apher. Sci. 2006, 35, 83-90.
17. Gouw, S. C., van der Bom, J. G., Auerswald, G., Ettinghausen, C. E., Tedgard, U., van den Berg, H. M., Blood 2007, 109, 4693-4697.
18. Davis-Jackson, R., Correa, H., Horswell, R., Sadowska-Krpwicka, H., McDonough, K., Debata, C., Gardner, R., Penn, D., Thromb. J. 2006, 4, 7-21.
19. Pipe, S. W., Thromb. Haemost. 2008, 99, 840-850.
20. Hedner, U., Blood Coag. Fibrinol. 1998, 9, 147-152.
21. Pipe, S. W. J. Thromb. Haemost. 2005, 3, 1692-1701.
22. White, G. C. 2nd, Beebe, A., Nielsen, B., Thromb. Haemost. 1997, 78, 261-265.
23. Avidan, M. S., Levy, J. H., van Aken, H., Feneck, R. O., Latimer, R. D., Ott, E., Martin, E., Birnbaum, D. E., Bonfiglio, L. J., Kajdasz, D. K., Despotis, G. J., J. Thorac. Cardiovasc. Surg. 2005, 130, 107-113.
24. Medzihradszky, K. F., Besman, M. J., Burlingame, A. L., Anal. Chem. 1997, 68, 3986-3994.
25. Sandberg, H., Almstedt, A., Brandt, J., Gray, E., Holmquist, L., Oswaldson, U., Sebring, S., Mikaelsson, M., Thromb. Haemost. 2001, 85, 93-100.
26. Arruda, V. R., Hangstrom, J. N., Deitch, J., Heiman-Patterson, T., Camire, R. M., Chu, K., Fields, P. A., Blood 2001, 97, 130-138.
27. Adkins, J. N., Varnum, S. M., Auberry, K. J., Moore, R. J., Angell, N. H., Smith, R. D., Mol. Cell. Proteomics 2002, 1, 947-955.
28. Li, X., Gong, Y., Wang, Y., Wu, S., Cai, Y., He, P., Lu, Z., Ying, W., Zhang, Y., Jiao, L., He, H., Zhang, Z., He, F., Zhao, X., Qian, X., Proteomics 2005, 5, 3423-3441.
29. Luque-Garcia, J. L., Neubert, T., J. Chromatogr. A 2007, 1153, 259-276.
30. Susanto, A., Knieps-Grunhagen, E., von Liers, E., Hubbuch, J., Chem. Eng. Technol. 2008, 31, 1846-1855.
31. Charlton, H., Galarza, B., Leriche, K., Jones, R., BioPharm 2006, 46, 20-26.
32. Coffman, J. L., Kramarczyk, J. F., Kelley, B. D., Biotechnol. Bioeng. 2008, 100, 605-618.
33. Pucic, M., 4th Int. Symp. Monoliths, Portoroz, Slovenia, 2010.
34. Brgles, M., Welsh, R., Rucevic, M., Cao, L., Huang, F., Clifton, J., Josic, D., J. Chromatogr. A 2011, in press, doi:10.1016/j.chroma.2010.11.059.
35. Burnouf, T., Transfusion Med. Rev. 2007, 21, 101-117.
36. Farrugia, A., Haemophilia 2004, 10, 334-340.
37. Piet, M. P., Chin, S., Prince, A. M., Brotman, B., Cundell, A. M., Horowitz, B., Transfusion 1991, 30, 591-598.
38. Bournof, T., Goubran, H. A., Radoshevich, M., Sayed, M. A., Gorgy, G., El-Ekiaby, M., Transfusion, 2006, 46, 2100-2108.
39. Rock, G., Vox Sang 2011, 100, 169-178.
40. Hellstern, P., Curr. Opin. Hematol. 2004, 11, 346-350.
41. Thadikkaran, L., Siegenthaler, M. A., Crettaz, D., Queloz, P. A., Schneider, P., Tissot, J. D., Proteomics 2005, 5, 3019-3034.
42. Heger, A., Svae, T.-E., Neisser-Svae, A., Jordan, S., Römisch, J., Vox Sang. 2009, 97, 219-225.
43. Heger, A., Kannicht, C., Römisch, J., Svae, T.-E., Vox Sang. 2007, 92, 206-212.
44. Lawrie, A. S., Green, L., Canciani, M. T., Mackie, I. J., Oeyvandi, F., Scully, M. A., Machin, S. J., Vox Sang. 2010, 99, 232-238.
45. Crettaz, D., Sensebe, L., Vu, D. H., Schneider, P., Depasse, F., Bienvenut, W.-V., Quadroni, M., Tissot, J.-D., Proteomics 2004, 4, 881-891.
46. Cardo, L. J., Rentas, F. J., Ketchum, L., Salata, J., Harman, R., Melvin, W., Weina, P. J., Mendez, J., Reddy, H., Goodrich, R., Vox Sang. 2006, 90, 85-91.
47. Smith, J., Rock, G., Transfusion 2010, 50, 926-931.
48. Steil, L., Thiele, T., Hammer, E., Bux, J., Kalaus, M., Völker, U., Greinacher, A., Transfusion 2008, 48, 2356-2363.
49. Mast, A. E., Stadanlick, J. E., Lockett, J. M., Dietzen, D. J., Blood 1999, 94, 3922-3927.
50. Anderson, L., Anderson, N. G., Mol. Cell. Proteomics 2002, 1, 845-867.
51. Belgacem, O., Stübiger, G., Allmaier, G., Buchacher, A., Pock, K., Biologicals 2007, 35, 43-49.
52. Gaso Sokac, D., Josic, D., Blood Transfusion 2010, 8, s86-s91.
53. Fortis, F., Guerrier, L., Areces, L. B., Antonioli, P., Hayes, T., Carrick, K., Hammond, D., Boschetti, E., Righetti, P. G., J. Proteome Res. 2006, 5, 2577-2585.
54. Thulasiraman, V., Lin, S., Gheorghiu, L., Lathrop, J., Lomas, L., Hammond, D., Boschetti, E., Electrophoresis 2005, 26, 3561-3571.
55. Lee, Y. Y., Wong, K. T. K., Tan, J., Toh, P. C., Mao, Y., Brusic, V., Yap, M. G. S., J. Biotechnol. 2009, 143, 34-43.
56. Cherin, P., Cabane, J., BioDrugs 2010, 24, 211-223.
57. Buchacher, A., Iberer, G., Biotechnol. J. 2006, 1, 148-163.
58. Radoshevich, M., Burnouf, T., Vox Sang. 2010, 98, 12-28.
59. Buchacher, A., Schluga, P., Mullner, J., Schreiner, M., Kannicht, C., Weinberger, J., Vox Sang. 2010, 98, 209-218.
60. Bussone, G., Dib, H., Dimitrov, J. D., Camoin, L., Broussard, C., Tamas, N., Guillevin, L., Kaveri, S. V., Mouthon, L., Proteomics 2009, 9, 2253-2262.
61. Debes, A., Bauer, M., Kremer, S., Pharmacoepidemiol. Drug Safety 2007, 16, 1038-1047.
62. Robak, T., Mainau, C., Pyringer, B., Chojnowski, K., Warzocha, K., Dmoszynska, A., Straub, J., Imbach, P., Hematology 2010, 15, 351-359.
63. Burkitt, W., Domann, P., O'Connor, G., Protein Sci. 2010, 19, 826-835.
64. Yang, X., Clifton, J., Huang, F., Kovac, S., Hixson, D. C., Josic, D., Electrophoresis 2009, 30, 1185-1193.
65. Page, M., Ling, P., Dilger, M., Bentley, T., Forsey, T., Longstaff, C., Thorpe, R., Vox Sang. 1995, 69, 183-194.
66. Guo, A., Han, M., Martinez, T., Ketchem, R. R., Novick, S., Jochheim, C., Balland, A., Electrophoresis 2008, 29, 2550-2556.
67. Wuhrer, M., Stam, J. C., Van de Geijn, F., Koeleman, C. A. M., Verrips, C. T., Dolhain, R. J. E. M., Hokke, C. H., Deelder, A. M., Proteomics 2007, 7, 4070-4081.
68. Huhn, C., Selman, M. H. J., Ruhaak, L. R., Deelder, A. M., Wuhrer, M., Proteomics 2009, 9, 882-913.
69. Knezevic, A., Polasek, O., Gornik, O., Rudan, I., Campbell, H., Hayward, C., Wright, A., Kolcic, I., J. Proteome Res. 2008, 7, 694-701.
70. Sapan, C. V., Reisner, H. M., Lundblad, R. L., Vox Sang. 2007, 92, 197-205.
71. Sadler, J. E., Ann. Rev. Biochem. 1998, 67, 395-424.
72. Lenting, P. J., van Mourik, J. A., Mertens, K., Blood 1998, 92, 3983-3996.
73. Cawthern, K. M., van't Veer, C., Lock, J. B., DiLorenzo, M. E., Branda, R. F., Mann, .K. G. Blood 1998, 91, 4581-4592.
74. Sadler, J. E., Budde, U., Eikenboom, J. C. J., Favaloro, E. J., Hill, F. G. H., and members of the Working Party on von Willebrand Disease Classification, J. Thromb. Haemost. 2006, 4, 2103-2114.
75. Mannucci, P. M., Haemophilia 1998, 4, 661-664.
76. Nasheim, M., Pittman, D. D., Giles, A. R., Fass, D. N., Wang, J., Slonsky, D., Kaufman, R. J., J. Biol. Chem. 1991, 266, 17815-17820.
77. Kasper, C. K., Lusher, J. M., and the Transfusion Practices Committee of the American Association of Blood Banks, Transfusion 1993, 33, 422-434.
78. Pock, K., Rizzi, A., Josic, D., J. Chromatogr. A 1999, 852, 175-188.
79. Josic, D., Buchacher, A., Kannicht, C., Lim, Y.-P., Löster, K., Pock, K., Robinson, S., Schwinn, H., Stadler, M., Vox Sang. 1999, 77, 90-99.
80. Tuddenham, E. G., J. Thromb. Haemost. 2003, 127, 379-391.
81. Mazsaroff, I., Yu, W., Kelley, B. D., Vath, J. E., Anal. Chem. 1997, 69, 2517-2524.
82. Andersen, D. C., Goochee, C. F., Curr. Opin. Biotechnol. 1994, 5, 546-549.
83. Kaufman, R. J., Ann. Hematol. 1991, 63, 155-165.
84. Leyte, A., van Schijndel, H. B., Niehrs, C., Huttner, W. B., Verbeet, M. P., Mertens, K., van Mourik, J. A.., J. Biol. Chem. 1991, 266, 740-746.
85. Kaufman, R. J., Thromb. Haemostasis 1998, 79, 1068-1079.
86. Kasper, C. K., Haemophilia 2002, 8, 161-165.
87. Gomperts, E. D., Haemophilia 2006, 12, 573-578.
88. Iorio, A., Marcucci, M., Marchesini, E., Manucci, P., J. Thromb. Haemost. 2009, 7, 115.
89. Goudemand, J., Rotschild, C., Demiguel, V., Vinciguerrat, C., Thierry Lambert, T., Chambost, H., Borel-Derlon, A., Blood 2006, 107, 46-51.
90. Rosendaal, F. R., Nieuwenhuis, H. K., van den Berg, H. M., Heijboer, H., and Dutch Hemophilia Study Group, Blood 1993, 81, 2180-2186.
91. Butenas, S., Parhami-Seren, B., Gissel, M. T., Gomperts, E. D., Fass, D. N., Mann, K. G., Haemophilia 2009, 15, 63-72.
92. Ansong, C., Miles, S. M., Fay, P. J., J. Thromb. Haemost. 2009, 4, 842-847.
93. Lenting, P. J., Pegon, J. N., Christophe, O. D., Denis, C. V., Haemophilia 2010, 16, 194-199.
94. Bihoreau, N., Veillon, J. F., Ramon, C., Scoyers, M., Schmitter, J. M., Rapid Commun. Mass Spectrom. 1995, 9, 1584-1588.
95. Severs, J. C., Carnine, M., Eguizabal, H., Mock, K. K., Rapid Commun. Mass Spectrom. 1999, 13, 1016-1023.
96. Kolind, M. P., Norbi, P. L., Flintegaard, T. V., Bertchold, M. W., Johnsen, L. B., J. Biotechnol. 2010, 147, 198-204.
97. MCKinnon, T. A. J., Chion, A. C. K., Birdsey, G., Laffan, M. A., J. Thromb. Haemost. 2009, 4, 127.
98. Fang, H., Wang, L., Wang, H., Thromb. Res. 2007, 119, 1-13.
99. Camire, R. M., Bos, M. H. A., J. Thromb. Haemost. 2009, 7, 1951-1961.
100. Liu, Z., Lin, L., Yuan, C., Nicolaes, G. A. F., Chen, L., Meehan, E. J., Furie, B., Furie, B., Huang, M., J. Biol. Chem. 2010, 285, 8824-8829.
101. Ngo, J. C. K., Huang, M., Roth, D., Furie, B. C., Furie, B., Structure 2008, 16, 597-606.
102. Pantazatos, D., Gessner, C. R., Woods, V. L., Gilbert, G. E., J. Thromb. Haemost. 2009, 4, 199.
103. Kemptner, J., Marchetti-Deschmannn, M., Muller, R., Ivens, A., Turecek, P., Schwarz, H. P., Allmaier, G., Rapid Commun. Mass Spectrom. 2010, 24, 761-767.
104. Vonhoff, S., Condfiffe, J., Sciffter, H., J. Pharm. Biomed. Anal. 2010, 51, 39-45.
105. Lin, Y., Yang, X., Chevrier, M.-C., Barrowcliffe, T. W., Lemieux, R., Ofosu, F. A., Haemophilia 2004, 10, 459-469.
106. Clifton, J. G., Huang, F., Kovac, S., Yang, X., Hixson, D. C., Josic, D., Electrophoresis 2009, 30, 3636-3646.
107. Basilico, F., Nardini, I., Mori, F., Brambilla, E., Benazzi, L., De Palma, A., Rosti, E., Farina, C., Mauri, P., J. Pharm. Biomed. Anal. 2010, 53, 50-57.
108. Timperio, A. M., Gevi, F., Grazzini, G., Vaglio, S., Zolla, L., Blood Transf. 2010, 8, S98-S104.
109. Josic, Dj., Hoffer, L., Buchacher, A., J. Chromatogr. B 2003, 790, 183-197.
110. Benzakour, O., Thromb. Haemost. 2008, 100, 527-529.
111. Larson, P. J., Stanfiel-Oakley, S. A., van Dusen, W. J., J. Biol. Chem. 1996, 271, 3869-3876.
112. Schmidt, A. E., Bajaj, S. P., Trends Cardiovasc. Med. 2003, 13, 39-45.
113. Warrier, I., Ewenstein, B. M., Koerper, M. A., Shapiro, A., Key, N., DiMichele, D., Miller, R. T., Pasi, J., Rivard, G. E., Sommer, S. S., Katz, J., Bergmann, F., Ljung, R., Petrini, P., Lusher, J. M., J. Pediatr. Hematol. Oncol. 1997, 19, 23-27.
114. Burnouf, T., Michalski, C., Goudemand, M., Huart, J. J., Vox Sang. 1989, 57, 225-232.
115. Brandstetter, H., Bauer, M., Huber, P., Lollar, P., Bode, W., Proc. Natl. Acad. Sci. USA 1995, 92, 9796-9800.
116. Zucker, M., Landau, M., Rosenberg, N., Seligsohn, U., J. Thromb. Haemost. 2009, 7, 134.
117. Toby, G., Peters, R. T., Bitonti, A. J., J. Thromb. Haemost. 2009, 7, 134.
118. Wang, S., Beck, R., Blench, T., Burd, A., Buxton, S., Malic, M., Ayele, T., Shaikh, S., Chahwala, S., Chander, C., Holland, R., Merette, S., Zhao, L., Blackney, M., Watts, A., J. Med. Chem. 2010, 53, 1465-1472.
119. Monahan, P. E., Di Paola, J., Semin. Thromb. Hemost. 2010, 36, 498-509.
120. Gomperts, E. D., Lee, M., Nichols, T., Griffith, M., J. Thromb. Haemost. 2009, 7, 135.
121. Kay, M. A., Manno, C. S., Ragni, M. V., Larson, P. J., Couto, L. B., McClelland, A., Glader, B., Chew, A. J., Tai, S. J., Herzog, R. W., Arruda, V., Johnson, F., Scallan, C., Skarsgard, C., Flake, A. W., High, K. A., Nat. Genet. 2000, 24, 257-261.
122. Bicocchi, M. P., Pasino, M., Rosano, C., Molinari, A. C., Della Valle, E., Lanza, T., Bottini, F., Acquila, M., Haemophilia 2006, 12, 263-270.
123. Enjolras, N., Plantier, J.-L., Rodriguez, M.-H., Rea, M., Attali, O., Vinciguerra, C., Negrier, C., J. Thromb. Haemost. 2004, 2, 1143-1154.
124. Peters, R. T., Low, S. C., Kamphaus, G. D., Dumont, J. A., Amari, J. V., Lu, Q., Zarbis-Papastoitsis, G., Reidy, T. J., Merricks, E. P., Nichols, T. C., Bitonti, A. J., Blood 2010, 115, 2057-2064.
125. Lin, C. N., Kao, C. Y., Miao, C. H., Hamaguchi, N., Wu, H. L., Shi, G. Y., Liu, Y. L., J. Thromb. Haemost. 2010, 8, 1773-1783.
126. Hansen, L., Ostergaad, H., Tranholm, M., Agersoe, H., J. Thromb. Haemost. 2009, 7, 134.
127. Rasmussen, N., Ditzel, H. J., J. Proteome Res. 2010, 8, 5048-5059.
128. Muller, E., Josic, D., Schroeder, T., Moosmann, A., J. Chromatogr. A 2010, 1217, 4696-4703.
129. Fischer, B., Mitterer, A., Dorner, F., J. Biotechnol. 1995, 38, 129-136.
130. Kavakli, K., Haemophilia 1999, 5, 392-396.
131. Coughin, S. R., Nature 2000, 407, 258-264.
132. Huntington, J. A., J. Thromb. Haemost. 2005, 3, 1861-1872.
133. Manseth, E., Skjervold, P. O., Flengsrud, R., J. Biochem. Biophys. Methods 2004, 60, 39-47.
134. Frasson, R., Pozzi, N., Johnson, D. J. D., Huntington, J. A., De Fillips, V., J. Thromb. Haemost. 2009, 7, 230.
135. Levi, M., Peters, M., Bueller, H. R., Crit. Care Med. 2005, 33, 883-890.
136. Ohkubo, Y. Z., Morrissey, J. H., Tajkhorshid, E., J. Thromb. Haemost. 2010, 8, 1044-1053.
137. Abshire, T., Kenet, G., J. Thromb. Haemost. 2004, 2, 899-909.
138. Pinotti, M., Rizzotto, L., Pinton, P., Ferraresi, P., Chuansumrit, A., Charoenkwan, P., Marchetti, G., Rizzuto, R., Mariani, G., Bernardi, F.; International Factor VII Deficiency Study Group, J. Thromb. Haemost. 2006, 4, 1308-1314.
139. Margaritis, P., Roy, E., Aljamali, M. N., Downey, H. D., Giger, U., Zhou, S., Merricks, E., Dillow, A., Ezban, M., Nichols, T. C., High, K. A., Blood 2009, 113, 3682-3689.
140. Olsen, O. H., Rand, K. D., Ostergaard, H., Persson, E., Prot. Sci. 2007, 16, 671-682.
141. Khing, J., Nature Biotechnol. 2009, 24, 302-304.
142. Heger, A., Grunert, T., Schulz, P., Josic, Dj., Buchacher, A., Thromb. Res. 2002, 106, 157-164.
143. Plematl, A., Demelbauer, U. M., Josic, Dj., Rizzi, A., Proteomics 2005, 5, 4025-4033.
144. Demelbauer, U. M., Plematl, A., Josic, D., Allmaier, G., Rizzi, A., J. Chromatogr. A 2005, 1080, 15-21.
145. Kremser, L., Bruckner, A., Heger, A., Grunert, T., Buchacher, A., Josic, D., Allmaier, G., Rizzi, A., Electrophoresis 2003, 24, 4282-4290.
146. Demelbauer, U. M., Plematl, A., Kremser, L., Allmaier, G., Josic, D., Rizzi, A., Electrophoresis 2004, 25, 2026-2032.
147. Zhou, Q., Kyazike, J., Echelard, Y., Maede, H. M., Higgins, E., Cole, E. S., Edmunds, T., J. Biotechnol. 2005, 117, 57-72.
148. Kolarich, D., Turecek, P., Weber, A., Mitterer, A., Graninger, M., Matthiessen, P., Nicolaes, G. A. F., Altmann, F., Schwarz, H. P., Transfusion 2006, 46, 1959-1977.
149. Kolarich, D., Weber, A., Turecek, P. L., Scgwarz, H.-P., Altman, F., Proteomics 2006, 6, 3369-3380.
150. Mathiessen, H. P., Willemse, J., Weber, A., Turecek, P. L., Deiteren, K., Hendriks, D., Ehrlich, H. J., Schwarz, H.-P., Transfusion 2008, 48, 314-320.
151. Griffiths, S., Cooney, C. L., J. Chromatogr. A 2002, 942, 133-143.
152. Josic, Dj., Brown, M. K., Huang, F., Lim, Y.-P., Rucevic, M., Clifton, J. G., Hixson, D., Proteomics 2006, 6, 2874-2885.
153. Mizon, C., Heron, A., Capon, C., Sautiere, P., Michalski, C., Sesboue, R., Mizon, J., J. Chromatogr. B 1997, 692, 281-291.
154. Mohamed, E., Abdul-Rahman, P. S., Doustjalali, S. R., Chen, Y., Lim, B.-K., Omar, S. Z., Bustam, A. Z., Singh, V. A., Mohd-Taib, N. A., Yip, C. H., Hashim, O. H., Electrophoresis 2008, 29, 2645-2650.
155. Weber, A., Butterweck, H., Mais-Paul, U., Teschner, W., Lei, L., Muchitsch, E.-M., Kolarich, D., Altmann, F., Ehrlich, H. J., Schwarz, H. P., Vox Sang 2011, 100, 285-297.
156. Kolarich, D., Weber, A., Pabst, M., Stadlmann, J., Teschner, W., Ehrlich, H., Schwarz, H.-P., Altmann, F., Proteomics 2008, 8, 254-263.
157. Wu, S. L., Kim, J., Karger, B. L., J. Proteome Res. 2005, 4, 1155-1167.
158. Wu, S., Kim, J., Bandle, R. W., Liotta, L., Petricoin, E., Karger, B. L., Mol. Cell. Proteomics 2006, 5, 1610-1627.
159. Zeng, X., Wu, S. L., Hancock, W. S., Int. J. Pharm. 2006, 322, 136-145.
160. Jiang, H., Wu, S.-L., Karger, B. L., Hancock, W. S., Anal. Chem. 2010, 82, 6154-6162.
161. Lu, Q., Zheng, X., McIntosh, T., Davis, H., Nemeth, J. F., Pendley, C., Wu, S.-L., Hancock, W. S., Anal. Chem. 2009, 81, 8715-8723.
162. Rafalko, A., Iliopoulos, O., Fusaro, V. A., Hancock, W., Hincapie, M., Anal. Chem. 2010, 82, 8998-9005.
163. Wu, S-L., Jiang, H., Lu, Q., Dai, S., Hancock, W. S., Karger, B. L., Anal. Chem. 2009, 81, 112-122.