Trp2313-his2315 of factor VIII C2 domain is involved in membrane binding: Structure of a complex between the C2 domain and an inhibitor of membrane binding

Journal of Biological Chemistry

Volumn 285, Issue 12, 2010, Pages 8824-8829

  Liu, Zhuo ^a,e   Lin, Lin ^b   Yuan, Cai ^a   Nicolaes, Gerry A F ^c   Chen, Liqing ^d   Meehan, Edward J ^d   Furie, Bruce ^b   Furie, Barbara ^b   Huang, Mingdong ^a,b  

^a FUJIAN INSTITUTE OF RESEARCH ON THE STRUCTURE OF MATTER   (China)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MAASTRICHT UNIVERSITY   (Netherlands)

^d UNIVERSITY OF ALABAMA IN HUNTSVILLE   (United States)

^e UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING MOTIF; BLOOD COAGULATION; CALCIUM IONS; CARBOXYL-TERMINAL; CRYSTALLIZATION CONDITIONS; FACTOR IXA; FACTOR VIII; FACTOR X; HEMOPHILIA A; HIGH RESOLUTION; HIGH THROUGHPUT SCREENING; MEMBRANE BINDING; MEMBRANE SURFACE; MOLECULAR INHIBITORS; MOLECULAR MECHANISM; RISK FACTORS; STRUCTURE-BASED; VON WILLEBRAND FACTOR;

BINDING SITES; BLOOD; CALCIUM; CELL MEMBRANES; COAGULATION; COMPLEXATION; CYTOLOGY; LAWS AND LEGISLATION; MEMBRANES; PHOSPHOLIPIDS;

CRYSTAL STRUCTURE;

BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 8 C2 DOMAIN; HISTIDINE; TRYPTOPHAN; UNCLASSIFIED DRUG; PHOSPHOLIPID; VON WILLEBRAND FACTOR;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; NONHUMAN; PICHIA PASTORIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN STRUCTURE; BLOOD CLOTTING; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; METABOLISM; METHODOLOGY; PROTEIN TERTIARY STRUCTURE; RISK; SURFACE PLASMON RESONANCE; THROMBOEMBOLISM; X RAY CRYSTALLOGRAPHY;

BLOOD COAGULATION; CELL MEMBRANE; CRYSTALLOGRAPHY, X-RAY; FACTOR VIII; HISTIDINE; HUMANS; MODELS, MOLECULAR; PHOSPHOLIPIDS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RISK; SURFACE PLASMON RESONANCE; THROMBOEMBOLISM; TRYPTOPHAN; VON WILLEBRAND FACTOR;

EID: 77950576377     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.080168     Document Type: Article

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